1 ampoule (12 ml) ntawm Berlition 300 muaj cov khoom xyaw nquag: ethylenediamine ntsev ntawm α-lipoic (thioctic) acid 0.388 g (hauv cov ntsiab lus ntawm α-lipoic (thioctic) acid - 0.300 g thiab cov tshuaj pab: dej rau kev txhaj, propylene glycol, ethylene diamine.
Cov ntsiav tshuaj pleev xim, txhua tus ntawm lawv muaj cov tshuaj ua kom nquag plhaw lip-lipoic (thioctic) acid - 300 mg lossis 600 mg;
Tsis tas li ntawd, muaj cov txuam:
- magnesium stearate;
- lactose monohydrate;
- croscarmellose sodium;
- microcrystalline cellulose;
- colloidal anhydrous silica;
- povidone (tus nqi K = 30);
Opadry OY-S-22898 "daj" hauv lub plhaub, suav nrog:
- hypromellose,
- sodium dodecyl sulfate,
- titanium dioxide (E 171),
- xim daj-xim txiv kab ntxwv (E 110),
- quinoline daj xim (E 104),
- kua paraffin.
Cov chaw muag tshuaj
Cov Tshuaj Hauv Tshuaj Lub hauv paus ua haujlwm tseem ceeb ntawm cov tshuaj yog cov tshuaj ntuj tso nrog tshuaj dawb. Acid yog tsim los ntawm lub cev vim los ntawm oxidative cuam tshuam rau α-keto acids.
Ua tib zoo mloog! Kev tshuaj xyuas ntawm cov kws kho mob tau qhia tias cov tshuaj muaj txiaj ntsig zoo rau kev txo cov ntshav qab zib, nce qib siab glycogen thiab kov yeej cov tshuaj insulin.
Los ntawm lawv cov khoom lag luam biochemical, Berlition 300 thiab 600 ntsiav tshuaj ze rau B vitamins.
- Koom tes nrog cov normalization ntawm carbohydrate thiab lipid metabolism.
- Txhim kho daim siab ua haujlwm, txhawb cov metabolism hauv roj.
- Lawv muaj cov tshuaj tiv thaiv hypoglycemic, hepatoprotective, hypochrontolemic, hypolipidemic effect.
Kev siv Berlition 300 thiab 600 hauv kev infusions rau kev txhaj tshuaj rau cov leeg tuaj yeem txo qhov hnyav mob tshwm sim tsis zoo.
Cov Tshuaj Pharmacokinetics Berlition 300 thiab 600 ntsiav tshuaj, ntau dua meej, lawv cov tshuaj nquag, muaj lub peev xwm "ua ntej dhau" los ntawm daim siab. Thioctic acid thiab nws cov khoom siv yuav luag ua tiav (80-90%) tawm los ntawm lub raum.
Kev daws rau kev txhaj tshuaj Berlition. Lub sijhawm kom mus txog qhov siab tshaj plaws hauv lub cev nrog kev tswj hwm yog 10-11 feeb. Thaj chaw hauv qab daim ntaub ntawv tshuaj (ua kom lub sij hawm tsom) yog 5 μg h / ml. Qhov siab tshaj plaws yog 25-38 mcg / ml.
Cov ntsiav tshuaj Berlition rau qhov ncauj tswj hwm tau muab nqus tau sai thiab ua kom tiav hauv cov hnyuv. Thaum noj nrog zaub mov, adsorption poob qis. Qhov siab tshaj plaws ntawm cov tshuaj yog tiav tom qab 40-60 feeb. Bioavailability yog 30%.
Ib nrab-lub neej yog 20-50 feeb. Tag nrho cov ntshav tshem tawm yog 10-15 ml / min.
Kev qhia rau kev siv tshuaj
Mob ntshav qab zib polyneuropathy mob ntshav qab zib lossis haus dej cawv. txhaj tshuaj siv kuj tseem siv. Kev noj tshuaj txhua hnub yog 300 lossis 600 mg. 1 ampoule muaj 300 mg.
Berlition yog diluted nyob rau hauv 0.9% sodium chloride tov thiab muab rau tus neeg mob los ntawm hnia tawm dej. Lub sijhawm taw qhia yog 30 feeb.
Thaum pib ntawm kev kho mob, Berlition yog raug rau 2-4 lub lis piam. Tom qab ntawd, koj tuaj yeem txuas ntxiv kev tswj hwm qhov ncauj ntawm Berlition ntsiav tshuaj ntawm koob ntawm 300-600 mg ib hnub.
Berlition ntsiav tshuaj tau qhia rau kev siv hauv 600 mg ib hnub ib zaug. Cov no yog 2 ntsiav tshuaj. Cov tshuaj yuav tsum noj rau ntawm lub plab khoob, li ib nrab teev ua ntej noj mov.
Cov ntsiav tshuaj yuav tsum nqos tag nrho yam tsis ntxo. Haus dej kom ntau. Tsuas yog tus kws kho mob txiav txim siab nyob rau lub sijhawm ntawm cov txheej txheem kho.
Qee qhov zoo ntawm cov tshuaj
Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob txog Berlition feem ntau yog qhov zoo, tab sis, zoo li lwm yam tshuaj, nws muaj nws tus yam ntxwv. Thaum lub sij hawm kho cov neeg mob, cov neeg mob yuav tsum yauv tsum tsis txhob haus cawv.
