Indapamide yog nyob rau qhov thib ob, feem ntau niaj hnub, tiam ntawm thiazide-zoo li diuretics. Cov nyhuv tseem ceeb ntawm cov tshuaj yog qhov txo nrawm, khov kho thiab lub sijhawm txo qis hauv cov ntshav siab. Nws pib ua haujlwm tom qab ib nrab ib teev, tom qab 2 teev cov nyhuv ua qhov siab thiab tseem nyob rau theem siab rau tsawg kawg 24 teev. Qhov zoo tseem ceeb ntawm cov tshuaj no yog qhov tsis muaj txiaj ntsig rau cov metabolism, lub peev xwm los txhim kho cov mob ntawm ob lub raum thiab lub siab. Zoo li txhua yam tshuaj diuretics, Indapamide tuaj yeem ua ke nrog cov neeg nyiam tshaj plaws thiab muaj kev nyab xeeb txhais tau tias kev muaj siab: sartans thiab ACE inhibitors.
Rau leej twg indapamide tshuaj
Txhua tus neeg mob kub siab yuav tsum tau kho lub neej, uas muaj cov tshuaj txhua hnub. Cov lus no tau ntev tsis tau nug nyob hauv cov kws khomob. Nws tau pom tias cov tshuaj tswj ntshav siab tsawg kawg 2 zaug txo qhov yuav ua rau muaj kev mob plawv, nrog rau cov ploj tuag. Tsis muaj kev sib cav txog lub siab uas pib noj tshuaj. Thoob ntiaj teb, qib tseem ceeb rau cov neeg mob feem ntau suav tias yog 140/90, txawm tias lub siab nce siab asymptomatically thiab tsis ua rau muaj kev tsis yooj yim. Zam txhob noj tshuaj tsuas yog mob ntshav siab me me xwb. Txhawm rau ua qhov no, koj yuav tau poob phaus, muab luam yeeb thiab dej cawv, hloov khoom noj haus.
Qhov tsuas yog qhia txog kev siv ntawm Indapamide qhia hauv cov lus qhia yog mob ntshav liab. Ntshav siab feem ntau ua ke nrog cov kab mob ntawm lub siab, lub raum, cov hlab ntsha, yog li, cov tshuaj uas tau hais kom txo nws, yuav tsum tau kuaj kom muaj kev nyab xeeb thiab ua tau zoo hauv cov pab pawg ntawm cov neeg mob no.
Dab tsi pab Indapamide:
- Qhov nruab nrab txo qis hauv lub siab thaum noj Indapamide yog: sab sauv - 25, qis dua - 13 hli Hg
- Cov kev tshawb fawb pom tau tias qhov kev ua los tiv thaiv kev ua si ntawm 1.5 g ntawm indapamide yog sib npaug rau 20 mg ntawm enalapril.
- Lub sij hawm ntev nce siab ua rau nce ntxiv ntawm sab laug ventricle ntawm lub plawv. Cov kev hloov pauv pathological no yog fraught nrog cov lus sib dhos cuam tshuam, mob stroke, plawv nres. Indapamide ntsiav tshuaj pab txhawb kom txo qis hauv sab laug ventricular myocardial loj, ntau dua li enalapril.
- Rau cov mob raum, Indapamide tsis muaj txiaj ntsig tsawg. Nws cov hauj lwm zoo tuaj yeem txiav txim los ntawm kev poob 46% hauv theem ntawm albumin hauv cov zis, uas yog suav tias yog ib qho ntawm cov cim ntxov ntawm kev ua haujlwm raum tsis ua haujlwm.
- Cov tshuaj tsis muaj kev cuam tshuam zoo rau cov piam thaj, cov poov tshuaj thiab ntshav cov roj, yog li ntawd, nws tuaj yeem siv dav kho mob ntshav qab zib. Txog kev kho mob ntshav siab hauv ntshav qab zib, tshuaj diuretics raug kho nyob rau hauv ib qho tshuaj me me, ua ke nrog ACE inhibitors lossis Losartan.
