Roxera yog tus neeg sawv cev ntawm ib pawg tshuaj uas cuam tshuam rau cov metabolism hauv lipid. Cov khoom xyaw tseem ceeb ntawm Roxers yog rosuvastatin, uas inhibits qhov enzyme uas hloov cov roj (cholesterol).
Lub ntsiab lus ntawm kev thov ntawm rosuvastatin yog hepatocytes, qhov twg cov roj cholesterol yog sib tov thiab cov atherogenic feem ntawm lipoproteins tawg. Tus txheej txheem ntawm kev ua yog nce tus naj npawb ntawm receptor endings ntawm hepatocytes rau LDL, yog li muab qhov nce siab thiab tawg ntawm LDL, yog li inhibiting cov synthesis ntawm atherogenic lipoproteins.
Ua tsaug rau Roxer, cov roj (cholesterol), atherogenic complexes, triglycerides (TAGs) txo qis, thiab qhov tshuaj ntawm anti-atherogenic feem ntawm lipoproteins ntau ntxiv.
Cov nyhuv hais tawm kho tau tshwm sim ib lub lim tiam tom qab pib ua haujlwm. Hauv plaub lub lis piam ntawm kev kho, qhov siab tshaj plaws ntawm kev siv tshuaj tau tiav, qhia tias cov tshuaj suav tau meej pem.
Cov tshuaj yuav tsum yog kws kho mob sau los ntawm kws kho mob mus koom rau hauv tus account tus yam ntxwv ntawm tus neeg mob.
Kev noj tshuaj rau tus kheej los ntawm Roxeroy tuaj yeem ua rau lub chaw tsis muaj kev phiv tsis txaus siab, suav nrog rhabdomyolysis thiab lub raum tsis ua haujlwm.
Pharmacokinetics thiab cov chaw muag tshuaj
Cov tshuaj muaj nees nkaum feem pua kev nyab xeeb. Kev hloov pauv thiab kev siv ntawm cov tshuaj yog nqa tawm los ntawm daim siab ua haujlwm.
Kwv yees li 90% ntawm Roxers sib xyaw nrog cov ntshav muaj protein ntau, tshwj xeeb nrog albumin. Pharmacokinetics tsis hloov pauv thaum noj tsis tu ncua.
Kwv yees li 90% ntawm rosuvastatin tau muab pov tseg rau hauv nws daim ntawv qub los ntawm kev zom zaub mov. Ib feem me me ntawm cov tshuaj siv tshuaj metabolized hauv lub raum hlaus.
Cov lus qhia rau kev teem caij Roxers yog:
- thawj hypercholesterolemia;
- tsis txaus ntawm lipids;
- caj mob hypercholesterolemia;
- hypertriglyceridemia;
- atherosclerosis;
- raws li ib qho yeeb tshuaj rau kev tiv thaiv thawj ntawm mob plawv tsis txaus hauv cov neeg mob tsis muaj kev soj ntsuam cov tsos mob ntawm lub plawv, tab sis muaj kev pheej hmoo siab.
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog lub plhaub tiv thaiv.
Ib ntsiav tshuaj muaj cov koob tshuaj hauv qab no: 5 milligrams, 10 milligrams, 15 milligrams, 20 milligrams, 30 milligrams, 40 milligrams.
Cov koob tshuaj yog xaiv nyob ntawm daim ntawv thiab qhov mob hnyav ntawm tus kab mob. Kev kho mob nyhuv yog nyob ntawm qhov ntau thiab tsawg zaus noj tshuaj.
Cov haiv neeg thiab caj ces ntawm cov tshuaj tau txawv. Hauv kev sim tshuaj, cov haiv neeg Mooboid, piv nrog Caucasoid, pom tias nce hauv plasma theem ntawm rosuvastatin.
Cov tshuaj Roxer muaj cov lactose carbohydrate, vim tias cov tshuaj no yog txwv rau cov neeg mob uas tsis muaj lactase, nrog rau cov teeb meem carbohydrate malabsorption syndrome.
Vim tias muaj kiv taub hau, mob taub hau thiab mob lwm yam tshwm sim, saib xyuas thiab ceev faj thaum yuav tsum tau tsav lub tshuab thiab tswj cov txheej txheem muaj tseeb.
Cov sijhawm tsis tu ncua thiab kev tswj hwm ntawm cov tshuaj tiv thaiv kev txhim kho ntawm kev phiv tshuaj. Nws yog ib qho tseem ceeb uas yuav tau noj cov tshuaj hauv cov tshuaj kom tsim nyog kom tsis txhob muaj kev ntxhov siab nyob rau daim siab thiab lub raum, vim nws nyob hauv cov kab mob no uas rosuvastatin metabolism tshwm sim.