Tus mob ntshav qab zib xav tau kev soj ntsuam cov ntshav qab zib ntshav qab zib. Qhov no yog qhov tshwj xeeb tshaj plaws thaum pib kho. Qee zaum nws yuav tsim nyog los txo cov koob tshuaj insulin lossis hypoglycemic los ntawm cov neeg mob sab hauv. Yog li, qhov kev pheej hmoo ntawm hypoglycemia yog tiv thaiv.
Berlition 300 lossis 600 txhaj tshuaj tiv thaiv yuav tsum tiv thaiv los ntawm UV hluav taws xob. Qhov no yog ua los ntawm kev sau lub raj mis rau hauv ntawv ci txhuas. Ib qho kev daws teeb meem tiv thaiv nyob rau hauv txoj kev no yuav khaws cia rau 7 teev.
Sab sij huam
Feem ntau, lawv tsis tshwm sim, tab sis, tsis tshua muaj tshwm sim, tom qab muaj kua ntawm kev daws, nriaj, cov ntshav tawm ntawm cov tawv nqaij thiab cov tawv nqaij, hemorrhagic pob, thrombocytosis yog ua tau. Nrog rau kev tswj hwm sai heev, muaj peev xwm ua haujlwm ntawm intracranial siab thiab ua pa nyuaj.
Kev tshuaj xyuas los ntawm cov neeg mob thiab kws kho mob tau hais tias tag nrho cov tsos mob no ploj mus yam tsis muaj kev cuam tshuam.
Muaj cov tshuaj tiv thaiv hauv zos uas tshwm sim hauv cheeb tsam txhaj tshuaj. Nws tuaj yeem yog qhov mob ua urticaria lossis lwm yam kev ua xua, txog kev poob siab anaphylactic. Kev txhim kho ntawm cov ntshav qog ntshav qab zib, uas tuaj yeem tshwm sim los ntawm kev txhim kho hauv cov kua dej nqus, tsis yog txoj cai.
Cov ntsiav tshuaj Berlition feem ntau ua siab ntev tsis muaj kev cuam tshuam tsis zoo. Tab sis qee zaus cov teeb meem hauv qab no muaj peev xwm ua tau:
- ua pa tsis ua haujlwm;
- Kev mob siab;
- xeev siab
- ntuav
- hypoglycemia thaum cev xeeb tub;
- urticaria.
Kev cuam tshuam nrog lwm yam tshuaj
Berlition "hauv vitro" reacts nrog ionic hlau txuas ntxiv. Ua piv txwv, cisplatin tuaj yeem txiav txim siab. Yog li, siv tib txhij nrog cisplatin txo cov nyhuv ntawm tom kawg.
Tab sis cov nyhuv ntawm qhov ncauj tshuaj hypoglycemic thiab cov tshuaj insulin, Berlition 300 lossis 600, ntawm qhov tsis sib xws, txhim kho. Ethanol, uas pom nyob hauv cov dej cawv, txo cov nyhuv kho mob ntawm cov tshuaj (nyeem tshuaj xyuas).
Cov tshuaj nquag ntawm Berlition, thaum reacted nrog qab zib, cov ntaub ntawv xyaum insoluble sib txuas. Nws ua raws los ntawm qhov no hais tias daws tau ntawm thioctic acid tsis tuaj yeem ua ke nrog Txoj kev lis ntshav ntawm dextrose, Ringer, thiab lwm yam kev daws teeb meem zoo sib xws.
Yog tias Berlition 300, 600 ntsiav tshuaj tau noj thaum sawv ntxov, koj tuaj yeem siv cov khoom noj siv mis, magnesium thiab hlau npaj tsuas yog tom qab noj su lossis yav tsaus ntuj. Hauv kev hais txog cov khoom noj siv mis, qhov no yog vim qhov tseeb tias lawv muaj cov calcium ntau ntxiv.
Muaj cov contraindications uas twb muaj lawm
- Lub caij nyoog ntawm cev xeeb tub thiab pub niam mis. Txawm hais tias qhov tshwm sim tsis zoo ntawm cov tshuaj tsis raug pov thawj, txij li tsis muaj kev txheeb xyuas thiab kev kawm txog cov phiaj xwm no.
- Siab rhiab heev rau lub Cheebtsam ntawm Berlition.
- Cov tshuaj tsis tau sau tseg rau cov menyuam yaus (tsis muaj tshuaj xyuas txog kev nyab xeeb thiab ua haujlwm zoo).
Muaj Peev Xwm Ntau Mob
- xeev siab
- ntuav
- mob taub hau.
Tsis muaj cov tshuaj antidote tshwj xeeb, nws yog cov tsos mob uas tau kho.
Cia, nyiaj so koobtsheej, ntim khoom
Cov tshuaj zwm rau hauv daim ntawv B. Nws yuav tsum khaws cia ntawm qhov kub tsis tshaj 25 ° C, hauv qhov chaw tsaus nti tsis pom kev rau menyuam yaus.
Lub sij hawm ntawm kev siv yog nyob ntawm daim ntawv tso tawm:
- daws rau kev txhaj tshuaj - 3 xyoos;
- ntsiav tshuaj - 2 xyoos.
Berlition tsuas yog tso tawm los ntawm lub chaw kuaj mob. Kev daws rau kev txhaj yog muaj nyob hauv qhov tsaus tsaus ntawm 25 mg / ml. Cov thawv ntawv (thawv) muaj 5 ampoules. Nov yog cov lus qhia rau siv.
Cov ntsiav tshuaj Berlition yog txheej thiab ntim hauv 10 daim hauv cov hlwv ua los ntawm cov khoom siv opaque PVC lossis ntawv ci txhuas. Kev thauj khoom cardboard muaj 3 xws li cov hlwv thiab cov lus qhia rau siv.
