Ntshav qab zib phosphate yog ib qho mob hnyav heev ntawm kev muaj keeb, uas tau kuaj pom tsuas yog menyuam yaus. Nws yuav tsum tau soj ntsuam tas li thiab kho mob, vim nws yog qhov tsis zoo nrog kev ua txhaum loj thiab kev nyuaj. Thiab ua ntej xav txog cov laj thawj thiab cov tsos mob ntawm tus kab mob no, nws yog ib qho tsim nyog yuav tsum pib los ntawm ob peb lo lus hais txog dab tsi nws yog.
Ntshav qab zib phosphate yog ...
Tus kab mob no muaj qee yam zoo sib xws nrog ntshav qab zib. Tab sis yog tias mob caj dab yog cuam tshuam rau cov ntshav qab zib thiab cov tshuaj tiv thaiv ntawm kev sib cuam tshuam ntawm tes nrog insulin cuam tshuam, ces hauv phosphate ntshav qab zib cov raum noj lub doog ntshav. Nrog nws txoj kev txhim kho, muaj qhov ua txhaum ntawm kev rov qab nqus ntawm phosphorus rau hauv cov ntshav hauv cov hlab ntsha, vim tias qib nws txo qis.
Vim lub phosphorus hauv cov ntshav tsis txaus, cov pob txha pob txha muaj kev cuam tshuam loj heev. Qhov tsim ntawm lub cev pob txha tsis tshwm sim raug, qhov tsis xws luag tshwm sim uas ua rau lub cev tsis meej. Yog li no, phosphate ntshav qab zib hauv menyuam yaus tuaj yeem "pom" nrog lub ntsej muag liab qab. Tab sis tsuas yog los ntawm cov tsos ntawm tus me nyuam, ntawm chav kawm, kev kuaj mob tsis yog. Ib qho kev kuaj mob txhij txhua yog nqa tawm, uas tso cai rau koj los txheeb xyuas tsis tsuas yog nws qhov kev txawv txav ntawm lub cev, tab sis kuj pom cov kev rau txim uas kev txhim kho ntawm qhov mob no tau coj los.
Provocative yam
Kev loj hlob ntawm phosphate mob ntshav qab zib hauv menyuam yaus tshwm sim tawm tsam keeb kwm ntawm kev mob caj ces thiab yog ib qho kev tshwm sim ntawm oncogenic rickets. Hypophosphatemic rickets (GHF luv luv) yog ib yam kab mob uas kev nqus ntawm phosphorus los ntawm thawj cov zis yog cuam tshuam. Hauv qhov no, qhov kev ua txhaum tshwm sim hauv kev ua haujlwm ntawm lwm qhov hauv nruab nrog cev thiab kab ke.
Nrog HFG, muaj kev ua haujlwm tsis zoo rau qhov nkag ntawm phosphates thiab calcium los ntawm txoj hnyuv, thiab kev tsim cov vitamin D hauv lub cev, uas tsim nyog rau kev tsim cov cev pob txha li qub, txo qis. Raws li cov txheej txheem no, lub siab ua haujlwm cuam tshuam, lub luag haujlwm ntawm lub hlwb lub luag haujlwm rau kev tsim cov khoom osteoblasts puas ntsoog, thiab kev tsis tuaj yeem hauv tus qauv ntawm lub cev tshwm sim.
Nws yuav tsum raug sau tseg tias GFR tuaj yeem yog ob qho tib si nrhiav pathology thiab yug menyuam. Thiab nyob rau hauv rooj plaub thib ob, nws yog cov keeb kwm. Raws li kev siv tshuaj kho mob qhia, feem ntau cov kab mob no kis tau los ntawm poj niam kab. Qhov no yog vim los ntawm X chromosome, uas yog tam sim no nyob rau hauv cov poj niam txuas nrog lub gene lub luag haujlwm rau kev ua haujlwm ntawm osteoblasts. Raws li rau cov txiv neej, los ntawm lawv cov FIU kis tau tsuas yog rau cov ntxhais.
