Glimecomb yog ib tus neeg sawv cev hypoglycemic nyob hauv kev xav hauv hom 2 mob ntshav qab zib mellitus. Cov tshuaj nyob rau hauv parallel tuaj txhim kho lub xeev ntawm cov rog rog, txo kev pheej hmoo ntawm atherosclerotic plaques rau ntawm cov leeg tshav, txo lub cev qhov hnyav hauv kev rog. Cov tshuaj yog kws kho tsuas yog nyob rau hauv qhov tsis muaj ntawm cov nyhuv ntawm kev noj haus thiab kev tawm dag zog.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Glyclazide + Metformin.
Glimecomb yog ib tus neeg sawv cev hypoglycemic nyob hauv kev xav hauv hom 2 mob ntshav qab zib mellitus.
ATX
A10BD02.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb rau kev siv lub qhov ncauj, tus yam ntxwv ntawm daj lossis cream zas thiab lub tiaj-cylindrical puab. Lub chaw ntim tshuaj ua ke 2 lub cev sib xyaw: 40 mg ntawm gliclazide thiab 500 mg ntawm metformin hydrochloride. Povidone, magnesium stearate, sorbitol thiab croscarmellose sodium ua haujlwm pabcuam. Cov ntsiav tshuaj muaj nyob hauv 10 units hauv cov hlwv ntim. Hauv daim ntawv tuab cardboard muaj 6 lub hlwv.
Pharmacological kev txiav txim
Cov tshuaj yog hais txog cov tshuaj hypoglycemic sib xyaw ua ke rau kev tswj hwm qhov ncauj. Cov tshuaj muaj cov nyhuv ua rau txiav thiab rov qab ntxiv.
Glyclazide yog sulfonylurea derivative. Tus txheej txheem ntawm kev ua ntawm kev paub txog cov tshuaj lom neeg yog ua raws cov kev tawm ntawm kev ua kom zais cov kev ua ntawm cov kab mob pancreatic beta hlwb. Raws li cov txiaj ntsig ntawm hypoglycemic, qhov ua tau rau lub cev lub cev rau insulin nce, qhov khoom lag luam ntau lawm. Cov tshuaj nquag rov qab ua haujlwm thaum ntxov ntawm cov islets ntawm Langerhans thiab ua kom lub sijhawm luv luv txij li lub sijhawm noj mov mus rau lub zais ntawm cov kua dej.
Glimecomb txhawb nqa kev poob phaus thaum ua raws kev noj haus ntawm cov keeb kwm yav dhau los ntawm kev rog dhau.
Ntxiv nrog rau kev koom nrog hauv cov metabolism hauv cov metabolism, cov tshuaj txhim kho capillary microcirculation, txo platelet sib sau ua ke, thiaj li tiv thaiv kev txhim kho vascular thrombosis. Tawm tsam keeb kwm ntawm kev noj Glimecomb, permeability ntawm lub vascular phab ntsa yog li qub, microthrombosis thiab atherosclerosis nres, thiab ntuj parietal fibrinolysis yog rov qab. Cov tshuaj yog antagonist ntawm cov lus hauv vascular nce ntxiv rau adrenaline hauv microangiopathies. Txhawb nqa kev poob phaus thaum ua raws kev noj haus ntawm cov keeb kwm yav dhau los ntawm kev rog.
Metformin hydrochloride yog ib pab pawg neeg loj ua ke. Cov kev nquag nquag txo cov ntshav plasma concentration ntawm qab zib los ntawm kev tiv thaiv gluconeogenesis nyob rau hauv hepatocytes thiab txo tus nqi ntawm cov piam thaj nqus hauv cov hnyuv. Cov tshuaj yuav siv ib feem hauv lipid metabolism, txo qis qib ntawm cov lipoproteins uas tsis ntom, triglycerides thiab roj nyob rau hauv cov ntshav. Nws pab txo qhov hnyav hauv lub cev, tab sis qhov tsis muaj tshuaj nyob rau hauv ntshav dej, txoj kev kho ua kom tiav tsis tiav. Thaum cov kev tshawb fawb soj ntsuam, tsis muaj cov tshuaj tiv thaiv hypoglycemic sau cia.
