Tricor yog ib hom tshuaj lipid-txo cov tshuaj uas siv rau dyslipidemia, thiab kuj tseem siv rau cov ntshav qab zib, yog tias kev noj zaub mov noj thiab ua kom lub cev muaj zog ua tsis tau zoo.
Cov tshuaj txo qis ntawm cov fibrinogen thiab cov ntsiab lus ntawm atherogenic feem ntawm cov roj (cholesterol) hauv cov ntshav (VLDL, LDL), nce ntxiv ntawm cov tshuaj uric acid.
Tso tawm daim ntawv thiab muaj pes tsawg leeg
Tricor yog muag hauv cov ntawv ua cov yeeb yaj kiab-tiav cov kua hauv ib pob ntawm 30 ntsiav tshuaj. Txhua ntsiav tshuaj suav nrog micronized fenofibrate 145 mg, thiab cov tshuaj nram qab no:
- lactose monohydrate,
- sodium lauryl sulfate,
- sucrose
- hypromellose,
- silicon dioxide
- crospovidone
- sodium docusate.
Kho nyhuv
Fenofibrate yog ib qho kev tso dag los ntawm fibric acid. Muaj peev xwm los hloov qib ntawm ntau feem ntawm cov lipids hauv cov ntshav. Cov tshuaj muaj cov qhia hauv qab no:
- Nce clearance
- Txo cov naj npawb ntawm atherogenic lipoproteins (LDL thiab VLDL) rau cov neeg mob uas muaj feem yuav ua mob plawv,
- Tsa nce qib ntawm cov roj "zoo" (HDL),
- Tseem ceeb txo cov ntsiab lus ntawm cov teeb meem kev rho tawm ntawm cov roj cholesterol,
- Qiv tshuaj fibrinogen siab,
- Txo cov qib uric acid hauv cov ntshav thiab C-reactive protein.
Qhov siab tshaj plaws ntawm fenofibrate hauv tib neeg cov ntshav tshwm li ob peb teev tom qab siv ib zaug. Nyob rau hauv cov xwm txheej ntawm kev siv lub sijhawm ntev, tsis muaj qhov cuam tshuam ntxiv.
Kev siv ntawm cov tshuaj Tricor thaum cev xeeb tub
Cov ntaub ntawv me me tau qhia txog kev siv cov fenofibrate thaum cev xeeb tub. Hauv kev sim rau tsiaj, teratogenic nyhuv ntawm fenofibrate tsis tau qhia tawm.
Embryotoxicity tshwm sim raws li ib feem ntawm kev kuaj mob ua ntej qhov tshuaj txhaj tshuaj lom rau lub cev ntawm tus poj niam cev xeeb tub. Tam sim no, tsis muaj kev pheej hmoo rau tib neeg tau txheeb xyuas. Txawm li cas los xij, cov tshuaj thaum cev xeeb tub tuaj yeem siv tsuas yog los ntawm kev soj ntsuam kom zoo ntawm qhov sib piv ntawm cov txiaj ntsig thiab kev pheej hmoo.
Txij li thaum tsis muaj cov ntaub ntawv muaj tseeb ntawm kev nyab xeeb ntawm cov tshuaj Tricor thaum pub niam mis, tom qab ntawd lub sijhawm no nws tsis yog kws kho.
Cov nram qab no contraindications kom noj cov tshuaj Tricor yog:
- Ib theem siab ntawm qhov rhiab heev hauv fenofibrate lossis lwm yam tshuaj ntawm cov tshuaj;
- Kev mob raum tsis zoo, piv txwv li, mob cov ntshav siab;
- Hnub nyoog txog 18 xyoo;
- Keeb kwm ntawm kev ua kom yoog tawm lossis kev thaij duab hauv kev kho ketoprofen lossis ketoprofen;
- Ntau yam kabmob ntawm lub zais zis;
- Kev pub niam mis;
- Cov kab mob endogenous galactosemia, cov theem tsis txaus ntawm lactase, malabsorption ntawm galactose thiab qabzib (cov tshuaj muaj lactose);
- Endogenous fructosemia, sucrose-isomaltase deficiency (cov tshuaj muaj sucrose) - Tricor 145;
- Kev ua xua rau cov txiv laum huab xeeb, txiv laum huab xeeb, taum pauv, lossis keeb kwm muaj khoom noj zoo sib xws (vim tias nws muaj qhov phom sij rau qhov tsis haum).
