Txhawb cov roj (cholesterol) hauv cov ntshav ua rau kev tsim cov phom sij txaus ntshai. Nrog hyperglycemia, cov hlab plawv cuam tshuam nrog, atherosclerosis zoo li, thiab cov plahaum rog ua rau cov leeg thiab cov hlab ntsha.
Thaum cov hlab ntsha tsis dhau, ua rau cov ntshav khiav tsis zoo thiab hypoxia tshwm sim. Qhov no tuaj yeem ua rau lub plawv nres, mob stroke, thiab mob ntsws. Txhua yam no feem ntau ua rau tuag.
Tshwj xeeb yog qhov kev pheej hmoo ntawm kev tsim mob atherosclerosis yog cov neeg mob ntshav qab zib, hauv leej twg, tawm tsam keeb kwm ntawm hyperglycemia, tag nrho lub cev tau cuam tshuam. Yog li, lawv yuav tsum tau ua tib zoo saib xyuas lawv txoj kev noj qab haus huv thiab tsis pub kom cov cholesterol tsis zoo ntxiv hauv cov ntshav.
Niaj hnub no, cov tuam txhab tshuaj muaj ntau cov roj (cholesterol) ntawm cov tshuaj txo qis. Ib qho tshuaj zoo tshaj plaws yog simvastol. Tab sis ua ntej noj cov tshuaj, koj yuav tsum paub koj tus kheej nrog cov lus qhia rau cov tshuaj thiab sab laj nrog kws kho mob.
Pharmacological kev txiav txim, muaj pes tsawg leeg thiab daim ntawv tso tawm
Simvastol thaiv kev tsim cov roj cholesterol thiab inhibits kev ua haujlwm ntawm cov enzyme uas koom nrog hauv kev sib txuas ntawm mevalonate. Cov tshuaj no txo cov concentration ntawm triglycerides, qis lipoproteins uas ntau thiab tsawg hauv cov ntshav.
Cov tshuaj muaj qhov ua haujlwm ntxiv, yog li nws cov nyhuv tseem pom tau tsuas yog tom qab 14 hnub siv. Simvastol nrawm nrawm rau hauv cov ntshav, qhov siab tshaj plaws tau tiav 120 feeb tom qab nws tswj hwm.
Hauv lub siab, cov tshuaj hloov pauv, ua rau muaj qhov tsim cov beta-hydroxyl acids, uas muaj cov nyhuv tshuaj muaj zog. Kev tshem tawm ib nrab-lub neej ntawm metabolites yog 2 teev. Lawv tawm hauv lub cev feem ntau los ntawm txoj hnyuv.
Lub ntsiab lus tseem ceeb ntawm simvastol yog simvastatin. Cov compound no tau txais los ntawm kev ua haujlwm ntawm Aspergillus terreus pwm.
Ntxiv tshuaj ntawm:
- macrogol;
- citric acid thiab lactose monohydrate;
- hlau zas;
- butylhydroxyanisole,
- magnesium stearate;
- hlau zas;
- titanium dioxide thiab hais txog.
Cov tshuaj muaj nyob hauv daim ntawv foos. Ib pob muaj 14 lossis 28 ntsiav tshuaj. Hauv qhov tshuaj ntsuab liab muaj 10 mg, hauv daj - 20 mg, hauv xim av - 40 mg ntawm cov tshuaj txuam.
Kev taw qhia thiab contraindications
Kev siv cov simvastatin yog qhia rau thawj hom hypercholesterolemia hom IIa lossis IIb nrog kev muaj peev xwm nce ntawm atherosclerosis nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj thiab kev tawm dag zog. Tsis tas li, cov tshuaj tuaj yeem pab rau plawv ischemia raws li kev tiv thaiv ntawm kev tshwm sim ntawm mob hlab ntsha tawg, plawv nres.
Simvastol yog tshuaj rau cov ntshav siab, ua ke nrog hypertriglyceridemia. Cov tshuaj tau sau tseg thaum lub sijhawm npaj txhim kho kom rov ua haujlwm txhawm rau txhawm rau txo qhov muaj feem ntawm cov teeb meem.
