NovoNorm yog tshuaj tua kab mob hlwb. Hauv cov ntshav qab zib mellitus, cov tshuaj no yog siv thaum insulin tsis txaus nyob rau hauv tus neeg mob cov ntshav, thiab nws cov khoom lag luam yuav tsum ua kom muaj zog. Ib lub ntsej muag ntawm cov tshuaj yog nws txoj kev sai thiab luv luv, uas tso cai rau koj siv nws los tswj cov theem ntawm postprandial glycemia, uas yog, txo cov piam thaj ntawm cov zaub mov.
Yog tias siv cov tshuaj tsis raug, NovoNorm tuaj yeem ua rau cov ntshav qab zib tsawg, yog li nws tseem ceeb heev uas yuav tau xaiv cov tshuaj kom ntau txaus. Qhov tshuaj tiv thaiv thawj zaug yog tus kws kho mob sau tseg, nws kuj sau tshuaj, raws li qhov koj tuaj yeem yuav cov tshuaj. Hauv lub neej tom ntej, cov ntshav qab zib tau tuaj yeem kho lub koob tshuaj, siv cov lus pom zoo los ntawm cov lus qhia rau kev siv.
Kev Sau ua ke thiab daim ntawv ntawm kev tso tawm
NovoNorm tau pib los ntawm kev txhawj xeeb txog NovoNordisk, yog ib tug muaj koob npe muaj npe hauv chaw tsim tshuaj paus tshuaj thiab cov khoom lag luam muaj feem rau cov ntshav qab zib. Cov ntsiav tshuaj yog tsim hauv Tebchaws Yelemees thiab Denmark. Cov tshuaj nquag ua haujlwm ntawm cov tshuaj, repaglinide, yog ib qho kev sib txuas ntawm cov amino acids thiab belongs rau cov lus tsis pub luv luv. Nws yog ntawm German keeb kwm (tsim tawm Beringer Ingelheim).
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Ib lub NovoNorm ntsiav tshuaj tuaj yeem muaj 0.5, 1 lossis 2 mg ntawm cov tshuaj tseem ceeb. Ntxiv rau nws, hmoov txhuv nplej siab, povidone, poov tshuaj polyacrylate, pluronic, glycerin, calcium hydrogen phosphate, thiab dyes suav nrog. Lawv yog cov koom haum pabcuam, uas yog, lawv tsis muaj cov nyhuv khomob.
Yuav ua li cas los txiav txim cov thawj cov tshuaj:
- Txhawm rau tiv thaiv cov cuav, txhua ntsiav tshuaj muaj cim nrog lub cim ntawm NovoNordisk - dawb huv Iyiv ib txwm heev.
- Cov tshuaj no tau muab tso rau hauv cov ntawv ci hlwv, txhua tus muaj 15 ntsiav tshuaj.
- Cov hlwv yog nruab nrog perforation, uas tso cai rau koj cais cov koob tshuaj txhua hnub yam tsis muaj kev siv txiab.
- Cov xim ntawm cov ntsiav tshuaj ntawm cov tshuaj sib txawv yog txawv: 0.5 mg dawb, 1 mg daj, 2 mg pinkish.
Tus nqi ntawm ib pob ntawv muaj 30 pob tsis tshaj 230 rubles. Cov tshuaj yuav khaws cia rau 5 xyoo ntawm qhov kub txog 15-30 ° C.
Lub hauv paus ntsiab lus ntawm kev ua haujlwm ntawm NovoNorma
Repaglinide yog ib feem ntawm ib pawg ntawm cov tshuaj hu ua meglitinides. Koj tuaj yeem paub lawv ntawm qhov kawg ntawm glinid hauv lub npe. Lawv yog cov derivatives ntawm ntau cov amino acids, hauv tshwj xeeb repaglinide - carbamoyl-methyl-benzoic. Cov tshuaj muaj peev xwm khi rau thaj chaw tshwj xeeb ntawm cov poov tshuaj raws nyob ntawm daim nyias nyias ntawm cov roj ntsha pancreatic. Nyob rau hauv kev cuam tshuam ntawm repaglinide, cov kab kev no raug thaiv, uas ua rau nkag mus ntawm calcium nyob rau hauv lub hlwb thiab nce insulin synthesis.