Nws yog ib qho tsim nyog yuav tsum siv cov khoom nrog ceev faj, yog tias muaj:
- Renal thiab / lossis daim siab ua haujlwm;
- Siv dej cawv;
- Cov Kev Hlwb Hypothyroidism;
- Tus neeg mob laus thaum muaj hnub nyoog laus;
- Tus neeg mob muaj lub nra keeb kwm nyob rau hauv kev sib txuas nrog cov kab mob leeg mob.
Kev noj tshuaj ntawm cov tshuaj thiab txoj kev siv
Cov khoom yuav tsum noj ntawm qhov ncauj, nqos tag nrho thiab haus dej kom ntau. Cov ntsiav tshuaj yog siv lub sijhawm twg los tau nruab hnub, nws tsis yog nyob ntawm kev noj zaub mov (rau Tricor 145), thiab tib lub sijhawm nrog zaub mov (rau Tricor 160).
Cov neeg laus noj 1 ntsiav tshuaj ib hnub ib zaug. Cov neeg mob uas noj 1 lub tshuaj Lipantil 200 M lossis 1 ntsiav tshuaj ntawm Tricor 160 ib hnub yuav pib noj 1 ntsiav tshuaj ntawm Tricor 145 yam tsis muaj kev hloov pauv ntxiv.
Cov neeg mob uas noj 1 lub tshuaj Lipantil 200 M ib hnub twg muaj txoj hauv kev hloov mus rau 1 ntsiav tshuaj ntawm Tricor 160 yam tsis muaj kev hloov pauv ntxiv.
Cov neeg laus yuav tsum siv cov tshuaj rau cov neeg laus: 1 ntsiav tshuaj ntawm Tricor ib hnub ib zaug.
Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum txo qhov ntau npaum li cas los ntawm kev sab laj nrog kws kho mob.
Thov nco tseg: kev siv cov tshuaj Tricor hauv cov neeg mob siab tsis tau kawm. Kev txheeb xyuas tsis muab cov duab ntshiab.
Cov tshuaj yuav tsum tau noj rau ntev, thaum soj ntsuam cov tshuaj rau kev noj haus uas ib tug neeg ua raws li ua ntej pib siv cov tshuaj. Qhov ua tau zoo ntawm cov tshuaj yuav tsum raug tshuaj los ntawm tus kws kho mob saib xyuas.
Txoj kev kho yog ntsuas los ntawm cov qib lipid. Peb tab tom tham txog roj LDL, cov roj (cholesterol) tag nrho thiab triglycerides. Yog hais tias qhov kev ua kom zoo li tsis pom tshwm sim hauv ob peb hlis, tom qab kev teem caij ntawm lwm txoj kev kho mob yuav tsum tau tham.
Tshuaj ntau dhau
Tsis muaj kev piav qhia txog kev muaj mob ntau dhau. Tab sis yog tias koj xav tias muaj tus mob no, koj tuaj yeem nqa tawm cov tsos mob thiab txhawb kev kho mob. Hemodialysis yog qhov tsis muaj txiaj ntsig ntawm no.
Cov tshuaj cuam tshuam li cas nrog lwm cov tshuaj
- Nrog cov tshuaj tiv thaiv kab mob hauv qhov ncauj: fenofibrate ua rau muaj txiaj ntsig ntawm kev tiv thaiv qhov ncauj thiab ua rau muaj kev pheej hmoo los ntshav. Qhov no yog vim qhov hloov chaw ntawm anticoagulant los ntawm cov ntshav protein khi cov chaw.