- Cov cuab yeej tshwj xeeb ntawm Indapamide ntawm cov tshuaj diuretics yog nce ntxiv ntawm cov qib "zoo" roj cholesterol HDL los ntawm qhov nruab nrab ntawm 5.5%.
Cov tshuaj ua haujlwm li cas?
Cov cuab yeej tseem ceeb ntawm diuretics yog nce ntxiv ntawm cov zis cia. Tib lub sijhawm, cov kua dej hauv cov ntaub so ntswg thiab cov hlab ntshav poob, thiab lub siab poob qis dua. Hauv lub hli ntawm kev kho mob, qhov tso dej ntxiv ua kom tsawg dua li ntawm 10-15%, qhov hnyav vim qhov dej tsis haum yog li ntawm 1.5 kg.
Indapamide hauv nws pab pawg nyob qhov chaw tshwj xeeb, cov kws kho mob hu nws ua cov diuretic tsis muaj cov nyhuv diuretic. Cov lus no tsuas siv tau rau koob tshuaj me me. Cov tshuaj no tsis cuam tshuam qhov ntim ntawm cov zis, tab sis nws muaj kev cuam tshuam ncaj qha rau cov hlab ntsha tsuas yog thaum siv hauv koob tshuaj ≤ 2.5 mg. Yog tias koj noj 5 mg, cov zis yuav nce ntxiv 20%.
Vim dab tsi siab dauv:
- Cov kav hlau calcium yog qhov thaiv, uas ua rau txo qis qhov kev mloog khoom ntawm calcium nyob hauv phab ntsa ntawm cov hlab ntsha, thiab tom qab ntawd mus rau kev nthuav dav ntawm cov hlab ntshav.
- Cov poov tshuaj tso tawm yog qhib kom ua haujlwm, yog li ntawd, kev nkag mus ntawm calcium nyob rau hauv cov hlwb poob qis, kev sib txuas ntawm nitric oxide hauv cov vascular phab ntsa nce, thiab cov hlab ntsha so.
- Qhov tsim los ntawm prostacyclin yog tsa, vim tias lub peev xwm ntawm platelets los ua cov ntshav txhaws thiab txuas rau cov phab ntsa ntawm cov hlab ntsha poob qis, lub suab ntawm cov leeg ntawm cov leeg ntshav ntsa poob qis.
Daim ntawv tso tawm thiab ntau npaum li cas
Tus thawj tshuaj muaj indapamide yog tsim los ntawm lub tuam txhab tshuaj Servier nyob rau hauv cov tshuaj uas nrov npe Arifon. Ntxiv rau qhov qub Arifon, ntau cov generics nrog indapamide tau sau npe nyob hauv Russia, suav nrog tib lub npe Indapamide. Arifon analogs yog ua nyob rau hauv daim ntawv ntawm tsiav tshuaj los yog zaj duab xis-ntsiav tshuaj. Tsis ntev los no, cov tshuaj nrog hloov kho tawm ntawm indapamide los ntawm ntsiav tshuaj tau nrov.
Kev siab thiab tawg surges yuav yog ib yam ntawm yav dhau los - pub dawb
Kev mob plawv thiab mob nkees yog qhov ua rau kwv yees li 70% ntawm tag nrho cov neeg tuag hauv ntiaj teb. Xya tawm ntawm kaum tus neeg tuag vim kev txhaws ntawm cov hlab ntsha ntawm lub plawv lossis paj hlwb. Yuav luag txhua qhov teeb meem, qhov laj thawj rau qhov txaus ntshai kawg yog qhov zoo ib yam - lub siab surges vim kub siab.
Nws yog qhov ua tau thiab tsim nyog los daws lub siab, txwv tsis pub muaj dab tsi. Tab sis qhov no tsis kho tus kab mob nws tus kheej, tab sis tsuas yog pab txhawm rau txhawm rau tshawb fawb, thiab tsis yog qhov ua kom muaj tus kab mob.
