Dilaprel yog siv los kho ntshav siab thiab mob myocardial infarction. Muab cov nyhuv ntev ntev thiab txhim kho cov ntshav suav. Cov tshuaj tsis quav tshuaj ntxiv thiab thim tawm.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Ramipril (zoo ib yam li lub npe ntawm cov nquag nquag).
Dilaprel yog siv los kho ntshav siab thiab mob myocardial infarction.
ATX
Qhov ATX code yog C09AA05.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj ntsiav
Qhov sib xyaw ua ke ntawm cov tshuaj ntsiav muaj 2.5 mg ntawm ramipril, 0.143 g ntawm lactose.
Daim ntawv tsis muaj
Ntsiav tshuaj yog ib hom tshuaj uas tsis muaj nyob niaj hnub no.
Pharmacological kev txiav txim
Nyob rau hauv kev cuam tshuam ntawm daim siab enzymes hauv lub cev, tshuaj lom biologically compound, ramiprilat, yuav muab tso ua ke. Hais txog ACE inhibitors ntev ntev - kininase. Hauv cov ntshav, ACE nrawm dua qhov kev hloov ntawm angiotensin-1 rau angiotensin-2, uas muaj vasoconstrictor effect.
Nrog rau cov hlab ntsha o, qhov kev txo qis hauv cov ntshav siab tshwm sim vim yog nthuav dav ntawm cov hlab ntsha tsis nce nrawm dua cov lej hauv lub plawv.
Txais tos ntawm Dilaprel txhawb kev tsub zuj zuj ntawm bradykinin hauv cov hlwb thiab cov nqaij hauv lub cev. Tus txheej txheem no pab txhawb kev nthuav dav ntawm cov hlab ntsha thiab txo qis siab. Cov tshuaj pab tiv thaiv cov leeg mob plawv los ntawm kev nce cov ntsiab lus ntawm cov potassium ions hauv cov ntshav thiab sodium hauv ntshav. Raws li cov ntsiab lus ntawm angiotensin-2 txo, qib ntawm renin txo.
Nrog rau cov hlab ntsha o, qhov kev txo qis hauv cov ntshav siab tshwm sim vim yog nthuav dav ntawm cov hlab ntsha tsis nce nrawm dua cov lej hauv lub plawv. Tus txheej txheem no tshwm sim yam tsis muaj kev cuam tshuam ntawm cov hlab ntshav ntawm lub raum thiab qhov tsis pom kev ua haujlwm hauv lub raum glomeruli.
Qhov pib ntawm antihypertensive kev ua si ntawm cov tshuaj pib 60 feeb tom qab kev tswj hwm qhov ncauj. Qhov kawg kev kho mob ua rau nws tus kheej tom qab 6 teev thiab tseem nyob rau theem siab thoob plaws hnub. Hauv kev kho mob, cov nyhuv no txuas ntxiv rau 4 lub lis piam tom qab tshem tawm, tom qab ntawd me ntsis poob qis thiab kav ntev mus ntev.
Qhov tsis tau npaj txhij txog ntawm kev siv cov tshuaj tsis ua rau muaj kev nce siab, i.e. ntsoos ntsoos mob tsis muaj mob.
Cov tshuaj txo qhov hnyav ntawm lub siab thiab nce qhov ntim ntawm lub txaj venous. Tawm tsam keeb kwm yav dhau los ntawm kev siv Dilaprel, cov khoom ntim hauv plawv ntau dua. Cov neeg mob noj cov tshuaj no ntau dua los xav txog kev ua si.
Cov tshuaj txo qhov hnyav ntawm lub siab thiab nce qhov ntim ntawm lub txaj venous.
Cov cuab yeej ua haujlwm qeeb ntxiv rau kev txhim kho ntxiv rau lub raum tsis ua hauj lwm thiab qeeb rau lub sijhawm ntawm nws lub davhlau ya nyob twg, thaum qhov kev ua haujlwm tseem ceeb tsuas yog txhawb los ntawm kev lim ntshav lossis hloov raum. Qhov sib ntxiv ntawm Dilaprel rau txoj kev sib xyaw ua ke txo txoj kev pheej hmoo ntawm lub plawv nres, mob hlab ntsha tawg, tuag los ntawm kab mob plawv thiab cov hlab ntshav. Tom qab sau tshuaj rau hauv cov tshuaj tiv thaiv mob plawv, qhov yuav tshwm sim muaj kev tuag txo los ntawm ¼.
Cov Tshuaj Pharmacokinetics
Tom qab kev tswj hwm sab hauv, cov tshuaj feem cuam tshuam tau yooj yim ntawm txoj hnyuv. Noj qee yam qeeb qeeb hauv cov txheej txheem no. Lub bioavailability tsis tshaj 28% rau ramipril thiab 45% rau nws cov metabolite ramiprilat. Lub plasma concentration ntawm ramipril nce sai, thiab nyob rau hauv kev cuam tshuam ntawm daim siab enzymes ua lub siab tshaj plaws tom qab 4 teev. Kev khi rau ntshav cov ntshav los ntawm kwv yees li 73%.
