AMARIL: TSHUAJ XYUAS KEV NOJ TSHUAJ, PHIV THIAB QHIA

Send

Coob leej ntau tus muaj ntshav qab zib. Ntxiv mus, txhua txhua xyoo muaj pes tsawg tus neeg uas raug tus mob no tsuas muaj loj zuj zus tuaj xwb.

Nws yog tsis yooj yim sua los kho tus mob ntawd, txawm li cas los xij, nws muaj peev xwm tswj hwm nws thiab tswj hwm qhov qub ntawm lub cev.

Txog rau qhov kawg no, tsim ntau yam tshuaj, ib qho yog Amaryl. Kev tshuaj xyuas cov tshuaj feem ntau zoo. Qhov loj tshaj plaws yog los soj ntsuam kev noj thiab lub sijhawm ntawm kev tswj hwm. Nyeem ntxiv txog cov tshuaj hauv tshooj no.

Pharmacological kev txiav txim

Kev npaj cov sulfonylurea pawg hais txog cov kab mob hypoglycemic rau kev siv ncauj. Los ntawm kev thaiv cov cytoplasmic potassium ATP-nyob rau ntawm cov kab mob hlwb nyob rau hauv kev txiav, ua tiav kev zais cia tshwm sim.

Raws li qhov tshwm sim, insulin tso tawm los ntawm beta hlwb, uas qhia tau hais tias muaj txiaj ntsig pancreatic. Cov txiaj ntsig ua ke kuj tseem pom tau, vim tias qhov kev nqis tes ua ntawm cov insulin yog qhov ua kom zoo dua.

Amaril

Cov tshuaj nquag ntawm cov tshuaj muaj peev xwm sib txuas tau sai txaus nrog cov roj ntsha beta-cell. Nws cov lev molecular yog 65 kD / SURX. Muaj exocytosis ntawm insulin. Nws yog ib qho tseem ceeb tias cov ntsiab lus hormone thiab nws cov txiaj ntsig tsis txaus ntseeg yog tus yuam sij rau txo qis kev pheej hmoo ntawm hypoglycemia.

Amaryl kuj tseem muaj antioxidant, antiplatelet, anti-atherogenic nyhuv. Nws cov txiaj ntsig txuas ntxiv mus rau txoj hlab plawv, txo cov tshuaj insulin tsis ua haujlwm. Kev siv cov piam thaj los ntawm cov leeg thiab cov nplais adipose nce vim tias muaj cov protein nqa khoom tshwj xeeb.
Los ntawm nce lawv cov kev ua ub no, lub cuab tam pab tau cov piam thaj zoo dua. Lipogenesis thiab glycogenesis puav leej txheeb ze.

Hepatic qabzib ntau lawm yog txhaws, vim tias tus nqi ntawm fructose-2,6-bisphosphate hauv hepatocytes nce.

Kev zais ntshis ntawm COX thaum lub sijhawm saib xyuas cov tshuaj yog thaiv, arachidonic acid txo qhov kev hloov pauv. Qhov no pab rau txo cov platelet aggregation, i.e. muaj cov nyhuv antithrombotic.

Alpha-tocopherol ntau ntxiv thaum raug cov tshuaj. Tsis tas li ntawd, cov kev ua ntawm superoxide dismutase, catalase, glutathione peroxidase yog qhov ua kom zoo dua ntxiv, thiab qhov tshwm sim oxidative uas tshwm sim hauv cov ntshav qab zib mellitus yog txo qis.

Kev ntsuas rau siv

Amaryl yog tsim tshwj rau kev siv hom ntshav qab zib hom 2. Siv nws ua kev kho mob monotherapy, thiab rau kev kho mob sib xyaw ua ke. Cov tshuaj Amaril rau cov ntshav qab zib hom 2 muaj kev txheeb xyuas zoo thaum noj nrog metformin lossis insulin.

Cov tshuaj muaj pes tsawg leeg, tshuaj tso tawm daim ntawv

Amaryl yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tuaj yeem muaj cov tshuaj sib txawv, uas yog 1, 2, 3, 4 mg.

Cov tshuaj nquag ntawm no yog glimepiride, thiab cov tshuaj tiv thaiv kab mob suav nrog lactose monohydrate, magnesium stearate, microcrystalline cellulose, dyes E132 thiab E172, povidone.

Txhua lub ntsiav tshuaj muaj txoj kab sib cais, nrog rau txua. Cov pob ntawv muaj ob lub hlwv nyob rau hauv uas muaj 15 ntsiav tshuaj.

Nws yooj yim dua kom paub qhov txawv cov ntsiav tshuaj nrog cov sib txawv vim lawv cov xim sib txawv. Cov tshuaj nrog cov tshuaj nquag 1 mg liab, 2 mg ntsuab, 3 mg daj, 4 mg xiav.