Cov Tshuaj Pharmacokinetics
| Gliclazide | Metformin |
| Nrog cov thawj coj ntawm qhov ncauj, qhov ntsuas siab nqus tau pom tau. Thaum siv 40 mg, qhov siab tshaj plaws ntawm ib yam khoom hauv cov ntshav tau tsau tom qab 2-3 teev. Kev sib txuas lus nrog plasma protein yog qhov siab - 85-97%. Vim yog qhov tsim cov protein ntau, cov tshuaj tau faib tawm sai heev thoob plaws cov ntaub so ntswg. Nws yauv hloov pauv hauv hepatocytes. Qhov kev tshem tawm ib nrab-lub neej ua rau 8-20 teev. Cov khoom ua si nquag tau tawm hauv cov zis 70%, nrog quav los ntawm 12%. | Sai sai nqus los ntawm microvilli hauv txoj hnyuv me li 48-52%. Lub bioavailability thaum coj ntawm lub plab khoob yog 50-60%. Qhov siab tshaj plaws tau tiav 1-2 teev tom qab tswj hwm. Plasma protein khi yog tsawg. Kev ntsuas ntshav liab ntawm cov ntshav. Ib nrab-lub neej yog 6,2 teev. Cov tshuaj tau tawm dhau los ntawm lub raum hauv lawv daim ntawv qub thiab 30% los ntawm txoj hnyuv. |
Cov tshuaj yog siv los kho ntshav qab zib hom 2.
Kev ntsuas rau siv
Cov tshuaj yog siv los kho hom 2 mob ntshav qab zib mellitus, thaum muaj kev ua haujlwm zoo ntawm kev noj zaub mov zoo, kev tawm dag zog thiab kev siv tshuaj nrog Metformin thiab Gliclazide.
Tus neeg sawv cev hypoglycemic yog siv los hloov cov tshuaj nrog 2 tshuaj nyob hauv cov neeg mob uas tsis muaj cov kabmob ntshav qab zib-insulin-tso ntshav qab zib, muab cov ntshav qabzib tswj tau zoo.
Cov Yuav Tsum Muaj
Cov tshuaj tsis pom zoo rau siv rau hauv rooj plaub hauv qab no:
- yam 1 mob ntshav qab zib mellitus;
- lactic acidosis;
- cov plasma ntshav qab zib ntau ntau;
- mob plab zom mov tsis xeev, precoma;
- mob ketoacidosis;
- cov txheej txheem kab mob hnyav nyob hauv lub raum thiab cov kab mob uas cuam tshuam rau kev ua haujlwm ntawm cov khoom nruab nrog (lub cev qhuav dej, mob hnyav thiab cov txheej txheem mob, ua rau poob siab);
- porphyria;
- noj miconazole;
- daim siab ua haujlwm tsis zoo;
- cardiogenic poob siab, oxygen oxygen starvation, ua pa tsis ua haujlwm, myocardial infarction;
- cawv intoxication, tshem tawm cov tsos mob;
- cov kev mob hauv kev kho mob insulin yog qhov tsim nyog (tom qab raug mob tom qab, raug kho kom rov zoo tom qab kev phais mob ntau dhau, hlawv roj);
- tsawg dua 48 teev thiab nyob hauv 2 hnub tom qab hluav taws xob xaj hluav taws xob siv tshuaj sib piv iodine;
- kev noj zaub mov kom tsawg thiab thaum noj tsawg dua 1000 kcal ib hnub;
- Kev siv tshuaj tiv thaiv tsis zoo ntawm tus neeg mob lub cev mus rau qhov sib xyaw ntawm cov tshuaj.
Tsis tas li ntawd, cov tshuaj tsis pom zoo rau cov neeg laus ua haujlwm hauv cov xwm txheej ntawm lub cev hnyav dhau los, vim tias muaj kev txhim kho ntawm cov kab mob lactic acidosis.
Kev ceev faj yuav tsum tau siv rau thaum muaj mob kub taub hau, qog ua haujlwm ntawm lub qog ua haujlwm, tsis ua haujlwm ntawm lub plua plav ntawm anterior pituitary, lub qog ua haujlwm.
Yuav ua li cas coj glimecomb
Cov tshuaj yog npaj rau hauv lub qhov ncauj noj thaum noj mov lossis tam sim ntawd tom qab ib pluas noj. Qhov ntau npaum li cas thiab qhov ntev npaum li cas ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob mus koom, kev teeb tsa tus qauv kho mob nyob ntawm seb cov ntshav qab zib hauv cov ntshav.