Cov kev txwv tsis pub siv rau simvastatin - ua mob rau daim siab, myopathy, tsis mob siab rau cov tshuaj ntawm cov tshuaj. Cov tshuaj tsis tau teev tseg rau thaum yau thiab thaum tiav hluas.
Nrog kev ceev faj, simvastol yog siv rau hauv cov xwm txheej hauv qab no:
- kab mob siab;
- kev quav cawv;
- kev cuam tshuam ntawm cov dej-electrolyte sib npaug;
- tsis tshua muaj ntshav siab;
- kev raug mob
- lub raum tsis ua haujlwm;
- atonicity ntawm cov leeg ntawm cov leeg pob txha;
- cov kabmob endocrine;
- cov kab mob kis hnyav;
- ua tsis tiav hauv cov txheej txheem hauv metabolic;
- cev xeeb tub thiab kab mob siab B.
Tsis tas li, cov ntsiav tshuaj yuav tsum tsis txhob noj tom qab kev phais mob. Hauv tshwj xeeb, cov tshuaj yog contraindicated rau hauv kev hloov ntawm cov khoom nruab nrog cev thaum siv tshuaj tiv thaiv kab mob.
Cov lus qhia rau kev siv ntsiav tshuaj
Phau ntawv qhia rau kev siv tshuaj yaj yeeb hais tias nws tau haus ib hnub ib zaug nyob rau yav tsaus ntuj, ntxuav tawm nrog dej. Ntxiv mus, lub sijhawm noj Simvastol yuav tsum tsis txhob cuam tshuam nrog kev siv khoom noj.
Ua ntej pib thiab thaum siv tshuaj kho, yuav tsum ua raws li kev noj tshuaj anticholesterol. Thaum pib theem ntawm kev kho mob, nws raug nquahu kom haus cov ntsiav tshuaj hauv qhov ntau npaum 10 thiab 20 mg.
Ua raws li qhov mob hnyav ntawm hypercholesterolemia, tus kws kho mob tuaj yeem hloov qhov nyiaj ntawm cov tshuaj nquag ua haujlwm ntawm 10 mus rau 80 mg ib hnub. Yog tias tsim nyog, txhua 28 hnub tus kws kho mob kho cov tshuaj ntau npaum li cas. Hauv feem ntau cov neeg mob, qhov ua siab tshaj plaws kho tau yog ua tiav los ntawm kev noj 20 mg ntawm Simvastol ib hnub.
Nrog cov muaj keeb hypercholesterolemia (homozygous), qhov tshuaj txhua hnub yog 40 mg / hnub lossis 80 mg ib hnub, muab faib ua peb koob (20/20/40 mg).
Nrog rau cov kab mob plawv, cov tshuaj pom zoo yog 20-40 mg rau ib hnub. Yog tias qhov concentration ntawm LDL tsawg dua 1.94 mmol / L, thiab qib ntawm tag nrho cov cholesrol yog 3.6 mmol / L, tom qab ntawd cov koob tshuaj tau txo.
Hauv cov kab mob hauv lub raum ntev, noj cov tshuaj fibrates, nicotinic acid thiab Simvastol, cov lus pom zoo ntawm ib hnub tom qab tsis ntau tshaj 10 milligrams.
Cov neeg mob uas haus Amiodarone lossis Verapamil yuav tsum noj Simvastol hauv ib qhov ntau txog 20 mg rau ib hnub.
Kev phiv thiab tshuaj sib cuam tshuam
Hauv kev kho mob nrog Simvastol, ntau qhov kev tsis zoo tuaj yeem tshwm sim. Yog li, tom qab noj tshuaj, lub plab zom mov feem ntau cuam tshuam, uas yog pom los ntawm kev zawv plab, cem quav, tsam plab, mob pancreatitis, xeev siab, mob siab.
Qee zaum cov kev mob tshwm sim cuam tshuam rau lub cev musculoskeletal. Qhov tsim nyog ntawm qhov no yog cov leeg nqaij, myalgia, malaise, myopathy, rhabdomyolysis.
