C-PEPTIDES NYOB RAU HAUV COV NTSHAV QAB ZIB

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Nrog rau txhua yam ntawm cov ntshav qab zib mellitus, kev saib xyuas nws tus mob yog qhov tseem ceeb heev rau tus neeg mob.

Ua ntej tshaj plaws, nws yog tshuaj saib ntshav qab zib hauv ntshav. Cov txheej txheem no tuaj yeem xyaum nrog kev pab ntawm cov tib neeg kuaj mob - glucometers. Tab sis tsis muaj tsawg tshaj li qhov tseem ceeb yog kev tsom xam ntawm C-peptide - qhov taw qhia ntawm cov tshuaj insulin hauv lub cev thiab cov metabolism hauv cov metabolism. Xws li kev tshawb nrhiav tsuas yog ua hauv chav kuaj: tus txheej txheem yuav tsum tau nqa tawm tsis tu ncua rau cov neeg mob ntshav qab zib ntawm ob hom.

Dab tsi yog C-peptide

Kev kawm kho mob muab lub ntsiab txhais nram qab no:

C-peptide yog ib qho ruaj khov ntawm cov khoom siv los ua ke hauv tib neeg lub cev - proinsulin.

C-peptide thiab insulin raug cais thaum tsim kev ua tiav ntawm qhov kawg: yog li, qib C-peptide qhia ncaj qha txog theem ntawm insulin.

Cov xwm txheej tseem ceeb hauv kev lees rau C-peptide tshuaj yog:

Kev kuaj mob ntshav qab zib mellitus thiab kev sib txawv ntawm hom I thiab ntshav qab zib hom II;
Kev kuaj mob ntawm insulinoma (mob qog lossis mob hlav ntawm cov txiav);
Txheeb xyuas cov khoom seem ntawm cov nqaij ntshiv uas twb muaj lawm tom qab tshem tawm (rau mob qog nqaij hlav hauv lub cev);
Kev kuaj mob ntawm daim siab mob;
Kev kuaj mob ntawm polycystic ovary;
Kev ntsuam xyuas cov tshuaj insulin ntau ntau hauv daim siab mob siab;
Kev soj ntsuam kev kho mob ntshav qab zib.

C-peptide synthesized nyob hauv lub cev li cas? Proinsulin, uas tsim nyob rau hauv lub txiav (ntau dua qhov tseeb, nyob rau hauv β-hlwb ntawm pancreatic islets), yog qhov loj polypeptide saw uas muaj 84 amino acid seem. Hauv daim foos no, cov tshuaj tsis pub ua los ntawm cov tshuaj hormones keeb kwm.

Kev hloov pauv ntawm cov tsis muaj zog proinsulin rau insulin tshwm sim los ntawm kev txav ntawm cov proinsulin los ntawm cov ribosomes hauv lub hlwb mus rau cov roj ntsha secretory los ntawm cov txheej txheem ntawm ib feem ntawm kev faib tawm ntawm cov qauv. Nyob rau tib lub sijhawm, 33 amino acid residues, paub tias txuas peptide lossis C-peptide, tau muab pov tseg los ntawm ib kawg ntawm cov saw.

Hauv cov ntshav, yog li ntawd, muaj qhov hais tawm txog qhov sib cuam tshuam ntawm tus nqi ntawm C-peptide thiab insulin.

Vim li cas kuv thiaj yuav tsum kuaj C-peptide?

Txhawm rau kom nkag siab meej ntawm cov ncauj lus, koj yuav tsum nkag siab yog vim li cas cov chaw soj nstuam xyuas kev soj ntsuam ntawm C-peptide, thiab tsis nyob rau ntawm insulin tseeb.

Cov xwm txheej hauv qab no pab txhawb rau qhov no:

Ib nrab-lub neej ntawm peptide nyob rau hauv cov hlab ntshav ntev dua li cov kua dej, yog li thawj qhov ntsuas yuav ruaj khov;
Kev soj ntsuam tshuaj rau C-peptide tso cai rau koj los ntsuas kev tsim tawm cov tshuaj insulin txawm tias tiv thaiv keeb kwm yav dhau los ntawm kev muaj cov tshuaj tua hluav taws xob hauv cov ntshav (hauv cov lus kho mob - C-peptide tsis "hla dhau" nrog insulin);
Kev soj ntsuam rau C-peptide muab kev soj ntsuam txaus ntawm cov tshuaj insulin ntau ntau txawm tias muaj cov tshuaj tiv thaiv kab mob autoimmune hauv lub cev, uas tshwm sim hauv cov neeg mob ntshav qab zib hom I.

