Ofloxin 200 yog yeeb tshuaj los ntawm pawg fluoroquinolones, tus neeg sawv cev rau ntau-cov tshuaj tiv thaiv kab mob. Nov yog ib qho ntawm cov tshuaj feem ntau thiab siv tshuaj tua kab mob.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN - Ofloxacin.
ATX
J01MA01.
Tso cov ntawv thiab cov nyob ua ke
Muaj nyob hauv ntau daim ntawv txiav cov khoom - khoom, kua, mos. Nws muaj ntau txoj kev thov. Cov khoom ua si nquag ntawm txhua daim ntawv yog ofloxacin, quinolone ntawm II tiam.
Ofloxin 200 yog yeeb tshuaj los ntawm pawg fluoroquinolones, tus neeg sawv cev rau ntau-cov tshuaj tiv thaiv kab mob.
Ntsiav tshuaj
Them thiab muaj cov nqi sib txawv ntawm cov ntsiab cai nquag. Ofloxin ntsiav tshuaj, ntxiv rau lub zog hluavtaws tshuaj ofloxacin (200 thiab 400 mg ib qho), muaj cov khoom ntxiv:
- mis nyuj qab zib;
- pob kws nplej siab;
- talc;
- hypromellose 2910/5.
Cov ntsiav tshuaj yog coated thiab muaj cov nqi sib txawv ntawm cov ntsiab cai nquag.
Cov ntsiav tshuaj sib txawv raws li cov duab thiab cov ntawv luam qhia qhov muaj nyiaj npaum li cas (200 thiab 400 mg rau ib). Txhua lub thawv ntawv muaj 1 blister muaj 10 ntsiav tshuaj.
Ncos
Ntsej thiab lub qhov muag pom yog muaj. 1 ml ntawm cov tshuaj ntshiab muaj:
- 3 mg ofloxacin;
- saline daws;
- benzalkonium chloride;
- hydrogen chloride;
- npaj dej.
Ntim rau hauv lub raj mis yas nrog dej poob.
Ofloxin 200 muaj nyob rau hauv daim ntawv ntawm pob ntseg thiab qhov muag pom kev.
Hmoov
Nws tsis muaj daim foos no ntawm kev tso tawm.
Tshuaj
Kev daws rau Txoj kev lis ntshav ntawm lub pob tshab daj-ntsuab yog ntim hauv 100 ml vials. Lub raj mis muaj 200 mg ntawm qhov tseem ceeb thiab cov neeg xa tawm:
- saline daws;
- Trilon B;
- hydrogen chloride;
- npaj dej.
Cov tshuaj ntsiav
Daj tsiav daj ua ke nrog lub hau liab-xim av muaj:
- ofloxacin - 200 mg;
- hypromellose;
- sodium lauryl sulfate;
- mis nyuj qab zib;
- calcium phosphate bisubstituted anhydrous;
- talcum hmoov.
Cov nkaws daj hauv cov tshuaj ua ke hauv cov hlwv ntawm 10 daim.
Cov tshuaj ntsiav tau ntim rau hauv cov hlwv ntawm 10 daim.
Tshuaj pleev
Cov tshuaj muaj nyob hauv daim ntawv me - tshuaj pleev rau kev kho qhov txhab (Oflokain) thiab qhov muag pleev rau kev tso rau hauv lub hnab ntim conjugate. Tshuaj pleev yog muab ntim rau hauv cov hlab li 15 lossis 30 g. Hauv 1 g ntawm cov khoom muaj:
- 1 mg ofloxacin;
- 30 mg lidocaine hydrochloride;
- propylene glycol;
- poloxamer;
- macrogol 400, 1500, 6000.
Qhov muag tshuaj pleev qhov muag tau tsim hauv cov hlab 3 thiab 5 g, uas muaj:
- ofloxacin - 0.3 g;
- nipagin;
- nipazole;
- roj av jelly.
