Kev siv cov protease inhibitors rau kev kho ntawm tus txiav

Nrog rau cov kab mob pancreatitis, kev ua kom cov proteases ua rau ua rau muaj kev puas tsuaj rau cov khoom hauv nruab nrog cev thiab kev txhim kho ntawm thaj chaw necrotic.

Txhawm rau tiv thaiv cov txheej txheem pathological, cov kws tshaj lij sau ntawv rau Contrical, Trasilol, Gordoks lossis Antagozan. Kev siv cov tshuaj no rau kev tswj hwm ntawm qhov quav yog qhov tseem ceeb ntawm thawj hnub ntawm kev mob tuaj yeem ua mob rau hauv siab.

Cov Hom Tshuaj Pancreatic Enzymes

Lub luag haujlwm tseem ceeb ntawm tus txiav yog ua kom endocrine (sab hauv) thiab exocrine (sab nraud) txoj haujlwm. Kev ua haujlwm ntawm endocrine muaj nyob rau hauv kev tsim cov tshuaj hormones - insulin, uas ua kom cov piam thaj qis, thiab glucagon, uas txhawb nqa qhov kev tso tawm ntawm cov piam thaj hauv lub siab.

Lub exocrine muaj nuj nqi ntawm lub caj pas yog qhov khoom tsim tshwj xeeb (enzymes) rau kev zom cov zaub mov. Lawv yuav tsum tau muab faib ua ntau pawg - lipolytic, amylolytic thiab enzymes proteolytic. Cia peb xav txog hauv kev piav qhia txhua ntu.

Lipolytic cov enzymes. Pab pawg no yog lub luag haujlwm rau qhov tawg ntawm cov rog rau cov roj ntsha thiab glycerol. Prolipase yog qhov muaj zog lipase enzyme uas, thaum nws nkag rau hauv duodenum, sib xyaw nrog colipase.

Kev ua kom lipase tshwm sim nrog kev them nyiaj txaus ntawm cov kua tsib thiab trypsin. Kev rhuav tshem cov lipolytic xyaw ua hauv 7-14 teev. Lub raum glomeruli yog lub luag haujlwm rau lawv cov pom: lawv txhawb kev nqus ntawm lipase hauv cov qauv ntaub so ntswg, yog li ntawd cov khoom ntawm lipolytic tsis pom nyob hauv cov zis. Cov tshuaj zoo li lipase kuj tseem ua los ntawm lub siab, lub ntsws thiab txoj hnyuv.

Cov ntshav enzyme Amylolytic. Muaj ntau ntau yam - alpha, beta thiab gamma amylase. Pab pawg ntawm cov enzymes no tseem hu ua cov hmoov txhuv nplej siab. Hauv cov txheej txheem kev zom, tsuas yog alpha-amylase nkaus xwb.

Nws kuj tseem ua tawm me me ntawm cov qog ua kua qaub ncaug, tshwj xeeb tshaj yog thaum zom zaub mov. Yog li, peb hnov ​​lub qab zib thaum zom cov zaub mov uas muaj hmoov nplej - mov los yog qos yaj ywm ua noj. Ua tsaug rau amylase, txoj kev hais kom ua paug ntawm cov hmoov txhuv nplej siab thiab lwm cov kev ua kom thoob tsib yuav yooj yim.

Cov Proteolytic enzymes. Lub luag haujlwm tseem ceeb ntawm pawg neeg no yog qhov tawg ntawm cov nqaijrog. Proteolytic enzymes pab txhawb kom tawg ntawm cov amino acids uas muaj nyob hauv peptides thiab cov protein. Muaj ob yam sib txawv ntawm cov protease hauv cov kua txiv quav yeeb:

1. Peptidase, lossis exopeptidase, lub luag haujlwm rau lub hydrolysis ntawm cov tebchaw sab nraud ntawm peptides.
2. Proteinase, lossis endopeptidase, uas tawg rau hauv cov sib txuas sab hauv ntawm peptides.

