Gensulin yog tsim rau cov neeg mob uas kuaj ntshav qab zib, haum rau kev sib xyaw nrog lwm yam ntawm insulin. Nrog kev ceev faj, nws yuav tsum tau ua ke nrog cov tshuaj uas tuaj yeem txhim kho lossis txo qis cov nyhuv hypoglycemic.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Soluble tib neeg lub cev insulin hom hloov ntshav.
Gensulin yog tsim rau cov neeg mob uas kuaj ntshav qab zib, haum rau kev sib xyaw nrog lwm yam ntawm insulin.
ATX
A10AB01.
Tso cov ntawv thiab cov nyob ua ke
Txoj kev daws teeb meem meej, ib qho kev tshem tawm dawb, muab tshuaj subcutaneously. Ib qho nag lossis daus yuav tshwm sim uas yaj yooj yim thaum shaken. Cov tshuaj tau ntim rau hauv 10 ml fwj lossis 3 ml cartridges.
Hauv 1 ml ntawm cov tshuaj, cov tshuaj tiv thaiv nquag muaj nyob rau hauv tsab ntawv ntawm recombinant tib neeg insulin 100 IU. Cov khoom siv ntxiv yog glycerol, sodium hydroxide lossis hydrochloric acid, metacresol, dej txhaj.
Hauv 1 ml ntawm cov tshuaj, cov tshuaj tiv thaiv nquag muaj nyob rau hauv tsab ntawv ntawm recombinant tib neeg insulin 100 IU.
Pharmacological kev txiav txim
Hais txog cov insulins uas ua yeeb yam luv luv. Los ntawm cov tshuaj tiv thaiv nrog cov receptor tshwj xeeb rau ntawm lub cell membrane, nws txhawb nqa qhov tsim ntawm insulin-receptor complex, uas ua kom lub luag haujlwm hauv lub cell thiab kev sib txuas ntawm qee cov enzyme tebchaw.
Cov theem ntawm cov piam thaj hauv cov ntshav yog sib npaug los ntawm kev nce hauv kev thauj mus los hauv cov hlwb, kev nqus ntxiv los ntawm tag nrho cov ntaub so ntswg hauv lub cev, txo kev tsim cov suab thaj los ntawm daim siab, thiab ua rau glycogenogenesis.
Lub sijhawm sijhawm ntawm cov kev kho kom zoo ntawm cov tshuaj nyob ntawm:
- kev nqus ntawm tus nquag nquag;
- cheeb tsam thiab txoj kev ntawm kev coj ntawm lub cev;
- tsuas tshuaj.
Cov Tshuaj Pharmacokinetics
Tom qab qhov kev txhaj tshuaj tiav pib ua nyob rau hauv ib nrab ib teev, qhov siab tshaj plaws tau pom los ntawm 2 mus rau 8 teev thiab kav ntev txog 10 teev.
Kev faib tawm tsis zoo nyob rau hauv cov ntaub so ntswg, cov khoom ua kom nquag plias tsis dhau mus rau niam mis, tsis txhob hla cov leeg, i.e. Tsis txhob cuam tshuam dab tsi hauv lub fetus. Ib nrab-lub neej yuav siv sijhawm 5-10 feeb, ua rau lub raum tso nyob rau hauv ntau npaum li 80%.
Cov tshuaj nquag ua ke ntawm cov tshuaj tsis hla tus txiv neej, i.e. Tsis txhob cuam tshuam dab tsi hauv lub fetus.
Kev ntsuas rau siv
Nws yog qhia hauv kev kho mob ntawm cov mob hauv qab no:
- Yam 1 ntshav qab zib.
- Hom Kab Mob II (nyob rau tsam muaj tshuaj tiv thaiv cov ntshav tsis haum).
- Intercurrent pathology.
Cov Yuav Tsum Muaj
Nws yog txwv rau:
- Kev tsis qaug rau tus kheej ib leeg ib feem ntawm cov tshuaj.
- Kev ntshav siab.
Yuav noj Gensulin li cas?
Cov tshuaj tau muab tshuaj nyob rau hauv ntau txoj kev - intramuscular, subcutaneous, leeg pob leeg. Cov koob tshuaj thiab thaj chaw rau kev txhaj tshuaj yog xaiv los ntawm cov kws kho mob koom rau txhua tus neeg mob. Cov txheej txheem ntau npaum li cas nws txawv ntawm 0.5 txog 1 IU / kg ntawm tib neeg qhov hnyav, coj mus rau hauv tus account theem ntawm qab zib.
Tshuaj insulin yuav tsum tau muab tshuaj rau ib nrab ib teev ua ntej noj mov lossis noj khoom txom ncauj raws li carbohydrates. Kev daws yog preheated rau chav tsev kub. Kev kho mob monotherapy cuam tshuam nrog kev txhaj tshuaj txog li 3 zaug hauv ib hnub (tshwj xeeb, qhov muab ntau ntxiv nce mus txog 6 npaug).
