Glucophage - pharmacology thiab siv cov tshuaj

Glucophage yog thawj cov tshuaj Fabkis txoj tshuaj tiv thaiv kev ua raws li metformin hydrochloride. Ua ntej cov tshuaj tshwm sim hauv cov tshuaj ua lag luam, Fabkis tuam txhab Merck Sante tsim thiab tshawb xyuas nws rau 10 xyoo. Nws tsis yog qhov raug xwm txheej tias cov qub Glucophage yog me ntsis kim dua li cov generics uas tsim los ntawm cov tuam txhab uas tau yuav ib daim ntawv rau daim ntawv thov.

Glucophage yog qhov zoo tshaj plaws, vim hais tias nws tau kawm meej hauv cov lus sib xyaw uas nws tau muag, suav nrog lub plhaub, cov neeg tsis meej. Cov hom lag luam dav dav siv lwm yam excipients thiab txhua yam kev sib txuas ua ke, tsis muaj delving rau txoj kev kawm ntawm lawv cov hauj lwm zoo, thiab yog li ntawd cov txiaj ntsig tuaj yeem tsis muaj peev xwm xaiv tau.

Cov lus sib xyaw thiab cov ntawv ntau npaum

Cov tshuaj tiv thaiv tseem ceeb ntawm cov tshuaj yog metformin hydrochloride (metformin hydrochloride). Nyob ntawm seb ntau npaum li cas, ib ntsiav tshuaj ntawm cov tshuaj yuav muaj 500, 850 lossis 1000 mg ntawm cov tshuaj no. Ntxiv nrog rau cov khoom siv yooj yim, cov tshuaj Glucofage kuj tseem muaj cov neeg mob (povidone K 30, magnesium stearate). Lub plhaub yog ua los ntawm hypromellose thiab macrogol.

Round (1000 mg oval) convex ntsiav tshuaj muaj kev tiv thaiv los ntawm ib lub plhaub. Ntxiv nrog rau qhov kev qhia cais tsis suav, muaj ib rab koob engraving. Lawv tau ntim rau hauv cov hlwv hlwb ntawm 15-20 daim. Hauv pob ntawv cardboard muaj los ntawm 2 txog 4 xws li daim hlau.

Tso cov tshuaj uas kws kho mob sau tseg. Rau Glucofage, tus nqi nyob ntawm qhov ntau npaum, thaj av, hom kev faib tawm network. Nyob rau hauv txhua rooj plaub, nws yog tus nqi pheej yig: piv txwv li, tus nqi nruab nrab ntawm 30 ntsiav tshuaj ntawm 500 mg - los ntawm 100 txog 130 rubles. Lawv tso cov tshuaj qub nrog cov muaj peev xwm ntev - Glucophage Ntev.

Lub txee lub neej ntawm cov tshuaj nyob ntawm koob tshuaj: rau cov hlwv ntawm 500 lossis 850 mg rau 5 xyoos, rau 1000 mg rau 3 xyoos. Cov tshuaj tau khaws cia rau hauv nws cov khoom ntim thawj, cov lus qhia rau kev siv tsis tau hais tseg tshwj xeeb rau kev mob ntshav qab zib.

Kws Tshuaj

Ntsiav tshuaj hypoglycemic tshuaj nyob ntawm pawg biagunids thiab yog nws tus sawv cev nkaus xwb. Metformin, lub ntsiab lus ntawm Glucofage, inhibits qhov nqus ntawm cov piam thaj hauv cov hnyuv thiab nws cov khoom hauv lub siab. Tsis tas li ntawd, cov tshuaj ua rau nrawm siv ntawm carbohydrates. Glucophage piv rau qhov zoo dua nrog lwm cov tshuaj tiv thaiv kab mob ntawm lwm cov chav kawm uas nws tsis tuaj yeem ua rau mob glycemia, vim tias nws cov tshuab ntawm kev ua tsis muab rau kev txhawb ntawm cov tshuaj insulin endogenous.