Tus kws kho mob mus koom yuav tsum xaiv tsis yog txoj kev noj tshuaj nkaus xwb, tabsis tseem muaj cov tshuaj sib txuam nrog lawv tus kheej. Qhov no yog vim qhov tseeb tias feem ntau cov neeg mob nrog atherosclerosis kuj muaj concomitant cardiological pathology.
Cov lus qhia rau kev siv tshuaj
Roxer yog coj raws li cov lus pom zoo ntawm cov ntawv teev lus qhia rau kev siv.
Cov tshuaj yog npaj rau kev siv qhov ncauj. Nws yog txwv tsis pub zom thiab zom cov tshuaj. Cov ntsiav tshuaj yuav tsum tau muab sau rau hauv nws cov ntawv qub, ntxuav cia nrog cov kua ntau dhau. Txais sijhawm twg los tau, tsis hais los ntawm cov khoom noj.
Cov nyhuv ntawm cov tshuaj yog pom tsuas yog tshwj xeeb kev noj zaub mov raws. Thaum pib ntawm kev kho mob, 5 milligrams ntawm cov tshuaj yog kws kho ib hnub. Thaum xaiv cov tshuaj ntau npaum li cas, ntshav hauv cov qib ntshav yog coj mus rau hauv tus lej thiab coj mus rau hauv tus account qhov kev pheej hmoo ntawm cov hlab plawv kev puas tsuaj. Ib qho ntxiv, xyuam xim rau kev pheej hmoo tus kheej ntawm kev phiv.
Koj tuaj yeem nce qhov ntxiv tom qab ib hlis txij thaum pib kho. Kev noj tshuaj ntawm 40 mg yog fraught nrog ntau qhov tshwm sim piv nrog kev txo qis ntawm cov tshuaj. Xws li lub siab xav nce ntxiv tau pub rau ib hlis thiab tau nqa tawm tshwj xeeb hauv cov neeg mob uas muaj kev paub tseeb ntawm hypercholesterolemia thiab nrog txoj kev pheej hmoo loj ntawm kev txhim kho plawv hlab ntsha. Txoj kev kho yog ua tiav los ntawm kev saib xyuas ntawm tus kws kho mob.
Tom qab ib hlis ntawm txoj kev kho mob lossis thaum muaj kev hloov pauv ntawm cov tshuaj, yuav tsum tau siv cov lipid. Rau cov neeg mob uas muaj lub raum tsis zoo lub raum tsis ua hauj lwm (kev tsim muaj peev xwm tsis pom zoo tsawg dua 30 milliliters ib feeb), kev siv tshuaj muaj yees tsis tso cai.
Rosuvastatin tsis tuaj yeem siv tshuaj rau cov neeg mob mob siab mob thaum lub sijhawm mob hnyav. Cov neeg mob hnub nyoog tshaj 65 xyoos yuav tsum tau pib noj nrog qhov tsawg kawg ib hnub twg tshuaj.
Cov Kev Txwv Tsis Zoo thiab Kev Txwv Roxers
Kev phiv tshuaj tsis ncaj qha nyob ntawm qhov koob tshuaj thiab ntawm tus kheej ntawm tus neeg mob.
Cov kev mob tshwm sim yog cais raws li qhov nquag tshwm sim thiab cov yam ntxwv ntawm kev ua kom pom.
Cov kev nquag tshwm sim feem ntau suav nrog kev tsis haum lub ntsej muag (Quincke's edema, urticaria, anaphylactic shock); mob taub hau Kiv taub hau polyneuropathy; ua txhaum ntawm lub cim xeeb ua haujlwm. Kev ua txhaum ntawm lub plab zom mov nyob rau hauv daim ntawv ntawm quav tawv, ua raws li zawv plab, xeev siab thiab ntuav, mob thiab tsis xis nyob hauv plab tsis cais; daim siab ua paug, kab mob siab nrog rau qhov mob ua paug loj; Stevens-Johnson mob; mob leeg nqaij; myopathy thiab rhuav tshem cov leeg nqaij; mob tej pob txha poob ntawm cov protein nyob hauv cov zis; poob ntawm cov ntshav liab hauv cov zis; mob asthenic; cov ua cov thyroid hormones txaus.
Vim tias lub siab haus tshuaj ntau dhau ntawm cov tshuaj, cov chaw tsim khoom lag luam qhia qee qhov kev txwv ntawm kev siv Roxers. Cov kev txwv tseem ceeb yog:
- Tus nquag daim ntawv ntawm tus kab mob siab lossis lwm yam kab mob siab.
- Mob raum tsis ua haujlwm.
- Myopathy
- Txais tos nrog cytostatic cyclosporin.
- Ib txhij siv nrog fibrates.