- Normalization ntawm siab - 97%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 80%
- Ntaus tau ntawm lub plawv dhia muaj zog - 99%
- Kom tshem tau mob taub hau - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj - 97%
Cov ntaub ntawv dab tsi yog Indapamide tsim thiab ntau npaum li cas:
| Daim ntawv tso tawm | Tsuas tshuaj mg | Chaw tsim tshuaj paus | Ncig Teb Chaws | Nqe ntawm ib hlis ntawm kev kho mob, tshiav. |
| Cov tshuaj ntsiav Indapamide | 2,5 | Pranapharm | Lavxias | los ntawm 18 |
| AlsiPharma | ||||
| Cov Kws Muag Tshuaj | ||||
| Tus kws tshuaj Biochemist | ||||
| PromomedRus | ||||
| Ozoov | ||||
| CUA | ||||
| Avva-Rus | ||||
| Canonpharma | ||||
| Obolenskoe | ||||
| Valenta | ||||
| Nizhpharm | ||||
| Teva | Ixayees | 83 | ||
| Hemofarm | Seev | 85 | ||
| Capsules Indapamide | 2,5 | Ozoov | Lavxias | los ntawm 22 |
| Vertex | ||||
| Teva | Ixayees | 106 | ||
| Ua ntev ntsiav tshuaj indapamide | 1,5 | PromomedRus | Lavxias | los ntawm 93 |
| Tus kws tshuaj Biochemist | ||||
| Izvarino | ||||
| Canonpharma | ||||
| Tathimpharmaceuticals | ||||
| Obolenskoe | ||||
| AlsiPharma | ||||
| Nizhpharm | ||||
| Krka-Rus | ||||
| MakizPharma | ||||
| Ozoov | ||||
| Hemofarm | Seev | 96 | ||
| Kide-oo Richter | Hungary | 67 | ||
| Teva | Ixayees | 115 |
Raws li kws kho plawv, nws yog qhov zoo dua los yuav Indapamide zoo tib yam hauv tshuaj ntsiav. Cov tshuaj raug khaws cia rau hauv cov tshuaj ntsiav ntev dua, muaj lub zog ntau dua qub, yog nqus tau sai, muaj cov khoom siv tsawg dua, uas txhais tau tias nws ua rau ua xua tsawg dua.
Cov qauv niaj hnub ntawm indapamide yog cov ntsiav tshuaj ntev dhau los. Cov tshuaj nquag los ntawm lawv tau tso tawm qeeb dua vim siv tshuab tshwj xeeb: me me ntawm indapamide tau muab faib rau hauv cov cellulose. Ib zaug hauv cov hnyuv, cellulose maj mam hloov mus rau hauv ib lub gel. Nws yuav siv txog 16 teev kom yaj lub ntsiav tshuaj.
Piv nrog rau cov ntsiav tshuaj zoo, ua ntev ntev indapamide muab lub zog ntxiv thiab muaj zog los tiv thaiv kev cuam tshuam, kev hloov siab txhua hnub thaum noj tsawg dua. Raws li lub zog ntawm kev ua, 2.5 mg ntawm Indapamide zoo tib yam yog 1.5 mg ntev. Feem ntau cov kev mob tshwm sim yog koob tshuaj, uas yog, lawv qhov ntau zaus thiab mob heev ntxiv nrog nce koob tshuaj. Kev noj tshuaj Indapamide ntev ntev txo qhov kev pheej hmoo ntawm kev phiv, feem ntau yog poob hauv cov ntshav poov tshuaj ntau ntau.
Tshwj xeeb sib cais ncua ntev tuaj yeem tuaj yeem yog ntau npaum li 1.5 mg. Ntawm pob ntawv yuav tsum tau ua pov thawj ntawm "kev ncua ntev", "hloov kho tso tawm", "tswj kev tso tawm", lub npe yuav muaj "rov qab", "MV", "ntev", "SR", "CP".
Yuav noj li cas
Kev siv cov indapamide los txo qis siab tsis tas yuav tsum maj mam nce ntxiv zuj zus. Cov ntsiav tshuaj tam sim ntawd pib haus hauv ib qho kev muab tshuaj. Cov tshuaj accumulates nyob rau hauv cov ntshav maj, yog li nws muaj peev xwm los txiav txim nws cov hauj lwm tsuas yog tom qab 1 lub lim tiam ntawm kev kho mob.
