Gabapentin 300 yog tshuaj lom neeg tshuaj lom neeg uas muaj cov nyhuv anticonvulsant. Cov tshuaj yog ib feem ntawm cov tshuaj thiab raug muag hauv qab cov npe uas tsis muaj npe: Neurontin thiab Gabagamma. Cov tshuaj nquag siv los kho cov mob qaug dab peg hauv cov menyuam yaus txij thaum muaj 3 xyoos thiab kom tshem tawm cov mob neuropathic rau cov neeg laus. Cov tshuaj tsis raug tso cai rau siv nyob rau hauv daim ntawv ntawm kev txhaj tshuaj.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Gabapentin.
Gabapentin 300 yog tshuaj lom neeg tshuaj lom neeg uas muaj cov nyhuv anticonvulsant.
ATX
N03AX12.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob hauv cov ntsiav tshuaj ntau npaum cas thiab hauv tshuaj ntsiav tshuaj rau qhov ncauj tswj hwm. Tsis tsim hauv ampoules rau kev txhaj tshuaj.
Ntsiav tshuaj
Cov ntsiav tshuaj dawb muaj lub ntsej muag zoo nkauj thiab yog coated nrog zaj duab xis nkag. Muaj kev pheej hmoo thiab thav duab ntawm lub chaw tsim khoom lag luam ntawm ob sab ntawm cov khoom siv tshuaj ntsuab. 1 ntsiav tshuaj muaj 800 mg ntawm cov tshuaj nquag - gabapentin thiab cov khoom siv ntxiv, uas suav nrog:
- crospovidone;
- pob kws nplej siab;
- magnesium stearate;
- poloxamer 407.
Cov duab ua qauv membrane muaj candelila (tshuaj ntsuab ciab), talc thiab hyprolose. Cov ntsiav tshuaj tau ntim rau hauv 10 daim hauv cov hlwv. Cardboard pob tuaj yeem muaj 2, 5 lossis 10 pob ntawv ntim.
Cov tshuaj ntsiav
Cov kaus poom tau pleev xim nrog lub tawv tawv gelatin ntawm cov xim ntsuab. Sab hauv daim ntawv tshuaj tsuas muaj cov hmoov dawb dawb, uas yog kev sib xyaw ntawm cov neeg excipients thiab cov nquag sib xyaw - 300 mg ntawm gabapentin. Raws li cov khoom xyaw ntxiv siv hauv kev tsim cov khoom lag luam:
- macrogol 6000;
- magnesium stearate;
- qos yaj ywm hmoov txhuv nplej siab;
- dihydrogenated calcium hydrogen phosphate.
Lub cev tsiav tshuaj muaj li ntawm titanium dioxide thiab gelatin. Kev sib xyaw ua ke ntawm dyes: quinoline daj thiab indigo carmine muab cov xim ntsuab rau lub plhaub.
Gabapentin muaj nyob hauv daim ntawv tshuaj ntsiav.
Pharmacological kev txiav txim
Lub gabapentin compound rov ua dua cov qauv morphological ntawm gamma-aminobutyric acid (GABA), uas ua cov neurotransmitter hauv lub cev. Hauv qhov no, cov tshuaj nquag sib txawv los ntawm cov neurotransmitter hauv kev nqis tes ua pharmacological. Gabapentin tsis khi rau barbiturates, GABA aminotransferase blockers, valproic acid thiab derivatives ntawm γ-aminobutyric acid, yog li tsis cuam tshuam rau kev zais thiab rhuav tshem GABA.
Hauv chav kawm ntawm kev tshawb fawb kws tshuaj, nws tau sau tseg tias cov tshuaj nquag ua rau muaj kev cuam tshuam nrog alpha2-raws subunit ntawm calcium channels, uas tau koom nrog hauv kev txhim kho ntawm cov mob neuropathic. Vim tias qhov kev ua ntawm Gabapentin, kev tso tawm cov calcium ions rau hauv qhov chaw sib cais tsawg dua, kev zais ntawm gamma-aminobutyric acid nce, kev tuag ntawm cov hlab ntsha kis los ntawm kev cuam tshuam rau glutamic acid txo, thiab qhov thaiv ntawm cov zis neurotransmitters ntawm amine pawg tshwm sim. Raws li qhov tshwm sim, kev mob neuropathic tsis tshwm sim.