Metformin ua haujlwm nyob rau hauv peb qhov kev qhia:

• Txo cov piam thaj ntau hauv cov nplooj siab, inhibiting gluconeogenesis thiab glycogenolysis;
• Txhim kho qhov kev cuam tshuam ntawm cov cell receptors rau cov tshuaj hormones, ua kom tiav kev ua tiav ntawm carbohydrates;
• Nws nplov qhov nqus ntawm cov suab thaj hauv plab hnyuv phab ntsa.

Cov Tshuaj Pharmacokinetics

Thaum noj nyob rau hauv lub plab zom mov, metformin nquag yoog, nrog tib lub sij hawm tau txais ntawm cov zaub mov, tus nqi ntawm nqus ntawm cov tshuaj qeeb qeeb. Qhov ntau tshaj plaws ntawm kev sib txuam ntawm cov tshuaj hauv cov ntshav cov ntshav tau pom tom qab 2 thiab ib nrab teev.

Kev yooj yim ntawm bioavailability txawv ntawm 50-60%. Cov kev tshawb fawb tau ua nrog kev koom tes nrog cov neeg tuaj yeem pab dawb noj qab haus huv uas tau haus dej qab zib hauv thaj tsam 500-850 mg.

Biguanide tsis muaj zog khi rau cov ntshav plasma, nws los rau hauv cov ntshav liab. Qhov xa tawm ntim yog nyob hauv qhov ntau ntawm 63-276 litres.

Metformin cov tshuaj tiv thaiv kab mob hauv lub cev tsis pom, nws tau tshem tawm feem ntau los ntawm lub raum, qee qhov (txog 30%) nkag mus rau cov hnyuv. Qhov kev tshem tawm ib nrab-lub neej yog qhov nruab nrab ntawm 6 thiab ib nrab teev. Nrog lub raum tsis ua haujlwm, metformin tshem tawm kom tsawg zuj zus hauv qhov sib piv rau cov ntsuas cov cim ua rau muaj qhov txo qis ntawm creatinine qhov tshem tawm (CC).

Glucophage - cim qhia rau siv

Cov tshuaj tau tawm rau cov neeg mob ntshav qab zib nrog hom mob thib ob, yog tias kev hloov kho lub neej tsis muab 100% glycemic tswj. Rau cov neeg mob rog, glucophage ua hauj lwm zoo dua li lwm cov tshuaj tiv thaiv kab mob. Nws yog siv:

• Rau cov tshuaj tua kab mob (monotherapy) los yog sib xyaw ua ke nrog cov tshuaj ntshav qab zib ntawm lwm pawg pharmacological lossis hauv kev sib txuam nrog cov tshuaj insulin;
• Raws li cov tshuaj pib lossis ua ke nrog cov tshuaj insulin rau kev tswj ntshav qab zib hom 2 hauv cov menyuam yaus;
• Thaum siv ceev xwmphem cov metabolic syndrome;
• Rau kev tiv thaiv kev laus (tom qab 45 xyoo).

Mob caj pas kuj tseem siv rau polycystic ovary. Kev laus ntawm lub cev feem ntau yog vim qhov nce hauv plasma cov ntshav concentration: cov protein ua haujlwm candied, cov hlab ntsha tawg muaj cov roj ua rau lub cev, ua rau tawv nqaij. Txhua cov dej qab zib tsis tsim nyog hloov pauv yuav pauv mus rau ob lub roj rog rog.

Los ntawm kev ntsuas glycemic ib txwm ua, atherosclerosis tuaj yeem tiv thaiv, ntshav siab tuaj yeem hloov kho tau, vim tias cov protein tsis ua kom lub cev nyob ntev dua. Rau kev tiv thaiv kev laus, glucophage yog siv ntawm koob tshuaj 250 mg / hnub. Qee zaum cov glucophage siv hauv kev tsim kho lub cev lossis rau kev kho tus kheej.