Cov tshuaj insulin tso tawm los ntawm NovoNorm pib 10 feeb tom qab lub ntsiav tshuaj nkag mus rau hauv lub plab zom mov. Qhov siab tshaj plaws hauv cov ntshav tau pom tom qab 50 feeb. Yog tias koj noj cov tshuaj 15 feeb ua ntej noj mov, txoj kev loj hlob ntawm cov ntshav qabzib thiab txhawb kev tsim cov tshuaj insulin nyob rau lub sijhawm, uas txhais tau tias cov piam thaj tuaj yeem sai thiab tag nrho tawm ntawm cov hlab ntsha.
Tsis zoo li sulfonylurea derivatives (Maninil, Amaril, Glibenclamide, thiab lwm yam), qhov kev txiav txim ntawm NovoNorm nyob ntawm glycemia. Nrog rau cov piam thaj ib txwm, nws yog ob peb zaug tsis tshua muaj siab dua li muaj suab thaj nce ntxiv. Tom qab thov tshuaj Repaglinide, cov tshuaj insulin rov qab los rau tom qab 3 teev. Raws li cov kws kho mob, qhov no tseem ceeb txo cov zaus thiab mob heev ntawm cov qog ntshav qab zib nyob rau hauv yog tias muaj kev noj ntau dhau. Xws li lub sijhawm luv luv ntawm kev tsim tawm ntawm cov kua dej yog suav tias yog qhov loj me, tiv thaiv kev ua kom sai ntawm cov qe ntshav ntawm lub cev, thiab yog li qhov kev nce qib ntawm cov ntshav qab zib.
Cov yam ntxwv ntawm kev tshem tawm los ntawm lub cev
Repaglinide muaj peev xwm ua kom nrawm rau hauv cov hnyuv, uas yog vim qhov pib ntawm nws txoj haujlwm. Bioavailability thiab kev txiav txim siab zaum kawg ntawm cov tshuaj hauv cov ntshav txawv (txog 60%) hauv cov neeg mob ntshav qab zib sib txawv, yog li ntawd, ntau npaum li cas rau txhua tus neeg mob yuav tsum tau xaiv ib tus zuj zus.
Repaglinide yog metabolized los ntawm daim siab, tom qab ib teev nws qhov kev txiav txim siab yog txo los ntawm ib nrab. Lub ntsiab tseem ceeb ntawm pharmacokinetics ntawm ib yam khoom yog kev tawm ntawm lub cev tsuas yog los ntawm cov hnyuv plab zom mov. Raws li cov lus qhia, 92% ntawm repaglinide tawm nrog cov quav, 2% ntawm lawv hauv daim ntawv ntawm cov tshuaj nquag, tshuav 90% hauv daim ntawv ntawm metabolites. Lub raum muaj li ntawm 8%, uas tso cai rau NovoNorm siv rau hauv cov neeg mob ntshav qab zib uas muaj mob raum tsis zoo. Tom qab 5 teev, repaglinide tsis pom pom hauv cov ntshav ntxiv lawm.
Leej twg yog tus muab tshuaj
NovoNorm yog tau txhaj rau cov ntshav qab zib hom 2 hauv cov mob hauv qab no:
- Ua ke nrog metformin tam sim ntawd tom qab kev kuaj mob ntawm tus kab mob, yog tias glycated hemoglobin ntau dua 9%, uas qhia tau tias tsis pom tseeb tias mob ntshav qab zib mellitus lossis nws qhov nce zuj zus.
- Raws li hloov chaw rau sulfonylureas, yog tias lawv contraindicated vim muaj kab mob raum, kev fab tshuaj tsis haum.
