Movoglechen yog lub cim thib 2 tiam sulfonylurea derivative uas muaj cov roj ntsha tsis zoo rau lub cev. Lub tshuab ntawm kev nqis tes ua yog ua raws li kev nce siab ntawm cov ntaub so ntswg mus rau insulin thiab ntawm kev txhim kho cov tshuaj hormonal tso pa ntawm pancreatic beta hlwb. Hauv kev xyaum kho mob, ib qho tshuaj hypoglycemic yog kho rau tus mob ntshav qab zib hom 2. Nws raug txwv tsis pub siv nrog cov ntshav qab zib insulin-tiv thaiv cov ntshav qab zib.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Glipizide. Hauv Latin - Glipizide.
Cov tshuaj Movoglecen muaj cov npe neeg thoob ntiaj teb Glipizide.
ATX
A10BB07.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob hauv daim ntawv ntau npaum ntawm cov ntsiav tshuaj dawb. Nyob rau sab xub ntiag ntawm chav tsev ntawm cov tshuaj, muaj kev pheej hmoo yog carved, thaum lub engraving ntawm tsab ntawv "U" hauv lub voj voog yog pom los ntawm nraub qaum. Daim ntawv foos muaj 5 mg ntawm cov nquag nquag - glipizide. Yuav kom nce tus nqi nqus thiab bioavailability, lub ntsiav tshuaj tseem ceeb muaj cov khoom ntxiv:
- pregelatinized hmoov txhuv nplej siab;
- hypromellose;
- mis nyuj qab zib;
- stearic acid;
- microcrystalline cellulose.
Cov ntsiav tshuaj muaj lub ntsej muag cylindrical puab, raug them rau theem kawg ntawm kev tsim khoom los ntawm zaj duab xis nkag. Cov tom kawg muaj talc, titanium dioxide, macrogol. Cov chav kuaj tshuaj tso rau hauv lub hlwv blooj ntawm 24 daim. Hauv ib lub npov thawv tau muab tso rau 48 ntsiav tshuaj.
Pharmacological kev txiav txim
Tus tshuaj pleev qhov ncauj ntshav hypoglycemic yog sulfonylurea derivative.
Cov tshuaj Movoglechen muaj feem cuam tshuam rau kev ua haujlwm ntawm tus txiav thiab tib lub sijhawm muaj cov nyhuv ntxiv-txiav txim siab.
Cov khoom hluavtaws synthes belongs rau II tiam. Lub tshuab nruab nrab ntawm kev ua ntawm cov nquag muaj feem cuam tshuam rau kev ua haujlwm ntawm tus txiav thiab tib lub sijhawm muaj cov yeeb yaj kiab ntxiv-ntxiv. Glipizide ua rau cov txheej txheem ntawm insulin ntau lawm los ntawm pancreatic beta hlwb thaum mob voos los ntawm cov kua nplaum, txhim kho qhov ua rau muaj kev cuam tshuam ntawm cov ntaub so ntswg mus rau hypoglycemic nyhuv ntawm lub cev.
Hauv kev ua tiav ntawm kev kho kom zoo, lub nquag sib xyaw ua ke yuav ua rau muaj kev cuam tshuam ntawm cov tshuaj insulin rau cov phiajcim hlwb, nce kev tso tawm ntawm pancreatic hormone. Raws li qhov tshwm sim, cov nyhuv inhibitory ntawm cov tshuaj insulin rau ntawm cov kua dej molecules yog kho kom zoo, thiab cov neeg kawm ntawv ntawm kev nqus ntawm cov piam thaj los ntawm cov leeg pob txha thiab hepatocytes yog nce. Muaj qhov txo qis hauv gluconeogenesis nyob rau hauv daim siab thiab lipid tshwm sim hauv cov nqaij mos adipose.
Qhov mob hnyav npaum li cas ntawm kev kho kom haum xeeb yog nyob ntawm tus naj npawb ntawm active beta hlwb ntawm cov txiav.
Cov tshuaj ntxiv muaj ib qho fibrinolytic, diuretic thiab lipid-txo cov nyhuv, inhibits platelet adhesion, tom qab los ntawm kev tsim cov ntshav txhaws.