Glucophage yog cov tshuaj siv thoob plaws ntiaj teb: nws yog tshuaj los ntawm kws kho mob thiab kws kho keeb, tus kws kho plawv thiab kws kho mob, kws kho mob thiab kws kho tsiaj.

Cov sib txuam thiab cov kev txwv

Glucophage yog qhov ntseeg tau tshaj plaws ntawm cov tshuaj tiv thaiv kab mob, vim tias nws cov hauj lwm zoo thiab kev nyab xeeb tau raug kuaj xyuas los ntawm ntau xyoo ntawm cov kev tshawb fawb hauv kev kho mob thiab cov kev tshawb fawb txog ntau yam. Tab sis, zoo li ib yam tshuaj, nws muaj nws tus kheej contraindications thiab lub sijhawm txwv:

• Cev xeeb tub thiab lactation (pom zoo hloov mus rau tshuaj insulin);
• Ob hnub ua ntej kev ua haujlwm loj thiab ob hnub tom qab lawv, metformin hloov nrog cov tshuaj insulin;
• Nrog kev xoo hluav taws xob xoo ntsuas kev soj ntsuam uas siv iodine-based cov cim, cov kev txwv zoo sib xws;
• Hauv kev kho ntawm kev raug mob thiab kub hnyiab, ib qho hloov mus ib ntus rau insulin kuj tseem pom zoo;
• Daim siab ua haujlwm siab;
• Kev tsis ua haujlwm raum (CC saum 0.132 thiab 0.123 rau txiv neej thiab poj niam, feem);
• Lub neej muaj xwm txheej phom sij uas ua rau muaj kev mob plab lactic acidosis;
• Rau cov menyuam yaus me (txog 10 xyoo) menyuam yaus - tsis muaj pov thawj txog kev nyab xeeb thiab ua haujlwm tau zoo;
• Kev noj haus hauv lub cev muaj suab npe (tsawg dua 1000 kcal / hnub) yog qhov txaus ntshai los ntawm kev tsim cov ketoacidosis metabolic vim kev ua haujlwm ntawm lub cev.

Qhov feem ntau txaus ntshai (zoo hmoo, tsis tshua muaj tshwm sim) cov kev mob uas cuam tshuam nrog kev kho mob nrog metformin yog lactic acidosis. Cov hauv qab no yam ua rau nws txoj kev loj hlob:

• Cov tsheb thauj khoom tshiab uas tsis tso cai ua kom tiav cov khoom pov tseg hauv cov khoom ntuj;
• Kev quav dej caw thiab qaug cawv quav cawv;
• Cov kab mob uas cuam tshuam cov ntaub so ntswg ua pa (kev mob plawv, lub plawv nres, kab mob kis ntawm lub ntsws ua pa);
• Ntshav qab zib ketoacidosis;
• Cov mob hnyav ua rau lub cev qhuav dej nrog cov zawv plab, ntuav, thiab kub cev.

Cov txiaj ntsig ntawm kev sib txuam nrog lwm cov tshuaj

Tsis pom zoo kev sib txuas ua ke

Hauv kev kho ntawm Glucofage, cawv yog nruj me ntsis txwv txhua yam.

Kev haus dej cawv lom yog qhov txaus ntshai ntxiv ntawm kev mob plab lactic acid, tshwj xeeb tshaj yog ua rau daim siab tsis ua haujlwm, tshaib plab, tsis ua haujlwm tsis zoo. Cov tshuaj uas muaj cawv haus cawv kuj tsis muaj.

Kev tswj hwm ntawm cov tshuaj iodine sib xyaw ua ke, uas tau siv hauv kev tshawb nrhiav xoo, tuaj yeem ua teeb meem lub raum, thiab yog li ntawd, kev txuam nrog metformin, uas ua rau muaj qhov tshwm sim ntawm lactatocidosis. Glucophage hloov pauv los ntawm insulin 48 teev ua ntej kev kuaj thiab 48 teev tom qab. Yog tias GFR> 60 ml / min / 1.73 sq. m, kev kuaj ntxiv ntawm kev ua haujlwm ntawm lub raum yog xav tau.