Yog li, lipase, amylase thiab protease tsim cov kua txiv pancreatic, uas, thaum nws nkag rau hauv duodenum, zom cov zaub mov molecules rau hauv cov khoom sib txig sib luag.

Ua rau thiab pom tshwm sim ntawm pancreatitis

Hauv cov neeg noj qab nyob zoo, kev ua kom muaj zog ntawm pancreatic enzymes tshwm sim hauv duodenum.

Yog tias kev ua haujlwm ntawm amylase, protease thiab lipase pib tshwm sim hauv lub nqus ntshav nws tus kheej, peb tuaj yeem tham txog qhov tsis ua haujlwm ntawm cov khoom nruab nrog.

Pancreatitis yog to taub hais tias muaj kev nyuaj ntawm cov mob sib kis thiab cov kab mob nrog los ntawm kev ua kom cov enzymes hauv lub qog, uas ua rau cov txheej txheem ntawm "kev zom tus kheej". Raws li qhov tshwm sim, lawv tsis nkag mus rau hauv duodenum, thiab kev zom plab tau cuam tshuam.

Muaj ntau qhov laj thawj uas ua rau lub luag haujlwm ntawm pathological:

• nquag haus
• tsis ua raws li kev noj zaub mov zoo;
• ntev li ntawm kev noj cov khoom kib thiab roj;
• noj zaub mov zoo dhau tom qab noj zaub mov nruj lossis yoo mov;
• kev tswj tsis tau ntawm qee yam tshuaj noj;
• lub plab zom mov raug mob;
• pathology ntawm qhov kis tau.

Nrog rau kev ua kom ntev ntawm cov enzymes hauv cov txiav, mob tshwm sim: nws nce qhov loj me, thiab thaj chaw necrotic tshwm sim. Xws li tus txheej txheem tsis tuaj yeem yog asymptomatic, ntxiv rau, muaj kev ua txhaum ntawm txoj hnyuv plab.

Nrog lub cev tsis tuaj yeem ua mob ntawm pancreatic enzymes hauv duodenum thiab mob ntawm lub txiav, cov tsos mob hauv qab no tau pom:

1. Kev mob nyob rau hauv sab laug hypochondrium, feem ntau ntawm ib tug shingles xwm.
2. Kev txo qis hauv kev ua tsis taus, kev hais tsis zoo thiab tsis muaj zog.
3. Dyspeptic tsis meej - tsam plab, xeev siab lossis ntuav, tsis qab los noj mov, tso quav tsis hnov ​​lus.

Cov tsos mob ntawm tus kab mob tuaj yeem sib txawv raws qhov tsis muaj ib qho enzyme tshwj xeeb:

• Amylase deficiency ua rau lub plab zom mov, vitamin tsis txaus, poob ceeb thawj poob. Cov quav ua kua, cov tsis muaj quav cais ntawm cov zaub mov nyob hauv nws.
• Qhov tsis txaus ntawm lipase uas zom cov rog ua rau steatorrhea - kev nce ntxiv ntawm cov roj ntau hauv cov quav. Nrog kev mob pancreatitis, txoj hnyuv plab hnyuv mus ua daj lossis txiv kab ntxwv, ib qho admixture ntawm hnoos qeev yog pom hauv lawv.
• Nrog lub cev tiv thaiv tsis muaj zog, cov protein tsis tau txais kev pab uas pom muaj nyob hauv cov quav. Cov yam ntxwv ntawm tus yam ntxwv yog kev loj hlob ntawm lub cev tsis muaj ntshav.

Yog tias ib tug neeg paub txog cov phiajcim no, nws yuav tsum nrhiav kev pab kho mob sai li sai tau. Tus kws kho mob yuav sau ntawv hla dhau ntawm kev sim thiab kev kho txaus.

Pancreatic Ntuj Enzyme Inhibitors

Lub cev tsim tawm tsis tsuas yog cov enzymatic tshuaj uas pab txhawb kev puas tsuaj ntawm cov lwg me me, tab sis kuj txwv tsis pub ua kom zais cov kab mob uas tsis tuaj yeem tawm, i.e. Cheebtsam uas tiv thaiv ntau dhau los ntawm kev ua kua txiv kab ntxwv.