Movoglechen inhibits platelet adhesion, tom qab los ntawm kev tsim thrombus.
Cov Tshuaj Pharmacokinetics
Tom qab siv, lub qhov ncauj hypoglycemic tus neeg sawv cev yog yuav luag tag nrho nqus rau hauv phab ntsa ntawm qhov sib thooj me me ntawm txoj hnyuv ntawm kev kub ceev.
Kev nkag noj cov zaub mov kom tsawg tsis ua rau muaj kev hloov pauv hauv cov khoom lag luam pharmacokinetic. Hauv qhov no, lub sij hawm nqus nce ntxiv los ntawm 45 feeb. Thaum cov tshuaj siv mus rau qhov kev tiv thaiv kab ke, cov ntshav siab tshaj plaws tuaj yeem kho nyob rau hauv 1-3 teev tom qab siv ib ntsiav tshuaj.
Lub bioavailability ntawm glipizide ncav cuag 90%. Hauv cov ntshav, cov nquag tivthaiv khi rau albumin los ntawm 98-99%. Thaum glipizide kis tau los ntawm hepatocytes, cov tshuaj nquag tau muab pov tseg rau hauv cov khoom lag luam metabolic uas tsis nthuav tawm cov kev ua haujlwm hypoglycemic. Qhov kev tshem tawm ib nrab-lub neej ua rau 2-4 teev. Cov tshuaj tawm hauv tas 90% hauv daim ntawv ntawm cov tshuaj tiv thaiv kab mob los ntawm lub raum, 10% hauv nws cov ntawv qub.
Kev ntsuas rau siv
Cov tshuaj Movoglechen tuaj yeem txo cov ntshav plasma cov piam thaj hauv ntshav qab zib hom 2 yog tias cov ntshav qab zib tsis muaj tshuaj tua kab mob tsis kho nrog kev noj zaub mov noj, kev tawm dag zog thiab lwm yam kev ntsuas los txo qhov hnyav.
Cov Yuav Tsum Muaj
Kev noj tshuaj yog txwv tsis pub nyob hauv cov xwm txheej nram no:
- hais tau qhov nkag siab ntawm cov ntaub so ntswg mus rau sulfonamides, glipizide, Movogleken ntxiv lossis sulfonylurea derivatives;
- yam 1 mob ntshav qab zib mellitus;
- cov kab mob lactose tsis haum, qabzib thiab galactose nqus kev tsis haum, tsis muaj lactase;
- kub hnyiab thiab phais kev cuam tshuam ntawm ntau qhov ntawm kev ua, kev mob hnyav tom qab kev mob thiab kev raug mob, kev kis thiab mob;
- mob ntshav qab zib thiab hyperosmolar coma, precomatous xeev;
- ketoacidosis;
- cov kab mob hnyav ntawm daim siab thiab lub raum.
Nws yog ib qho tsim nyog yuav tsum tau sau tshuaj kom zoo nrog kev saib xyuas ntawm lub xeev ntawm kev tshem tawm cov tsos mob, cov neeg muaj adrenal tsis txaus, nrog rau leukopenia, kub taub hau thiab kev puas tsuaj rau cov thyroid caj pas, nrog los ntawm kev cuam tshuam ntawm nws cov keeb kwm kev tsis haum xeeb.
Yuav noj Movoglechen li cas
Cov koob tshuaj tau hloov kho los ntawm tus kws kho mob tshwj xeeb nyob ntawm lub cev qhov hnyav thiab hnub nyoog ntawm tus neeg mob, nrog rau cov yam ntxwv ntawm cov txheej txheem pathological.
Tus kws kho mob tuaj yeem hloov pauv kev noj tshuaj ntau npaum li cas nrog kev hloov pauv hauv cov ntshav qabzib ntau ntau.
Yog li, kev saib xyuas ntawm cov ntshav qab zib kom ntau yog tsim nyog: ntsuas ntawm lub plab khoob thiab tom qab 2 teev tom qab noj mov.