Cov txheej txheem uas yuav tsum tau siv kom zoo

Qee cov tshuaj (sympathomimetics, corticosteroids) tuaj yeem ua rau mob hyperglycemia. Thaum pib ntawm chav kawm, ib qho kev hloov kho koob tshuaj Glucofage thiab kev soj ntsuam tas li ntawm glycemia yog qhov tsim nyog.

Diuretics (tshwj xeeb, lub voj) tsim ib qho ntxiv rau ntawm lub raum, thiab, yog li ntawd, ua rau mob lactic acidosis.

Cov lus pom zoo ntxiv

Lactic acidosis yog ib tug mob uas tsis tshua pom muaj tab sis muaj kev phom sij heev nrog rau qhov muaj neeg tuag coob, tshwj xeeb yog kev tsis pw hauv tsev kho mob. Ib qho dhau heev ntawm metformin hauv lub cev, tshwm sim los ntawm lub raum tsis zoo, ua rau nws txoj kev loj hlob.

Lwm qhov laj thawj tseem ua rau cov kab mob lactic acidosis: tsis txaus ntseeg hom 2 mob ntshav qab zib, kev haus cawv, ketosis, kab mob siab, thiab cov nqaij mos hypoxia.

Koj tuaj yeem paub txog tus mob los ntawm mob hnyav asthenia, ua tsis taus pa, hypothermia, mob plab, mob plab, mob epigastric, mob leeg. Yog tias Glucofage dhau los tsis ua rau muaj mob tshwm sim loj, txhua qhov kev hloov yuav tsum tau ceeb toom sai sai rau tus kws kho mob endocrinologist. Txog thaum cov laj thawj tau meej meej, metformin thim tawm thiab rov ua haujlwm ntxiv tom qab kuaj raum. Cov kab mob lactic acid yog txaus ntshai tsis nco qab nrog qhov muaj peev xwm ntawm kev tuag, yog li tsev kho mob ntawm tus neeg raug mob thaum thawj lub sijhawm xav tias yuav tsum ua. Thaum kos duab ntawm txoj kev kho mob, tus kws kho mob yuav tsum qhia cov ntshav qab zib txog qhov ua tau tshwm sim thiab cov tsos mob ntawm tus mob lactic acidosis.

Cov chav kawm ntawm kev kho mob nrog metformin rau tus mob ntshav qab zib tau ntev, yog li cov xwm txheej ntawm lub raum yuav tsum raug txheeb xyuas tsis tu ncua: rau lub raum zoo - 1 r. Yog tias CC nyob qis dua 45 ml / min., Qabzib tso tseg. Hauv cov neeg laus ntshav qab zib, qhov txo qis hauv lub raum feem ntau tshwm sim asymptomatically. Cov tshuaj tiv thaiv kabmob, lub cev qhuav dej, tshuaj diuretics, NSAIDs kuj cuam tshuam lawv tus mob. Ua ntej kev teem sij hawm ntawm glucophage nyob rau hauv cov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tsum tau kuaj.

Feem ntau, metformin favorably cuam tshuam lub xeev ntawm cov hlab ntsha, nrog rau lub siab. Lub Koom Haum Ntshav Qab Zib Canadian txawm pom zoo siv Glucophage rau kev mob plawv ntawm cov mob hnyav nrog kev soj ntsuam tas li ntawm cov mob ntawm lub plawv thiab lub raum. Tab sis nrog ib qho kev mob hnyav thiab tsis khov, qhov txaus ntshai ntawm hypoxia, glucophage yog contraindicated.

Thaum Glucophage raug xaj rau menyuam yaus, kev kuaj mob (hom 2 ntshav qab zib) yuav tsum tau tsim thiab lees paub. Cov kev tshawb fawb hauv ib xyoos tsis qhia txog kev puas tsuaj ntawm glucophage rau kev loj hlob thiab kev muaj me nyuam ntawm cov menyuam yaus. Tab sis nyob rau lub sijhawm ntev, cov txiaj ntsig ntawm kev kho mob tsis tau soj ntsuam, yog li cov niam txiv yuav tsum ua tib zoo saib xyuas cov mob ntawm cov menyuam muaj ntshav qab zib, tshwj xeeb tshaj yog thaum siv cov tshuaj los ntawm cov hluas.

