Txawm hais tias qhov tseeb hais tias cov kws tshawb fawb tswj kom ua tiav cov insulin molecule, uas tsim tawm hauv tib neeg lub cev, qhov kev ua ntawm cov tshuaj hormones tseem ua kom qeeb vim lub sijhawm xav kom nqus mus rau hauv cov ntshav. Thawj cov tshuaj ntawm kev ua kom zoo dua yog cov tshuaj insulin Humalog. Nws pib ua haujlwm tau ntev lawm 15 feeb tom qab txhaj tshuaj, yog li ntawd cov suab thaj los ntawm cov ntshav pauv mus rau cov ntaub so ntswg hauv lub sijhawm, thiab txawm tias lub sijhawm luv luv-hyperglycemia tsis tshwm sim.
Piv rau cov neeg tsim insulins yav dhau los, Humalog qhia tau zoo dua: hauv cov neeg mob, txhua hnub hloov pauv hauv qab zib yog 22%, glycemic qhov ntsuas tau zoo, tshwj xeeb tshaj yog yav tav su, thiab qhov muaj feem yuav ua rau lub cev tsis muaj ntshav qab zib tsawg dua. Vim tias qhov nrawm nrawm, tab sis qhov kev txiav txim ruaj khov, cov kua dej no tau siv ntau dua rau cov ntshav qab zib.
Qhia me ntsis
Cov lus qhia txog kev siv tshuaj insulin Humalog yog qhov hluav taws xob heev, thiab cov ntu piav qhia txog kev phiv thiab cov lus qhia rau kev siv nyob ntau dua ib kab lus. Cov lus piav qhia ntev ntev uas sib xyaw nrog qee cov tshuaj tau pom los ntawm cov neeg mob yog lus ceeb toom txog kev phom sij ntawm kev coj lawv. Qhov tseeb, txhua yam muaj qhov sib txawv: ib qho loj, cov lus qhia ntxaws ntxaws - cov ntaub ntawv pov thawj ntawm ntau yam kev sim siabtias cov tshuaj no thev taus zoo.
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Humalogue tau txais kev pom zoo rau kev siv ntau dua 20 xyoo dhau los, tam sim no nws muaj kev ruaj ntseg hais tias cov tshuaj insulin no muaj kev nyab xeeb ntawm kev siv tshuaj. Nws tau txais kev pom zoo rau kev siv los ntawm ob tus neeg laus thiab menyuam yaus; nws tuaj yeem siv rau hauv txhua kis nrog los ntawm kev tsis muaj tshuaj tiv thaiv hnyav: hom 1 thiab hom 2 ntshav qab zib, mob ntshav qab zib hauv lub plab, thiab phais mob phais.
Cov ntaub ntawv dav dav txog qhov Humalogue:
| Kev piav qhia | Cov tshuaj daws meej. Nws yuav tsum tau tshwj xeeb cia cov khoom, yog tias lawv tau ua txhaum, nws tuaj yeem poob nws cov khoom yam tsis muaj kev hloov pauv lub ntsej muag, yog li ntawd, cov tshuaj yuav tsuas yuav hauv cov khw muag tshuaj. |
| Lub hauv paus ntsiab lus ntawm kev khiav haujlwm | Nws muab cov piam thaj rau hauv cov ntaub so ntswg, txhim kho kev hloov pauv ntawm cov piam thaj hauv daim siab, thiab tiv thaiv kev cuam tshuam ntawm cov rog. Cov suab thaj txo qis cov nyhuv pib ua ntej tshaj li cov tshuaj insulin luv luv, thiab kav ntev dua. |
| Daim Ntawv | Kev daws nrog kev saib xyuas ntawm U100, kev tswj hwm - subcutaneous lossis intravenous. Ntim hauv cartridges lossis cwjmem uas phwj siv. |
| Chaw tsim tshuaj paus | Cov kev daws teeb meem tsuas yog tsim los ntawm Lilly Fabkis, Fab Kis. Ntim yog tsim nyob rau hauv Fabkis, Tebchaws Asmeskas thiab Russia. |
