Kev siv tshuaj tiv thaiv kabmob hypoglycemic - ua haujlwm ntawm lub cev, cov lus qhia rau kev siv

Invokana yog lub npe lag luam rau cov tshuaj noj kom txo qis ntshav qab zib.

Cov cuab yeej yog npaj rau cov neeg mob kev mob ntshav qab zib hom II. Cov tshuaj muaj txiaj ntsig zoo nyob rau hauv lub moj khaum ntawm monotherapy, thiab ua ke nrog lwm txoj hauv kev kho mob ntshav qab zib.

Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab daim ntawv tso tawm

Invocana yog tshuaj uas muaj qhov cuam tshuam hypoglycemic. Cov khoom lag luam yog npaj rau kev tswj hwm qhov ncauj. Invokana tau siv ua tiav hauv cov neeg mob ntshav qab zib hom II.

Cov tshuaj muaj ob-xyoos txee lub neej. Khaws cov tshuaj ntawm qhov kub tsis dhau 30⁰C.

Cov chaw tsim tshuaj txog cov tshuaj no yog Janssen-Ortho, uas yog tuam txhab nyob hauv Puerto Rico. Kev ntim khoom yog tsim los ntawm lub tuam txhab Janssen-Silag nyob hauv Ltalis. Tus tuav txoj cai ntawm cov tshuaj no yog Johnson & Johnson.

Cov tshuaj tseem ceeb ntawm cov tshuaj yog Canagliflozin hemihydrate. Hauv ib ntsiav tshuaj ntawm Invokana, muaj txog 306 mg ntawm cov tshuaj nquag no.

Tsis tas li ntawd, 18 mg ntawm hyprolose thiab anhydrous lactose (txog 117.78 mg) yog tam sim no muaj pes tsawg leeg tshuaj sib xyaw. Sab hauv cov tub ntxhais cov tub ntxhais muaj tseem muaj cov calcium stearate (4.44 mg), microcrystalline cellulose (117.78 mg) thiab croscarmellose sodium (li 36 mg).

Lub khauj khaum ntawm cov khoom muaj cov yeeb yaj kiab, uas muaj:

• macrogol;
• talc;
• polyvinyl cawv;
• titanium dioxide.

Invokana muaj nyob rau hauv cov qauv ntawm cov ntsiav tshuaj ntawm 100 thiab 300 mg. Hauv cov ntsiav tshuaj ntawm 300 mg, lub plhaub uas muaj cov xim dawb yog tam sim no; rau ntawm cov ntsiav tshuaj ntawm 100 mg, lub plhaub yog daj. Ntawm ob hom ntsiav tshuaj, ntawm ib sab muaj tus txaug “CFZ”, thiab nyob sab nraum qab muaj cov lej 100 lossis 300 nyob ntawm qhov hnyav ntawm lub ntsiav tshuaj.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov hlwv. Ib qhov hlwv muaj 10 ntsiav tshuaj. Ib pob muaj peev xwm ntim 1, 3, 9, 10 hlwv.

Pharmacological kev txiav txim

Canagliflozin yog cov tshuaj tseem ceeb ntawm cov tshuaj txo cov reabsorption (reabsorption) ntawm cov piam thaj. Vim qhov no, nws kev nthuav tawm los ntawm lub raum nce ntxiv.

Vim tias rov thim rov qab, qhov txo qis hauv cov piam thaj hauv cov neeg mob cov ntshav tau tshwm sim. Nrog kev tshem tawm ntawm qabzib, ib qho diuretic effect tshwm sim. Vim qhov no, systolic ntshav siab poob qis.

Canagliflozin ua rau muaj kev poob cev tsis zoo. Invokana tuaj yeem siv los ua cov tshuaj poob phaus. Thaum muab tshuaj ntawm 300 mg, nws pab txo cov piam thaj hauv ntshav ntau dua li ib koob ntawm 100 mg. Kev siv Canagliflozin tsis ua rau kom cov kua nplaum tsis zoo.

Cov tshuaj yuav pab txo kom lub raum txo qis rau qabzib. Thaum noj cov tshuaj, cov kua nplaum tawm los ntawm lub raum ua kom zoo dua. Thaum noj Invokana ntev ntev, ib qho kev txo qis ntawm cov piam thaj hauv cov ntshav tau sau tseg.

Kev yoo mov pab ncua kev nqus ntawm cov piam thaj hauv cov hnyuv. Hauv kev kawm ntawm kev tshawb fawb, nws muab tawm tias cov ntshav qab zib cov ntshav thaum noj cov tshuaj ua ntej thiab tom qab noj mov txawv. Kev yoo mov glycemia thaum noj 100 mg ntawm cov tshuaj hloov mus rau -1.9 mmol / L, thiab thaum noj 300 mg rau -2.4 mmol / L.