Cov Yuav Tsum Muaj

Amaril yuav tsum tsis txhob coj los ua qee yam hauv qab no:

lactation thiab cev xeeb tub;
yam 1 mob ntshav qab zib mellitus;
tus kheej intolerance rau Cheebtsam;
cov menyuam hnub nyoog;
mob ketoacidosis;
daim siab thiab mob raum;
lactose deficiency, qabzib-galactose malabsorption.

Nws yog qhov tseem ceeb tshwj xeeb uas yuav tau ua nrog ceev faj hauv thawj lub lim tiam. Nws tsim nyog los soj ntsuam cov xwm txheej ntawm lub cev kom txo qis kev phom sij ntawm kev mob tshwm sim, suav nrog hypoglycemia.

Sab sij huam

Nrog rau kev siv tshuaj tsis raug, ntau cov kev mob tshwm sim tuaj yeem pom:

cuam tshuam ntawm lub paj hlwb: kev tsaug zog, tsis muaj kev sib koom tes, kev nyuaj siab, nkees, ntxhov siab, kiv taub hau, ua pa txawv, tshee tshee, tshee tshee, ntxhov siab, pom kev thiab tsis hnov lus, ua nruj ua tsiv, pw ntxhov tsawv, mob taub hau, tsis tuaj yeem tswj tus kheej, ua kom mob;
hlab plawv - tachycardia, angina pectoris, mob ntshav siab, ntshav nce hlwb, lub suab ntawm lub plawv tawg;
teeb meem ntawm metabolic - kev qhia paub txog cov tshuaj tiv thaiv hypoglycemic;
lub plab zom mov - mob plab, ntuav, daj ntseg, raws plab, mob siab, mob siab, mob siab, cholestasis;
circulatory system - thrombocytopenia, granulocytopenia, agranulocytosis, erythrocytopenia, hemolytic lossis aplastic anemia;
lwm yam tshuaj tiv thaiv pom kev ua tsis taus pa thiab qhov ncauj ua pa, qhov pom kev ua kom khaus khaus, ua pob khaus, ua pob rau ntawm daim tawv nqaij, tso zis, ua xua vasculitis.

Cov lus qhia rau kev siv

Koj yuav tsum noj cov ntsiav tshuaj sab hauv tsis ntxo. Haus yuav tsum muaj tsawg kawg yog ib nrab ib khob dej.

Nco ntsoov tias noj cov tshuaj yuav tsum raug khi rau ib pluag mov, txwv tsis pub nws hawv nrog qhov txo qis hauv cov ntshav qab zib.

Qhov no txhais tau tias koj yuav tsum haus ib ntsiav tshuaj tam sim ntawd ua ntej noj mov lossis thaum tab tom ua cov txheej txheem no. Qhov no ua tau zoo tshaj plaws thaum sawv ntxov, yog tias daim ntawv thov tsuas nyob rau ib hnub, txhawm rau kom muaj peev xwm tswj hwm cov piam thaj hauv qab.

Thawj qhov tshuaj ntawm cov tshuaj yog 1 mg ntawm cov tshuaj ib hnub. Ntxiv mus, yog tias tsim nyog, nws yog qhov ua tau los txhawm rau txhawm rau ntau ntxiv nrog cov sijhawm ntawm 1-2 lub lis piam. Hauv qhov no, koob tshuaj ntxiv yog 2 mg, tom qab ntawd 3 mg, tom qab ntawd 4 mg, thiab tom qab ntawd 6 mg tuaj yeem siv tau. Qhov tshuaj no yog qhov siab tshaj plaws, thiab nws tsis pom zoo kom siab dua nws.

Kev nce ntxiv ntawm lub koob yuav tsum tau nqa los ntawm tus kws kho mob, raws li tus neeg tus yam ntxwv, tus neeg mob lub neej, hauv chav kawm ntawm tus kab mob.

Amaril yuav raug coj los ua ke nrog kev siv tshuaj insulin lossis metformin. Nyob rau kis uas Metformin tsis nqa ib qho kev txo qis hauv cov piam thaj, tom qab ntawv Amaril tau raug sau tseg.

Hauv qhov xwm txheej no, Metformin tseem raug noj tom qab npaum li cas yav dhau los, thiab Amaryl tseem pib haus nrog qhov tsawg kawg ntawm 1 mg, uas tuaj yeem maj mam nce mus rau 6 mg. Yog tias qhov kev sib xyaw ua ke no tseem tsis muaj txiaj ntsig, ces Metformin hloov los ntawm cov tshuaj insulin. Hauv qhov no, qhov ntau npaum ntawm Amaril raug tso cia tsis hloov pauv, thiab cov tshuaj insulin yog noj tsawg kawg, maj mam nce cov tshuaj.

Thaum noj tshuaj, tshwj xeeb tshaj yog nrog kev sib xyaw ntawm Amaryl-insulin, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam cov ntshav qab zib kom tsis tu ncua. Nws yuav tsum nco ntsoov tias thaum siv Amaril, ntau npaum li cas ntawm cov tshuaj insulin yog qhov xav tau 40% tsawg dua nyob rau hauv rooj plaub ntawm kev kho mob monotherapy.