Enzyme blockers suav nrog pancreatic polypeptide (PPP), YY peptide, somatostatin, pancreatic glucagon, pancreastatin thiab neuropeptides.

Cov islets ntawm Langerhans, feem ntau nyob hauv tus Tsov tus tw ntawm qhov txiav, ua cov tshuaj hormones tshwj xeeb, PPP, uas inhibits pancreatic ntau lawm dej, enzymes thiab bicarbonates. Nws tseem inhibits zus ntawm acetylcholine.

PPP kev zais ntxiv nyob rau hauv cov xwm txheej zoo li no:

1. nrog kev xav qhov xav noj lossis noj zaub mov;
2. tom qab stimulation ntawm lub paum plab hlab ntsha;
3. nrog acidification ntawm duodenum;
4. thaum kis mus rau gastrin thiab gastrin-tso peptide;
5. thaum kis mus rau secretin, cholecystokinin thiab VIP.

Lub distal ileum thiab hnyuv tso tawm YY peptide sai li sai tau cov rog nkag mus rau hauv lub plab zom mov. Cov peptide no pab txo qis kev muaj peev xwm ntawm lub qog rau qhov cuam tshuam ntawm cholecystokinin thiab secretin.

Pancreatic D hlwb thiab cov roj ntsha ntawm lub plab zom zaub mov ua kom somatostatin. Qhov cov tshuaj no qhov tshuaj tiv thaiv kev tsim cov enzymes thiab bicarbonates. Lub autonomic lub paj hlwb siv sijhawm hauv kev tsim cov tshuaj somatostatin, sai li sai tau cov rog thiab amino acids tuaj ntawm cov zaub mov.

Lwm qhov kev txiav txim siab pancreatic yog sawv cev los ntawm cov tshuaj hormones no:

• Pancreatic glucagon, uas nres qhov kev tsim cov tshuaj ua kua, bicarbonates thiab enzymes.
• Pancreatin, inhibiting kev tso tawm ntawm acetylcholine. Nws yog tsim nyob rau ntawm qhov kawg efferent ntawm lub paum ntawm lub paum.
• Neuropeptides, uas muaj cov calcitonin-peptide-cov ntaub ntawv peptide (txhawb kev somatostatin) thiab enkephalins (txo cov khoom ntawm acetylcholine).

Nrog rau cov txheej txheem ua rau lub qog, lub tso pa tawm ntawm pancreatic enzyme inhibitors yuav tsis muaj zog, yog li ntawd, cov tshuaj yuav tsum tau noj.

Cov ntsiab cai ntawm kev kho rau pancreatitis

Ob lub ntsiab lus tseem ceeb ntawm kev kho mob rau tus mob yog kev noj haus thiab tshuaj kho. Txoj kev kho mob yog tsim kho tus kheej nyob ntawm qhov mob hnyav ntawm tus kab mob thiab kev puas tsuaj rau ntawm lub txiav.

Cov khoom noj tshwj xeeb rau kab mob pancreatitis yog ua raws cov zaub mov noj naj npawb 5 raws li Pevzner. Nws tshem tawm ntau dhau los ntawm kev noj cov khoom noj uas muaj cov carbohydrate thiab cov rog, thiab tseem ua rau noj cov zaub mov muaj protein ntau.

Nrog rau qhov pib ntawm mob caj dab ntev, 3-4 hnub ntawm kev yoo mov yog kho. Nyob rau lub sijhawm no, koj yuav tsum kiag li tsis kam noj thiab haus dej sov ua kua alkaline, piv txwv li, Borjomi.

Tom qab tshaib plab nrog pancreatitis, cov zaub mov txawv txawv tau nkag mus rau hauv kev noj haus uas yuav tsis tsim txom cov plab zom mov. Cov neeg mob uas muaj mob pancreatitis raug tso cai siv:

• kev noj haus ntau hom nqaij thiab ntses;
• zaub kua zaub thiab ntxim nyiam cov kua zaub;
• nag hmo mov ci thiab khob cij;
• skim cov khoom noj siv mis;
• txiv hmab txiv ntoo tshiab, tshuaj ntsuab thiab zaub;
• cereals siav hauv dej los yog skim mis nyuj;
• qe hauv cov naj npawb tsawg;
• rosehip broth, zib ntab los yog jam (txwv).