Tom qab 2 teev tom qab noj mov, cov ntshav qab zib cov ntshav tau hloov pauv ntawm -2.7 mmol / L thaum noj 100 mg thiab los ntawm -3,5 mmol / L thaum noj 300 mg ntawm cov tshuaj.

Kev siv Canagliflozin txhim kho β-cell muaj nuj nqi.

Cov Tshuaj Pharmacokinetics

Canagliflozin yog tus cwj pwm los ntawm kev nqus sai. Cov tshuaj pharmacokinetics ntawm cov tshuaj tsis muaj qhov sib txawv thaum noj los ntawm tus neeg noj qab haus huv, lossis thaum noj los ntawm tus neeg muaj mob ntshav qab zib hom II.

Qhov siab tshaj plaws ntawm Kanagliflosin tau sau tseg tom qab 1 teev tom qab noj Invokana. Ib nrab-lub neej ntawm cov tshuaj yog 10.6 teev thaum siv 100 mg ntawm cov tshuaj thiab 13,1 teev thaum noj 300 mg ntawm cov tshuaj.

Lub bioavailability ntawm cov tshuaj yog 65%. Nws tuaj yeem noj ua ntej thiab tom qab noj mov, tab sis rau cov nyhuv zoo, nws pom zoo kom noj cov tshuaj ua ntej noj mov thawj zaug.

Canagliflozin yog muab faib rau hauv cov ntaub so ntswg ntau. Cov tshuaj yog zoo txuam nrog cov ntshav protein. Tus nqi yog 99%. Cov tshuaj yog tshwj xeeb tshaj yog nyob rau hauv khi rau albumin.

Kanagliflosin muaj tus nqi tsawg ntawm kev ua kom huv ntawm lub cev nqaij los ntawm nws. Kev ua kom huv huv lub raum los ntawm cov tshuaj tawm (rov ua haujlwm rau lub cev) yog 1,55 ml / min. Qhov nruab nrab tag nrho tus nqi ntawm kev ntxuav lub cev los ntawm Canagliflozin yog 192 ml / min.

Kev taw qhia thiab contraindications

Cov tshuaj yog tawm rau cov neeg mob ntshav qab zib hom II.

Cov tshuaj yuav siv tau:

• raws li ywj siab thiab tsuas yog txhais tau tias ntawm kev kho mob;
• ua ke nrog lwm cov tshuaj ua kom ntshav qab zib thiab insulin.

Ntawm cov contraindications rau siv, cov pab txhawb nqa sawv:

• mob raum tsis ua haujlwm;
• tus kheej intolerance Canagliflozin thiab lwm yam tshuaj ntawm cov tshuaj;
• lactose tsis kam lees;
• hnub nyoog txog 18 xyoo;
• daim siab ua haujlwm siab;
• ntshav qab zib hom I;
• mob plawv tsis ua hauj lwm (3-4 chav kawm ua haujlwm);
• pub niam mis;
• mob ketoacidosis;
• cev xeeb tub

Cov lus qhia rau kev siv

Thaum nruab hnub, 1 ntsiav tshuaj ntawm tshuaj (100 lossis 300 mg) raug tso cai. Nws raug nquahu kom noj cov tshuaj thaum sawv ntxov thiab ntawm lub plab khoob.

Thaum siv cov tshuaj ua ke nrog rau lwm cov kab mob hypoglycemic thiab insulin, nws raug nquahu kom txo cov tshuaj ntawm tom kawg kom tsis txhob muaj qhov tshwm sim ntawm cov mob ntshav qab zib.

Txij li thaum canagliflozin muaj cov nyhuv diuretic muaj zog, ntau npaum li cas ntawm cov tshuaj rau cov neeg mob uas lub raum lub raum tsis ua haujlwm, nrog rau cov neeg laus dua 75 xyoo, yuav tsum yog 100 mg ib zaug.

Cov neeg mob uas tiv taus zoo rau canagliflozin raug pom zoo kom noj 300 mg ntawm ib zaug ib hnub.

Hla kev siv tshuaj yog qhov tsis zoo. Yog tias qhov no tau tshwm sim, koj yuav tsum noj cov tshuaj sai. Nws tsis raug tso cai los siv qhov muab ob npaug ntawm cov tshuaj thaum nruab hnub.