Glucophage tsis muaj peev xwm ua rau cov ntshav qog ntshav siab thaum lub sij hawm monotherapy, tab sis hauv kev kho mob nyuaj nrog meglitinides, sulfonylurea pawg tshuaj thiab lwm cov tshuaj tiv thaiv kab mob nrog rau cov kev sib txawv ntawm kev txiav txim siab tshaj metformin, kev hloov kho koob tshuaj thiab kev saib xyuas tas li ntawm glycemia yog qhov yuav tsum tau.

Glucophage yog ib qho tshuaj tiv thaiv kab mob siab heev, tab sis nws yuav tsum pab. Yog tias tsis ua raws li cov ntsiab lus ntawm kev noj zaub mov kom tsawg carb, kev ua si lub cev txhua hnub, tswj glycemic, lub siab lub ntsws, pw thiab so, 100% cov piam thaj tsis tuaj yeem suav nrog.

Glucophage thiab cev xeeb tub

Tsis hais yam twg (cev xeeb tub lossis xeeb ceem), mob ntshav qab zib tsis pom zoo thaum cev xeeb tub muaj feem yuav ua kom xeeb tub thiab xeeb menyuam coob ua ke. Cov kev tshawb fawb sib txawv tsis tau sau cia qhov sib txawv hauv kev loj hlob ntawm tus me nyuam hauv plab thiab lub xeev ntawm niam txoj kev noj qab haus huv, nrog rau kev cuam tshuam ntawm kev yug menyuam thiab kev muaj sia nyob ntawm cov menyuam yug tshiab. Thiab, txawm li cas los xij, cev xeeb tub thiab lactation nyob rau hauv daim ntawv ntawm contraindications, yog li ntawd, twb tau nyob rau theem ntawm tus me nyuam phiaj xwm nws yog ib qho tsim nyog yuav tsum hloov mus rau insulin.

Nws tau tsim muaj tias metformin hla mus rau niam mis, thiab txawm hais tias nyob rau ntawm menyuam mos, raws li cov lus ceeb toom, qhov tseeb no tsis ua rau muaj kev loj hlob tsis zoo, qhov kev qhia pom zoo hloov xa menyuam mus rau kev pub mis lossis kev kho mob insulin rau tus niam saib xyuas. Txawm li cas los xij, kev pheej hmoo muaj kev tsis txaus siab xav tau los ntawm metformin thiab kev tso tseg cov mis niam rau tus menyuam raug suav nrog.

Cov nyhuv ntawm metformin ntawm kev muaj me nyuam tau raug sim hauv cov tsiaj. Ntawm qhov ntau npaum ntawm 600 mg / hnub. (qhov no yog 3 npaug ntau dua li qib siab tshaj ntawm qhov kev cai, suav mus rau thaj chaw thaj tsam ntawm lub cev), qhov muaj feem yuav cev xeeb tub hauv poj niam tseem nyob rau tib theem.

Kev cuam tshuam rau kev tswj hwm kev siv tshuab thiab thauj khoom

Nrog Glucofage monotherapy, qhov tshuaj tiv thaiv ceev ntawm lub log lossis lub siab ntawm kev mloog ntawm lub chaw tsim kev puas tsuaj tsis hloov, vim tias cov tshuaj tsis cuam tshuam rau kev mob ntshav qab zib.

Yog hais tias Glucofage siv nyob rau hauv txoj kev kho mob, tshwj xeeb nrog cov tshuaj ntawm sulfonylurea series, insulin, meglitinides uas tuaj yeem ua rau hypoglycemic lub xeev, ceev faj yuav tsum siv thaum ua haujlwm ntawm qhov siab, tswj kev ua cov nyom thiab thauj.