Nrog ntshav qab zib
Kev noj tshuaj ib zaug nyob rau theem pib ntawm kev kho yog 540 mg ntawm cov ntsiav tshuaj nrog rau kev tswj hwm ib hnub ib zaug txog li 1-3 zaug. Feem ntau, cov tshuaj tau noj 2 zaug hauv ib hnub - thaum sawv ntxov thiab ua ntej mus pw. Tus nqi them txhua hnub yog xaiv maj mam kom txog thaum them nyiaj ntawm tus txheej txheem pathological.
Qhov tshwm sim ntawm glimecomb
Cov kev xav tsis zoo hauv tus neeg mob lub cev tau tsim nrog kev siv tshuaj tsis raug cai los yog tawm tsam keeb kwm ntawm cov kab mob theem ob.
Cov tshuaj yog npaj rau hauv lub qhov ncauj noj thaum noj mov lossis tam sim ntawd tom qab ib pluas noj.
Kev kho mob txoj hnyuv
Phiv rau hauv lawv plab zom mov ua:
- dyspepsia, lub plab zom mov tsis txaus ntseeg;
- kev xav ntawm cov khoom hnyav hauv plab;
- xeev siab, ntuav;
- mob epigastric;
- cov tsos ntawm saj ntawm hlau nyob rau hauv lub hauv paus ntawm tus nplaig;
- tsis qab los.
Hauv qee qhov tsis tshua muaj tshwm sim, cov haujlwm ntawm hepatocytic aminotransferases, alkaline phosphatase yog kho kom zoo. Tej zaum qhov kev loj hlob ntawm hyperbilirubinemia mus txog rau qhov tshwm sim ntawm cholestatic jaundice, uas yuav tsum tau txiav tawm cov tshuaj.
Hematopoietic plab hnyuv siab raum
Cov tshuaj muaj peev xwm ua rau inhibition ntawm kev ua ub no ntawm cov pob txha pob txha liab, vim qhov tshwm sim ntawm cov xov tooj ntawm cov ntshav hloov qis, agranulocytosis, hemolytic anemia pib.
Nruab nrab hauv lub paj hlwb
Tej zaum yuav txo qis hauv qhov pom tseeb tseeb, mob taub hau.
Los ntawm cov hlab plawv system
Arrhythmia, kev hnov ntawm cov ntshav ntws.
Endocrine system
Yog hais tias kev noj tshuaj ntau dua yog ua txhaum thiab kev noj haus tsis ua raws, kev pheej hmoo ntawm kev mob ntshav qab zib nce, uas yog nrog los ntawm kev tsis muaj zog txaus, tsis muaj zog ntawm cov hlab ntaws ib ntus, ua rau tawm hws, poob ntawm kev tswj lub siab, tsis meej pem thiab kev sib koom tes tsis sib haum.
Los ntawm ib sab ntawm cov metabolism
Tawm tsam keeb kwm ntawm cov teeb meem ntawm metabolic, cov kab mob lactic acidosis yuav tshwm sim. Cov txheej txheem pathological muaj cov yam ntxwv tsis muaj zog, mob hnyav hauv cov leeg, ua pa tsis ua hauj lwm, mob plab, txo qis kub thiab ntshav siab poob qis, thiab muaj ntshav txhaws.
Kev ua xua
Cov tshuaj tiv thaiv anaphylactoid rau sulfonylurea derivatives yog ua kom pom kev ua xua vasculitis, urticaria, macula, pob khaus thiab mob pruritus, Quincke's edema, ceeb toom tsis nco qab.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Thaum kho nrog Glimecomb, yuav tsum saib xyuas thaum tsav tsheb, ua haujlwm nrog cov txheej txheem nyuaj thiab lwm yam haujlwm uas yuav tsum muaj kev kub siab los ntawm tus neeg mob.
Cov lus qhia tshwj xeeb
Thaum noj sulfonylurea derivatives, muaj kev pheej hmoo ntawm kev mob ntshav qab zib ntau thiab ntev heev, uas yuav tsum tau kho tshwj xeeb hauv cov chaw mob thiab cov tshuaj ua haujlwm ntawm cov tshuaj pleev 5% nyob rau 4-5 hnub.
Txoj kev pheej hmoo ntawm kev txhim kho pathology nce nrog kev noj zaub mov tsis txaus, ua haujlwm lub cev ntev lossis nrog kev coj ua ke ntawm ob peb cov tshuaj hypoglycemic. Txhawm rau txo txoj kev nyiam ntawm cov txheej txheem pathological, ib qho yuav tsum ua raws nraim li cov lus pom zoo ntawm cov lus qhia txuas nrog rau cov tshuaj thiab tau txais cov ncauj lus kom ntxaws thaum sib tham nrog tus kws kho mob uas koom nrog.