Hauv thawj theem ntawm kev kho fenofibrate, nws yog ib qho tsim nyog los txo cov tshuaj ntawm cov tshuaj tiv thaiv los ntawm ib feem peb, thiab maj mam xaiv ib koob. Qhov tsuas tshuaj yuav tsum tau xaiv hauv qab tswj hwm ntawm INR qib.
- Nrog cyclosporine: muaj cov lus piav qhia ntawm ob peb yam mob hnyav uas ua rau daim siab ua haujlwm thaum kho nrog cyclosporine thiab fenofibrate. Nws yog ib qho tsim nyog los soj ntsuam daim siab ua haujlwm hauv cov neeg mob thiab tshem tawm fenofibrate yog tias muaj kev hloov loj hauv cov ntsuas tsis haum.
- Nrog HMG-CoA reductase inhibitors thiab lwm cov khoom siv fibrates: thaum noj fenofibrate nrog HMG-CoA reductase inhibitors lossis lwm cov fibrates, txoj kev pheej hmoo ntawm intoxication ntawm cov leeg pob txha ntau ntxiv.
- Nrog rau cytochrome P450 cov enzymes: kev tshawb fawb ntawm tib neeg lub siab microsomes qhia tias fenofibroic acid thiab fenofibrate tsis ua raws li inhibitors ntawm cytochrome P450 isoenzymes:
- CYP2D6,
- CYP3A4,
- CYP2E1 lossis CYP1A2.
Ntawm kev siv tshuaj kho mob, cov tebchaw no yog cov tsis muaj zog ntawm CYP2C19 thiab CYP2A6 isoenzymes, nrog rau cov muaj peev xwm me lossis hnyav CYP2C9.
Ob peb cov lus qhia tshwj xeeb thaum noj cov tshuaj
Ua ntej koj pib siv cov tshuaj, koj yuav tsum tau ua kev kho mob los txiav tawm qhov ua rau ntawm hypercholesterolemia theem nrab, peb tab tom tham txog:
- tswj tsis tau tus mob ntshav qab zib hom 2,
- hypothyroidism
- cov tsos mob nephrotic
- dysproteinemia,
- obstructive daim siab mob
- kev rau txim los ntawm kev kho tshuaj,
- quav cawv.
Qhov ua tau zoo ntawm kev kho yog ntsuas raws cov ntsiab lus ntawm lipids:
- tag nrho cov roj (cholesterol)
- LDL
- ntshav dej triglycerides.
Yog tias qhov kho tau zoo dua qub tsis tau tshwm sim ntau dua peb lub hlis, nws yog ib qho tsim nyog yuav tsum pib kho lwm txoj kev kho mob lossis pom zoo.
Cov neeg mob hyperlipidemia uas noj tshuaj tiv thaiv hormonal tshuaj lossis estrogens yuav tsum nrhiav qhov xwm txheej ntawm hyperlipidemia, nws tuaj yeem yog thawj lossis theem nrab. Hauv cov rooj plaub no, qhov nce ntawm cov lipids tuaj yeem tshwm sim los ntawm kev noj tshuaj ntawm estrogen, uas tau lees paub los ntawm tus neeg mob tshuaj xyuas.
Thaum siv Tricor lossis lwm yam tshuaj uas ua rau txo qis qhov lipids, qee tus neeg mob yuav muaj tus kab mob siab hepatic hloov ntxiv.
Hauv ntau qhov xwm txheej, qhov nce yog me thiab ib ntus, hla dhau yam tsis muaj cov tsos mob pom. Rau thawj 12 lub hlis ntawm kev kho mob, nws yog ib qho tsim nyog yuav tau ua tib zoo saib xyuas qib ntawm transaminases (AST, ALT), txhua peb lub hlis.
Cov neeg mob uas, thaum kho, muaj kev nce siab ntau dua ntawm kev hloov tsheb, yuav tsum tau saib xyuas tshwj xeeb yog tias qhov kev txiav txim ntawm ALT thiab AST yog 3 lossis ntau zaus siab dua qhov ntsuas siab dua. Hauv cov xwm txheej zoo li no, cov tshuaj yuav tsum nres sai sai.