Nrog rau mob ntawm tus txiav, nws yog ib qho tsim nyog yuav tsum tsis kam noj cov zaub mov uas ua rau kev zom zaub mov ntxiv:

1. Cov khoom qab zib, ncuav qab zib, ncuav qab zib.
2. Mov tshiab.
3. Fried zaub mov.
4. Khaws cia, nqaij nqaij thiab pickles.
5. Rog tej nqaij thiab ntses.
6. Rog rau khoom noj siv mis.
7. Si haus dej.
8. Cov txuj lom.
9. Cov nplua nuj kua zaub.
10. Muaj ntau lub qe.
11. Lub zog tshuaj yej thiab kas fes.
12. Nqaij tawv.
13. Legumes thiab txiv lws suav.

Nrog exacerbation ntawm kev mob caj dab ntev, nws yog ib qho tsim nyog yuav tsum ua raws li lub txaj so.

Cov tshuaj noj rau cov txiav ua kab mob nrog:

• enzyme inhibitors kom txo qis kev ua haujlwm ntawm pancreatic proteases (proteinases);
• cov kab mob tua kab mob kom tsis txhob muaj cov kab mob ua rau lub plab ua kom plab, purulent mob ntawm lub plab bursa, kev txhim kho ntawm pancreatic necrosis thiab rotul cellulitis cellulose ntawm qhov chaw tom qab peritoneum;
• Cov H2 blockers kom txo qis cov kua txiv hydrochloric acid;
• antacids rau neutralize hydrochloric acid nyob rau hauv cov hnyuv;
• antispasmodics rau cov leeg txhawm rau ua kom cov leeg nqaij txuas nrog ua haujlwm tsis zoo ntawm lub cev ua haujlwm hauv tus kab mob pancreatic duct;
• anticholinergic tshuaj txhawm rau txhawm rau thaiv cov kev ua haujlwm tsis txaus ntseeg hauv ganglia thiab cerebral cortex;

Ntxiv rau, cov tshuaj tiv thaiv enzymatic yog siv los txhim kho kev zom zaub mov thiab tshem tawm dyspeptic tsis txaus ntseeg.

Tshuaj kho mob zoo

Thawj hnub ntawm exacerbation ntawm daim ntawv ntev, kev siv ntawm protease inhibitors rau kev kho mob ntawm pancreatitis yog yam. Cov tshuaj no tshem tawm qhov ua rau ntawm qhov tshwm sim ntawm inflammatory foci thiab kev sib kis ntawm thaj chaw necrotic.

Cov tshuaj noj tau txais los ntawm kab mob ntsws pulmonary parenchyma thiab nyuj rawm.

Hauv qab no yog cov tshuaj zoo tshaj plaws, qhov ntau npaum ntawm tau txiav txim siab ib tus zuj zus los ntawm tus kws kho mob koom nrog. Lawv tsis muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tab sis nyob rau hauv daim ntawv ntawm mloog zoo los yog lyophilisate rau Txoj kev lis ntshav.

Kev kho ntawm pancreatitis nrog inhibitors nrog kev tswj hwm ntawm lub cev yog nqa tawm tsuas yog hauv txoj haujlwm supine. Ntxiv mus, tus kws tu mob thiab kws kho mob yuav tsum ua tib zoo saib xyuas tus neeg mob lub sijhawm. Kev noj haus No. 5 kuj yuav tsum muaj kev soj ntsuam nruj me ntsis, uas, nrog rau kev siv tshuaj kho mob, yuav ua kom ntseeg tau tias tus neeg mob tau ua tiav zoo yam tsis muaj teeb meem.

Yuav kho tus mob pancreatitis li cas yuav piav los ntawm cov kws txawj hauv video hauv tsab xov xwm no.