Cov Tshuaj Pharmacokinetics
Thaum muab cov lus ntawm lub qhov ncauj, cov tshuaj tiv thaiv nquag ncav cuag nws qhov siab tshaj plaws hauv ntshav li ntawm 2-3 teev. Bioavailability yog 60%. Cov ntsiav tshuaj thiab cov tshuaj ntsiav plam lawv cov qog ua nyob rau ntawm qhov chaw ze ntawm cov hnyuv me hauv qab kev ua ntawm cov enzymes tshwj xeeb (esterases). Cov tshuaj ua kom muaj zog yog nqus tau mus rau hauv cov phab ntsa hauv cov hnyuv, los ntawm qhov uas nws nthuav tawm rau hauv cov hlab ntsha.
Cov tshuaj tsis muaj qhov hloov pauv hauv lub siab hauv lub siab.
Cov zaub mov muaj roj ntau hauv cov rog tsis txo qis kev nqus thiab bioavailability ntawm cov tshuaj. Hauv lub txaj vascular, tsawg dua 3% ntawm cov nquag sib txuas khi rau cov ntshav protein. Cov tshuaj tsis muaj qhov hloov pauv hauv lub siab hauv lub siab. Qhov kev tshem tawm ib nrab-lub neej mus txog qhov nruab nrab ntawm 5-7 teev. Gabapentin tawm hauv lub cev los ntawm kev tso zis hauv nws daim ntawv qub.
Nws siv rau dab tsi?
Cov tshuaj yog siv los kho mob hauv cov menyuam yaus txij thaum hnub nyoog 12 txog 18 xyoo thiab muaj nyob hauv kev kho mob hauv cov laus. Cov tshuaj yog qhov tsim nyog los tshem tawm qee qhov qaug dab peg ntawm keeb kwm yav dhau ntawm tus mob vwm. Cov neeg mob uas laus dua 12 xyoos tau txais kev kho mob, tsis hais txog ntawm kev muaj theem siab dav dav lossis qhov nws tsis tuaj. Muaj qee zaus, gabapentin yog qhov muaj kev kho mob ruaj khov ntawm tus mob vwm rau cov neeg mob uas laus dua 3 xyoos.
Ib qho tshuaj pub rau siv rau qhov thaiv cov leeg mob neuropathic hauv cov neeg mob hnub nyoog 18 xyoo.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub noj tshuaj thiab tsiav tshuaj nyob rau hauv qhov chaw muaj qhov muaj peev xwm ntau ntxiv ntawm cov ntaub so ntswg lub cev mus rau kev ua haujlwm thiab pabcuam.
Nrog saib xyuas
Ceev faj yuav tsum tau siv rau thaum lub raum tsis ua haujlwm.
Ceev faj yuav tsum tau siv rau thaum lub raum tsis ua haujlwm.
Yuav ua li cas siv gabapentin 300
Cov foos siv yog xav rau cov kev tswj hwm qhov ncauj tsis ntxo. Kev sib tsoo tshuab ua rau txo qis hauv qhov nqus ntawm qhov tshuaj. Thaum hloov mus rau lwm cov tshuaj, koj yuav tsum tsis txhob sai tsis noj cov tshuaj Gabapentin. Kev hloov pauv yog nqa nrog maj mam txo hauv cov tshuaj ntau dua 7 hnub.
Txhawm rau tshem tawm cov txheej txheem pathological hauv somatosensory lub paj hlwb uas ua rau mob neuropathic, nws yog qhov yuav tsum tau noj 900 mg rau ib hnub. Qhov tshuaj txhua hnub tau muab faib ua 3 koob. Nrog txoj kev kho qis, qhov tshuaj tau tuaj yeem maj mam nce mus rau qhov ntau tau tso cai - 3.6 g ib hnub. Kho tshuaj pib nrog 900 mg / hnub lossis lwm txoj kev kho mob ntxiv. Hauv rooj plaub tom kawg, kev noj tshuaj txhua hnub yog maj maj rau qhov yuav tsum tau 0.9 g tshaj 3 hnub:
- 1 hnub noj ib zaug 0.3 g;
- rau 2 hnub, qhov ntau zaus siv yog 2 zaug 300 mg;
- nyob rau hnub 3, 900 mg tau noj, muab faib ua 3 koob.
Yuav kom ua tiav cov nyhuv antiepileptic, cov neeg mob uas muaj 12 xyoos rov hauv yuav tsum tau los ntawm 900 rau 3600 mg ib hnub twg. Qhov sij hawm ntau tshaj nruab nrab ntawm cov koob tshuaj lossis cov tsiav tshuaj yuav tsum tsis pub ntev tshaj 12 teev los tiv thaiv kev txhim kho ntawm qaug dab peg.
