Cov tshuaj Siofor 1000, cov lus qhia rau kev siv uas yog qhov tseem ceeb heev rau kev kho kom zoo ntawm tus kabmob, belongs rau cov pab pawg ntawm biguanides. Mob ntshav qab zib mellitus yog ib qho mob loj heev uas feem ntau tsis yooj yim kho.
Yuav kom ntseeg tau tias cov nyhuv raug kho tau, tus neeg mob yuav tsum hloov pauv nws txoj kev ua neej. Tab sis nrog ntshav qab zib hom II (uas tsis yog-insulin-tiv thaiv), tsuas yog hloov pauv hauv kev noj zaub mov noj thiab qoj ib ce tsis txaus. Txhawm rau txhim kho tus mob, cov tshuaj tshwj xeeb tau sau tseg rau tus neeg mob, ib qho yog Siofor 1000.
Cov tshuaj no yog rau cov neeg laus thiab menyuam yaus hnub nyoog 10 xyoo. Raws li tau sau tseg hauv kev txheeb xyuas, cov tshuaj no feem ntau tau hais rau cov neeg mob rog rog, qhia tias cov txheej txheem ib txwm ntawm kev hnyav yog qhov tsis muaj txiaj ntsig (kev noj zaub mov zoo, kev tawm dag zog). Hauv qhov no, cov tshuaj yuav pab txo qis qhov uas muaj ntshav qab zib hauv cov khoom nruab nrog cev.
Txog kev kho mob ntshav qab zib hauv cov neeg laus, cov tshuaj Siofor tau raug tso tawm ua ke nrog lwm cov tshuaj tsom rau txo cov ntshav qabzib hauv cov ntshav. Cov tshuaj no suav nrog cov tshuaj rau qhov ncauj tswj hwm, nrog rau cov tshuaj insulin. Ib qho ntxiv, Siofor yog tshuaj yam tsis tau siv tshuaj ntxiv. Rau cov menyuam yaus, tsuas yog Siofor yog cov kws kho mob tshwj xeeb tshaj yog tsis muaj cov tshuaj ntxiv (tshwj tsis yog thaum tsim nyog insulin txhaj tshuaj)
Pharmacodynamics thiab pharmacokinetics ntawm cov tshuaj
Cov tshuaj Siofor 1000 belongs rau biguanides - ib pawg ntawm cov tshuaj hypoglycemic rau cov kab mob ntshav qab zib tsis yog-insulin. Pharmacological kev ua ntawm Siofor yog tsom rau txo qis dua ntawm cov piam thaj hauv cov ntshav, uas yog, nws muaj cov nyhuv tshuaj tiv thaiv kab mob.
Cov tshuaj muaj cov nyhuv cuam tshuam hauv ntau cov lus qhia. Ua ntej tshaj plaws, cov txheej txheem ntawm kev tsim khoom thiab kev nqus ntawm cov piam thaj los ntawm kev mob plab hnyuv tau ua kom qeeb. Tib lub sijhawm, insulin tsis kam (insulin tsis kam) tsawg.
Tsis tas li ntawd, nyob rau hauv txoj kev ntawm Siofor 1000, kev siv qab zib txhim kho, lipid metabolism yog nrawm. Ua tsaug rau qhov no, tsis tsuas yog nws muaj peev xwm txhim kho me ntsis ntawm kev noj qab haus huv ntawm tus neeg mob, tab sis kuj, yog tias tsim nyog, pab ua kom poob phaus. Tsis tas li ntawd, cov tshuaj yeeb tshuaj muaj peev xwm txo qis kev qab los noj mov, uas tseem yuav pab tau rau hauv kev kho cov rog dhau.
Tsis hais txog qib ntawm cov piam thaj hauv cov ntshav, cov tshuaj pabcuam hauv kev txo qis ntawm cov roj triglycerides, cov roj (cholesterol) - tag nrho cov dav dav thiab qhov ntom ntom.
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj xwb, tab sis muaj ntau yam kev hloov pauv tau:
- cov ntsiav tshuaj tsis tu ncua
- txhawb nqa cov ntsiav tshuaj
- zaj duab xis coated
- nrog enteric txheej.
Txhua cov ntsiav tshuaj muaj qhov tsis yooj yim rau kev sib cais, nrog rau tus snap-tab so ua si.
Cov kev ua haujlwm tseem ceeb ntawm Siofor yog metformin hydrochloride. Cov lus sib xyaw kuj suav nrog titanium dioxide, magnesium stearate, povidone K-25, thiab lwm yam Ib ntsiav tshuaj muaj 1000 mg ntawm cov tshuaj nquag.
