Cov tshuaj diuretic rau cov ntshav qab zib hom 2 feem ntau siv rau kev kho mob uas tshwm sim nrog kev muaj mob ntawm cov ntshav qab zib ntshav siab, tsis txaus los yog thaum muaj qhov yuav tsum tau ua kom tshem tawm ceg ceg tawv.
Txog rau hnub no, ntau ntawm ntau yam tshuaj tau tsim tawm tuaj yeem ua rau kom cov zis muaj zis ntau ntxiv.
Cov kev xaiv ntawm diuretic, yog tias tsim nyog, yuav tsum tau nqa los ntawm tus kws kho mob koom nrog cov txiaj ntsig ntawm kev tshuaj ntsuam, suav txog tus kheej ntawm tus neeg mob lub cev.
Ib hom tshuaj siv yog indapamide.
Indapamide belongs rau cov pab pawg ntawm thiazide zoo li diuretics. Cov tshuaj no muaj cov nyhuv vasodilating.
Diuretics raug siv los ua cov khoom sib xyaw ua ke ntawm kev kho mob ntshav qab zib. Cov tshuaj no txhim kho qhov cuam tshuam ntawm ACE inhibitors.
Taizide-zoo li diuretics, uas suav nrog Indapamide, muaj cov mob ntshav qab zib me ntsis. Cov tshuaj no tsis tshua muaj txiaj ntsig ntawm cov txheej txheem ntawm kev zam ntawm cov poov tshuaj thiab theem ntawm cov piam thaj thiab cov rog hauv cov ntshav.
Kev tso cai ntawm Indapamide rau cov ntshav qab zib hom 2 tsis ua rau muaj kev ua tsis zoo rau kev ua haujlwm ntawm cov neeg mob lub raum.
Cov tshuaj muaj cov nyhuv nephroprotective hauv tus neeg mob lub cev ntawm txhua theem ntawm lub raum puas, uas ua ke nrog kev txhim kho cov ntshav qab zib mellitus ntawm ib hom tshuaj insulin-ywj siab.
Kev sib xyaw ntawm cov tshuaj, cov lus piav qhia dav dav thiab cov chaw muag tshuaj
Cov tshuaj yog tsim los ntawm kev lag luam kws tshuaj hauv daim ntawv ntawm cov ntsiav tshuaj rau kev tswj hwm qhov ncauj.
Cov tshuaj rau saum npoo muaj ib txheej zaj duab xis.
Lub ntsiab tseem ceeb nquag noj ntawm cov tshuaj yog indapamide, ib ntsiav tshuaj muaj 2.5 mg ntawm qhov sib txuas.
Ntxiv nrog rau cov tshuaj nquag, ntxiv cov tshuaj sib txuas uas muaj lub luag haujlwm pabcuam yog qhia rau hauv kev sib xyaw nrog cov tshuaj.
Tej ntu kev sib txuas yog cov haujlwm hauv qab no:
- lactose monohydrate;
- povidone-K30;
- crospovidone;
- magnesium stearate;
- sodium lauryl sulfate;
- talcum hmoov.
Muaj pes tsawg leeg ntawm lub plhaub saum npoo ntawm cov ntsiav tshuaj suav nrog cov tshuaj hauv qab no:
- Hypromellose.
- Macrogol 6000.
- Talc.
- Titanium dioxide
Cov ntsiav tshuaj muaj puag ncig, convex puab thiab pleev xim dawb.
Ib qho tshuaj yog nyob nrog pab pawg tshuaj diuretic. Nws cov khoom tau ze rau thiazide diuretics.
Tom qab siv cov tshuaj, tso zis tawm ntawm sodium thiab chlorine los ntawm tib neeg lub cev nce. Txhawm rau tsawg dua cuam tshuam cov txheej txheem ntawm kev nthuav dav ntawm cov poov tshuaj thiab magnesium ions los ntawm lub cev.