Tawm tsam keeb kwm yav dhau los ntawm lub raum tsis ua haujlwm, tus kws kho mob hloov cov tshuaj txhua hnub raws li Cl (creatinine tshem tawm).
| Kev tshem tawm Creatinine, ml / min | Cov kev cai niaj hnub, mg (ntau zaus ntawm kev tswj hwm - 3 zaug hauv ib hnub) |
| ntau dua 80 | Tus qauv muab tshuaj. |
| ntawm 50 txog 79 | 600-1800 |
| 30-49 | 300-900 |
| tsawg dua 29 | 300 mg noj nrog ncua sijhawm 24 teev. |
Cov tshuaj ua kom mob tsis cuam tshuam rau lub cev ua haujlwm ntawm cov islets ntawm Langerhans ntawm cov txiav.
Ntawm cov neeg mob hemodialysis nws raug nquahu kom noj 300-400 mg rau thawj hnub ntawm kev kho, tom qab noj tshuaj yuav yog 0.2-0.3 g 4 teev ua ntej txheej txheem.
Nrog ntshav qab zib
Cov tshuaj ua kom tsis muaj zog tsis cuam tshuam rau kev ua haujlwm ntawm cov islets ntawm Langerhans ntawm cov txiav thiab tsis tsim cov khoom glycemic rau lub plasma concentration ntawm cov piam thaj hauv cov ntshav. Yog li, cov neeg mob ntshav qab zib tsis tas yuav tsum tau kho ntxiv ntawm cov koob tshuaj pom zoo.
Sab sij huam
Kev phiv tshwm sim nrog kev siv tshuaj tsis raug. Thaum muaj kev phiv tshuaj rau gabapentin, nws yog ib qho tsim nyog yuav tsum tsis txhob noj cov tshuaj thiab nrhiav tswv yim kho mob.
Kev kho mob txoj hnyuv
Cov kev hloov hauv cov zom zaub mov yog nrog paj, mob epigastric, raws plab. Tawm tsam keeb kwm ntawm kev zom cov zaub mov tsis txaus, tsis nco qab lossis nce siab yuav tshwm sim. Muaj qee zaus, kev tshem tawm hniav txha hniav laus yog pom, lub qhov ncauj qhuav pom, tus quav thiab lub siab ua mob, theem ntawm bilirubin thiab kev ua si ntawm hepatocyte aminotransferases nce.
Hematopoietic plab hnyuv siab raum
Thrombocytopenic purpura, leukocytopenia thiab platelet deficiency yog ua tau.
Nruab nrab hauv lub paj hlwb
Kev tawm tsam ntawm cov hlab hlwb tau pom nyob hauv cov tsos mob xws li:
- Kiv taub hau
- tsis muaj reflexes hauv tendons;
- rhiab rhiab hloov;
- ploj ntawm kev tswj hwm (kev nyuaj siab, ntxhov siab);
- ua kom pom tseeb;
- tsaug zog
- tshee hnyo ntawm nqua;
- feem ntau tsis muaj zog.
Muaj qee zaus, mob ataxia, nystagmus, choreoathetosis tshwm sim.
Los ntawm lub tshuab ua pa
Nrog kev siv sijhawm ntev ntawm cov tshuaj, hnoos qhuav, ua tsis taus pa, txhaws ntswg, thiab kis tus kab mob ntawm cov pa ua pa tuaj yuav tshwm sim.
Ntawm ib sab ntawm daim tawv nqaij
Cov tawv nqaij ua xau: pob txuv, o, ua pob, mob pob, thiab Stevens-Johnson kab mob.
Los ntawm cov hlab plawv system
Tus cov leeg ntawm cov leeg ntsa tau so, cov ntshav nce siab thiab lub plawv nce.
Kev ua xua
Yog tias tus neeg mob tau mob siab rau qhov tshwm sim ntawm kev tsis haum tshuaj, kev txhim kho ntawm mob caj pas thiab mob qa, mob ntsws thiab mob anaphylactic ua tau. Nrog rau kev ua xua ntawm me me mus rau mob hnyav, kev txhim kho ntawm cov tawv nqaij ua xeb thiab o ntawm lub ntsej muag yog ua tau.
Cov lus qhia tshwj xeeb
Thaum lub sij hawm sim tshuaj ntawm cov tshuaj, tsis muaj cov cim ntawm kev rho tawm syndrome nrog kev txiav ntse ntawm kev tswj hwm tshuaj. Qhov maj mam txo hauv qhov ntau npaum li cas yog qhov tsim nyog los txo qhov muaj feem ntawm kev huam tuaj ntawm qaug dab peg thiab qaug dab peg thaum siv tshuaj antiepileptic tawm
Cov tshuaj tsis yog kws kho mob rau kev qaug dab peg nrog convoxive paroxysms.