Tom qab kev tswj hwm sab hauv, cov tshuaj feem cuam tshuam tau yooj yim ntawm txoj hnyuv.
Cov txheej txheem metabolism tshwm sim hauv daim siab ua haujlwm, qhov twg ramiprilat yog tsim. Hauv lub cev no, kev tsim cov tshuaj tsis muaj zog tshwm sim - ramipril glucuronides lossis diketopiperazine ether thiab acid, uas tsis muaj tus nqi kho.
Ib nrab-lub neej ntawm cov tshuaj uas muaj nyob hauv qhov kev npaj yog txog 5 teev. Cov txheej txheem ua rau qeeb qis hauv lub raum pathologies. Nws yog khiav tawm hauv cov ntshav feem ntau los ntawm txoj hnyuv thiab tsawg dua - nrog quav.
Kev ntsuas rau siv
Cov tshuaj yog qhia rau cov kab mob zoo li no:
- Tawg (kho raws li kev kho ib cov tshuaj thiab ua ib feem ntawm txoj kev kho mob hnyav). Nws kuj tseem tuaj yeem tau sau tseg thaum noj cov tshuaj diuretics los ua kom ntshav nce siab.
- Tus mob ntshav qab zib ntshav qab zib uas muaj ntshav qab zib, suav nrog thiab hauv cov theem preclinical ntawm tus kab mob.
- Proteinuria (qhov pom ntawm protein nyob hauv cov zis) tawm tsam keeb kwm ntawm kev mob ntshav siab ntev.
- Ischemic tus kab mob, lub plawv nres (keeb kwm). Nws yog kws kho mob rau cov neeg mob uas underwent percutaneous transluminal angioplasty lossis coronary artery bypass grafting.
- Mob hnyav ncig hauv cov hlab hlwb, suav nrog thiab hauv anamnesis.
- Mob ntshav qab zib, nyuaj los ntawm cov tsos hauv cov zis ntawm albumin, ntshav siab, nce ntxiv hauv lub plasma concentration ntawm txhua feem ntawm cov roj cholesterol hauv cov ntshav.
- Kev soj ntsuam mob hnyav mob ntshav txhaws.
Cov Yuav Tsum Muaj
Nws raug txwv tsis pub noj tshuaj nyob rau hauv xws li:
- Kev tsis haum rau ACE inhibitor kev kho.
- Kev nce qib ntawm angioedema edema (mob muaj keeb, nrhiav los yog idiopathic).
- Qhov nqaim ntawm cov hlab ntsha ntawm ob lub raum (tsis suav thiab ob tog) thaum tswj kev ua haujlwm tsuas yog lub raum.
- Kev nce hauv systolic siab siab tshaj 90 hli, thaum tswj hwm ntawm pathological hemodynamics.
- Ib txhij tswj hwm ntawm angiotensin-2 antagonists rau nephropathy ntawm ntshav qab zib keeb kwm.
- Qhov nqaim ntawm lub plawv li qub.
- Ib qho kev nce ntxiv ntawm aldosterone hauv cov ntshav.
- Kev mob tsis zoo rau lub raum nrog creatinine tshem tawm tsawg dua 20 cm3 ib feeb.
- Kev lim ntshav.
- Nees Qaum Ntuj
- Decompensated mob plawv tsis ua haujlwm.
- Kev kho mob cuam tshuam nrog kev tshem tawm cov roj tsawg kawg ntawm lub cev.
- Ua cov tshuaj tiv thaiv kev ua xua nyob rau hauv cov neeg raug kev txom nyem los ntawm kev ua si rau lub sijhawm lom ntawm cov muv, ntxais thiab lwm yam hymenoptera.
- Txais yuav ib qho tshuaj twg uas muaj aliskiren.
- Cov lactose tsis txaus ntseeg thiab ntshav tsis txaus lactase, incl. malabsorption.
- Lub sijhawm so.
- Lub plawv dhia tsis zoo thiab tsis khov kho lub pob pectoris.
- Lub cev tsis muaj pa (muaj kev pheej hmoo rau lub neej).
- Lub plawv mob ntsws.
Nrog saib xyuas
Kev saib xyuas yuav tsum tau ua rau thaum muaj:
- kev siv tshuaj ib txhij nrog Aliskiren;
- nce ntxiv ntawm cov concentration ntawm cov poov tshuaj nyob rau hauv cov ntshav tawm tsam keeb kwm ntawm kev ua tsis zoo ntawm lub raum
- kev ua rau lub siab poob qis;
- kev nkag ua ntej ntawm diuretics;
- imbalance ntawm dej thiab electrolytes;
- kev loj hlob ntawm cov kab mob siab mob rau daim siab, ascites (ua kua);
- mob raum;
- qee qhov kab mob autoimmune;
- hnub nyoog siab heev.