Yog tias qhov koob tshuaj txhua hnub ntau dua li 0.6 IU / kg, nws muab faib ua ntau qhov tshuaj, kev txhaj tshuaj tso rau ntau qhov chaw ntawm lub cev - deltoid brachial leeg, lub plab ua ntej pem hauv ntej. Txhawm rau tsis tsim kho lipodystrophy, cov chaw rau kev txhaj tshuaj yog hloov tas li. Ib rab koob tshiab siv rau txhua txoj kev txhaj tshuaj. Txog ntawm IM thiab IV tswj hwm, nws tsuas yog ua rau hauv tsev kho mob los ntawm tus kws kho mob.
Kev phiv los ntawm Gensulin
Nrog kev ua txhaum ntawm kev txhaj tshuaj thiab kev txhaj tshuaj, cov kev mob tshwm sim los ntawm hom:
- tshee hnyo
- mob taub hau;
- pallor ntawm daim tawv nqaij;
- paresthesia ntawm lub qhov ncauj kab noj hniav;
- kev xav ntawm kev tshaib plab;
- tawm hws hnyav;
- tachycardia.
Nrog rau cov ntshav qog ntshav qab zib siab heev, qhov pib ntawm hypoglycemic coma yog ua tau.
Ntawm kev fab tshuaj, Quincke's edema, ua pob rau ntawm daim tawv nqaij, anaphylactic ceeb feem ntau tshwm sim. Cov kev tawm tsam hauv zos yog qhia los ntawm khaus thiab o, tsis tshua muaj lipodystrophy, hyperemia. Thaum pib kho, qee cov neeg mob ntsib cov teeb meem tsis zoo uas tshwm sim yam tsis muaj kev pab thaum muaj xwm ceev.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Thaum pib ntawm kev siv tshuaj insulin lossis hloov mus rau lwm hom yuav ua rau muaj kev tsis sib haum xeeb nyob rau hauv kev muaj txiaj ntsig, kev txhim kho muaj kev phiv tshuaj. Nyob rau lub sijhawm no, ib tus neeg tsis tas yuav tsav tsheb, cov txheej txheem nyuaj. Nws tsim nyog tso haujlwm uas yuav muaj kev phom sij.
Cov lus qhia tshwj xeeb
Kev tswj hwm tshuaj yog qhov tsis tuaj yeem thaum lub sijhawm huab, qhov tsim ntawm cov khoom haum, staining hauv xim sib txawv. Lub sijhawm tag nrho ntawm txoj kev kho mob, tus neeg mob yuav tsum saib xyuas cov ntshav qabzib tas li. Kev mob ntshav siab ntshav qis tshwm sim thaum:
- noj tshuaj tuag;
- txhawb nqa lub cev;
- hloov ntawm kev siv cov tshuaj insulin;
- ntuav nrog raws plab;
- hla kev noj mov;
- qis ua haujlwm ntawm lub raum lossis mob siab, mob qog, lub qog adrenal;
- qhov chaw tshiab rau kev txhaj tshuaj;
- ua ke nrog lwm yam tshuaj.
Qhov ua txhaum kev noj haus zoo tshaj plaws, kev tsis muaj tshuaj, tshwj xeeb tshaj yog thaum nws los rau hom ntshav qab zib hom 1, yuav ua rau muaj mob ntshav qab zib. Cov tsos mob nce zuj zus thiab pom qhov tseeb nrog tso zis ntxiv, nqhis dej tas li, ziab tawm thiab ua kom tawv nqaij, raws sij hawm kiv taub hau, muaj acetone nyob rau hauv kev ua pa. Yog tias tsis muaj sijhawm thiab kev kho kom raug, mob ketoacidosis, mob qog ntshav qab zib tsis tuaj yeem loj tuaj.
Kev kho tshuaj ntawm lub koob tshuaj yog nqa nrog hypopituitarism, Addison's disease, kev cuam tshuam ntawm cov thyroid caj pas, lub raum lossis mob siab, hauv lub hnub nyoog laus (txij li 65 xyoos). Feem ntau, qhov ntau npaum ntawm cov tshuaj hauv cov neeg mob uas raug rau lub cev ntau dhau dhau ntawm lub cev, hloov pauv lawv cov zaub mov noj ntau. Yog tias ib tus neeg pib noj lwm yam tshuaj, kev tswj kom pom tseeb ntawm cov piam thaj hauv qab no yog nqa tawm.
Cov tshuaj insulin yog qhov nquag ua rau pob lwg; yog li ntawd, cov tshuaj insulin yuav tsum tsis txhob siv.
Siv rau lub sijhawm qub
Tom qab 65 xyoo, yuav tsum tau hloov kho qhov koob tshuaj thiab ntsuas cov ntshav qab zib ib txwm muaj.
Txiag tej menyuam
Tsis muaj kev paub dhau los siv Gensulin rau menyuam yaus.
Tsis muaj kev paub dhau los siv Gensulin rau menyuam yaus.
Siv thaum cev xeeb tub thiab lactation
Cov neeg mob kuaj mob ntshav qab zib mellitus thaum npaj lub sijhawm muaj menyuam hauv plab, tom qab kev xeeb tub yuav tsum saib xyuas cov piam thaj hauv ntshav, vim tias tej zaum koj yuav tsum tau hloov pauv qhov ntau npaum li cas ntawm cov tshuaj.