Kev mob caj dab
Muaj cov lus piav qhia ntawm kev muaj mob ntawm kev mob ntsig txog lub sijhawm siv Traicor. Cov teeb meem ua rau ntawm pancreatitis:
- Qhov tsis muaj txiaj ntsig ntawm cov tshuaj nyob rau hauv cov neeg muaj mob hypertriglyceridemia,
- Raug cov tshuaj,
- Qhov tshwm sim thib ob cuam tshuam nrog pob zeb lossis tsim kom muaj kev txo qis hauv lub zais plab, uas yog nrog los ntawm kev cuam tshuam ntawm cov bile duct.
Nqaij
Thaum siv Tricor thiab lwm yam tshuaj uas txo qis cov concentration ntawm lipids, cov teebmeem ntawm kev mob lom rau cov leeg nqaij tau raug tshaj tawm. Tsis tas li ntawd, tsis tshua muaj cov xwm txheej ntawm rhabdomyolysis tau sau tseg.
Cov kev tsis zoo no muaj ntau dua yog tias muaj cov mob raum tsis ua haujlwm lossis keeb kwm ntawm hypoalbuminemia.
Yuav ua rau qaug tshuaj rau cov leeg nqaij yog tias tus neeg mob yws tias:
- Nqaij mob thiab cramps
- General tsis muaj zog
- Diffuse myalgia,
- Myositis
- Ib qho cim nce ntawm cov kev ua ntawm creatine phosphokinase (5 lossis ntau dua lub sijhawm piv nrog cov kev txwv sab saud ntawm tus qauv).
Nws yog ib qho tseem ceeb kom paub tias hauv txhua kis no, kev kho mob nrog Tricor yuav tsum tsis ua mus ntxiv.
Hauv cov neeg mob predisposed rau myopathy, nyob rau hauv cov neeg laus dua 70 xyoo, thiab hauv cov neeg mob uas muaj keeb kwm muaj lub nra hnyav, rhabdomyolysis yuav tshwm sim. Tsis tas li, tus mob cuam tshuam:
- Kab mob leeg mob kab mob
- Mob raum tsis zoo,
- Ntshav Qab Zib,
- Haus dej cawv.
Cov tshuaj tau sau tseg rau cov neeg mob zoo li no tsuas yog thaum xav tias yuav muaj txiaj ntsig zoo ntawm kev kho mob ntau tshaj qhov txaus ntshai pheej hmoo ntawm rhabdomyolysis.
Thaum siv Traicor ua ke nrog HMG-CoA reductase inhibitors lossis lwm qhov ua rau fibrates, qhov kev pheej hmoo ntawm kev phiv los ntawm cov leeg nqaij ua rau nce ntxiv. Qhov no muaj tseeb tshwj xeeb tshaj yog thaum tus neeg mob tau mob leeg ua ntej pib kev kho mob.
Kev sib koom tes nrog Triicor thiab statin tuaj yeem tsuas yog yog tias tus neeg mob tau mob ntshav sib xyaw ua ke thiab muaj kev pheej hmoo mob plawv heev. Yuav tsum tsis muaj keeb kwm mob cov leeg mob. Kev txheeb xyuas nruj ntawm cov cim qhia txog kev phiv tshuaj ntawm cov leeg nqaij yog qhov tsim nyog.
Renal muaj nuj nqi
Yog tias nce ntawm creatinine concentration ntawm 50% lossis ntau dua yog sau tseg, tom qab ntawd kev kho tshuaj yuav tsum nres. Hauv thawj 3 lub hlis ntawm kev kho mob Treicor, kev tsim tshuaj muaj zog creatinine yuav tsum txiav txim siab.
Kev tshuaj xyuas txog cov tshuaj tsis muaj cov ntaub ntawv hais txog kev hloov pauv hauv kev noj qab haus huv thaum tsav tsheb thiab tswj cov tshuab.