Cov pob ntawv yuav ntim nrog 10, 30, 60, 90 lossis 120 ntsiav tshuaj, tab sis tsis yog txhua lub tsev muag tshuaj yuav tag nrho cov kev xaiv rau tshuaj, yog li cov pob nrog ntau cov ntsiav tshuaj yuav tsis muaj.
Cov ntsiab lus siab tshaj plaws ntawm cov tshuaj hauv lub cev tau tiav 2.5 teev tom qab noj tshuaj. Bioavailability (rau tus neeg muaj kev noj qab haus huv) - txog 60%. Cov txiaj ntsig ntawm cov tshuaj feem ntau txiav txim siab los ntawm lub sijhawm ntawm cov pluas noj zaum kawg: yog li, yog tias koj noj cov tshuaj nrog zaub mov, ces nws cov hauj lwm zoo yuav ua rau tsis txawv txav.
Metformin hydrochloride yog xyaum ua tsis tau khi rau cov ntshav protein. Txog rau kev tawm ntawm cov tshuaj los ntawm lub cev, qhov nruab nrab yog 5 teev nrog lub raum tsis ua haujlwm.
Yog tias lawv txoj haujlwm ua tsis tau zoo, kev cia siab ntawm metformin hauv cov ntshav nce siab, txij li lub sijhawm tshem tawm tau nce.
Cov Yuav Tsum Muaj
Txawm hais tias qhov tseeb tias cov tshuaj tau zoo rau ntawm cov neeg mob feem ntau, muaj contraindications rau noj Siofor 1000 ntsiav tshuaj. Lub ntsiab contraindication yog hom ntshav qab zib I.
Cov tshuaj tsis raug sau tseg yog tias koj muaj kev fab tshuaj rau cov tshuaj tsis txuam nrog - metformin hydrochloride - lossis lwm yam tshuaj ntawm cov tshuaj.
Ib qho kev mob uas tshwm sim los ntawm cov ntshav qab zib-insulin muaj peev xwm ua tus sau. Cov no suav nrog, piv txwv, muaj ntau dua li cov piam thaj ntau hauv cov ntshav ntshav, ntshav oxidation vim lub siab cov ntsiab lus ntawm cov khoom lwj (cov ketone lub cev) los ntawm cov qog thiab qee yam. Qhov xwm txheej no tuaj yeem txiav txim siab los ntawm kev mob hnyav hauv plab, txiv hmab txiv ntoo hauv lub qhov ncauj, tsaug zog thiab ua pa nyuaj.
Cov lus qhia ua haujlwm rau kev noj cov tshuaj tseem qhia lwm yam mob thiab cov kab mob uas nws tsis pom zoo kom noj Siofor 1000:
- Nrog rau kev txhim kho ntawm tus mob tsis zoo, vim qhov kev ua txhaum hauv kev ua haujlwm ntawm lub raum tshwm sim, nyob rau ntawm qhov muaj kev kis tus kabmob, nrog rau qhov poob ntawm ib qhov dej tseem ceeb vim ntuav, raws plab, mob ntshav tsis txaus,
- Taw qhia thaum lub sijhawm kawm txog kev sib piv raws li iodine. Xws li cov tshuaj yog siv, piv txwv, hauv kev xoo hluav taws xob.
- Kab mob thiab mob uas ua rau muaj pa oxygen tsis txaus - ua rau lub plawv dhia tsis zoo, raug mob plawv sai ua ntej cov tshuaj kho mob, ua rau cov ntshav khiav tsis zoo, mob raum, raum, mob siab,
- Kev quav dej quav cawv / quav cawv.
Kuj contraindications suav nrog:
- mob ntshav qab zib coma (los yog ua ntej coma mob);
- ketoacidosis;
- starvation noj haus (tsawg dua 1000 kcal / hnub);
- cov menyuam yaus hnub nyoog (txog 10 xyoo);
- nyuam qhuav raug mob lossis raug mob;
- kev kho mob nrawm nrog hom 2 mob ntshav qab zib;
- tas lub zog ntawm insulin ntau lawm.
Yog tias ib qho ntawm cov xwm txheej no tshwm sim, koj yuav tsum sab laj nrog tus kws kho mob kom nws sau tshuaj rau lwm cov tshuaj.
Ib qho kev txwv nruj heev rau kev siv cov tshuaj yog lub caij cev xeeb tub thiab lactation.
Rau kev kho mob hauv qhov no, ntau cov tshuaj insulin-raws li siv tau.
Cov lus qhia rau kev siv tshuaj
Txhawm rau kom ua tiav cov txiaj ntsig yam xav tau, nws yog qhov tsim nyog thaum lub sijhawm kho nrog Siofor 1000, cov lus qhia rau kev siv txhawm rau ua raws li qhov tseeb tau.