Kev npaj tshuaj insulin tsis muaj C-peptide, yog li, kev txiav txim siab ntawm qhov sib xyaw no hauv cov ntshav cov ntshav tso cai rau peb soj ntsuam cov haujlwm ntawm pancreatic beta hlwb hauv cov neeg mob kho. Qib ntawm cov hauv paus C-peptide, thiab tshwj xeeb tshaj yog cov tshuaj lom ntawm cov khoom no tom qab cov piam thaj tso rau hauv, ua rau nws muaj peev xwm txiav txim siab qhov chaw muaj qhov tsis hnov (lossis tawm tsam) ntawm tus neeg mob rau insulin. Yog li, cov theem ntawm kev tshem tawm lossis exacerbation tau tsim thiab kho cov txheej txheem tau kho.

Nrog exacerbation ntawm ntshav qab zib mellitus (tshwj xeeb tshaj yog hom I), cov ntsiab lus ntawm C-peptide hauv cov ntshav muaj tsawg: qhov no yog cov pov thawj ncaj qha ntawm cov tsis muaj peev xwm ntawm cov tshuaj insulin endogenous (sab hauv). Txoj kev kawm txog kev tsom tawm ntawm cov txuas peptide tso cai rau kev soj ntsuam ntawm insulin secretion hauv ntau qhov xwm txheej.

Qhov piv ntawm insulin thiab C-peptide yuav hloov pauv yog tias tus neeg mob tau mob siab rau lub siab thiab lub raum.

Cov tshuaj insulin yog qhov tseem ceeb hauv daim siab ua rau daim siab, thiab C-peptide ua rau sab hauv ob lub raum. Yog li, qhov ntsuas ntawm qhov ntau npaum li cas ntawm C-peptide thiab insulin yuav yog qhov tseem ceeb rau kev txhais kom raug ntawm cov ntaub ntawv hauv cov kab mob ntawm daim siab thiab lub raum.

Kev tsom xam ntawm C-peptide li cas

Kev kuaj ntshav rau C-peptide feem ntau yog ua tawm ntawm lub plab khoob, tshwj tsis yog muaj kev qhia tshwj xeeb los ntawm tus kws endocrinologist (tus kws tshaj lij no yuav tsum tau sab laj yog tias koj xav tias muaj kab mob metabolic). Lub sijhawm ua kev yoo mov ua ntej muab ntshav yog 6-8 teev: lub sijhawm zoo tshaj plaws rau kev muab ntshav yog thaum sawv ntxov tom qab sawv.

Qhov ntsuas ntshav nws tus kheej tsis txawv ntawm qhov ib txwm muaj: ib qho hlab ntsha raug punctured, cov ntshav tau sau rau hauv lub raj khoob (qee zaum ib lub raj siv gel siv). Yog hais tias hematomas daim ntawv tom qab venipuncture, tus kws kho mob sau ib qho khoom sov kom sov. Cov ntshav tso tawm yog khiav los ntawm lub centrifuge, cais cov ntshav dej, thiab khov, thiab tom qab ntawd kuaj hauv qhov chaw kuaj ntshav kuaj mob hauv qab tsom tsom siv cov tshuaj reagents.

Nws tshwm sim uas nyob rau ntawm lub plab khoob theem ntawm C-peptide hauv cov ntshav sib raug raws li kev txwv lossis yog ntawm nws thaj chaw qis. Qhov no tsis muab cov kws kho mob rau kev kuaj mob tseeb. Nyob rau hauv xws li mob stimulated xeem.

Raws li cov ntsiab lus txhawb zog, cov kev ntsuas hauv qab no tuaj yeem siv:

Kev txhaj tshuaj ntawm ib qho insulin antagonist - glucagon (rau cov neeg muaj ntshav siab, txoj kev coj ua no yog contraindicated);
Ua tshais mov noj ua ntej tsom xam (tsuas yog noj 2-3 "chav ua mov ci").

Qhov kev xaiv zoo tshaj plaws rau kev kuaj mob yog ua 2 qhov kev ntsuam xyuas:

kev soj ntsuam yoo mov
tsa.