Nkag tau txais txoj cai los ntawm cov lus qhia rau kev siv:
| Siv thaum sawv ntxov lossis yav tsaus ntuj | Cov lus qhia pom zoo rau thaum sawv ntxov thaum sawv ntxov, tab sis yog tias tsim nyog (piv txwv li, ua haujlwm hmo ntuj lossis nyiam ua kom muaj zog ntau ntxiv thaum sawv ntxov), cov tshuaj yuav ua rau qaug cawv thaum yav tsaus ntuj. |
| Muaj ntau lub sijhawm nkag nyob rau ib hnub | Ib zaug. Ob daim ntawv ntawm cov tshuaj ua haujlwm tsawg kawg 24 teev. |
| Noj ua ntej lossis tom qab noj mov | Nws tsis muaj teeb meem. Khoom noj khoom haus me ntsis ua rau maj mam nqus ntawm indapamide, tab sis nws tsis txo nws cov hauj lwm zoo. |
| Daim ntawv thov nta | Pa Indapamide ntsiav tshuaj tuaj yeem faib thiab phua. Ntev mus Indapamide yuav tsuas haus cawv kom tag nrho xwb. |
| Txheem tshuaj rau txhua hnub | 2.5 mg (lossis 1.5 mg rau lub sijhawm ntev) rau txhua pawg ntawm cov neeg mob. Yog tias qhov tshuaj no tsis txaus rau lub siab qhov ib txwm, lwm tus neeg mob tau muab 1 tshuaj. |
| Puas yuav ua tau kom nce lub koob tshuaj | Nws yog qhov tsis tsim nyog, vim tias qhov nce ntxiv ntawm koob tshuaj yuav ua rau kom tso zis ntau ntxiv, ua rau muaj kev phom sij. Hauv qhov no, qhov ua kom hypotensive ntawm Indapamide yuav nyob rau tib theem. |
Thov nco ntsoov: ua ntej pib kho nrog ib qho tshuaj diuretics, nws raug nquahu los soj ntsuam qee cov ntshav: potassium, qab zib, creatinine, urea. Yog tias cov ntawv ntsuas pom qhov txawv ntawm qhov tsis zoo, tham nrog koj tus kws kho mob, vim tias kev noj tshuaj diuretics tuaj yeem yog txaus ntshai.
Kuv tuaj yeem coj ntev npaum li cas indapamide yam tsis muaj kev so
Indapamide siab tshuaj tau tso cai haus rau lub sijhawm tsis pub tshaj, muab hais tias lawv muab lub hom phiaj ntawm qib siab thiab tiv thaiv tau zoo, uas yog, lawv tsis ua rau muaj kev phiv uas tsim kev puas tsuaj rau kev noj qab haus huv. Tsis txhob tsum tsis txhob noj cov tshuaj, txawm tias lub siab rov qab zoo li qub.
Tsawg dua li 0.01% ntawm cov neeg mob ntshav siab nrog kev kho mob mus ntev nrog Indapamide ntsiav tshuaj thiab nws cov tshuaj sib hloov, cov kev hloov hauv cov ntshav tshwm tuaj: qhov tsis muaj zog ntawm leukocytes, platelets, hemolytic lossis aplastic anemia. Txhawm rau kom paub lub sijhawm ua txhaum ntawm qhov kev ua txhaum cai no, cov kev qhia pom zoo kom kuaj ntshav txhua 6 lub hlis.