Qhov ntau npaum ntawm cov tshuaj tau teeb tsa ib tus zuj zus rau txhua tus neeg mob, nyob ntawm seb cov ntshav qab zib cov ntshav, tom qab ntawd nws yuav kho.
Thaum pib kho, tsis ntau tshaj 1 g ntawm Siofor (500 lossis 850) feem ntau yog kws kho. Tom qab ntawd, kev noj tshuaj txhua lub lim piam tau nce txhua lub lis piam mus rau 1.5 g, uas sib raug rau 3 ntsiav tshuaj ntawm Siofor 500 lossis 2 ntsiav tshuaj ntawm Siofor 850.
Rau cov tshuaj Siofor, 1000 mg ntawm qhov nruab nrab yog suav tias yog los ntawm 2 g (i.e. 2 ntsiav tshuaj), tab sis tsis ntau tshaj 3 g (3 ntsiav tshuaj), ntawm qhov nruab nrab, raws li ib txwm noj.
Txhawm rau kom cov ntsiav tshuaj ua haujlwm tau txais txiaj ntsig zoo tshaj plaws, nws yog qhov yuav tsum ua raws nraim li cov lus qhia uas tau muab rau hauv cov lus qhia rau cov tshuaj.
Nws yog qhov tsim nyog yuav tsum coj Siofor nrog cov zaub mov. Cov ntsiav tshuaj yuav tsum tsis txhob raug tom lossis ntxo. Hloov pauv, haus dej kom ntau.
Yog tias koj xav noj ntau tshaj 1 ntsiav tshuaj ntawm Siofor nyob rau ib hnub, ces nws raug nquahu kom faib nws ua 2 lossis 3 qhov sib luag thiab nqa txhua nrog ib pluag mov. Kev yuam kev raug mob tsis zoo rau kev noj tshuaj yuav tsum tsis tau ntxiv hauv qab no, noj ob feem ntawm qhov tshuaj.
Lub sijhawm tiv thaiv ntawm kev kho mob uas siv Siofor npaj yog txiav txim los ntawm tus kws kho mob uas tuaj koom.
Raws li twb tau hais, Siofor yog nruj me ntsis contraindicated thaum cev xeeb tub, lactation. Txij li tsis muaj cov ntaub ntawv soj ntsuam raug, cov tshuaj tsis raug cai rau kev kho mob ntawm cov ntshav qab zib insulin-rau cov menyuam yaus.
Ntxiv rau ntshav qab zib, Siofor tso cai rau koj kom sai sai poob phaus. Tab sis thaum tsis muaj hom mob ntshav qab zib hom I, yog tias cov tshuaj yuav tsum siv rau qhov hnyav xwb, koj yuav tsum muaj lub tswv yim zoo uas yuav siv Siofor li cas nyob hauv qhov no. Nyob rau hauv tsis muaj qhov xwm txheej yuav tsum koj tshaj qhov tsawg kawg ntawm 0.5 ntsiav tshuaj Siofor 1000.
Thaum lub cev yuag, nws yog ib qho tseem ceeb kom ua raws kev noj haus thiab ua kom lub cev muaj zog. Yog tias muaj tej yam tshwm sim tshwm sim, nws raug nquahu kom tsis txhob noj cov tshuaj no.
Mus txuas ntxiv chav kawm ntawm kev siv Siofor rau kev poob phaus yog tsis tshaj 3 hlis.
Muaj kev phiv ntau
Zoo li lwm yam tshuaj, nyob rau qee kis, Siofor 1000 tuaj yeem ua rau muaj kev phiv ntau yam, txawm hais tias lawv tsis tshua muaj thiab tsis yog rau txhua tus siv cov tshuaj no.
Feem ntau cov feem ntau, lawv tshwm sim vim muaj ntau dua qhov cia siv tau ntawm cov tshuaj.
Ntawm cov kev nquag muaj, cov kev mob tshwm sim nram qab no yog qhov txawv - xeev siab, ua rau lub cev tsis zoo lossis tsis qab los noj mov, raws plab, hloov ntawm qhov tsis hnov.
Cov kev mob tshwm sim ntawm Siofor feem ntau tshwm sim tsuas yog thaum pib kho nrog cov tshuaj no. Feem ntau lawv dhau tsis muaj kev kho tshwj xeeb tom qab ib ntus. Txhawm rau kom tsis txhob muaj qhov pom ntawm cov tsos mob li no, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam nruj kev noj haus uas tau qhia nyob rau hauv cov lus qhia ntawm txoj cai rau cov tshuaj.
Cov tshuaj pom zoo ntawm cov tshuaj yuav tsum tau muab faib ua 2-3 koob. Yog tias, ua raws li txhua qhov xav tau, cov tsos mob tsis ploj, koj yuav tsum tau sab laj nrog kws kho mob sai.