Thaum txheeb xyuas hauv lub plab khoob, koj raug tso cai rau haus dej, tab sis koj yuav tsum tsis kam noj cov tshuaj uas cuam tshuam qhov tseeb ntawm kev tshuaj ntsuam. Yog tias cov tshuaj tsis tuaj yeem raug tshem tawm vim kev mob, qhov tseeb no yuav tsum muaj qhia hauv daim foos xa mus.

Qhov tsawg kawg nkaus tsom xam npaj lub sijhawm yog 3 teev. Archive whey khaws cia ntawm -20 ° C tuaj yeem siv rau 3 lub hlis.

Dab tsi yog cov ntsuas ntawm kev txheeb xyuas rau C-peptides

Kev hloov pauv hauv theem ntawm C-peptide hauv cov ntshav dej ua kom haum rau cov nqi ntawm cov tshuaj insulin hauv cov ntshav. Cov ncauj lus ceev ceev peptide cov ntsiab lus nyob ntawm 0.78 txog 1,89 ng / ml (hauv SI system, 0.26-0.63 mmol / l).

Rau kev kuaj mob ntawm insulinoma thiab nws qhov sib txawv ntawm qhov cuav (qhov tseeb) hypoglycemia, qhov sib piv ntawm theem C-peptide mus rau theem ntawm insulin yog txiav txim siab.

Yog tias qhov sib piv yog ib qho lossis tsawg dua tus nqi no, qhov no qhia tau qhov nce ntawm cov kua dej sab hauv. Yog tias cov ntsuas yuav ntau dua 1, qhov no yog pov thawj ntawm kev qhia txog cov tshuaj insulin sab nraud.

Txhawb nqa qib

Qhov xwm txheej thaum qib C-peptide nce siab yuav qhia tau cov kab hauv qab no:

Ntshav Qab Zib Hom II;
Insulinoma;
Itsenko-Cushing's disease (kab mob neuroendocrine los ntawm kev ua rau lub qog mob);
Raum tsis ua haujlwm;
Kab mob siab (mob ntsws, mob siab);
Polycystic lub zes qe menyuam;
Tus txiv neej rog;
Kev siv ntev ntev ntawm estrogens, glucocorticoids, lwm yam tshuaj hormonal.

Cov qib C-peptide siab heev (thiab yog li insulin) yuav qhia tau tias kev qhia txog cov kua qab zib ua rau muaj qhov ncauj qis dua. Nws yuav yog qhov txiaj ntsig los ntawm kev hloov kho lub paj hlwb los yog hloov khoom nruab nrog cev.

Qib theem

Qes qis hauv kev sib piv nrog qib qub ntawm C-peptide raug pom thaum:

Ntshav Qab Zib Hom 1;
Khoom neeg ntshav siab;
Radical pancreatic tshem tawm txoj kev phais.

C peptide muaj nuj nqi

Cov neeg nyeem yuav muaj lus nug cov laj thawj: vim li cas peb thiaj li yuav tsum muaj C-peptides hauv lub cev?

Txog thaum nyuam qhuav, tau ntseeg tias seem ntawm cov amino acid saw yog lom tsis muaj sia thiab yog cov khoom lag luam tsim los ntawm cov kua dej. Tab sis cov kev tshawb fawb tsis ntev los no los ntawm endocrinologist thiab cov kws kho ntshav qab zib tau ua rau qhov kev txiav txim siab tias cov tshuaj tsis muaj txiaj ntsig thiab ua lub luag haujlwm hauv lub cev, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib.

Raws li cov lus qhia tsis tau lees paub, txoj kev tswj hwm tib lub sijhawm ntawm C-peptide thaum lub sij hawm insulin txoj kev kho rau cov neeg mob ntshav qab zib tso cai kom tsis txhob muaj cov kev mob hnyav ntawm cov kab mob li nephropathy (lub raum tsis ua haujlwm), neuropathy thiab angiopathy (kev puas tsuaj rau cov hlab ntsha thiab cov hlab ntshav,).

Nws yog tau tias nyob rau yav pem suab C-peptide npaj yuav muab nrog ua ke nrog insulin rau cov ntshav qab zib, tab sis tam sim no qhov kev pheej hmoo txaus ntshai thiab kev mob tshwm sim ntawm kev kho mob tsis tau txiav txim siab hauv chaw kho mob. Kev tshawb nrhiav dav nyob ntawm cov ncauj lus no tseem tsis tau tuaj.

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