| Nqi | Hauv Lavxias, tus nqi ntawm ib pob khoom muaj 5 cartridges ntawm 3 ml txhua yog li 1800 rubles. Hauv Tebchaws Europe, tus nqi rau cov ntim zoo sib xws yog txog tib yam. Hauv tebchaws Asmeskas, cov tshuaj insulin no yuav luag kim 10 npaug. |
| Cov Khoom Qhia |
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| Cov Yuav Tsum Muaj | Cov tib neeg tawm tsam cov tshuaj insulin lyspro lossis cov ntu pabcuam. Ntau zaus qhia nyob rau hauv kev ua xua ntawm qhov chaw txhaj tshuaj. Nrog rau qhov mob nyhav qis, nws hla dhau ib lub lim tiam tom qab hloov mus rau qhov tshuaj insulin no. Cov mob hnyav yog muaj tsawg; lawv xav hloov Humalog nrog analogues. |
| Cov yam ntxwv ntawm kev hloov mus rau Humalog | Thaum xaiv cov koob tshuaj, kev ntsuas ntau dua ntawm glycemia, yuav tsum tau muaj kev sib tham txog kev kho mob tas li. Raws li txoj cai, cov ntshav qab zib tau xav tau tsawg dua cov Humalog nyob rau ib 1 XE dua li cov neeg insulin luv. Kev xav tau ntau ntxiv rau lub cev yog pom nyob hauv ntau yam kabmob, kev txhawj xeeb ntawm lub siab tawv, thiab ua haujlwm lub cev. |
| Noj ntau dhau | Tshaj dhau cov koob tshuaj no ua rau cov ntshav qab zib tsawg. Txhawm rau tshem tawm nws, koj yuav tsum tau noj sai carbohydrates. Cov mob hnyav yuav tsum tau kho mob sai. |
| Co-administration nrog lwm cov tshuaj | Humalog tuaj yeem txo qis kev ua haujlwm:
Txhim khu cov nyhuv:
Yog tias cov tshuaj no tsis tuaj yeem hloov los ntawm lwm tus, qhov tshuaj ntawm Humalog yuav tsum tau kho ib ntus. |
| Cia | Hauv lub tub yees - 3 xyoos, nyob rau hauv chav tsev kub - 4 lub lis piam. |
Ntawm cov kev mob tshwm sim, hypoglycemia thiab kev tsis haum tshuaj yog feem ntau pom (1-10% ntawm neeg mob ntshav qab zib). Tsawg dua 1% ntawm cov neeg mob tsim muaj lipodystrophy ntawm thaj chaw txhaj tshuaj. Qhov ntau zaus ntawm lwm cov kev tsis sib haum yog tsawg dua 0.1%.
Qhov tseem ceeb tshaj plaws txog Humalog
Nyob hauv tsev, Humalog tau txais kev tso tshuaj subcutaneously siv rab koob xaum qhuav los yog lub tshuab nqus insulin. Yog tias yuav tsum tau tshem tawm hyperglycemia, kev tswj hwm ntawm kev mob leeg nyob hauv tsev kho mob. Hauv qhov no, nquag tswj cov piam thaj yog qhov tsim nyog kom tsis txhob noj ntau dhau.
Cov tshuaj insulin
Cov tshuaj nquag ua haujlwm ntawm cov tshuaj yog insulin lispro. Nws txawv ntawm tib neeg cov tshuaj hormones hauv kev npaj cov amino acids hauv cov qauv molecule. Xws li kev hloov kho tsis tiv thaiv cov cell receptors los ntawm kev paub txog cov tshuaj hormones, yog li lawv yooj yim dhau suab thaj rau lawv tus kheej. Qhov humalogue tsuas yog muaj cov tshuaj insulin monomers - ib qho, tsis txuas yam tsis txawv. Vim tias qhov no, nws yog nqus tau nrawm thiab tusyees, pib ua haujlwm kom txo cov piam thaj sai dua li cov tshuaj insulin tsis haum.