Nrog ntshav qab zib
Cov ntsiav tshuaj xav tau rau kev tswj hwm qhov ncauj 30 feeb ua ntej noj mov. Thaum sawv ntxov ua ntej noj tshais, koj yuav tsum noj 5 mg ntawm cov tshuaj, thaum tsis muaj qhov ua kom zoo, nce qhov ntau npaum li ntawm 2.5-5 mg, nyob ntawm kev thev taus.
Qhov siab tshaj plaws tau tso cai rau noj txhua hnub ntawm Movoglek yog 40 mg, qhov ntau rau kev siv tshuaj ib zaug yog 15 mg.
Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 40 mg, koob tshuaj rau kev siv ib leeg yog 15 mg. Cov ntsiav tshuaj yuav tsum quag cawv 1 zaug hauv ib hnub. Nrog rau qhov kev cai txhua hnub tshaj 15 mg, nws yog qhov tsim nyog los faib cov koob tshuaj 2-4 zaug.
Phiv txav ntawm Movoglyken
| Cov kab ke hauv lub cev uas nthuav tawm qhov cuam tshuam tsis zoo ntawm cov tshuaj | Muaj kev phiv ntau |
| Endocrine system |
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| Lub plab zom mov |
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| Tej leeg hauv siab thiab cov plab hnyuv siab raum |
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| Hematopoietic plab hnyuv siab raum |
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| Daim tawv nqaij thiab ua xua tawm |
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| Lwm yam |
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Cuam tshuam rau lub peev xwm los tswj cov tshuab
Kev siv tshuaj hypoglycemic tsis muaj kev cuam tshuam loj ntawm cov leeg hlwb thiab cov txuj ci zoo rau lub cev, yog li thaum lub sijhawm kho nws tsis txwv tsis pub tsav tsheb lossis ua haujlwm nrog cov cuab yeej siv uas yuav tsum tau teb sai thiab mob siab.
Thaum kho nrog Movogleken nws tsis txwv tsis pub tsav tsheb.
Cov lus qhia tshwj xeeb
Qhov ntau tau hloov kho tau nyob rau hauv qhov chaw muaj kev ntxhov siab uas ua rau lub hauv paus tswj kev puas siab puas ntsws, nyob rau hauv cov xwm txheej ntawm kev tawm dag zog lub cev, nrog kev hloov pauv ntawm kev noj zaub mov.
Thaum decompensating tsis-insulin-mob ntshav qab zib thiab thaum sau ntawv rau kev phais mob, nws yuav tsum tau sab laj nrog koj tus kws kho mob txog kev hloov kho nrog insulin.
Ua ntej sau ntawv rau tus neeg sawv cev hypoglycemic, tus neeg mob yuav tsum paub tias qhov muaj peev xwm ntawm kev txhim kho hypoglycemia thiab lub cev mob ntshav qab zib nce ntxiv nrog cawv, cov tshuaj uas tsis yog tshuaj steroidal, thiab lub caij ntev ua rau qaug zog. Thaum noj cawv, haus cov tshuaj disulfiram zoo li tshwm sim los ntawm qhov mob plab, ntuav, thiab xeev siab.
Txhawm rau kom txo qis kev pheej hmoo ntawm hypoglycemia vim muaj cov kab mob kis, cov khoom siv tu cev yuav tsum siv los tiv thaiv tus tom kawg.
Nrog rau kev siv tshuaj Movoglecen ntev ntev, nws muaj peev xwm los tsim kev tawm tsam ntawm qhov kev ua ntawm cov tshuaj nrog rau qhov txuas ntxiv uas tsis muaj zog ntawm kev kho mob. Hauv qhov no, nws raug nquahu kom nce cov tshuaj txhua hnub hauv lub cev lossis hloov cov tshuaj hypoglycemic.
Cov tshuaj yuav raug txwv rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Txiag tej menyuam
Cov yeeb tshuaj txwv tsis pub rau cov menyuam yaus hnub nyoog qis dua 18 xyoo vim tias tsis muaj ntaub ntawv qhia txog cov txiaj ntsig ntawm glipizide rau kev loj hlob thiab kev loj hlob ntawm tib neeg lub cev thaum menyuam yaus thiab thaum tiav hluas.