Cov tshuaj muaj nyob rau hauv daim ntawv me - tshuaj pleev rau kho qhov txhab thiab qhov muag pleev rau qhov tso rau hauv lub hnab ntim conjugate.
Cov tswm ciab
Lub paum suppositories muaj nyob rau hauv ntau cov npe khoom lag luam.
Pharmacological kev txiav txim
Cov kab mob muaj zog ntawm Ofloxin 200 yog vim qhov inhibition ntawm DNA-gyrase - cov enzymes lub luag haujlwm rau cov synthesis ntawm DNA hauv cov kab mob hlwb thiab lawv kev yug me nyuam. Cov enzymes no koom tes nrog ob ntawm cov txheej txheem tseem ceeb tshaj plaws - kauv thiab ua kom nws txoj kev ruaj khov. Fluoroquinolone ua rau muaj kev puas tsuaj rau cov kab mob ntsws, yog li txoj kev pheej hmoo ntawm cov ntaub ntawv tsis kam yog tsawg.
Cov tshuaj nquag tshaj tawm tsam cov kab mob gram-negative. Ofloxin 200 lub hom phiaj thaum kis rau lawv yog topoisomerase II. Ntawm cov pab pawg ntawm fluoroquinolones, cov tshuaj sawv tawm rau nws qhov haujlwm tshwj xeeb tawm tsam gram-zoo cocci. Nws lub hom phiaj yog topoisomerase IV.
Cov tshuaj nquag tshaj tawm tsam cov kab mob gram-negative.
Cov chaw muag tshuaj ntawm cov tshuaj yeeb yam yog raws li kev puas tsuaj ntawm kev sib txuas ntawm cov DNA pab (kev puas tsuaj ntawm nws), uas ua rau cov kab mob tuag ntawm tes. Cov kev xaiv zoo li no ua rau muaj koob npe nrov ntawm ofloxacin thiab lwm yam fluoroquinolones - cov kab mob feem ntau tiv taus lwm hom tshuaj tua kab mob thiab sulfonamides muab rau lawv cov kev puas tsuaj.
Cov tshuaj muaj tsawg kawg ntawm kev siv tshuaj lom, ua li ua tsuas yog ntawm cov khoom siv caj ces ntawm cov kab mob ntawm tes, tsis muaj kev puas tsuaj rau cov qauv ntawm tib neeg DNA. Yog li, cov tshuaj siv rau hauv menyuam yaus kev kawm andrological.
Cov Tshuaj Pharmacokinetics
Cov tshuaj tau nrawm thiab nrawm nyob rau hauv txoj hnyuv, kom txog lub siab nyob rau hauv cov ntshav tom qab 1-3 teev. Cov zaub mov me ntsis cuam tshuam cov txheej txheem nqus, tab sis tsis cuam tshuam rau nws qhov tiav. Cov tshuaj muaj ib qhov siab tshaj plaws ntawm kev zom zaub mov ntawm fluoroquinolones - txog 100%.
Cov tshuaj tau nrawm thiab nrawm nyob rau hauv txoj hnyuv, kom txog lub siab nyob rau hauv cov ntshav tom qab 1-3 teev.
Nws ib nrab-lub neej yog 5-10 teev, yog li cov tshuaj muaj peev xwm noj 1-2 zaug ib hnub. Qhov concentration ntawm cov tshuaj nyob rau hauv cov ntaub so ntswg yog sib npaug los yog siab dua ntshav dej. Yog tias kev noj tshuaj loj rau noj, ces cov tshuaj tuav dej hauv:
- Nruab nrab cev;
- bronchial leeg;
- articular hnab;
- urogenital system;
- sab hauv lub cev tiv thaiv kab mob.
Vim tias cov cuab yeej no, cov tshuaj muaj txiaj ntsig ntawm kev kho mob ntawm tus mob intracellular. Ofloxacin muaj tsawg kawg ntawm kev hloov pauv hauv lub cev - 75-90% ntawm cov khoom raug tshem tawm tsis hloov pauv hauv cov zis, uas yog qhov tseem ceeb hauv kev kho pathologies ntawm ob lub raum thiab lub plab.