Cov hau kev thov qauv

Cov neeg laus

Nrog rau cov tshuaj monotherapy lossis hauv txoj kev kho mob nyuaj siv siv cov tshuaj uas muaj suab thaj nrog lub tshuab sib txawv ntawm kev txiav txim siab tshaj li metformin, qhov pib noj tshuaj tsis tshaj 500-850 mg. Cov tshuaj yog coj li 2-3r. / Hnub. nrog lossis tom qab khoom noj. Tom qab ob lub lis piam, ntsuas qhov tshwm sim thiab kho qhov koob tshuaj, tsom mus rau kev yoo mov thiab tom qab qab zib.

Kev maj mam dhau ntawm qhov kev txhaj tshuaj tso cai rau lub cev hloov kho kom yooj yim rau cov xwm txheej tshiab thiab txo qhov kev pheej hmoo ntawm kev phiv, tshwj xeeb tshaj yog los ntawm txoj hnyuv txuas.

Thaum sau ntawv yuav tsum tau txhaj tshuaj ntau dua, koj tuaj yeem haus ob 500 mg xwb tsis tas ib ntsiav tshuaj hnyav txog 1000 mg. Tus nqi niaj hnub ntau yog 3000 mg, nws muab faib ua 3 koob.

Thaum hloov mus rau Glucophage nrog lwm txoj kev siv tshuaj tiv thaiv kab mob, kev kho mob yav dhau los thiab qib kev them nyiaj glycemic raug coj mus rau hauv tus account thaum xam qhov ntau npaum.

Yog hais tias qhov ua tau Glucofage tsis txaus rau 100% glycemic them, ib qho kev kho mob nrog metformin ua ke nrog cov tshuaj insulin npaj tau. Nrog rau qhov kev kho no, qhov pib noj yog qhov tsawg kawg (500 mg) lossis 850 mg, kev siv yog peb zaug. Kev siv tshuaj insulin yog kho raws li kev nyeem ntawv ntawm glucometer, uas yuav tsum tau soj ntsuam tas li.

Glucophage yog tshuaj rau cov neeg mob paub tab mus rau hauv tus account qhov mob ntawm lub raum, uas yuav tsum tau kuaj xyuas tsis tu ncua. Nrog mob raum tsis ua haujlwm (CC 45-59 ml / min.) Thiab thaum tsis muaj lwm yam cuam tshuam rau cov kab mob lactic acidosis, metformin tau txais ib zaug ib hnub ib zaug ntawm 500-850 mg. Hauv kev tawm tsam ib txwm ntawm cov tshuaj, qhov tshuaj tuaj yeem yog titrated txog 1000 mg / hnub, faib nws 2 zaug. Txhua 3-6 lub hlis, kev kuaj mob raum.

Cov menyuam

Koj yuav tsis ceeb leej twg nrog kev kuaj mob ntshav qab zib hom 2 hauv menyuam yaus thiab tub ntxhais hluas: lub cev tsis ua haujlwm, kev ntxhov siab, cov zaub mov muaj zaub mov ntau ... Tebchaws Asmeskas thiab lwm lub tebchaws tau tawg cov ntaub ntawv hauv qhov no. Glucophage yog xaj rau cov menyuam yaus txij thaum 10 xyoo. Qhov pib siv tshuaj ntawm metformin yog nce txog 850 mg / hnub. Lawv noj tshuaj ib zaug, niam txiv muaj lub luag haujlwm tswj hwm kom tus menyuam noj cov tshuaj no tib lub sijhawm thiab nco ntsoov "rhais" cov tshuaj nrog rau noj su lossis noj tshais.