Siv thaum cev xeeb tub thiab lactation
Nws tseem tsis tau paub li cas kev siv tshuaj lom neeg lub cev muaj peev xwm cuam tshuam cov txheej txheem ntawm txoj kev loj hlob ntawm embryonic. Nws yog raws li qhov ua tau txoj kev nkag mus ntawm glipizide los ntawm cov teeb meem hematoplacental nrog kev ua txhaum ntxiv ntawm phau ntawv ntawm cov leeg ua haujlwm. Hauv kev txuas nrog cov kev xav no, cov poj niam cev xeeb tub raug txwv tsis pub siv tshuaj yeeb tshuaj hypoglycemic rau kev tswj hwm qhov ncauj.
Nws raug nquahu kom siv cov roj daub nrog tib neeg cov kua dej los txo cov ntshav qabzib.
Thaum kho nrog Movogleken, nws yog qhov yuav tsum hloov xa tus menyuam mus rau khoom noj khoom haus thiab tsis pub niam mis.
Thaum kho nrog Movogleken, nws yog qhov yuav tsum hloov xa tus menyuam mus rau khoom noj khoom haus dag.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv cov kab mob hauv lub raum hnyav, kev noj cov tshuaj no yog txwv tsis pub siv, vim tias cov tshuaj tawm hauv cov zis.
Siv rau lub siab ua haujlwm tsis zoo
Nws yog qhov tsim nyog los tswj lub luag haujlwm ntawm kev ua haujlwm ntawm lub siab thiab nws cov enzymes hauv cov neeg mob me txog rau qib kev ua haujlwm tsis txaus. Nyob rau hauv muaj qhov qhia tau txoj kev pathological, kev kho tshuaj yeeb yog txwv tsis pub.
Noj ntau dhau ntawm Movoglyken
Kev siv tshuaj ntau dhau yuav tuaj yeem ua rau cov ntshav qis. Tus mob yog nrog los ntawm:
- zoo nkaus kev tshaib nqhis nqhis;
- Lub siab ntsws hloov tam sim ntawd nrog qhov kev npau taws thiab kev npau taws;
- nce hws;
- qhov tshwm sim ntawm kev poob siab hauv lub xeev;
- insomnia;
- hypoglycemic coma;
- hais lus tsis pom kev;
- tsis hnov qab ntawm kev saib xyuas;
- tsis nco qab.
Kev siv tshuaj ntau dhau tuaj yeem ua rau tawm hws.
Yog hais tias tus neeg mob nco qab, nws yog ib qhov tsim nyog yuav tau muab nws los daws cov suab thaj. Yog tias tsis nco qab, 40% kev daws teeb meem yuav tsum tau txhaj tshuaj rau qhov quav lossis ib qho dej ntws tawm yuav tsum muab tso nrog kua dej 5%. 1-2 mg ntawm glucagon yog muab tshuaj subcutaneously. Thaum rov ua haujlwm rau lub xeev thaum tus neeg mob rov qab nco qab, nws yuav tsum noj zaub mov ntau hauv carbohydrates. Qhov no yog qhov tsim nyog los txhawm rau tiv thaiv kev tsim kho tshiab ntawm hypoglycemia. Nrog rau kev mob hlwb txhaws, kev kho mob nrog Dexamethasone lossis Mannitol yog xav tau.
Kev cuam tshuam nrog lwm yam tshuaj
Kev pom zoo ntawm Pharmacological nrog miconazole raug pom.
| Txhim kho cov nyhuv hypoglycemic | Txo txo cov nyhuv kho mob ntawm cov ntsiav tshuaj |
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Movoglecen txo cov kev kho mob nyhuv ntawm furosemide.
Kev siv cov tshuaj myelotoxic ib txhij ua rau muaj kev pheej hmoo ntawm agranulocytosis, tuaj yeem ua rau qhov tsos mob ntawm thrombocytopenia.