Kev pub mis niam pub rau muab tso ua ke nrog kev siv cov tshuaj insulin, yog tias qhov xwm txheej ntawm tus me nyuam tseem zoo txaus, tsis muaj mob plab. Cov koob tshuaj kuj tseem raug hloov raws li cov kua nplaum nyeem.
Daim ntawv thov rau lub raum khiav tsis zoo
Cov hauj lwm raum tsis zoo yog qhov kev qhia ncaj qha rau kev hloov cov tshuaj ntau dua.
Siv rau lub siab ua haujlwm tsis zoo
Xav tau cov tshuaj kho kom haum qog.
Gensulin Noj Ntau Tshaj
Kev siv cov insulin hauv cov neeg loj yuav ua rau lub qog ntshav qab zib. Cov neeg mob mentsis ntawm pathology yog tshem tawm los ntawm kev noj qab zib, noj cov khoom noj uas muaj carbohydrate. Nws raug nquahu kom tib neeg ib txwm muaj qab zib thiab haus nrog lawv.
Yog mob hnyav yuav ua rau tsis nco qab. Hauv qhov xwm txheej no, txoj cai dextrose iv daws tau muab ceev rau tus neeg. Ib qho ntxiv, glucagon yog tswj hwm iv lossis s / c. Thaum ib tug neeg los, nws yuav tsum noj zaubmov carbohydrate kom txaus tiv thaiv kev ua mob zaum ob.
Yog mob hnyav yuav ua rau tsis nco qab.
Kev cuam tshuam nrog lwm yam tshuaj
Muaj cov npe tshuaj uas tuaj yeem hloov lub cev xav tau insulin. Cov nyhuv hypoglycemic yog kho kom zoo thaum siv ua ke:
- qhov ncauj hypoglycemia;
- carbonic anhydrase inhibitors, monoamine oxidase inhibitors, angiotensin hloov enzyme inhibitors;
- sulfonamides;
- Bromocriptine;
- tsis xaiv khoom beta-blockers;
- Clofibrate;
- theophylline;
- lithium-uas muaj cov tshuaj;
- cyclophosphamide;
- cov yeeb yaj kiab uas muaj tshuaj ethanol nyob rau ntawd.
Cov nyhuv hypoglycemic yog txo thaum siv:
- thiazide diuretics;
- cov thyroid hormones;
- glucocorticosteroids;
- sympathomimetics;
- Danazole;
- calcium channel blockers;
- morphine;
- Phenytoin.
Nrog salicylates, ob qho tib si cov nyhuv ntawm cov tshuaj no nce thiab txo qis.
Cawv tau zoo
Kev siv cov tshuaj insulin ib txhij nrog cov cawv muaj cawv yog tsis tsim nyog.
Analogs
Cov tshuaj tiv thaiv kab mob hauv qab no muaj nyob rau: Insuman, Monodar, Farmasulin, Rinsulin, Humulin NPH, Protafan.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Nws yog tsis yooj yim sua. Nruj me ntsis raws li hauv daim ntawv qhia.
Nqi
Txij li 450 rub.
Cia rau cov neeg mob rau cov tshuaj
Ntawm qhov kub thiab txias ntawm + 2 ° С txog + 8 ° С.
Hnub tas sij hawm
2 xyoos
Chaw tsim tshuaj paus
BIOTON S.A. (BIOTON S.A.), Tebchaws Poland.
Insuman yog ib qho tshuaj ntawm cov tshuaj.
Xyuas
Ekaterina 46 xyoo, Kaluga
Kuv tau siv Gensulin R tau ntau xyoo. Ua ntej nws kuv tau sim tshuaj ntau yam uas tsis haum. Thiab cov no haum thiab zoo zam. Kuv nyiam qhov tseeb tias lub hwj qhib qhib tau txig yog khaws cia, cov tshuaj tsis poob nws cov nyhuv. Cov nyhuv ntawm nws mob tsawv tau ntev.
Sergey muaj 32 xyoos, Moscow
Thaum cov tshuaj tau xaj tau, Kuv tau ntshai kev mob tshwm sim, tab sis nyob hauv qhov tsis muaj qab hau. Kuv nkag mus hauv nws, raws li kws kho nyob rau hauv cov lus qhia siv ib tug xaum xim. Gensulin M30 thaum pib kho mob ua rau lub sij hawm kiv taub hau, tab sis txhua yam ploj mus tom qab ob peb lub lis piam. Kuv zoo siab, qab zib cia li.
Inga 52 xyoo, Saratov
Kuv cia siab tias qhov tshwm sim tsis zoo tshaj plaws los ntawm cov tshuaj, tab sis nws tig los ua qhov zoo heev. Zoo heev rau kev siv ob npaug, kev siv tshuaj kho mob ua ke. Kev tawm tsam tsis haum nws tsis tau tshwm sim nws tus kheej, txawm hais tias muaj ntau yam ua pob rau ntawm daim tawv nqaij thaum pib ntawm daim ntawv thov Gensulin N.