Cov kev mob tshwm sim hnyav dua yog muaj tsawg:
- Tawv tawv nqaij, khaus, khaus.
- Tawm tsam keeb kwm yav dhau los ntawm kev noj tshuaj, qhov tsis muaj peev xwm ntawm vitamin B12 yuav tshwm sim vim yog megaloblastic anemia (tsis muaj cov ntshav liab),
- Ntau cov teeb meem ntawm cov khoom noj hauv lub cev, piv txwv li, lactate acidosis - ntshav oxidation nyob rau hauv tus ntawm lactic acid. Cov tsos mob ntawm lactic acidosis zoo ib yam li cov kev mob tshwm sim feem ntau (raws plab, ntuav, mob plab). Tab sis tom qab ob peb teev, cov tsos mob hnyav dua tshwm sim (ua pa sai, mob nqaij thiab mob ib ce, tsis nco qab, ua rau tsis nco qab lawm).
Tsis tshua muaj, kev hloov pauv hauv lub xeev ntawm lub siab yog pom: qhov txawv txav ntawm lub siab kuaj ntshav kab mob siab, kab mob siab, nrog mob daj ntseg (lossis tsis muaj nws). Feem ntau cov feem ntau, nrog txoj kev tshem tawm ntawm Siofor, tag nrho cov kev phiv ploj hauv lub sijhawm luv.
Muaj qee qhov tshwm sim ntawm kev phiv tshuaj ntawm cov menyuam yaus, yog li cov txheeb cais nyob rau hauv cov ntaub ntawv no tsis raug. Txhua qhov kev tshwm sim thiab qhov mob hnyav tau zoo ib yam rau cov laus. Yog tias tus menyuam yaus tau muaj kev mob tshwm sim tom qab noj Siofor uas tsis muaj qhov qhia hauv cov lus qhia rau cov tshuaj, nws yuav tsum tau qhia tus kws kho mob lossis kws muag tshuaj txog lawv.
Kev noj tshuaj ntau dhau ntawm Siofor hauv cov ntshav qab zib tsis ua rau cov ntshav qog ntshav qab zib (qhov txo qis hauv cov ntshav qab zib). Tab sis qhov txaus ntshai nyob rau hauv qhov kev pheej hmoo siab ntawm kev tsim cov kab mob lactic acidosis nrog rau txhua tus yam ntxwv ntawm tus kheej. Yog li ntawd, nws yog ib qhov tsim nyog yuav tsum qhia rau tus kws kho mob.
Txij li kev siv tshuaj ntau dhau ua rau muaj kev phom sij txaus ntshai, tus neeg mob tau kho hauv tsev kho mob.
Tus nqi thiab tshuaj tshuaj
Koj tuaj yeem yuav cov tshuaj hauv txhua lub tsev muag tshuaj. Nyob rau tib lub sijhawm, tus nqi ntawm Siofor nyob rau hauv Russia nyob rau ntau thaj chaw hloov pauv ib ncig ntawm 450 rubles rau ib pob ntawm cov tshuaj.
Cov tshuaj feem ntau ntawm cov tshuaj yog Formmetin, Glucofage, Metformin 850.
Hauv cov network koj tuaj yeem pom ntau cov kev tshuaj xyuas txog ntawm cov tshuaj, ob leeg los ntawm cov kws kho mob thiab los ntawm cov neeg uas tau kho tus mob ntshav qab zib. Cov kws tshaj lij tawm ntawm kev tshuaj xyuas txog Siofor zoo, vim nws tau sau tseg tias cov tshuaj tso cai rau koj kom cov ntshav qabzib hauv lub cev ua kom tsawg thiab txo qhov hnyav, uas yog qhov tseem ceeb rau cov neeg mob ntshav qab zib ntau. Tab sis, raws li kws kho mob, nws tsim nyog noj tshuaj tsuas yog kuaj pom tus mob ntshav qab zib hom II.
Ntawm cov neeg mob ntshav qab zib, cov tshuaj tau txais feem ntau zoo, vim Siofor pab tswj cov suab thaj thiab qee qhov yooj yim lub neej nyob hauv ntshav qab zib hom II.
Cov neeg uas tau siv Siofor rau cov kev poob phaus thov tias cov tshuaj yeej muab cov txiaj ntsig tsim nyog, pab txo kev qab los noj mov, thiab dua li, nws muag hauv tus nqi tsim nyog. Txawm li cas los xij, tom qab qhov kawg ntawm kev nqus, qhov hnyav rov qab los. Tsis tas li ntawd, xws li phiv los ua kev cuam tshuam ntawm lub zom zaub mov feem ntau tshwm sim. Cov vis dis aus hauv tsab xov xwm no txuas ntxiv Siofor ntsiab lus rau cov ntshav qab zib.