- Lub sijhawm ntawm cev xeeb tub thiab lactation.
- Lactose tsis txaus ntseeg.
- Cov me nyuam lub hnub nyoog.
- Tus neeg tsis qaug rau yeeb tshuaj.
Kev noj cov tshuaj thaum cev xeeb tub thiab lactation yog kiag li contraindicated. Contraindication yog txuam nrog kev ua haujlwm teratogenic siab ntawm cov tshuaj yeeb dej caw.
Rosuvastatin yog sib kis rau cov neeg tsis tau muaj 18 xyoo. Nrog kev ceev faj, cov tshuaj yuav tsum raug qhia rau cov neeg laus.
Kev xaiv cov tshuaj txhaj rau cov tshuaj muaj zog yog tsim rau lub raum ua haujlwm tsis zoo, vim rosuvastatin muaj cov nyhuv nephrotoxic. Thaum noj ntau dua 30 mg rau ib hnub twg ntawm cov tshuaj yeeb dej caw, kev kuaj xyuas lub raum ua haujlwm yog qhov tsim nyog.
Cov tshuaj yog myotoxic. Myalgia thiab leeg leeg mob tau sau tseg thaum ua ke nrog lwm cov tshuaj lipid-txo qis. Yog hais tias tus neeg mob tau mob nqaij, tsis muaj zog, mob plab me ntsis nrog rau kev sib xyaw ua ke ua ke nrog mob, tus kws kho mob uas koom nrog yuav tsum paub tam sim. Nws tseem yog ib qho tseem ceeb los txiav txim siab sai sai ntawm lub siab ntawm creatine phosphokinase hauv cov ntshav.
Kev kho yog nres nrog qhov nce ntawm creatine phosphokinase lossis nrog qhov kev vam meej ntawm cov tsos mob ntawm cov leeg mob, mob plab thiab tsis muaj zog.
Kev cuam tshuam ntawm Roxers nrog lwm cov tshuaj
Tshuaj Roxers yog tus cwj pwm los ntawm qee qhov kev sib txuam tshuaj nrog lwm cov tshuaj.
Thaum siv cov tshuaj nrog lwm tus neeg sawv cev, kev cuam tshuam tau ntawm kev sib txuam ntawm lawv yuav tsum raug txiav txim siab.
Nrog rau cov tshuaj hauv qab no, cov tshuaj yeeb yaj kiab muaj qee yam nyhuv pharmacokinetic:
- Antimetabolite "Nonklosporin". Nrog rau kev siv ua ke ntawm kev siv tshuaj, ib qho kev nce ntxiv ntawm rosuvastatin hauv ntshav tau sau tseg.
- Warfarin. Kev tswj hwm ib txhij ntawm cov tshuaj kuj ua rau muaj kev phom sij rau tus neeg mob. Ua ke tswj hwm nrog indirect anticoagulants tsub kom lub siab ntawm rosuvastatin thiab ntau dua li qub rau qhov feem pua neeg txawv teb chaws.
- Ezetimibe. Kev siv cov tshuaj thaum lub caij ua ke tsis nce siab ntxiv ntawm ob qho tib si hauv cov ntshav. Tab sis ezetimibe yuav ua rau muaj kev pheej hmoo ntawm myotoxic kev tsis haum.
- Lwm yam tshuaj lipid-txo qis. Nrog rau kev tswj hwm tib lub sijhawm, ob npaug ntawm qhov kev coj ua ntawm Rosuvastatin hauv ntshav yog sau tseg. Xws li kev sib xyaw ua ke ua rau muaj feem pheej hmoo ntawm kev txhim kho cov nqaij ntshiv pathology.
- Cov tshuaj tua kab mob tiv thaiv: tib neeg cov tshuaj tiv thaiv kab mob tiv thaiv kab mob protease inhibitors. Xws li kev sib xyaw ua kom nce qib plasma ntau ntawm rosuvastatin.
- Tshuaj Antacids. Kev sib xyaw ntawm rosuvastatin nrog tshuaj tua kab mob, uas suav nrog aluminium thiab magnesium hydroxide, ua rau txo qis ntshav ntawm rosuvastatin los ntawm ntau dua ib nrab. Txo kom txo tau cov txiaj ntsig zoo ib yam li ntawd, tshuaj tiv thaiv kab mob tau muab tshuaj li ob teev tom qab txhaj koob tshuaj tiv thaiv rosuvastatin kawg.
- Tshuaj tua kab mob Erythromycin. Ib txhij tswj kev tswj hwm ua rau txo qis hauv kev ua kom muaj zog ntawm rosuvastatin. vim muaj plab hnyuv ntau ntxiv.