Cov tshuaj nyob rau hauv cov ntshav ntshav tsis tau khi rau cov protein thiab tuaj yeem nkag mus los ntawm lub txaj vascular mus rau cov ntaub so ntswg.
Cov tshuaj nyob rau hauv cov ntshav ntshav tsis tau khi rau cov protein thiab tuaj yeem nkag mus los ntawm lub txaj vascular mus rau cov ntaub so ntswg. Cov tshuaj yog txawv:
- kev ua tau zoo ntawm ib qho pH;
- tsis muaj cov nyhuv ntawm cov tshuaj pharmacokinetics ntawm methylxanthines;
- muaj cov kev ua ntawm postantibiotic;
- qis qis dua ntawm dysbiosis;
- dej siab kev nyab xeeb profile.
Cov tshuaj tsis cuam tshuam rau cov intrauterine thiab tom qab kev txhim kho ntawm tus me nyuam hauv plab.
Kev ntsuas rau siv
Qhia rau kev kho mob ntawm kab mob:
- cov kab mob zis;
- poj niam thiab txiv neej qhov chaw mos;
- Kab Mob STI
- txoj hnyuv;
- biliary system;
- nosocomial thiab postoperative;
- ua pa;
- septicemia thiab bacteremia;
- Nruab nrab cev;
- tuberculosis, mob ruas.
Cov tshuaj pleev no yog siv los kho cov kab mob ntawm daim tawv nqaij, kab mob hniav, thiab kho cov mob txhab.
Cov Yuav Tsum Muaj
Cov lus qhia ua kev sib txuas nrog kev siv Ofloxin 200 qhia tias:
- kev ua haujlwm tsis txaus siab;
- cev xeeb tub thiab lactation;
- kev kho rau cov menyuam yaus hnub nyoog qis dua 18 xyoo;
- mob vwm thiab mob plab hlwb;
- muaj cov leeg puas tsuaj vim yog siv cov tshuaj fluoroquinolones;
- cytosolic enzyme deficiency (G6FD).
Nrog saib xyuas
Ceev faj tshuaj rau:
- cerebral arteriosclerosis;
- circulatory mob hauv lub hlwb;
- lub raum tsis ua haujlwm;
- kev txawv txav ntawm kev txhim kho thiab mob ntawm lub hauv nruab nrab lub paj hlwb;
- lub plawv atherosclerosis tsis ua hauj lwm nrog lub caij nyoog ntawm QT luv.
Ntau cov contraindications tau raug tshuaj xyuas.
Yuav ua li cas noj Ofloxin 200
Cov neeg mob cov laus tau hais qhia 200-600 mg. Lub sijhawm siv ntawm kev kawm yog 7-10 hnub. Ib cov tshuaj hauv qhov ntau npaum li ntawm 400 mg tuaj yeem noj ib zaug, nyiam dua thaum sawv ntxov, ib nrab teev lossis ib teev ua ntej noj mov, ntau qhov koob tau muab faib ua 2 koob. Nws raug nquahu kom nqos cov ntsiav tshuaj tag nrho nrog dej. Hauv kev mob hnyav thiab rog rog, nce ntxiv kom txog li 800 mg / hnub tau tso cai.
Yog hais tias muaj cov kab mob ntawm cov kab mob tso zis qis dua (prostatitis, cystitis, urethritis) tsis nyuaj, tom qab ntawd nws txaus los noj 200 mg 1 zaug hauv ib hnub rau 3-5 hnub. Txog kev kho kab mob gonorrhea, ib koob tshuaj nkaus xwb 400 mg pom zoo.