Cov tshuaj muaj peev xwm txhawm rau thaiv cov calcium raws ntawm daim nyias nyias thiab nce lub cev kev ywj pheej ntawm cov hlab ntsha ntawm cov hlab ntsha, txo tag nrho cov kev tawm tsam ntawm cov leeg ntshav ntawm lub cev.
Noj tshuaj pab txo cov ntshav siab ntsws ntawm nplooj siab tsis ntsws.
Kev siv cov tshuaj tsis cuam tshuam rau theem ntawm lipid concentration hauv cov ntshav thiab tsis cuam tshuam rau cov metabolism ntawm cov piam thaj.
Kev noj tshuaj tso cai rau koj kom txo qis qhov tsis haum xeeb ntawm phab ntsa vascular kom muaj kev cuam tshuam ntawm norepinephrine thiab angiotensin II rau nws, thiab tso cai rau koj los ntxiv dag zog cov synthesis ntawm prostaglandin E2 hauv lub cev.
Kev siv cov tshuaj txo cov kev siv ntawm kev tsim dawb thiab ruaj khov nyob rau hauv lub cev.
Cov nyhuv hypotensive tsis tu ncua ntawm cov tshuaj tshwm sim ib lub lim tiam tom qab pib noj tshuaj thiab muaj mob ntxiv rau ib hnub tom qab ib koob noj ib hnub.
Pharmacokinetics ntawm cov tshuaj
Tom qab siv cov tshuaj, nws yog kiag li nqus los ntawm txoj hnyuv mus rau hauv txoj hlab ntshav. Cov tshuaj muaj lub siab bioavailability, uas yog li ntawm 93%.
Kev noj mov tau ua kom qeeb qeeb ntawm kev nqus ntawm cov tshuaj mus rau hauv cov ntshav, tab sis tsis cuam tshuam rau qhov ntau ntawm cov tshuaj nqus tawm. Qhov siab tshaj plaws yog ua tiav hauv cov ntshav 1-2 teev tom qab noj cov tshuaj hauv.
Nrog kev siv ntau zaus ntawm cov tshuaj, hloov pauv ntawm nws cov peev xwm hauv lub cev nruab nrab ntawm cov koob tshuaj tau raug txo. Cov tshuaj nce mus txog qhov muaj kev sib luag hauv lub cev tom qab 7 hnub ntawm kev siv tshuaj.
Ib nrab-lub neej ntawm cov tshuaj yog los ntawm 14 txog 24 teev. Cov tshuaj no tuaj rau hauv kev sib cuag nrog cov protein ua ntxiv ntawm cov ntshav ntshav. Cov qib ntawm cov protein khi yog li 79%.
Cov nquag ua haujlwm ntawm cov tshuaj kuj tseem tuaj yeem khi nrog elastin ntawm cov leeg txhim kho cov leeg uas yog ib feem ntawm cov vascular phab ntsa.
Cov tshuaj muaj peev xwm hla dhau ntawm cov ntaub so ntswg, tuaj yeem hla qhov chaw nres. Thaum noj tshuaj, nws kis mus rau niam mis.
Kev zom cov roj ntsha ntawm cov khoom txuam ua ke tshwm sim hauv daim tawv nqaij lub siab. Kev nqhis ntawm cov khoom siv nquag yog nqa tawm hauv daim ntawv ntawm cov tshuaj tiv thaiv kab mob los ntawm lub raum hauv qhov ntim ntawm 60 txog 80%. Nrog quav, li 20% yog dhau ntawm txoj hnyuv.
Yog tias tus neeg mob lub raum tsis ua haujlwm, lub chaw muag tshuaj ntawm cov tshuaj tsis hloov. Kev sib txuam ntawm cov nyiaj hauv lub cev tsis tshwm sim.
Kev taw qhia thiab contraindications rau kev noj tshuaj
Qhov tseem ceeb tshaj plaws qhia txog kev noj tshuaj rau ntshav qab zib yog txoj kev loj hlob ntawm tus neeg mob ntshav siab.
Zoo li lwm yam khoom siv kho mob, Indapamide muaj ib tug xov tooj ntawm contraindications rau siv.