Indapamide, rau qhov tsawg dua li lwm cov tshuaj diuretics, txhawb kev tshem tawm cov poov tshuaj hauv lub cev. Txawm li cas los xij, kev mob ntshav siab rau cov neeg mob uas yuav muaj kev pheej hmoo rau kev siv cov ntsiav tshuaj mus sij hawm ntev yuav tsim muaj hypokalemia. Tej yam txaus ntshai muaj xws li cov laus laus, mob ntsws, mob ntsws, mob plawv. Cov cim ntawm hypokalemias yog nkees, mob leeg. Hauv kev txheeb xyuas ntawm cov neeg mob ntshav siab uas tau ntsib tus mob no, lawv kuj hais txog qhov tsis muaj zog txaus - "tsis tuav lawv sab ceg", nquag cem quav. Kev tiv thaiv ntawm hypokalemia yog kev noj zaub mov ntau nyob hauv cov poov tshuaj: legumes, zaub, ntses, txiv hmab txiv ntoo qhuav.
Muaj kev phiv ntau
Kev tsis xav ua ntawm Indapamide thiab lawv cov xwm txheej ntawm tshwm sim:
| Zaus% | Kev phiv tshuaj |
| mus txog 10 | Kev fab tshuaj tiv thaiv Maculopapular pob khaus liab feem ntau pib nrog lub ntsej muag, xim txawv ntawm paj yeeb-liab doog kom saturated burgundy. |
| mus txog 1 | Ntuav |
| Ntshav yog ua pob tshwm rau ntawm daim tawv nqaij, ua rau cov ntshav tawm hauv cov leeg. | |
| mus txog 0.1 | Mob taub hau, qaug zog, tingling hauv tus taw lossis txhais tes, kiv taub hau. |
| Kev zom plab zom mov: xeev siab, cem quav. | |
| nce mus txog 0.01 | Hloov ntshav sib xyaw. |
| Arrhythmia. | |
| Tus nqi siab dhau heev. | |
| Pancreatic o. | |
| Kev ua xua nyob rau hauv daim ntawv ntawm urticaria, Quincke's edema. | |
| Tsis hlauv. | |
| Raug rho tawm cov teeb meem, ntau zaus tsis tau txiav txim | Kev Muaj Hypokalemia, hyponatremia. |
| Pom kev tsis pom kev. | |
| Kab mob siab. | |
| Qog Ntshav. | |
| Nce ntau ntau ntawm daim siab enzymes. |
Cov lus qhia rau kev siv qhia tau tias kev ntxim siab ntawm kev phiv tshuaj ntau dua nrog kev siv ntau tshaj ntawm Indapamide ntsiav tshuaj, qis dua thaum siv daim ntawv ntev.
Cov Yuav Tsum Muaj
Daim ntawv ntawm contraindications rau Indapamide yog luv heev. Cov tshuaj tsis tuaj yeem noj:
- yog tias tsawg kawg ib qho ntawm cov khoom siv cuam tshuam kev tsis haum;
- nrog rau kev fab tshuaj rau sulfonamide derivatives - nimesulide (Nise, Nimesil, thiab lwm yam), celecoxib (Celebrex);
- nrog lub raum loj lossis hepatic tsis txaus;
- nyob rau hauv cov ntaub ntawv ntawm tsim hypokalemia;
- nrog hypolactasia - ntsiav tshuaj muaj lactose.
Cev xeeb tub, menyuam yaus, pub mis niam tsis txiav txim siab nruj me ntsis. Hauv cov rooj plaub no, noj Indapamide yog qhov tsis xav tau, tab sis tuaj yeem ua tau los ntawm kev teem caij thiab nyob rau hauv kev tswj hwm ntawm tus kws kho mob nruj.
Cov lus qhia rau kev siv Indapamide tsis qhia txog kev muaj peev xwm coj nws ua ke nrog cawv. Txawm li cas los xij, hauv kev tshuaj xyuas ntawm kws kho mob, kev sib xyaw ntawm cov cawv nrog tshuaj yog tau txheeb xyuas tias muaj kev phom sij rau kev noj qab haus huv. Ib qho kev siv cov tshuaj ethanol tuaj yeem ua rau ntau tshaj tawm hauv lub siab. Kev tsim txom tsis tu ncua hnyav ua rau muaj kev pheej hmoo ntawm hypokalemia, nullifies nyhuv hypotensive ntawm Indapamide.