Cov Neeg Mob Tshwj Xeeb thiab Cov Lus Qhia

Invokana yog contraindicated rau cov poj niam cev xeeb tub thiab cov menyuam hnub nyoog qis dua 18 xyoo. Cov tshuaj yuav tsum tsis txhob noj los ntawm lactating poj niam, txij li Canagliflozin nquag nkag mus rau hauv niam mis thiab muaj peev xwm cuam tshuam tsis zoo rau kev noj qab haus huv ntawm tus menyuam mos.

Nws yog siv nrog ceeb toom los ntawm tib neeg tshaj 75 xyoo. Lawv tau raug txwv yam tsawg kawg ntawm cov tshuaj.

Nws tsis raug pom zoo kom muab tshuaj rau cov neeg mob:

• nrog kev ua haujlwm tsis zoo ntawm lub raum ntawm cov neeg mob hnyav;
• nrog mob raum tsis ua haujlwm nyob rau hauv lub caij xaus kawg;
• raug lim ntshav.

Cov tshuaj yog noj nrog ceev faj hauv cov neeg mob raum tsis ua haujlwm. Hauv qhov no, cov tshuaj no yog qhov tsawg kawg - 100 mg ib hnub ib zaug. Nrog lub raum tsis ua hauj lwm, kev noj tshuaj tsawg kawg nkaus kuj tseem muaj.

Nws raug txwv tsis pub noj cov tshuaj rau cov neeg mob ntshav qab zib hom 1 mob ntshav qab zib thiab ketoacidosis. Qhov tsim nyog yuav tau txais kev kho mob los ntawm kev noj cov tshuaj nyob rau theem kawg ntawm kev mob raum tsis zoo yuav tsis pom.

Invokana tsis muaj cov carcinogenic thiab mutagenic nyhuv rau tus neeg mob lub cev. Tsis muaj cov ntaub ntawv qhia txog cov nyhuv ntawm cov tshuaj rau ntawm kev ua me nyuam lub luag haujlwm ntawm ib tus neeg.

Nrog cov kev kho mob ua ke nrog kev siv tshuaj kho mob thiab lwm yam kab mob hypoglycemic, nws raug nquahu kom txo cov tshuaj ntawm tom kawg kom tsis txhob mob ntshav qab zib.

Kev txo qis hauv cov ntshav ntim hauv lub cev ntau zaus tshwm sim hauv thawj ib thiab ib hlis txij thaum pib kho nrog Invocana.

Kev tshem tawm cov tshuaj yog qhov yuav tsum tau vim muaj qee qhov tshwm sim:

• vulvovaginal candidiasis hauv poj niam;
• candida balanitis rau cov txiv neej.

Ntau tshaj li 2% ntawm cov poj niam thiab 0.9% ntawm cov txiv neej tau rov qab muaj mob ntxiv thaum noj cov tshuaj. Feem ntau ntawm vulvovaginitis tshwm sim rau cov poj niam thaum thawj 16 lub lis piam los ntawm kev pib kho nrog Invocana.

Muaj cov pov thawj ntawm cov nyhuv ntawm cov tshuaj rau ntawm pob zeb hauv av muaj pes tsawg leeg hauv cov tib neeg mob plawv. Cov tshuaj muaj peev xwm txo cov pob txha muaj zog, uas ua rau muaj kev pheej hmoo ntawm cov pob txha puas tsuaj nyob rau hauv pab pawg ntawm cov neeg mob. Kev ceev faj kev kho mob yuav tsum tau.

Vim tias qhov kev pheej hmoo siab ntawm kev txhim kho hypoglycemia nrog kev sib xyaw ua ke ntawm Invokana thiab insulin, nws raug nquahu kom tsis txhob tsav tsheb.

Phiv thiab haus tshaj

Ntawm cov kev phiv los ntawm kev noj cov tshuaj yog:

• kev xav ntawm kev nqhis dej;
• kev txo qis hauv lub cev ntim hauv daim ntawv ntawm kiv taub hau, lub cev qhuav dej, txo qis ntshav siab, tsaus muag;
• vulvovaginal candidiasis hauv poj niam;
• cem quav;
• polyuria;
• xeev siab
• urticaria;
• qhov ncauj qhuav
• balanitis, balanoposthitis rau txiv neej;
• cystitis, mob raum;
• hypoglycemia nrog tswj hwm nrog insulin;
• nce hauv hemoglobin qib;
• qis dua uric acid ntau ntau;
• mob ketoacidosis;
• tsis tshua muaj pob txha muaj zog;
• nce theem ntawm ntshiab poov tshuaj;
• nce rau hauv cov cholesterol nyob rau hauv cov ntshav.

Hauv qee qhov tsis tshua muaj tshwm sim, kev noj tshuaj ua rau lub raum tsis ua haujlwm, ceeb toom tshuaj tiv thaiv, thiab mob paj hlwb.