Kev siv cov tshuaj yog tso cai nyob rau hauv qhov tsis muaj qee yam contraindications hauv tus neeg mob.
Lub ntsiab contraindications rau kev siv tshuaj yog cov nram qab no:
- tus neeg mob tau rhiab siab heev rau cov tshuaj uas tsim los ntawm sulfonamide;
- intolerance rau cov neeg mob lactose;
- tus neeg mob tau mob galactosemia;
- yog tias ib tug neeg qhia tias muaj tsos mob ntawm malabsorption ntawm qabzib lossis galactose;
- kev txheeb xyuas ntawm daim foos hnyav tsis ua haujlwm ntawm lub raum hauv cov neeg mob;
- muaj cov cim ntawm hypokalemia;
- muaj qhov ua rau lub siab ua haujlwm siab hnyav;
- mob raum;
- lub sijhawm ua poj niam tes taw thiab pub mis;
- tus neeg mob lub hnub nyoog txog 18 xyoo;
- ua txoj kev kho nyob rau hauv uas ib txhij tswj hwm ntawm cov neeg sawv cev muaj peev xwm ntawm lengthening QT luv yog nqa tawm.
Nrog kev ceev faj, koj yuav tsum siv cov tshuaj thaum kuaj pom kev ua tsis zoo hauv kev ua haujlwm ntawm lub raum thiab mob siab, yog tias muaj tus neeg mob lub cev tsis sib xws hauv cov dej-electrolyte tshuav, yog tias muaj hyperparathyroidism hauv lub cev.
Ntxiv rau, Indapamide yuav tsum tau ua tib zoo siv thaum ua kev kho mob nyob rau hauv uas cov tshuaj tiv thaiv kab mob uas twb siv lawm.
Kev ceev faj yog siv thaum siv tshuaj yeeb tshuaj rau kev txhim kho ntshav qab zib mellitus nyob rau theem ntawm decompensation.
Cov lus qhia rau kev siv ntsiav tshuaj
Kev lees txais ntawm cov tshuaj yog nqa tawm tsis hais lub sijhawm rau kev noj zaub mov. Kev nqus cov ntsiav tshuaj yuav tsum nrog nrog haus cov dej kom ntau. Lub sijhawm zoo tshaj plaws rau kev siv tshuaj yog thaum sawv ntxov.
Cov tshuaj uas ib txwm siv rau kev kho mob yog 2.5 mg lossis ib ntsiav tshuaj ib hnub. Yog tias tom qab 4-8 lub lis piam ntawm kev kho mob qhov xav tau tsis tiav, cov tshuaj yuav tsum tsis txhob nce ntxiv. Kev nce ntxiv ntawm cov tshuaj yuav cuam tshuam kev loj hlob hauv lub cev ntawm kev phiv los ntawm kev siv tshuaj.
Thaum tsis muaj kev tshwm sim hauv kev kho, nws raug pom zoo kom hloov cov tshuaj mus rau ib qho zoo dua. Thaum muaj kev kho mob nrog kev siv ob yam tshuaj, kev noj ntau npaum ntawm Indapamide tseem tsis hloov ntawm 2.5 mg rau ib hnub.
Thaum noj Indapamide nyob rau hauv tus neeg, qee qhov kev mob tshwm sim tuaj yeem tshwm sim hauv kev cuam tshuam hauv kev ua haujlwm ntawm ntau lub cev.
Cov kev phiv ntau tshaj ntawm Indapamide rau ntshav qab zib yog:
- Lub plab zom mov. Tej zaum muaj kev txhim kho mob raws plab, quav tawv, ntsej muag zoo li mob plab. Feem ntau muaj lub siab xav xeev siab thiab dryness hauv lub qhov ncauj kab noj hniav. Tej zaum qhov zoo li pom tshwm sim ntawm ntuav hauv cov neeg tsis tshua muaj mob, kev txhim kho ntawm pancreatitis yog tau.