Qhov tshuaj Humalog yog qhov tshuaj yeeb-luv dua li piv txwv li, Humulin lossis Actrapid. Raws li kev faib tawm, nws tau xa mus rau cov tshuaj insulin sib piv nrog cov kev ua kom haum. Qhov pib ntawm nws cov kev ua tau nrawm dua, li 15 feeb, yog li cov neeg mob ntshav qab zib tsis tas tos kom txog thaum cov tshuaj ua haujlwm, tab sis koj tuaj yeem npaj zaub mov noj tom qab txhaj tshuaj. Ua tsaug rau qhov kis luv luv no, nws yuav yooj yim dua rau kev npaj zaub mov noj, thiab qhov kev pheej hmoo kom tsis nco qab cov zaub mov tom qab kev txhaj tshuaj yog txo qis dua.
Rau kev tswj zoo glycemic, kev siv tshuaj tua kab mob sai yuav tsum tau ua ke nrog qhov yuav tsum tau siv ntawm insulin ntev. Tib qho kev zam tsuas yog kev siv lub tshuab nqus dej twj ywm hauv kev tawm mus ib zaug.
Xaiv xaiv
Kev noj tshuaj Humalog ntau nyob ntawm ntau yam thiab txiav txim siab ntawm tus kheej rau txhua tus mob ntshav qab zib. Kev siv cov qauv txheem yog tsis pom zoo, vim tias lawv ua rau kev mob ntshav qab zib hnyav dua. Yog tias tus neeg mob ua raws li cov zaub mov tsis zoo, lub cev ntawm Humalog yuav tsawg dua li tus qauv ntawm cov thawj coj tuaj yeem muab tau. Hauv qhov no, nws raug nquahu kom siv cov tshuaj insulin uas tsis muaj zog tuaj.
Ultrashort cov tshuaj hormones muab cov nyhuv loj tshaj. Thaum hloov mus rau Humalog, nws qhov kev pib noj tshuaj yog xam raws li 40% ntawm kev siv insulin luv luv. Raws li cov txiaj ntsig ntawm glycemia, ntau npaum li cas tau kho. Qhov nruab nrab xav tau ntawm kev npaj rau ib chav ua mov ci yog 1-1.5 units.
Cov sijhawm txhaj tshuaj
Lub humalogue yog pricked ua ntej txhua pluas noj, tsawg kawg peb zaug hauv ib hnubCov. Nyob rau hauv cov ntaub ntawv ntawm cov piam thaj siab, kho cov menyuam hlob nyob nruab nrab ntawm kev txhaj tshuaj tseem ceeb tau tso cai. Cov lus qhia rau kev siv pom zoo tias koj yuav tsum xam cov insulin uas yuav tsum tau ua raws li cov carbohydrates los npaj rau pluas noj tom ntej. Txog 15 feeb yuav tsum dhau los ntawm kev txhaj tshuaj mus rau cov zaub mov.
Raws li kev txheeb xyuas, lub sijhawm no feem ntau tsawg dua, tshwj xeeb yog thaum tav su, thaum cov tshuaj insulin tsawg dua. Qhov nqus tus nqi yog nruj me ntsis rau ib tus neeg, nws tuaj yeem raug suav siv rov ua ntsuas ntsuas cov ntshav qab zib sai sai tom qab txhaj. Yog tias qhov ua kom lub ntsej muag hypoglycemic pom sai dua li cov lus qhia, lub sijhawm ua ntej noj mov yuav tsum raug txo kom tsawg.
Humalog yog ib qho tshuaj sai tshaj plaws, yog li nws yooj yim siv nws ua kev pabcuam thaum muaj xwm txheej ceev rau cov ntshav qab zib yog tias tus neeg mob tau hem nrog qhov mob ceev heev.
Lub sijhawm ua haujlwm (luv lossis ntev)
Lub ncov ntawm ultrashort insulin yog pom 60 feeb tom qab nws tswj hwm. Lub sijhawm ua haujlwm nyob ntawm lub koob tshuaj; qhov loj dua nws yog, ntev li ntawm cov suab thaj txo qis dua yog nyob hauv nruab nrab - kwv yees li 4 teev.