Ib qho tso zis feem ntau yuav qhia qhov tsis muaj tseeb rau tus mob proteinuria. Txhawm rau kom tsis txhob rov kuaj ntxiv kom pom cov protein nyob hauv cov zis, nws yog qhov yuav tsum ceeb toom cov neeg ua haujlwm hauv chaw kuaj ntshav txog kev noj Gabapentin. Cov kws tshaj lij yuav ua haujlwm tshawb fawb siv sulfosalicylic acid.
Qhov tso zis feem ntau yuav qhia qhov tsis zoo rau kev muaj proteinuria hauv cov neeg mob noj gabapentin.
Siv rau lub sijhawm qub
Cov neeg uas muaj hnub nyoog tshaj 65 xyoos tsis tas yuav kho cov tshuaj ntau npaum li cas.
Tshuaj me nyuam Gabapentin rau 300 tus menyuam
Rau cov menyuam muaj hnub nyoog tshaj 12 xyoos, kev noj tshuaj ib txwm dhau los ntawm 900 mg rau ib hnub yog raug kho rau kev kho qee qhov qaug dab peg.
Siv thaum cev xeeb tub thiab lactation
Noj tshuaj tsis zoo thaum cev xeeb tub tsis pom zoo. Cov kev tshawb fawb uas tsim nyog ntawm kev muaj peev xwm ntawm Gabapentin los hla cov placental barrier tsis tau ua, yog li muaj kev pheej hmoo ntawm kev txhim kho cov nqaij mos thaum lub sij hawm embryonic kev loj hlob thaum noj cov tshuaj.
Thaum kho nrog gabapentin, kev pub mis niam yuav tsum tau nres.
Noj ntau dhau
Nrog kev siv yeeb tshuaj, kev tsim kho ntawm:
- Kiv taub hau
- tsaug zog
- kev cuam tshuam ntawm kev hais lus kev ua haujlwm;
- nkees;
- daim ntawv pov thawj.
Tus neeg raug tsim txom yuav tsum yaug lub plab thiab muab ib qho adsorbent. Txhawm rau tshem tawm cov cim ntawm kev txhaj tshuaj, kev mob tshwm sim yog ua.
Yog tias muaj kev noj ntau dhau, tus neeg mob yuav tsum yaug lub plab.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau kev siv txig sib xyaw ntawm gabapentin nrog lwm cov tshuaj, cov tshuaj tiv thaiv tau pom hauv qab no:
- Cov tshuaj nquag tsis cuam tshuam rau qhov kev siv tshuaj sib deev ntawm lub qhov ncauj txwv tsis pub muaj cov poj niam txiv neej cov tshuaj hormones los yog ethinyl estradiol.
- Morphine raug noj 2 teev ua ntej siv Gabapentin, vim tias thaum ob qho tshuaj thaum tib lub sijhawm, qhov nruab nrab AUC ntawm gabapentin tau nce li ntawm 43%. Qhov mob ntawm qhov ntsuas tau nthuav dav. Ib nrab ntawm lub neej qhov tseem ceeb thiab kev ua tiav ntawm qhov siab tshaj plaws ntshav plasma concentration ntawm Morphine tsis hloov, yog li ntawd, hauv kev coj ua, kev kho no tsis cuam tshuam rau tus neeg mob lub neej.
- Phenobarbital, Mexidol, Valproic acid thiab lwm yam tshuaj antiepileptic tsis cuam tshuam rau cov kev lag luam tshuaj ntawm Gabapentin.
- Nrog rau cov kev ua haujlwm loj tib yam ntawm cov tshuaj tiv thaiv kab mob thiab cov neeg sawv cev uas muaj cov tshuaj txhuas thiab ntsev ntsev, kev txo qis hauv bioavailability ntawm Gabapentin los ntawm 22% tau kaw. Yog li ntawd, cov tshuaj anticonvulsant tau noj 2 teev tom qab siv tshuaj antacids.
- Probenecid tsis muaj kev cuam tshuam lub raum tshem tawm ntawm Gabapentin.