Kev hloov koob tshuaj yog qhov yuav tsum tau ua rau lub cev thiab lub siab lub ntsws dhau los lossis hloov ntawm kev noj zaub mov.
Siv rau lub sijhawm qub
Cov neeg laus dua 60 xyoo yuav tsum tsis txhob noj cov tshuaj nyob rau ntawm qhov muaj zog ntawm lub cev ua haujlwm vim muaj kev pheej hmoo ntawm lactic acidosis.
Txiag tej menyuam
Cov tshuaj tsis pom zoo kom noj mus txog thaum muaj hnub nyoog 18 xyoo.
Cov tshuaj tsis pom zoo kom noj mus txog thaum muaj hnub nyoog 18 xyoo.
Siv thaum cev xeeb tub thiab lactation
Thaum cev xeeb tub tshwm sim, kev tswj hwm Glimecomb yuav tsum tau hloov nrog cov tshuaj insulin, vim hais tias kev tshawb nrhiav qhov nkag ntawm cov tshuaj nquag los ntawm thaj chaw tiv thaiv kab mob yog ua tau. Tsis muaj ntaub ntawv hais txog teratogenic effect ntawm ob lub tebchaw nquag.
Glyclazide thiab metformin tuaj yeem tawm hauv niam cov kua mis, yog li ntawd, thaum lub sij hawm kho nrog hypoglycemic tus neeg sawv cev, lactation yuav tsum tau tshem tawm.
Daim ntawv thov rau lub raum khiav tsis zoo
Cov tshuaj yog contraindicated nyob rau hauv rooj plaub ntawm tsis ua hauj lwm raum thiab ntshav qab zib nephropathy.
Siv rau lub siab ua haujlwm tsis zoo
Cov tshuaj yog txwv nrog daim siab tsis zoo.
Glimecomb Tsuav
Nrog kev tsim txom cov tshuaj, lactic acidosis thiab ib lub xeev ntawm cov ntshav ntog ntshav qab zib tej zaum yuav muaj zog. Yog tias muaj cov cim ntawm cov kab mob lactic acid oxidation ntawm cov nqaij, koj yuav tsum hu rau lub tsheb thauj neeg mob tam sim ntawd rau tus neeg raug mob. Hauv cov chaw nyob ruaj ruaj, hemodialysis ua haujlwm tau zoo.
Yog tias tsis nco qab, qhov tso ntshav nkag ntawm 40% kua nplaum tov yog qhov tsim nyog intramuscularly lossis subcutaneously.
Yog tias tsis nco qab, tso ntshav tawm ntawm 40% kua nplaum tov, glucagon, intramuscularly lossis subcutaneously, yog qhov tsim nyog. Tom qab ua kom ruaj khov, tus neeg mob xav tau cov zaub mov muaj cov khoom noj uas yog carbohydrate.
Kev cuam tshuam nrog lwm yam tshuaj
Thaum noj lwm yam tshuaj nyob rau hauv parallel nrog Glimecomb, kev coj ua hauv qab no tau pom:
- Ua kom muaj zog rau kev kho mob ua ke nrog captopril, coumarin anticoagulants, beta-blockers, bromocriptine, antifungal agents, salicylates, fibrates, MAO inhibitors, tetracycline tshuaj tua kab mob, tsis-steroidal anti-inflammatory tshuaj thiab los tiv thaiv tuberculosis.
- Glucocorticosteroids, barbiturates, tshuaj antiepileptic, calcium tubule inhibitors, thiazide, diuretics, Terbutaline, Glucagon, Morphine ua rau txo qis hauv hypoglycemic kev ua.
- Mob glycosides nce ntxiv yuav ua rau mob ventricular extrasystole, thaum suppressing pob txha mob hematopoiesis, nce ntawm myelosuppression.
Cov tshuaj txo cov ntshav plasma concentration ntawm Furosemide los ntawm 31% thiab nws ib nrab-lub neej los ntawm 42%. Nifedipine nce tus nqi nqus ntawm metformin.
Cov tshuaj txo cov ntshav plasma concentration ntawm Furosemide los ntawm 31% thiab nws ib nrab-lub neej los ntawm 42%.
Cawv tau zoo
Nws yog nruj me ntsis txwv tsis pub haus dej cawv thaum lub sijhawm kho. Ethanol provokes qhov kev pheej hmoo ntawm intoxication loj thiab kev txhim kho ntawm cov kab mob lactic acidosis. Ethanol tsub kom muaj feem ntau yuav txhim kho hypoglycemia.