Txais HFR tuaj yeem tshwm sim rau menyuam yaus thiab cov neeg laus laus. Nws txoj kev loj hlob feem ntau tshwm sim tawm tsam keeb kwm ntawm cov qog uas ua rau hauv cov pob txha los yog hauv cov nqaij mos ntawm lub raum thiab mob siab.
Nrog rau kev txhim kho phosphate mob ntshav qab zib, cov pob txha qauv overgrow. Nyob rau tib lub sijhawm, lawv poob lawv qhov ntom thiab ua mos. Tag nrho cov no ua rau lawv cov deformation thiab lub cev tsis zoo. Thiab feem ntau feem ntau pob taws thiab hauv caug pob qij txha raug kev txom nyem los ntawm tus kab mob no.
Txhawm rau txhawm rau kuaj pom tus kab mob thaum tseem me, koj yuav tsum tau raug kuaj mob ntau zaus.
Cov cim ntawm tus kab mob
Feem ntau, cov mob ntshav qab zib phosphate pib tshwm sim rau cov menyuam yaus hnub nyoog 10-14 hlis, thaum lawv pib taug kev ntawm nws tus kheej. Txog rau tam sim no, cov cim qhia ntawm kev txhim kho ntawm txoj kev mob no yuav ua rau tsis tuaj kiag li.
Cov tsos mob tseem ceeb ntawm HFR yog kev lag luam ntawm kev loj hlob lub cev. Nws hlob tsis zoo thiab poob qab deb ntawm nws cov phooj ywg hauv qhov no. Tom qab qee lub sijhawm, zoo li tus menyuam pib taug kev, nws muaj mob ntawm nqua, ua rau nws los kua muag thiab chim siab. Qee tus menyuam yaus tau kuaj pom tus mob HFR, vim yog mob hnyav, tsis tuaj yeem txav mus ib leeg yam tsis muaj kev pabcuam.
Thaum muaj hnub nyoog 1.5-2 xyoo hauv cov menyuam yaus, curvature ntawm qis qis dua, ua txhaum ntawm tus qauv ntawm lub hauv caug thiab pob qij txha, tuab ntawm cov pob txha qauv hauv dab teg yog pom. Hauv qhov no, txha hniav laus puas tsuaj - nws tau rhiab, thiab cov hniav uas nyuam qhuav tawg tuaj yeem cuam tshuam los ntawm caries. Nrog lub hnub nyoog, cov duab hauv tsev kho mob yog ntxiv kev ua phem thiab ntxiv tsis yog los ntawm curvature ntawm qis qis, tab sis kuj ntawm txha nraub qaum thiab pelvic pob txha.
Thiab yog tias peb tham txog qhov tshwm sim dav dav ntawm GHF, tom qab ntawd cov tsos mob hauv qab no tus yam ntxwv ntawm qhov mob no yuav tsum pom qhov txawv:
- cov leeg tsis tshua muaj zog;
- spasmophilia, nrog ib qho mob ntawm qhov mob ntawm cov leeg ntawm lub ntsej muag, lub ntsej muag thiab caj npab;
- kev ua kom luv luv ntawm qaum qis thiab sab nraud;
- pseudo-pob txha tawg;
- curvature ntawm ob txhais ceg nyob rau hauv daim ntawv ntawm "O" (qhov tsos mob no yog pom meej nyob hauv daim duab).