Noj ntau dhau

Yog tias cov koob tshuaj ntawm cov tshuaj tau dhau, ces tus neeg mob tau hem nrog hypoglycemia, kav ntev li 12-72 teev.

Nws cov tsos mob yog tib yam li cov kev mob tshwm sim ntawm cov tshuaj uas tau hais ua ntej hauv tsab xov xwm. Nyob rau ntawm cov mob loj, qhov ntxim nyiam ntawm kev tsis hnov qab yog qhov siab.

Yog tias cov tsos mob zoo li no tshwm sim, thawj qhov koj yuav tsum noj ib qho qab zib, haus kua txiv lossis tshuaj yej qab zib. Nws ib txwm tseem ceeb kom nqa cov piam thaj tsawg kawg 20 g nrog koj, piv txwv li, nws tuaj yeem ua 4 daim piam thaj. Cov txiv ntoo hauv qhov xwm txheej no yuav coj mus siv me ntsis.

Yog tias qhov xwm txheej no hnyav, yuav tsum tau pw hauv tsev kho mob. Nyob hauv tsev kho mob, kev mob plab zom mov tau ua, thiab adsorbents kuj tseem. Kev tswj cov qabzib yog qhov tseem ceeb heev. Lwm qhov ua tsis txaus siab raug tshem tawm los ntawm kev kho mob.

Yeeb tshuaj sib cuam tshuam

Nrog rau lwm cov tshuaj, Kev siv cov Amaril tuaj yeem ua rau nce ntxiv lossis txo qis hauv cov nyhuv hypoglycemic.

Hauv thawj kis, cov nyhuv yuav poob qis thaum noj cov tshuaj no: cov thyroid hormones, adrenaline, chlorpromazine, sympathomimetics, glucocorticosteroids, diazoxide, barbiturates, laxatives, saluretics, thiazide diuretics, glucagon, phenytoin, phenothiazine, acetazolamide, ntau ntawm nicotinic acid. , progestogens thiab estrogens, ntsev lithium.

Kev nce ntawm hypoglycemic yog pom thaum noj cov tshuaj no nrog Amaril: lwm yam tshuaj rau kho hypoglycemia, angiotensin-converting factor inhibitors, allopurinol, anabolic steroids, coumarin derivatives, tritokvalin, tshuaj nrog txiv neej pw ua ke, oxyphenbutazone, pentoxifylline, hloramphen , fibrates, pheniramidol, MAO inhibitors, azapropazone, fenfluramine, probenecid, salicylates, sulfinpyrazone, tetracyclines, tro-, cyclo-, isophosphamide, sulfonyls lub caij nyoog ua dy.

Kev sib xyaw ntawm Amaril nrog qee cov tshuaj tuaj yeem ua rau qhov kev xav tsis txaus hypoglycemic, uas nyob rau qee qhov xwm txheej tuaj yeem txo qis, thiab lwm tus nce ntxiv. Cov no suav nrog Reserpine, Clonidine.

Kev tshuaj xyuas txog cov tshuaj Amaryl

Txog cov tshuaj Amaril, kev ntsuam xyuas ntawm cov ntshav qab zib muaj ntau qhov zoo. Cov neeg mob noj Amaryl ntseeg hais tias cov tshuaj no muaj peev xwm tua cov ntshav qab zib hom ntshav qab zib hom 2 ntau.

Qhov loj tshaj plaws yog xaiv txoj kev ntau npaum ntawm tshuaj. Qhov zoo ib sab kuj tseem muaj xim sib txawv ntawm cov ntsiav tshuaj, thov ntim rau ntau cov tshuaj. Qhov no tso cai rau koj kom koj tsis txhob lees paub qhov yog.

Txawm li cas los xij, muaj ntau qhov tsis zoo tshuaj xyuas, feem ntau cuam tshuam nrog kev tshwm sim ntau dhau ntawm cov kev mob tshwm sim, xws li tshee, tsis muaj zog, kiv taub hau, tshee tshee hauv lub cev, ua kom qab los. Muaj qee yam mob ntshav qab zib, yog li nws yog qhov tseem ceeb uas yuav tau nqa khoom qab zib lossis lwm yam khoom muaj cov piam thaj ntau.

Cov lus pom tsis zoo kuj tuaj yeem hnov los ntawm cov tsav tsheb coj Amaryl. Cov tshuaj cuam tshuam rau cov hlab ntsha hlwb, yog li qhov tshuaj tiv thaiv yog txo, uas yog qhov txaus ntshai heev thaum tsav tsheb. Tsis tas li ntawd, txawm hais tias qhov ua tau zoo ntawm cov tshuaj, nws tus nqi yog ntau dua li ntawm analogues.