Thaum siv simvastatin, kev tsis haum tshwm sim tuaj yeem tshwm sim, xws li urticaria, polymyalgia, lupus, kub taub hau, vasculitis, angioedema, mob rheumatoid, mob ua tsis taus pa. Dermatological tshua tuaj yeem tsim kho - hyperemia thiab khaus ntawm daim tawv nqaij, dermatomyositis, photosensitivity, alopecia.
Kev siv cov simvastol tuaj yeem cuam tshuam tsis zoo rau lub luag haujlwm ntawm lub paj hlwb:
- saj kev ua txhaum;
- mob taub hau
- peripheral neuropathy;
- asthenic syndrome;
- pom kev tsis zoo hauv ntshav qab zib;
- insomnia
- mob leeg;
- paresthesia.
Cov kev tsis zoo uas tshwm sim tom qab noj Simvastol kuj suav nrog kev txo qis ntawm potency, mob raum tsis ua haujlwm, ntshav liab, kub npau, thiab lub plawv dhia ceev ceev. Simvastatin kuj tseem tuaj yeem cuam tshuam rau cov kev sim hauv chav kuaj, uas yog pom los ntawm thrombocytopenia, kev nce ntawm ESR, eosinophilia.
Hais txog kev sib txuam nrog tshuaj, nws tsim nyog paub tias cov tshuaj tsub kom tau txais txiaj ntsig ntawm anticoagulants, uas ua rau kom muaj kev pheej hmoo los ntshav. Cov txiaj ntsig kho ntawm Simvastol nce nrog nws txoj kev sib koom tes nrog kua txiv kab ntxwv qaub.
Yog tias koj noj cov ntsiav tshuaj nrog Verapamil, cytostatics, Erythromycin, nicotinic acid, Amiodarone, cov tshuaj tua kab mob, Diltiazem, HIV tiv thaiv cov tshuaj tiv thaiv kab mob, Telithromycin, Clarithromycin, ces qhov zoo li ntawm myopathy yuav nce ntxiv.
Kev ntsuas, kev kuaj xyuas thiab tus nqi
Muaj ntau ntau yam tshuaj uas tau ua ntawm cov qauv ntawm simvastatin. Yog li, koj tuaj yeem hloov Simvastol nrog cov hauv qab no - Simgal, Ariescor, Zovatin, Levomir, Zokor, Simvor, Actalipid.
Ib qho qauv zoo ntawm Simvastol yog Avestatin. Lwm txoj kev hloov tshuaj yog Vasilip. Tseem muaj tus nab npawb ntawm cov tshuaj hu ua cov khoom xyaw nquag.
Cov tshuaj no suav nrog Simvastatin Alkaloid / Vero / SZ / Teva / Pfizer / Chaikafarm / Ferein. Lwm yam tshuaj ntxiv thiab hloov rau cov tshuaj Simvastol - Simvakol, Zorstat, Simlo, Sinkard, Aterostat.
Simvastatin muaj feem ntau zoo xyuas. Qhov no yog vim muaj qhov kho tau zoo ntawm cov tshuaj thiab qhov tsawg kawg muaj kev pheej hmoo ntawm kev tsim cov kev tsis zoo.
Txawm li cas los xij, tib neeg noj cov tshuaj simvostatin-raws li pom tias cov tshuaj muaj peev xwm ua kom tsuas cov roj cholesterol tsis zoo txog 20%. Qhov LDL uas tseem tshuav yuav tau muab tshem tawm los ntawm lub cev los ntawm kev noj zaub mov noj.
Qee cov neeg mob tau tshaj tawm tias Simvastol pab lawv kom tsis txhob muaj kev phais mob. Thiab tom qab kev kawm kho mob rau lub hlis, qhov xwm txheej ntawm lub plawv thiab cov hlab ntshav tau zoo dua, uas tau lees paub los ntawm kev sim hauv chaw kuaj.
Tus nqi ntawm cov tshuaj yog nyob ntawm nws ntau npaum li cas. Yog li, Simvastol No. 28 10 mg nqi txog 187-210 rubles, thiab Simvastol 20 mg - txog 330 rubles.
Yuav ua li cas txo cov roj hauv cov ntshav yuav qhia tus kws tshaj lij hauv cov yeeb yaj kiab hauv tsab xov xwm no.