O-puab curvature ntawm ob txhais ceg
Kev kuaj mob
Kev kuaj mob ntshav qab zib phosphate tsis muaj teeb meem dab tsi. Raws li txoj cai, tus kab mob no tau kuaj pom ntawm ntau txoj hauv kev:
Mob ntshav qab zib mellitus hauv cov hluas- Kev kuaj mob xoo hluav taws xob
- ua kev kho mob nrog vitamin D
Qhov dav dav, qhov kev ua txhaum ntawm qhov ntom ntawm cov pob txha txhim kho vim yog cov ntsiab lus ntawm cov calcium thiab pob txha txhawm kom pom meej hauv cov duab xoo hluav taws xob. Thiab thaum ua kev kho vitamin D, tus neeg mob tus mob tsis zoo, zoo li feem ntau yog muaj kev txhim kho ntawm cov rickets raug. Kev soj ntsuam sab nraud ntawm tus neeg mob me me qhia pom tias kev lag luam ntawm kev loj hlob ntawm lub cev, curvature ntawm qis qis, txha nraub qaum thiab pelvis.
Tsis tas li, rau kev kuaj mob ntshav qab zib phosphate, ib qho kev kuaj zis kuaj tau ua haujlwm, hauv qhov ntawd muaj qhov nce ntawm phosphate cov ntsiab lus hauv cov khoom siv kuaj. Thiab nyob rau hauv kev ntsuas ntshav, phosphorus deficiency yog pom.
Tab sis txij li qhov txo qis hauv theem ntawm phosphate hauv cov ntshav kuj yog cov yam ntxwv ntawm lwm yam kab mob (piv txwv, cov kab mob ntawm parathyroid caj pas), kev tshawb fawb ntxiv yog ua rau theem ntawm parathyroid hormone. Raws li txoj cai, nrog txoj kev loj hlob ntawm cov ntshav qab zib phosphate, qhov tshuaj hormones no nce me ntsis, thiab nrog nws cov kev qhia, qhov kev cuam tshuam qis ntawm lub raum tubules raug sau tseg.
X-ray Phiab Ntshav Qab Zib Phosphate
Tsuas yog tom qab ua tiav kev soj ntsuam ntawm tus neeg mob thiab tau txais txhua yam kev sim, tus kws kho mob tuaj yeem ua qhov kev kuaj mob tseeb thiab sau ntawv kho mob uas yuav tiv thaiv qhov tshwm sim ntawm kev mob hnyav tiv thaiv keeb kwm ntawm HFR.
Yuav kho nws li cas?
Kev kho mob ntshav qab zib phosphate koom nrog kev txais phosphoric acid ntsev ntawm calcium thiab sodium. Lawv kev noj tshuaj yog xam ncaj qha rau ntawm tus kheej thiab nyob ntawm qhov hnyav tag nrho ntawm tus neeg mob. Raws li txoj cai, lawv raug coj mus txog 4 zaug hauv ib hnub ntawm tus nqi ntawm 10 mg rau 1 kg ntawm qhov hnyav.
Ntxiv rau, cov neeg mob tau qhia noj cov vitamin D, uas tuaj yeem tiv thaiv qhov tshwm sim ntawm ntau yam kev cuam tshuam hauv cov metabolism calcium. Qhov ntau thiab tsawg ntawm cov vitamin no tseem xaiv ib tus zuj zus. Thaum pib thaum kawg ntawm txoj kev kho, qhov tshuaj ntawm cov tshuaj tsis dhau 0.005 mcg rau 1 kg ntawm qhov hnyav. Ntxiv mus, nws nce mus rau 0.03 mcg rau 1 kg ntawm qhov hnyav. Thiab qhov koob tshuaj ntau dua, qib siab ntawm phosphorus hauv cov ntshav thiab txo qis cov kev ua ntawm alkaline phosphatase. Nrog rau kev nce ntxiv hauv cov tshuaj noj ntawm cov vitamin D, lawv ib txwm saib xyuas cov qib calcium hauv cov ntshav. Yog tias nws nce ntxiv, cov koob tshuaj tau raug txo kom tsawg, vim tias qhov no qhov muaj feem yuav ua rau kom cov ntsev tso rau hauv lub raum plab tau nce ntau zaus.
Txhawm rau txhawm rau txhawm rau txhim kho kev nkag mus ntawm calcium thiab phosphorus salts los ntawm cov hnyuv, calcium npaj tau siv nrog kev sib xyaw nrog citric acid. Coj lawv tawm mus ntev. Yam tsawg kawg nkaus ntawm kev kho mob yog 6 lub hlis.