Qhov ntau npaum cas thiab kev kho mob rau cov neeg mob raum tsis ua hauj lwm zoo yog nyob ntawm kev tshem tawm creatine:
| Cl creatine (ml / min.) | Cov khoom siv ntau npaum li cas (mg) | Viav vias (ib hnub ib zaug) |
| 50-20 | 200 | 2 |
| 400 | 1 | |
| < 20 | 200 - thawj | 1 |
| 100 | Txhua 2 hnub | |
| Hemodialysis, peritoneal lim ntshav tawm | 100 | 2 |
Kev kho mob pib nrog kev tswj hwm kom zoo thiab, tom qab kev tswj kho tus mob, qhov ncauj tswj hwm hauv tib lub tshuaj yog tshuaj.
Thaum twg tsis koob tshuaj
Yog tias tus neeg mob tsis nco qab noj tshuaj, ces nws raug tso cai kom noj sai li uas tus neeg mob nco qab txog nws.
Cov tshuaj hauv qhov ntau npaum li ntawm 400 mg tuaj yeem noj ib zaug, nyiam dua thaum sawv ntxov, ib nrab teev lossis ib teev ua ntej noj mov.
Noj cov tshuaj rau ntshav qab zib
Cov neeg mob uas kuaj pom tus kab mob ntshav qab zib lub caij thaum kawm nrog Ofloxin 200 xav tau cov tswj ntshav qabzib, vim tias tib lub sij hawm kho nrog kev noj qab zib-txo cov tshuaj, insulin thiab fluoroquinolones tuaj yeem ua rau mob hypo- lossis hyperglycemia.
Qhov tshwm sim ntawm inloxine 200
Cov tshuaj muaj kev tiv thaiv zoo - kev tsis zoo tshwm sim li 0.5-10% ntawm tus neeg mob. Txawm li cas los xij, muaj qhov tsis zoo tshwm sim qee zaum sau tseg.
Cov neeg mob uas kuaj pom tus kab mob ntshav qab zib ntshav qab zib thaum lub caij nrog Ofloxin 200 xav tau kev tswj ntshav qabzib.
Kev kho mob txoj hnyuv
Mob thiab mob plab tsis xis nyob, mob plab tsis haum. Tsis tshua muaj neeg pom:
- plab hnyuv siab;
- qab los noj mov tsis xis nyob;
- hyperbilirubinemia;
- kab mob siab.
Hematopoietic plab hnyuv siab raum
Mob ntshav liab, mob leukopenia, pancytopenia, thrombocytopenia yog sau tseg.
Nruab nrab hauv lub paj hlwb
Hauv daim ntawv ntawm kiv taub hau, ntxhov siab, pw tsis meej. Tsis tshua muaj manifested:
- xeev kev zoo siab lossis ntxhov siab;
- kev xav thiab phobias;
- nce siab intracranial;
- ua kom pom tseeb;
- kev nyuaj siab
Los ntawm cov leeg musculoskeletal
Tau:
- tendonitis;
- nqaij leeg;
- o ntawm cov pob txha sib txuas thiab ligamentous;
- leeg tsis muaj zog thiab mob.
Los ntawm lub tshuab ua pa
Tsis khij.
Ntawm ib sab ntawm daim tawv nqaij
Hauv daim ntawv ntawm petychia, tawm pob, dermatitis.
Los ntawm genitourinary system
Tsis tshua muaj nyob rau hauv daim ntawv ntawm:
- hypercreatininemia;
- jade;
- nce urea.
Los ntawm cov hlab plawv system
Lub plawv atherosclerosis tau tawg, ntshav siab poob qis, cov hlab ntshav tau kub hnyiab, cev qhuav dej tawm tuaj.
Endocrine system
Tsis pom.
Kev ua xua
Cov tawv nqaij ua pob khaus, khaus, ua tsis taus pa, tsis haum nephritis, o ntawm lub ntsej muag lossis caj dab, kev ua xua ntawm lub ntsws, Quincke's edema, qhov tsis nco qab ceeb.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nws yog txwv tsis pub tsav tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj uas yuav tsum muaj kev nkag siab.