Nws tsis muaj qhov tshwm sim ntawm kev haus dej ntau dhau nrog cov tshuaj no. Ib koob tshuaj 1600 mg tau pom zoo ua tiav los ntawm cov neeg noj qab haus huv thiab ib koob tshuaj 600 mg rau ib hnub rau cov neeg mob ntshav qab zib hom 2.

Nyob rau hauv rooj plaub ntawm kev noj haus ntau dhau, pais plab lav tso tawm, thiab tus neeg mob tshuaj xyuas. Kev lim ntshav nyob rau hauv cov ntaub ntawv ntawm kev siv ntau dhau yog tsis muaj txiaj ntsig.

Kev cuam tshuam nrog lwm cov tshuaj thiab cov tshuaj analogues

Cov tshuaj nquag ntawm cov tshuaj yog me ntsis cuam tshuam rau oxidative metabolism. Vim li no, cov nyhuv ntawm lwm cov tshuaj rau ntawm kev ua ntawm canagliflozin yog qhov tsawg.

Cov tshuaj cuam tshuam nrog cov tshuaj hauv qab no:

• Phenobarbital, Rifampicin, Ritonavir - kev txo qis hauv kev ua haujlwm ntawm Invokana, kev nce qib ntxiv yog tsim nyog;
• Probenecid - qhov tsis muaj qhov tseem ceeb ntawm cov nyhuv ntawm cov tshuaj;
• Cyclosporin - qhov tsis muaj qhov cuam tshuam tseem ceeb ntawm cov tshuaj;
• Metformin, Warfarin, Paracetamol - tsis muaj ib qho cuam tshuam tseem ceeb ntawm pharmacokinetics ntawm canagliflozin;
• Digoxin yog kev sib cuam tshuam me uas yuav tsum saib xyuas tus neeg mob lub sijhawm.

Cov tshuaj hauv qab no muaj tib lub txiaj ntsig zoo li Invokana:

• Glucobay;
• NovoNorm;
• Jardins;
• Glibomet;
• Piroglar;
• Guarem;
• Victoza;
• Glucophage;
• Methamine;
• Formmetin;
• Glibenclamide;
• Khoom Plig Ntsuas;
• Glidiab;
• Glykinorm;
• Raug Tsim Txiaj;
• Trazenta;
• Galvus;
• Glutazone

Tus neeg mob lub tswv yim

Los ntawm kev kuaj ntshav qab zib txog Invokan, peb tuaj yeem xaus tias cov tshuaj txo cov ntshav qab zib kom zoo thiab cov kev mob tshwm sim tsis tshua muaj, tab sis muaj tus nqi siab rau cov tshuaj, uas yuam ntau ntau hloov mus rau cov tshuaj analog.

Kuv tus kws kho mob tau koom tes pab kuv tawm tswv yim vim tias kuv muaj ntshav qab zib hom 2. Cov tshuaj zoo heev. Tsawg cov kev mob tshwm sim. Kuv tsis tau pom ib qho tshwm sim thaum tag nrho kev kho mob. Ntawm cov minuses, Kuv xav kom nco ntsoov tus nqi siab rau nws.

Tatyana, 52 xyoo

Tus kws kho mob pom zoo cov tshuaj rau ntshav qab zib ntawm Invokan. Cuab tam tau muaj pov thawj zoo. Tau sau tseg cia tsawg hauv cov piam thaj hauv ntshav tau sau tseg. Muaj cov kev mob tshwm sim nyob rau hauv daim ntawv ntawm lub pob me me, tab sis tom qab kho qhov koob tshuaj, txhua yam ploj mus. Qhov tsis zoo yog tus nqi siab. Muaj ntau ntau cov analogues muaj.

Alexandra, 63

Kuv tau mob ntshav qab zib ntev ntev thiab txiav txim siab hloov mus rau Invocana. Cov cuab yeej muaj nqi zoo nkauj, tsis yog txhua tus neeg tuaj yeem them nws. Ntawm efficiency tsis phem. Kuv txaus siab nrog qee qhov tsawg tsawg ntawm kev sib kis thiab kev mob tshwm sim piv nrog lwm cov tshuaj mob ntshav qab zib.

Oleg, 48 xyoo

Cov khoom siv video ntawm hom, cov tsos mob thiab kev kho mob ntshav qab zib:

Tus nqi ntawm cov tshuaj hauv khw muag tshuaj yog los ntawm 2000-4900 rubles. Tus nqi ntawm analogues ntawm cov tshuaj yog 50-4000 rubles.

Cov khoom yog xa tawm tsuas yog los ntawm kev kho mob ntawm tus kws tshaj lij.