- Sib xyaw ua ke ntawm lub qhov ncauj thiab lwm yam kev kho tshuaj hormones. Kev siv yooj yim nrog rosuvastatin tsub kom cov concentration ntawm cov tshuaj hormonally nquag nyob rau hauv cov ntshav ntshav. Txhawm rau tshem tawm cov kev tsis haum tawm li no, kev kho kom haum rau tom kawg yog nqa tawm.
- Mob glycosides.
Kev sib raug zoo nrog cov tshuaj saum toj no tsawg. Kev teem caij sib ntsib yuav tsum tau pom zoo kom meej raws li tus neeg tus yam ntxwv ntawm tus neeg mob.
Cov tshuaj nyob rau hauv lub lag luam domestic
Cov tshuaj no tuaj yeem tau yuav hauv txhua lub tsev muag tshuaj hauv tebchaws Russia thiab CIS.
Cov tshuaj muaj muag nyob rau tom khw lag luam nyob hauv teb chaws tsis tau tshuaj.
Tus nqi nce nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj.
Hnub no tus nqi nws txawv:
- ntsiav tshuaj nrog ib qhov tshuaj ntawm 5 mg rau 90 pcs. - 1056 rubles;
- ntsiav tshuaj nrog ib qhov tshuaj ntawm 10 mg rau 30 pcs. thiab 90 pcs. - 461 rub. thiab 999 rubles. kom yog;
- ntsiav tshuaj nrog qhov ntau npaum ntawm 15 mg rau 30 thiab 90 pcs. - 404 RUB. thiab 1225 rubles. kom yog;
- ntsiav tshuaj nrog ib qhov tshuaj ntawm 20 mg rau 30 pcs. txog 690 rub.
Ntawm kev lag luam pharmacological ntawm Russia muaj ntau ntawm Roxer analogues. Cov tshuaj analogue yog yeeb tshuaj nrog tshuaj muaj zog zoo ib yam. Cov tshuaj thoob ntiaj teb tsis zoo Rosuvastatin yog cov tshuaj muaj nyob hauv ntau cov tshuaj nyob rau hauv Lavxias khw. Lub npe ntawm cov tshuaj tej zaum tsuas txawv.
Cov tshuaj yog tsim los ntawm Slovenian txhawj xeeb "Krka". Tab sis kuj ntau cov tuam ntxhab, suav nrog cov neeg hauv tsev, koom nrog kev kawm tiav ntawm rosuvastatin. Tsis tas li ntawd, tseem muaj lwm tus neeg sawv cev ntawm pawg statin.
Kev npaj ntawm cov pab pawg muaj feem cuam tshuam (Atorvastatin, Rosuvastatin Canon, Tevastor, thiab lwm yam) tseem yog cov analogues hauv cov yam ntxwv ntawm cov mechanism ntawm kev nqis tes ua. Kev xaiv ntawm hom tshuaj tshwj xeeb yog nyob ntawm tus yam ntxwv ntawm tus neeg mob.
Roxer muaj ntau cov kev tshuaj xyuas ntawm cov neeg mob noj cov tshuaj no.
Feem ntau cov kev tshuaj xyuas dua yog qhov zoo, tshwj tsis yog muaj kev phiv tshuaj. Roxera tshuaj xyuas tsis pom zoo yog tias mob ntev.
Feem ntau muaj kev cuam tshuam tsis zoo rau lub cev tshwm sim vim qhov tseeb tias tus neeg mob haus cawv thaum kho, kho cov tshuaj ntawm nws tus kheej lossis siab dua cov koob tshuaj pom zoo rau nws tus mob. Xws li tshuaj xyuas cov tshuaj tsis yog lub hom phiaj thiab tsis tuaj yeem ua lub hauv paus tsim nyog ntawm qhov tsis kam siv tshuaj.
Nrog rau kev tswj hwm kev muaj peev xwm, cov tshuaj yuav tsum pab cov neeg mob. Nws yog cov lipid-txo cov khoom ntawm cov tshuaj uas tuaj yeem txo cov roj cholesterol thiab qhov kev pheej hmoo ntawm atherosclerosis thiab nws cov teeb meem tshwm sim. Ib qho kev mob tshwm sim ntawm kev noj tshuaj yog qhov tsawg dua qhov xav tias yuav kho tau.
Nws yog ib qho tseem ceeb rau kev ua ke ntawm kev haus dej ntawm txhua cov lipid-txo cov tshuaj nrog kev noj kom zoo thiab ib qho kev ua neej zoo.
Ib qho kev sib koom ua ke ntawm kev tawm tsam kev mob plawv thiab lwm yam kev mob tshwm sim ntawm atherosclerosis yog qhov ua tau zoo tshaj plaws thiab kev suav tias yog.
Statins tau piav qhia hauv daim video hauv kab lus no.