Dab tsi los hloov
Cov analogues ntawm cov tshuaj, zoo sib xws nyob rau hauv tshuaj lom neeg muaj pes tsawg leeg thiab muaj lub zog zoo, suav nrog:
- Diabefarm;
- Glyformin;
- Gliclazide MV.
Hloov mus rau lwm cov tshuaj muaj peev xwm ua tau yog tias tsis muaj qhov kho tau los ntawm kev noj Glimecomb thiab nyob rau hauv kev saib xyuas nruj ntawm cov kws kho mob tau koom.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj raug muag los ntawm daim ntawv sau xaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Muag dawb ntawm cov tshuaj yog raug txwv vim qhov kev pheej hmoo ntawm kev mob ntshav qab zib thaum noj cov tshuaj tsis yog.
Glimecomb Nqe
Tus nqi nruab nrab ntawm cov ntsiav tshuaj yog 567 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj yuav tsum khaws cia kom tsis ncav cov menyuam, kom nyob hauv qhov chaw qhuav, tsaus ntawm qhov kub tsis tshaj + 25 ° C.
Hnub tas sij hawm
2 xyoos
Chaw tsim tshuaj paus
Tshuaj thiab chaw muag tshuaj cog "AKRIKHIN", Russia.
Muag dawb ntawm cov tshuaj yog raug txwv vim qhov kev pheej hmoo ntawm kev mob ntshav qab zib thaum noj cov tshuaj tsis yog.
Kev Ntsuas Xyuas Mob Ntshav Qab Zib rau Glimecomb
Arthur Kovalev, hnub nyoog 40 xyoo, Moscow
Txog ntshav qab zib hom 2, Kuv tau noj cov tshuaj Glimecomb tau yuav luag ib xyoos. Lub cev hnyav tsis tau poob qis, vim tias tom qab noj cov tshuaj koj xav noj. Tab sis tom qab kuv noj tshuaj ntsiav hmo ua ntej yuav mus pw, qhov xwm txheej ib txwm muaj. Thaum sawv ntxov, cov piam thaj nws txawv ntawm 6 txog 7.2 tom qab noj cov ntsiav tshuaj nrog pluas tshais.
Kirill Gordeev, 29 xyoos, Kazan
Cov tshuaj zoo txo cov ntshav qab zib. Kuv txais 8 lub hlis. Kuv tseem muab cov tshuaj insulin. Tom qab muaj kev cuam tshuam nrog kev cuam tshuam los ntawm cov tshuaj hormones, Kuv yuav tsum tau noj ib co tshuaj noj ib pliag, tab sis lawv pom qhov kev ua haujlwm siab. Qab zib nyob twj ywm rau tib theem, txawm hais tias ua tsis tau lub siab ua haujlwm hauv kuv kis.
Cov kws kho mob tshuaj xyuas
Marina Shevchuk, tus kws kho mob endocrinologist, hnub nyoog 56 xyoo, Astrakhan
Cov tshuaj tiv thaiv rau cov keeb kwm yav dhau los ntawm hom 2 mob ntshav qab zib tsim tawm rau cov mob glycemia zoo. Kev tso tawm hloov kho tuaj yeem txo qhov kev pheej hmoo ntawm kev mob hypoglycemic syndrome, uas yog vim li cas cov neeg mob laus thiab cov neeg muaj mob los ntawm cov kab mob ntawm cov hlab plawv tuaj yeem siv tshuaj. Kuv nquag siv cov tshuaj hauv kuv qhov chaw kuaj mob nrog kev xaiv koob tshuaj ib tus neeg. Tus nqi qis nrog kev ua haujlwm siab.
Evgenia Shishkina, endocrinologist, 45 xyoo, St. Petersburg
Cov tshuaj muaj cov mob sib khuav thiab siv tau zoo. Nws pab kom cov ntshav qab zib kom qis. Thaum kho, nws yog ib qho tseem ceeb kom ua raws kev noj haus, tab sis noj kom tsis tu ncua, nrog rau kev tawm dag zog. Kuj tsis pom tias muaj kev cuam tshuam dab tsi los ntawm kev ua raws li kev noj tshuaj kom zoo. Kev ua ntawm cov tshuaj pib hauv lub sijhawm luv. Cov tshuaj tau tsim nws tus kheej hauv kev ua lag luam rau cov ntshav qab zib.