Raws li cov txiaj ntsig tau los ntawm kev kuaj ntshav, uas yuav tsum tau sau ntawv txhua hnub hauv phau ntawv kuaj mob ntshav qab zib, qhov koob tshuaj tuaj yeem hloov kho nyob rau hauv ib hlis ib zaug. Lawv nce nws maj mam kom tsis txhob muaj qhov xav tsis zoo rau lub plab zom mov. Qhov siab tshaj plaws hauv me nyuam yaus thiab tub ntxhais hluas yog 2000 mg / hnub. nrog rau kev faib tawm ntawm txhua cov ntsiav tshuaj 2-3 zaug.

Kev xaiv ntau dhau

Nrog rau kev siv ib zaug ntawm Glucophage hauv tus nqi ntawm 85 g, cov tsos mob hypoglycemic tsis tau sau tseg. Hauv cov xwm txheej zoo li no, cov kab mob lactic acidosis yuav loj hlob tuaj.Qhov tseem ceeb tshaj plaws ntawm lub koob tshuaj Glucofage lossis kev ua tsis tiav nrog hypoglycemic cov neeg sawv cev yog qhov txaus ntshai rau kev txhim kho ntawm cov kab mob lactic acidosis - qhov mob hnyav uas yuav tsum tau mus pw hauv tsev kho mob sai.

Txoj hauv kev zoo tshaj plaws los tshem tawm lactate yog hemodialysis.

Sab sij huam

Glucophage, raws li cov tshuaj qub, ua rau muaj qhov tsis tshua xav tau (piv rau generics). Feem ntau cov kev tshwm sim yog dyspeptic cuam tshuam, epigastric tsis xis nyob, thiab defecation atherosclerosis ntxhov. Cov tsos mob zoo sib xws, raws li txoj cai, dhau los ntawm nws tus kheej tom qab lub cev yoog raws cov xwm txheej tshiab. Muaj qee kis, yuav tsum tau muab cov tshuaj rho tawm.

Ua raws li WHO kev faib tawm, qhov ntau zaus cuam tshuam ntawm kev ntsuas raug ntsuas raws ntawm qhov ntsuas zoo li no:

• Ntau zaus -> 0.1;
• Feem ntau - txij li 0.01 txog 0.1;
• Tsis tshua muaj, txij li 0.001 txog 0.01;
• Tsis tshua muaj heev - los ntawm 0.0001 txog 0.001;
• Tsis paub - yog tias cov txheeb cais tsis pub txiav txim siab qhov ntau zaus ntawm cov xwm txheej.

Glucophage analogues

Glucophage los ntawm cov chaw tsim tshuaj paus Merck Sante yog ib daim tseem Fabkis txoj tshuaj ntawm cov khoom zoo. Ntawm tus nqi nws tuaj yeem raug ntaus nqi rau cov tshuaj siv nyiaj. Tab sis qee qhov xwm txheej (cev xeeb tub, khiav haujlwm loj, raug mob, tsis muaj nyob hauv lub khw muag tshuaj), nws yuav tsum tau muab tshem tawm.

Metformin yog tib tus neeg sawv cev hauv pawg loj pawg loj, tab sis tsuas yog cov neeg tub nkeeg tshaj plaws thiab luv luv lub tuam txhab tsis tsim cov tshuaj feem ntau raws li cov tshuaj metformin. Muaj ntau tshaj li ntawm lub kaum ntsej muag analogues rau Glucofage, feem ntau cov kws kho mob thiab cov ntshav qab zib siv:

• Argentine Bagomet;
• German Siofor thiab Metfogamma;
• Lavxias Formethine, Gliformin, Novoformin, Metformin-Richter;
• Serbian Metformin;
• Israeli Metformin Teva.

Qhov pheej yig tshaj plaws analogues ntawm Glucofage ntawm Suav thiab Indian tuam ntxhab, tab sis lawv qhov zoo yog qhov tsim nyog. Lub hauv paus tseem ceeb, ntawm lub hauv paus uas cov tshuaj analogues (metformin hydrochloride) raug xaiv, tseem siv rau hauv cov tshuaj sib xyaw, piv txwv li, Glibomet, Gluconorm, Galvus Met, Yanumet, Amaril M. Yog tias koj yuav tsum pov npav rau koj cov tshuaj thiab koj kev noj qab haus huv nrog koj tus kheej ruble, tsom rau tus thawj Glucofage thiab Cov kev ntsuas Generics, tab sis lo lus kawg hauv kev xaiv ib cov tshuaj yuav tsum nyob nrog tus kws kho mob uas tuaj koom.