Kev sib piv thiab hloov chaw
Cov tshuaj yog kiag li rov ua dua nyob rau hauv muaj pes tsawg leeg thiab ntau npaum li cas, uas yog, cov tshuaj hauv qab no sau npe hauv Lavxias Federation yog tag nrho cov tshuaj tiv thaiv ntawm Indapamide:
| Npe | Daim Ntawv | Chaw tsim tshuaj paus | Nqi rau 30 pcs., Rub. | |
| zoo tib yam | retard | |||
| Arifon / Arifon Retard | tab. | tab. | Servier, Fab Kis | 345/335 |
| Indap | lub kaus mom. | - | ProMedCs, Czech koom pheej | 95 |
| SR-Indamed | - | tab. | EdgeFarma, Is Nrias teb | 120 |
| Ravel SR | - | tab. | KRKA, RF | 190 |
| Lorvas SR | - | tab. | Torrent Tshuaj, Is Nrias teb | 130 |
| Ionic / Ionic Retard | lub kaus mom. | tab. | Obolenskoe, Lavxias Federation | tsis muaj khw muag tshuaj |
| Tenzar | lub kaus mom. | - | Ozone, RF | |
| Indipam | tab. | - | Balkanpharma, Bulgaria | |
| Indiur | tab. | - | Polfa, Poland | |
| Akuter-Sanovel | - | tab. | Sanovel, Qaib ntxhw | |
| Rov | - | tab. | Biopharm, Is Nrias teb | |
| Ipres Ntev | - | tab. | SchwartzFarma, Tebchaws Poland | |
Lawv tuaj yeem hloov los ntawm Indapamide yam tsis muaj kev sab laj ntxiv ntawm kws kho mob. Raws li kev tshuaj xyuas ntawm cov neeg mob noj cov tshuaj, qhov zoo tshaj plaws ntawm daim ntawv no yog Arifon thiab Indap ntsiav tshuaj.
Piv nrog tshuaj zoo sib xws
Ntawm cov thiazide thiab thiazide-zoo li diuretics, indapamide tuaj yeem sib tw nrog hydrochlorothiazide (tshuaj Hydrochlorothiazide, Hypothiazide, Enap tivthaiv, Lorista thiab ntau lwm cov tshuaj tiv thaiv kabmob) thiab chlortalidone (Oxodoline ntsiav tshuaj, ib qho ntawm cov khoom ntawm Tenorik thiab Tenoretik).
Piv cov yam ntxwv ntawm cov tshuaj no:
- lub zog ntawm kev ua ntawm 2.5 mg ntawm indapamide yog sib npaug rau 25 mg ntawm hydrochlorothiazide thiab chlortalidone;
- hydrochlorothiazide thiab chlortalidone hloov pauv tsis tau rau cov kab mob indapamide hauv lub raum. Lawv raug tawm los ntawm lub raum tsis hloov, yog li ntawd, nrog lub raum tsis ua haujlwm, kev siv ntau dhau yog qhov muaj peev xwm heev. Indapamide yog cov tshuaj tiv thaiv lub siab, tsis pub ntau tshaj 5% yog tawm hauv daim foos nquag, yog li nws muaj peev xwm ua kom qaug dej cawv mus txog qib siab ntawm lub raum tsis ua haujlwm;
- Piv nrog hydrochlorothiazide, indapamide muaj cov tiv thaiv zoo rau lub raum. Tshaj li 2 xyoos ntawm nws qhov kev nkag, GFR nce ntxiv li ntawm 28%. Thaum noj hydrochlorothiazide - txo los ntawm 17%;
- chlortalidone ua haujlwm ntev txog li 3 hnub, yog li nws tuaj yeem siv rau hauv cov neeg mob uas tsis tuaj yeem noj cov tshuaj ntawm lawv tus kheej;
- Cov ntsiav tshuaj Indapamide tsis cuam tshuam loj heev rau cov metabolism hauv cov metabolism, yog li ntawd, lawv tuaj yeem siv rau cov ntshav qab zib. Hydrochlorothiazide ua rau muaj zog tiv thaiv cov tshuaj insulin.