Tom qab noj cov tshuaj, nws yog txwv tsis pub tsav tsheb.
Cov lus qhia tshwj xeeb
Tsis muaj txiaj ntsig rau cov kab mob pathologies los ntawm pneumococci lossis mycoplasmas - mob ntsws ntev, mob ntsws, mob ntsws.
Yog tias muaj cov tsos mob ntawm kev ua xua, qhov tshwm sim tsis zoo los ntawm lub hauv nruab nrab hauv lub paj hlwb, koj yuav tsum tshem tawm cov tshuaj.
Thaum lub sijhawm kho mob, insolation, raug rau UV hluav taws xob hauv lub hnub ci thiab kho lub cev yuav tsum raug cais tawm.
Siv thaum cev xeeb tub thiab lactation
Contraindicated vim muaj kev hem thawj ntawm kev loj hlob ntawm pathologies ntawm cov pob qij txha thiab cov leeg nqaij hauv plab. Thaum pub niam mis, nws yog ib qhov tsim nyog yuav tsum xa cov menyuam mus rau niam cov mis.
Khaws Ofloxin rau 200 tus menyuam
Cov menyuam yaus tsis tau xaj tshuaj txog thaum txoj kev loj hlob thiab tsim cov leeg ua kom tiav. Txawm li cas los xij, rau kev noj qab haus huv thiab qhov tsis muaj txiaj ntsig zoo rau lwm cov tshuaj tua kab mob, Ofloxin 200 tej zaum yuav raug kho nyob rau ntawm ntau npaum li 7.5 mg rau 1 kg ntawm lub cev qhov hnyav. Qhov tso cai ntau tshaj yog 15 mg / kg.
Cov menyuam yaus tsis tau xaj tshuaj txog thaum txoj kev loj hlob thiab tsim cov leeg ua kom tiav.
Siv rau lub sijhawm qub
Nws tau sau tseg kom zoo vim tias qhov hloov ntsig txog lub hnub nyoog thiab cov kev pheej hmoo ntawm qhov tshwm sim tsis zoo.
Daim ntawv thov rau lub raum khiav tsis zoo
Nws yog qhov tsim nyog yuav tau kho cov tshuaj nyob rau hauv kev tswj hwm ntawm theem ntawm creatine.
Siv rau lub siab ua haujlwm tsis zoo
Cov cuab yeej siv raug rau kev soj ntsuam tsis tu ncua ntawm cov nyiaj bilirubin, nrog rau qhov nce ntxiv ntawm cov koob tshuaj, cov tshuaj no tau kho los yog txiav tawm.
Yog tias ua rau lub siab ua haujlwm tsis zoo, cov tshuaj siv yog raug rau kev soj ntsuam tsis tu ncua ntawm cov nyiaj bilirubin.
Kev Siv Overloose Ntawm Ofloxin 200
Cov tsos mob ntawm intoxication tau sau tseg:
- dyspeptic tshwm sim;
- hypersomnia;
- tsis meej pem.
Cov tshuaj raug muab tso tseg, kev mob plab zom mov yog ua. Nrog rau kev qaug cawv hnyav, mob hemodialysis ua tau.
Kev cuam tshuam nrog lwm yam tshuaj
Nws cuam tshuam nrog pab pawg sib txawv ntawm cov tshuaj.
Contraindicated kev sib txuas ua ke
Tsis txhob siv ua ke nrog:
- NSAIDs - muaj peev xwm txo qis ntawm txoj hlab ntsws qaug dab peg;
- quinolones thiab tshuaj nrog cov roj ntsha hauv lub raum - kev nce siab ntawm inloxin thiab lengthening lub sijhawm ntawm nws cov excretion;
- antihypertensive cov neeg sawv cev, barbiturates - txo qis hauv cov ntshav siab yog tau;
- glucocorticoids - kev pheej hmoo ntawm cov leeg mob;
- anthocyanins - txo qis kev zom zaub mov;
- txhais tau hais tias hloov pH ntawm cov zis mus rau sab alkaline - cov nyhuv nephrotoxic yog tau.