Neej Neeg tshaj 25
Txhawm rau ntsuas qhov tseeb ntawm qhov tshwm sim ntawm Humalog, qabzib yuav tsum tau ntsuas tom qab lub sijhawm no, feem ntau qhov no ua tiav ua ntej noj mov tom ntej. Kev ntsuas ua ntej yog xav tau yog xav tias tsam lub qog ntshav qab zib tsawg.
Lub sijhawm luv luv ntawm lub Humalog tsis yog qhov ua tsis zoo, tab sis qhov zoo ntawm cov tshuaj. Ua tsaug rau nws, cov neeg mob ntshav qab zib mellitus tsis tshua muaj kev tiv thaiv qog ntshav qab zib, tshwj xeeb tshaj yog thaum tsaus ntuj.
Neej Neeg Sib
Ntxiv rau qhov Humalog, lub tuam txhab kev lag luam kws tsim tshuaj Lilly France tsim cov Humalog Mix. Nws yog kev sib xyaw ntawm cov tshuaj insulin lispro thiab cov tshuaj sulfate. Ua tsaug rau qhov kev sib txuam no, lub sijhawm pib ntawm cov tshuaj hormone tseem zoo li qub, thiab lub sijhawm ua haujlwm tau nce ntxiv.
Humalog Mix muaj nyob rau hauv 2 ntau qhov:
| Tshuaj | Muaj pes tsawg leeg,% | |
| Lyspro insulin | Kev ncua ntawm insulin thiab tshuaj tiv thaiv | |
| Neej Neeg Qhia 50 | 50 | 50 |
| Neej Neeg Sib Xws 25 | 25 | 75 |
Qhov zoo dua ntawm cov tshuaj no yog cov tshuaj txhaj yooj yim dua. Kev tiv thaiv kab mob ntshav qab zib mellitus thaum lawv siv yog qhov phem dua li nrog kev kho mob ntxiv ntawm kev siv tshuaj insulin thiab kev siv Humalog li ib txwm, yog li ntawd, rau cov me nyuam Humalog Mix tsis siv.
Qhov tshuaj insulin no tau sau tseg:
- Cov neeg mob ntshav qab zib uas tsis tuaj yeem xam tus kheej ntawm koob tshuaj lossis ua ib qho kev txhaj tshuaj, piv txwv, vim tsis pom kev tsis zoo, tuag tes tuag taw lossis tshee.
- Cov neeg mob mob hlwb.
- Cov neeg laus uas muaj ntau yam mob ntshav qab zib thiab kev paub tsis zoo txog kev kho mob yog tias lawv tsis xav paub txoj cai los laij insulin.
- Tus neeg mob ntshav qab zib nrog hom 2 yog tias nws tus kheej ua cov tshuaj hormones tseem tab tom ua.
Kev kho mob ntshav qab zib nrog Humalog Mix yuav tsum noj zaub mov kom nruj, yuav tsum noj khoom txom ncauj thaum noj mov. Nws raug tso cai noj 3 XE rau noj tshais, txog 4 XE rau noj su thiab noj hmo, txog 2 XE rau noj hmo, thiab 4 XE ua ntej yuav mus pw.
Cov Kev Tshaj Tawm ntawm Humalog
Lyspro insulin raws li cov tshuaj nquag muaj tsuas yog nyob hauv thawj phau ntawv teev npe. Cov tshuaj uas ze ze yog NovoRapid (raws li aspart) thiab Apidra (glulisin). Cov cuab yeej no tseem yog ultra-luv, yog li nws tsis muaj teeb meem twg uas yuav tsum xaiv. Txhua tus tau txais txiaj ntsig zoo thiab muab cov suab thaj txo ntau. Raws li txoj cai, kev nyiam yog muab rau cov tshuaj, uas tuaj yeem muab pub dawb hauv chaw kho mob.
Qhov kev hloov pauv ntawm Humalog mus rau nws txoj kab ke paum yuav tau tsim nyog muaj kev fab ua txhaum. Yog tias tus mob ntshav qab zib ua raws li cov zaub mov tsis zoo, lossis feem ntau muaj ntshav qab zib hauv lub cev, nws yog qhov muaj kuab siv tib neeg ntau dua li siv cov tshuaj insulin.