Glucophage rau poob phaus

Glucophage yog tshuaj los ntawm tus neeg endocrinologist, vim nws nce siab ntawm cov kab mob ntawm tes ua rau insulin. Hauv qhov no, qhov tshuaj tua kabmob ua rau cov kua nplaum hloov mus rau hauv cov ntaub so ntswg rau lub zog xav tau ntawm lub cev, thiab tsis muab tso rau hauv lub qhov tso cia, hloov mus rau hauv cov rog. Cov ntsiav tshuaj thaiv qhov kev nqus ntawm cov piam thaj ntau hauv cov hnyuv, ua kom muaj suab thaj sai. Yog tias yoo mov qab zib thiab glycated hemoglobin yog qhov ib txwm, thiab muaj ib qho dhau ntawm cov insulin hauv lub cev, qhov no txhais tau tias qhov kev tawm tsam cov tshuaj insulin tsis txaus.

Hauv qhov no, Glucophage yog kev kho mob. Nws tsis ncaj qha cuam tshuam rau txheej txheej ntawm cov rog, tab sis, pab ua kom qhov glycemia thiab insulin tsis txaus siab, nws ua kom cov tshuaj hormones tsis cuam tshuam rau hepatocytes. Kev mob ntshav qab zib tsis yog tag nrho cov ntshav qab zib, tab sis ntawm kev nce sai sai ntawm cov tshuaj insulin, thiab nws pab tswj cov ntshav qab zib.

Nws kuj tseem muaj ntau yam zoo, piv txwv li, kev tiv thaiv kev mob qog noj ntshav, tab sis rau cov neeg uas xav kom poob phaus nrog Glucofage, nws yog ib qho tseem ceeb kom nco ntsoov: cov tshuaj tsis yog tsim los kom poob phaus, txawm hais tias rog dhau mus yuav ploj mus yog tias koj qhov teeb meem, uas ua rau cov rog rog, yog insulin tsis kam, mob metabolic syndrome, qab zib ntshav qab zib hom 2. Yog hais tias qhov ua rau kom yuag dhau heev yog qhov muaj keeb, koj yuav tsum xeem dhau caj ces, yog tias qhov teeb meem nyob rau hauv cov thyroid caj pas lossis cov tshuaj hormones ntawm adrenal cortex, ces Glucophage kuj tsis yog tus pabcuam.

Ntshav Cov Lus Ntsuam Xyuas

Txog Glucofage tshuaj xyuas cov kev poob phaus thiab cov ntshav qab zib yog qhov sib xws. Cov neeg uas suav rau ntawm cov ntsiav tshuaj ib leeg nrog kev siv zog me me los daws txhua yam lawv cov teeb meem yws ntawm cov txiaj ntsig tsis zoo ntawm metformin. Nrog txoj hauv kev loj, thaum cov tshuaj raug tswj hwm hauv kev saib xyuas kev noj qab haus huv, raug rau kev noj haus qis thiab ua kom lub cev qis, cov txiaj ntsig tau zoo.

Glucophage yog tus txheej txheem kub, indispensable nyob rau txhua theem ntawm kev tswj cov ntshav qab zib hom 2. Ib qho ntxiv, nws los ntawm 30% txo tus nqi tag nrho kev tuag, kev tuag los ntawm cov mob ntshav qab zib, tiv thaiv kev mob qog nqaij hlav thiab mob plawv. Metformin txo qhov qab los noj mov, tawm kev ua haujlwm ntawm kev txwv cov calories ntau ntawm cov zaub mov noj - ib txoj hauv kev ua kom ntev lub neej ntawm ob leeg mob ntshav qab zib thiab cov neeg noj qab nyob zoo.