Kev kho kab mob ntshav qab zib phosphate tsim nyog suav nrog kev noj tshuaj tocopherol thiab vitamin A, nrog rau kev hnav orthopedic corsets. Thaum muaj kev cuam tshuam loj heev ntawm cov pob txha los yog kuaj pom cov qog hauv cov pob txha, kev phais mob tau ua, tab sis tsuas yog qhov kawg ntawm kev loj hlob.
Nrog rau kev txhim kho cov ntshav qab zib phosphate, tsis yog lub cev txhua qhov kev ua haujlwm tuaj yeem pom, tab sis kuj ua rau lub hlwb
Yog tias tus kabmob nrog tus mob hnyav, cov neeg mob tau hais kom mus pw hauv tsev, noj cov tshuaj pleev thiab tshuaj tiv thaiv kab mob. Hauv cov theem ntawm kev zam txim, cov neeg mob tau pom zoo ua kev tawm dag zog tawm dag zog nyob rau hauv kev saib xyuas ntawm tus kws tshaj lij. Tsis tas li ntawd, txoj kev zaws kho yuav tsum yog qhov yuav tsum tau ua, thiab nyob ib zaug 1-2 zaug hauv ib xyoos hauv kev kho mob thiab tiv thaiv tshuaj.
Lub txim
Nrog rau kev txhim kho phosphate mob ntshav qab zib, ntau yam kev cuam tshuam hauv cov txheej txheem metabolic tshwm sim, yog li ntawd cov kab mob no tau muab faib ua 4 hom. Phosphate mob ntshav qab zib 1 yog suav tias yog qhov muaj txiaj ntsig zoo tshaj plaws thiab muaj nrog los txiav txim siab me ntsis ntawm cov pob txha pob txha. Hom Kab Mob 2 yog qhia tau los ntawm cov lus hais qhia txog qhov hloov pauv rau cov pob txha thiab muaj phosphorus hauv cov ntshav tsawg. Tus me nyuam qhov siab yog nws qis dua li nws cov phooj ywg, tab sis nws lub cev muaj zog.
Tus mob ntshav qab zib hom 3 phosphate yog pom los ntawm cov pob txha tsis meej thiab hais tawm tsam cov vitamin D Nyob rau tib lub sijhawm, cov kaus hniav txha hniav laus thiab ib leeg mob ib ce hauv caj npab. Cov kab mob o.
Ntshav qab zib hom 4 phosphate yog pom los ntawm hypovitaminosis, alopecia, deformation ntawm cov hniav, nqaj qis, txha nraub qaum thiab pelvis. Ntxiv mus, tag nrho cov xwm txheej no tau sau tseg thaum tseem me me.
Yog tias peb hais txog cov ntsiab lus dav dav txog cov teeb meem phosphate mob ntshav qab zib, cov hauv qab no yuav tsum raug qhia:
- curvature ntawm posture thiab nqua nqeg;
- kev mob lub cev;
- kev ua txhaum nyob rau hauv kev tsim thiab kev ncaj ncees ntawm cov hniav;
- kev tso ntsev rau hauv lub raum;
- qhov zoo li muaj teeb meem loj rau yav tom ntej thaum kev xeeb menyuam thiab kev yug menyuam.
Hmoov tsis zoo, nws yog qhov nyuaj los tiv thaiv qhov tshwm sim ntawm txhua qhov teeb meem no nyob rau hauv muaj phosphate mob ntshav qab zib, tshwj xeeb tshaj yog tias qhov mob tau tshawb pom thaum muaj hnub nyoog tom qab. Yog li no, nyob rau ntawm qhov muaj mob ntawm qhov muaj keeb (hereditary predisposition), nws raug nquahu kom kuaj xyuas tag nrho tus menyuam mos tom qab yug tas.