Cawv tau zoo
Kev haus dej cawv Ethyl ua rau lub ntsej muag hypoglycemic, inhibits hematopoietic system, lub siab ua haujlwm thiab ua rau muaj feem yuav ua rau muaj ntshav txhaws vim muaj kev sib txuam ntau ntxiv ntawm cov ntshav liab thiab platelets. Ethanol cuam tshuam tsis zoo rau lub hauv nruab nrab lub paj hlwb thiab trophism ntawm cov leeg hlwb, yog li ntawd, nws yog qhov yuav tsum tso tseg txoj kev haus cawv rau lub sijhawm kho nrog Movogleken.
Analogs
Koj tuaj yeem hloov cov tshuaj ntawm ib qho ntawm cov yeeb tshuaj hauv qab no:
- Glenez;
- Glibenesis;
- Antidiab;
- Lawj xeeb.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kev siv tshuaj hypoglycemic yog muag los ntawm cov tshuaj noj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Vim tias txoj kev pheej hmoo ntawm kev txhim kho hypoglycemic coma, kev siv cov tshuaj ntawm koj tus kheej yam tsis muaj kev qhia tshuaj kho mob raug txwv.
Nqe rau Movoglechen
Tus nqi nruab nrab hauv kev lag luam kws kho mob ncav cuag 1,600 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cov ntsiav tshuaj hauv qhov chaw sib cais los ntawm UV nkag mus ntawm qhov kub ntawm + 8 ... + 25 ° C.
Hnub tas sij hawm
42 hli.
Cov analogue ntawm Movogleken - cov tshuaj Diabeton yog khaws cia rau hauv ib qho chaw sib cais los ntawm UV nplua.
Chaw tsim tshuaj paus
Zhuhai United Laboratories Co., Suav.
Kev tshuaj xyuas ntawm Movogleken
Kristina Doronina, 28 xyoo, Vladivostok
Kuv tus txiv muaj ntshav qab zib cov ntshav siab. Tau ntau xyoo, lawv tsis tuaj yeem nrhiav tus neeg sawv cev glycemic kom tsawg, thiaj li tsis yog txo cov suab thaj, tab sis kuj ua kom cov nqi tsis pub dhau. Hauv kev sab laj tom ntej, Movoglecen ntsiav tshuaj tau raug sau tseg. Tom qab 30 hnub ntawm txoj kev kho, cov piam thaj rov qab zoo li qub, cov tshuaj nce los. Tam sim no nws yog nyob rau hauv 8,2 hli, tab sis nws zoo dua 13-15 hli, uas tau ua ntej.
Yaroslav Filatov, 39 xyoo, Tomsk
Cov tshuaj tsis pab thaum pib. Tom qab thov 5 mg thaum sawv ntxov, cov piam thaj khaws cia hauv 10-13 hli, ib qho pib mob ntawm daim tawv nqaij. Nrog rau qhov nce ntxiv ntawm koob rau 20 mg, qabzib maj mam poob hauv 2 lub lis piam mus txog 6 hli. Phiv los sis lawv tus kheej. Tab sis qhov ntsuas no yog nyob ntawm kev noj haus thiab cov lus pom zoo hauv cov lus qhia. Cov tshuaj tsis tuaj yeem txo cov piam thaj hauv qhov tsis txaus.
Ulyana Guseeva, 64 xyoo, Krasnoyarsk
Thaum muaj hnub nyoog 62, ntshav qab zib tau nce mus txog 16-18 hli. Nws tau pib rau lub caij nplooj ntoo hlav, tom qab so haujlwm. Nws tau pib coj lub neej kev ua si vim yog tsis muaj haujlwm, uas ua rau cov piam thaj hauv cov ntshav nce ntxiv. Ua ke Gluconorm thiab Siofor tsis haum.Cov tshuaj Movoglek tshuaj. Cov piam thaj txo qis 2 zaug. Hauv qab no 8 hli tsis txo. Kuv tsis tau pom cov kev mob tshwm sim rau 2 xyoos. Txog tam sim no, nws nyob zoo, tab sis yog tias nws mob ntxiv, nws yuav zoo dua rau hloov mus rau lwm cov tshuaj.