- Raws li ib feem ntawm cov kev kho mob nyuaj, cov neeg mob ntshav qab zib ntev ntev, yog tias lawv muaj cov insulin tsis txaus lossis theem 1 ntawm nws cov khoom tau cuam tshuam (cov piam thaj nce sai thiab tsis poob rau lub sijhawm ntev tom qab noj mov).
- Cov neeg mob ntshav qab zib uas tsis tuaj yeem npaj lawv li kev noj haus. Cov koob tshuaj NovoNorm tuaj yeem hloov pauv nyob ntawm seb muaj pes tsawg carbohydrates hauv cov zaub mov.
Cov kev qhia rau kev siv tswv yim qhia rau noj NovoNorm nrog metformin thiab glitazones. Raws li kev txheeb xyuas, cov tshuaj mus zoo nrog txhua pab pawg ntawm cov kab mob hypoglycemic, suav nrog insulin. Tib qho zam tsuas yog sulfonylurea npaj. Lawv txoj kev sib xyaw nrog NovoNorm tuaj yeem siv tau, tab sis tsis pom zoo, vim tias nws tuaj yeem ua rau ntshav qis thiab tsis zoo cuam tshuam rau lub xeev ntawm beta hlwb.
Cov Yuav Tsum Muaj
Daim ntawv teev npe ntawm contraindications rau kev siv NovoNorm hauv ntshav qab zib mellitus:
| Pom kev sib deev | Vim li cas rau qhov txiav npluav |
| Cov tshuaj tiv thaiv tsis haum rau cov Cheebtsam hauv ncoo. | Muaj peev xwm ua rau muaj kev tsis haum tshuaj loj txog qhov poob siab anaphylactic. |
| 1 yam mob ntshav qab zib. | Hom ntshav qab zib no tus yam ntxwv ua tiav los ntawm kev ua tiav ntawm cov qe ntshav, uas tsis suav nrog kev tsim tawm ntawm nws cov tshuaj insulin. |
| Ketoacidosis thiab mob hnyav ntxiv - ua ntej thiab coma. | Qhov nqus thiab tshem tawm cov tshuaj repaglinide tuaj yeem ua tsis taus, yog li cov neeg mob tau hloov mus rau kev kho mob insulin ib ntus. Cov kev txheeb xyuas tau qhia tias tom qab qhov mob zoo los ntawm cov mob hnyav, feem ntau cov neeg mob rov qab mus rau NovoNorm. |
| Muaj mob hnyav, cuam tshuam kev phais mob, ua rau lub neej tawg. | |
| Cev xeeb tub, kab mob siab B, hnub nyoog qis dua 18 xyoo thiab ntau dua 75 xyoo. | Kev siv yog raug txwv vim tsis muaj cov kev tshawb fawb lees paub txog kev nyab xeeb ntawm NovoNorm hauv cov pab pawg neeg mob ntshav qab zib. |
| Lub siab ua haujlwm tsis zoo. | Lub siab koom nrog cov metabolism hauv ntawm repaglinide, nrog nws qhov tsis txaus, qhov khoom ntawm cov ntshav hauv cov ntshav nce ntxiv. |
| Kev noj cov gemfibrozil los kho cov ntshav lipids. | Cov tshuaj pab txhim kho qhov kev txiav txim ntawm Novo Norm, tuaj yeem ua rau lub qog ntshav qab zib. Qhov kev tso siab ntawm repaglinide nce los ntawm 2.4 npaug, lub sij hawm nruab nrab ntawm kev ncua yog ncua ntev li 3 teev. |
Xaiv xaiv
NovoNorm haus 15 feeb ua ntej siv cov zaub mov uas muaj carbohydrate. Cov lus qhia pom zoo muab faib rau hauv 2-4 koob tshuaj ib hnub hauv vaj huam sib luag.