Tsis pom zoo kev sib txuas ua ke
Nws yog txwv tsis pub mus ua ke nrog:
- vitamin K antagonists - muaj peev xwm nce ntshav coagulation;
- Glibenkamide - yuav ua rau kev nce siab ntawm glibenclamide hauv cov ntshav cov ntshav;
- thaum lub sij hawm tshawb nrhiav, cov tshuaj muaj peev xwm muab qhov cuav tsis zoo rau cov tshuaj opiates thiab porphyrins hauv kev tso zis.
Tej kev sib txuam uas xav tau ceev faj
Cov neeg muaj peev xwm nce siab ntxiv ntawm cov kev ua ntawm cov tshuaj tiv thaiv qhov ncauj tau qhia nrog kev kho mob ua ke nrog fluoroquinolones.
Nrog rau kev tswj fwm ntawm cov tshuaj uas ua txhaum cov kev tawm tsam, nws yuav tsum tswj hwm ECG.
Ofloxin 200 tsis sib xws nrog ethylate.
Cawv tau zoo
Inpatpatible nrog ethylate.
Analogs
Hloov chaw suav nrog: Ofaxin, Oflo, Floksan, Oftagel, Ofor.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Daim ntawv yuav tshuaj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Tsis yog.
Tus nqi ntawm Ofloxin 200
Hauv Ukraine - 133.38-188 UAH. Ntawm thaj chaw ntawm Lavxias Lavxias - 160-180 rubles.
Cov tshuaj yog ntawv yuav tshuaj.
Cia rau cov neeg mob rau cov tshuaj
Hauv qhov chaw tsaus, txias, tsis muaj dej noo.
Hnub tas sij hawm
Tsis ntev tshaj 3 xyoos.
Chaw tsim tshuaj paus
Czech koom pheej.
Kev txheeb xyuas ntawm Ofloxin 200
Nws tau txais kev tshuaj xyuas zoo los ntawm cov kws kho mob thiab cov neeg mob.
Cov kws kho mob
Maxim Alexandrovich, urologist, Minsk: "Thoob plaws hauv kuv txoj haujlwm kev kho mob Kuv tau siv cov tshuaj fluoroquinolones kho mob rau cov neeg mob. Kuv xav txog Ofloxin 200 ua tau zoo. Nws ua rau muaj txiaj ntsig zoo thiab zam tau yam tsis muaj kev phiv tshuaj."
Galina Sergeevna, tus kws kho mob txog poj niam, Kiev: "Ofloxin 200 feem ntau yog tsim rau cov neeg mob urogenital. Nws yog daim ntawv yooj yim, nws zoo tswj thiab tswj hwm qhov ntau npaum li cas. Nws zoo uas koj tsuas xav siv nws 1-2 zaug hauv ib hnub."
Cov neeg mob
Olga, 32 xyoo, Kaluga: "Cov tshuaj tau siv los kho cystitis. Nws yog mob hnyav. Tom qab ob peb hnub tom qab noj Ofloxin 200, tag nrho cov tsos mob ploj. Tab sis tsis muaj kev phiv, txawm tias paub qhov tseeb ntawm cov tshuaj tua kab mob thrush."
Mikhail, 22 xyoo, Omsk: "Kuv tau khaub thuas thaum ua haujlwm, teeb meem ntawm cov hlab zis tau pom.Tus kws kho mob sau tseg Ofloxin 200 ntsiav tshuaj - lawv tau ua haujlwm sai. Pab tau zoo heev. "
Tamara, hnub nyoog 40 xyoo, Horlivka: "Kuv tau txais qhov kev kuaj tsis zoo rau kis tus kab mob latent. Nyob rau kev pom zoo ntawm tus kws kho mob, Kuv tau mus kawm Ofloxin.