- Nruab nrab hauv lub paj hlwb. Tej zaum qhov kev txhim kho ntawm lub xeev asthenic, qhov tshwm sim ntawm kev poob siab ntau dua, mob taub hau nrog ntshav qab zib, ua rau qaug zog. Hauv qee qhov tsis tshua muaj tshwm sim, kev ua kom qaug zog thiab dav dav pom tshwm sim. Qee lub sij hawm muaj qhov paub txog ntawm qhov tsis txaus ntshai, cov leeg pob txha mus los, ua lub siab dua thiab hnov cov kev ntxhov siab.
- Ntawm ib feem ntawm cov kab mob ua pa, kev txhim kho hnoos, pharyngitis, sinusitis thiab, muaj qee zaus, rhinitis muaj peev xwm ua tau.
- Kev kho plawv. Tej zaum muaj kev txhim kho orthostatic hypotension, hloov hauv electrocardiogram, nws yog qhov ua tau rau tus neeg mob tsim muaj arrhythmias hauv lub plawv thiab nce lub plawv dhia.
- Cov kab mob zis. Muaj feem ntau ntawm kev tsim cov mob sib kis thiab polyuria.
- Cov tawv nqaij. Tej zaum qhov kev loj hlob ntawm kev ua xua tshwm sim nyob rau hauv daim ntawv ntawm daim tawv nqaij ua pob, khaus ntawm daim tawv nqaij thiab mob hemorrhagic vasculitis.
Ntxiv rau cov kev mob tshwm sim no, thrombocytopenia, leukopenia, agranulocytosis, thiab exacerbation ntawm kab mob lupus erythematosus yuav tshwm sim hauv tus neeg mob lub cev.
Cov qauv tshuaj ntawm cov tshuaj, daim ntawv tso tawm, nqi thiab chaw cia
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated, txhua ntsiav tshuaj muaj 2.5 mg ntawm cov tshuaj.
Cov ntsiav tshuaj ntawm 10 daim yog ntim rau hauv ib lub cell contour tshwj xeeb ntim khoom ua los ntawm polyvinyl chloride zaj duab xis thiab coated nrog txhuas ntawv ci. Peb pob khoom tshwj xeeb pob, thiab cov lus qhia rau kev siv tshuaj, raug nqis peev hauv pob ntawv los qhia.
Cov tshuaj yog txwv kom muab cia rau hauv qhov chaw tsaus tsaus ntawm qhov kub ntawm qhov nruab nrab ntawm 15 txog 25 degrees Celsius. Qhov chaw khaws cia ntawm cov tshuaj yuav tsum tsis pub nkag mus rau me nyuam.
Lub txee lub neej ntawm cov tshuaj yog 3 xyoos. Tom qab tas sijhawm ntawm lub sijhawm khaws cia, cov tshuaj yog nruj me ntsis txwv tsis pub. Cov tshuaj tas sij hawm yog muab pov tseg.
Ntxiv rau Indapamide, tshuaj tau tsim tau uas yog nws txoj kev noj tshuaj.
Qhov feem ntau nrov thiab nrov yog cov tshuaj yeeb yaj kiab hauv qab no:
- Arifon Repard - kev sib piv ntawm Indapamide nrov tshaj plaws, tsis cuam tshuam rau cov khoom noj metabolism.
- Acripamide yog ib qho lus piv txwv ntawm Indapamide, uas yog keeb kwm Lav Xias.
- Indap yog ib qho yeeb tshuaj tsim hauv Czech koom pheej.
- Noliprel yog kev sib txuam tshuaj uas muaj peev xwm ua tau zoo.
- Perinid yog qhov nrov tshuaj uas haum rau ntau tus neeg mob.
Tus nqi ntawm Indapamide hauv thaj chaw ntawm Lavxias Federation nruab nrab li ntawm 12 txog 120 rubles, nyob ntawm cov chaw tsim khoom thiab thaj chaw muag tshuaj muaj yees.
Tus kws tshaj lij los ntawm daim vis dis aus hauv tsab xov xwm no yuav tham txog cov ntsiab lus ntawm pharmacological ntawm Indapamide.