Kev xaiv koob tshuaj yog nqa tawm nrog kev saib xyuas tas li ntawm glycemia. Txoj Cai Xaiv:
- Qhov pib ib koob yog 0.5 mg.
- Yog tias them nyiaj rau ntshav qab zib tsis tiav, nws tau nce siab tom qab 1 lub lis piam mus rau 1 mg.
- Los ntawm nce ntxiv cov koob tshuaj los ntawm 0.5 mg, nws tuaj yeem nqa mus txog 4 mg hauv 1 koob tshuaj. Qhov tshuaj ntau ntau rau txhua hnub yog 16 mg. Yog tias nws tsis muab cov ntshav qab zib kom tswj, tus neeg mob yuav tsum kho cov zaub mov noj, thiab yog tias qhov ntsuas no tsis ua hauj lwm zoo, hloov mus rau cov tshuaj muaj zog lossis cov tshuaj insulin.
Muaj qhov tsis xav ua
Raws li kev tshuaj xyuas ntawm cov neeg mob ntshav qab zib noj cov tshuaj, feem ntau lawv pom muaj qhov tsis txaus siab xav tau hauv qab zib tom qab noj tshuaj. Nws qhov teeb meem yuav yog qhov ntau dhau ntawm qhov ua kom rov ua dua, qhov tsis muaj carbohydrates rau hauv cov zaub mov, kev zom plab zom mov, kev tawm dag zog ntawm lub cev thiab lub hlwb. Txoj kev pheej hmoo ntawm kev mob ntshav qab zib yog soj ntsuam los ntawm cov lus qhia ua feem ntau (1-10%). Nrog tib txoj kev tuaj yeem yog qhov ua tau - raws plab thiab mob hauv plab.
Cov kev mob tshwm sim txuas ntxiv yog qhov tsawg dua, nyob hauv tsawg dua 0.1% ntawm cov neeg mob. NovoNorm tuaj yeem ua rau ua xua, cem quav, xeev siab, pab txhawb kom muaj ntau ntxiv ntawm daim siab enzymes.
Cov qauv ntsuas thiab hloov chaw NovoNorma
Dab tsi tuaj yeem hloov pauv NovoNorm yog tias nws tsis haum lossis tsis mus rau hauv cov chaw muag tshuaj:
| Cov pawg pab pawg | Lub npe, chaw tsim tshuaj paus | |
| Ua tiav cov tshuaj tua kab mob (analogues), cov khoom ua kom nquag plias - rov kho dua | Kev kuaj mob los ntawm Akrikhin. | |
| Iglinid los ntawm Pharmasynthesis. | ||
| Pawg analogues, meglitinides | Starlix (cov tshuaj yeeb tshuaj lom neeg - nateglinide, chaw tsim tshuaj paus NovartisPharma). | |
| Lwm cov tshuaj insulin txhim kho cov ntsiav tshuaj los ntawm lwm pab pawg | Sulfonylureas | Diabeton (gliclazide, Servier), Maninil (glibenclamide, Berlin-Chemie), Amaryl (glimepiride, Sanofi), Glurenorm (glycvidone, Beringer Ingelheim) thiab lawv cov analogues. |
| DPP4 Tus Neeg Saib Xyuas Kev Lag Luam | Xelevia (sitagliptin, Berlin-Chemie), Onglisa (saxagliptin, AstraZeneca), Galvus (vildagliptin, NovartisFarma), thiab lwm yam. | |
Hauv cov ntshav qab zib mellitus, qhov hloov ntawm NovoNorm nrog cov tshuaj tiv thaiv tag nrho tuaj yeem ua tau ntawm nws tus kheej, lawv haus cov tshuaj tshiab hauv tib lub tshuaj. Hloov mus rau lwm cov ntsiav tshuaj los ntawm cov lus hais saum toj no yuav tsum tau xaiv cov koob tshuaj thiab tsuas yog ua tau raws li kev saib xyuas thiab tshuaj ntawm kws kho mob.