Thaum kho nrog Gabapentin, nws yog txwv tsis pub haus dej cawv. Ethyl cawv ntau ntxiv ua rau muaj kev ntxhov siab ntawm lub hauv nruab nrab hauv lub paj hlwb thiab nce ntxiv ntawm cov kev mob tshwm sim. Tawm tsam keeb kwm ntawm qhov tshwm sim tsis zoo ntawm ethanol ntawm kev ua haujlwm ntawm cov ntshav ncig, ua kom tsis muaj zog ntawm kev kho mob ntawm Gabapentin tau pom.
Analogs
Cov tshuaj uas tuaj yeem hloov tau Gabapentin los ntawm cov tshuab ntawm kev txiav txim thiab tshuaj lom neeg muaj xws li:
- Katena
- Convalis;
- Neurontin;
- Tebantin;
- Gabagamma
Hloov mus rau lwm cov tshuaj yog nqa tawm hauv kev saib xyuas kev noj qab haus huv zoo vim muaj kev pheej hmoo ntawm kev qaug dab peg ib nrab.
Nyiaj so koobtsheej tej yam kev mob Gabapentina 300 los ntawm lub tsev muag tshuaj
Cov tshuaj tsis raug muag yam tsis raug tshuaj nyob hauv Latin.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Ib qho tshuaj anticonvulsant tsis tuaj yeem muas tsis tau cov lus qhia hais txog kev kho mob, vim tias yog koj noj Gabapentin tsis raug, koj yuav muaj qhov kev txo qis hauv cov kev ua ub no, qhov tshwm sim ntawm mob neuropathic thiab cov kev mob tshwm sim.
Ntau npaum li cas yog gabapentin 300
Tus nqi nruab nrab ntawm cov tshuaj txawv ntawm 349 txog 464 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu tias Gabapentin 300 ntsiav tshuaj thiab tshuaj ntsiav yuav tsum khaws cia rau hauv ib qho chaw nrog huab cua qis thiab ntawm qhov kub siab txog + 25 ° C.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus Gabapentin 300
CJSC Canonfarm Ntau Lawm, Russia.
Kev txheeb xyuas rau ntawm Gabapentin 300
Hauv cov ntawv kho mob muaj cov lus pom zoo los ntawm cov neeg mob txog cov tshuaj thiab cov lus pom zoo ntawm cov kws kho mob hlwb.
Cov kws kho mob
Ramil Dzhumabaev, kws kho mob hlwb, hnub nyoog 44 xyoo, Omsk
Txoj kev kho kom ua tiav tau tiav nrawm. Kuv xav tias Gabapentin yog ib qho tshuaj pheej yig tshaj plaws rau kev kho mob ntawm mob neuropathic thiab ua tiav cov teebmeem anticonvulsant. Tab sis feem ntau, Kuv nco ntsoov hauv kev xyaum cov kev mob tshwm sim: myalgia, mob nraub qaum, pob txha lov, nyob rau hauv cov mob loj, mob amnesia.
Ivan Tikhonov, kws kho mob hlwb, hnub nyoog 51 xyoo, Krasnoyarsk
Gabapentin zoo txo cov mob neuropathic ntawm ntau qhov chaw, uas tsis yog yooj yim los thaiv kev los ntawm cov tshuaj tsis-steroidal los tiv thaiv. Nrog kev siv ntev, koj yuav tsum ceev faj. Cov neeg mob qhia txog kev tab kaum thiab kev nyuaj siab. Cov koob tshuaj thiab ntau zaus ntawm kev tswj hwm yuav tsum tau tsim los ntawm cov kws kho mob nkaus xwb.
Cov neeg mob
Anastasia Koshkina, hnub nyoog 34 xyoo, Moscow
Kuv noj gabapentin nrog kev kuaj mob ntawm qhov paub txog mob hlwb-muaj ntshav qab zib mob neuropathy. Thaum noj, muaj cov nyhuv tshuaj loog, tab sis nws yog qaug zog. Tom qab kuv haus cov ntsiav tshuaj, Kuv mloog zoo li kiv taub hau, plam kev sib koom tes ntawm kev txav, qias neeg tsis zoo. Kuv pom zoo pw tom qab ntsiav tshuaj rau ib teev.
Lilia Alekseeva, 42 xyoo, Tomsk
Cov tshuaj pab tau zoo heev nrog qaug dab peg. Kuv txais nruj me ntsis raws li cov lus qhia. Nws muaj cov nyhuv anticonvulsant me me. Tsis muaj kev tawm tsam thaum siv cov tshuaj. Thaum kuv so li cas, lawv rov qab pib dua. Ntawm qhov mob tshwm sim, Kuv tuaj yeem hais txog kiv taub hau, uas ua ntu zus thaum sawv ntxov.