Yuav Ua Li Cas Noj Dilaprel
Tsuas yog siv cov tshuaj ntawm qhov ncauj, ntxuav nws nrog lub cev kua txaus. Thawj koob tshuaj yog 1 ntsiav tshuaj thaum sawv ntxov ib zaug ib hnub. Yog tias tom qab 21 hnub nws tsis tuaj yeem ua lub suab ntsuas qhov ntsuas qhov siab, ces cov tshuaj txhua hnub yog nce rau 5 mg. Yog tias qhov no tsis pab, tom qab ntawd noj Dilaprel ntxiv, thiab cov koob tshuaj tau kho rau 10 mg rau ib hnub hauv 2 tsiav tshuaj kom muaj cov tshuaj tiv thaiv muaj zog ntau dua qub.
Qee lub sij hawm es tsis txhob nce cov tshuaj ntxiv, lwm cov tshuaj tiv thaiv antihypertensive.
Nrog ntshav qab zib
Hauv cov kab mob ntshav qab zib nephropathy, 2.5 mg yog tshuaj. Qhov siab tshaj plaws ntawm cov tshuaj yog 5 mg.
Phiv los ntawm Dilaprel
Daim ntawv thov cuam tshuam nrog kev pheej hmoo ntawm kev tshwm sim tsis zoo rau ib leeg.
Ntawm ib feem ntawm cov plab hnyuv siab raum ntawm lub zeem muag
Qhov tshwm sim ntawm qhov muag pom kev tsis pom kev zoo (plooj duab) thiab kev txhim kho ntawm cov mob txuas yog ua tau.
Los ntawm ob sab ntawm cov plab hnyuv siab raum ntawm lub zeem muag, qhov zoo li pom ntawm qhov muag pom kev tsis pom tseeb (ntsej muag duab) yog tau.
Los ntawm cov leeg nqaij thiab pob txha sib txuas
Feem ntau cov tshuaj tuaj yeem ua rau mob nqaij pob txha, mob nqaij.
Kev kho mob txoj hnyuv
Kev tsim kho tau ntawm kev ntshawv siab:
- mob hauv lub plab thiab cov hnyuv;
- zawv plab
- dyspepsia
- xeev siab
- mob qa (nyob rau hauv qee kis tau nrog rau kev mob tshwm sim);
- nce kev ua si ntawm pancreatic enzymes;
- kev xav ntawm kev nqhis dej.
Hematopoietic plab hnyuv siab raum
Ua tsis tau, kev txhim kho ntawm tshwm sim yog ua tau:
- eosinophilia;
- qhov txo qis hauv cov qe ntshav dawb;
- poob hauv cov ntshav liab;
- qhov txo qis hauv cov hemoglobin;
- inhibition ntawm cov ntshav tsim hauv cov pob txha pob txha.
Nruab nrab hauv lub paj hlwb
Kev tsim kho tau:
- kev mob tob hau;
- Kiv taub hau
- leeg mob ruas;
- tsis txaus ib ntus;
- kev ntxhov siab nyob rau hauv qhov kev xav ntawm sib npaug;
- ntxuag cov ntshav khiav ua haujlwm hauv lub plawv;
- kev hnov mob hauv lub cev;
- ntws tawm ntawm daim tawv nqaij ntawm lub ntsej muag;
- muaj kev ntxhiab tsw txawv.
Los ntawm cov kab mob zis
Tsis tshua muaj qhov tsis txaus, lub raum lub ntsej muag nrog kev mob tsis zoo tuaj yeem tsim kho.
Los ntawm lub tshuab ua pa
Qhov hnoos qhuav, o ntawm lub ntsws thiab txoj hlab ntshav ntawm lub ntsej muag yuav tshwm sim. Tsis tshua muaj qhov ua rau mob ntsws thiab txhaws ntswg.
Ntawm ib sab ntawm daim tawv nqaij
Ntawm daim tawv nqaij, cov tsos ntawm:
- daim tawv nqaij xoo pob;
- mob hlwb;
- urticaria;
- kev puas tsuaj ntawm ntsia hlau phaj;
- lub siab hloov mus rau qhov kaj;
- Tus kab mob Stevens-Johnson;
- dermatitis zoo li psoriasis.
Los ntawm genitourinary system
Qee lub sij hawm cov txiv neej tuaj yeem txhim kho lub sijhawm erectile kawg, txo qis libido.
Los ntawm cov hlab plawv system
Tej zaum ib qho kev ua txhaum ntawm cov ntshav pub rau lub plawv mob, tachycardia, kev txhim kho ntawm edema. Cov neeg mob tej zaum yuav txhawj xeeb txog qhov txo qis hauv qhov ntsuas taw qhia, qhov kev vam meej ntawm cov hlab ntsha o tuaj nrog kev hloov chaw hauv lub cev, mob rau ntawm cov hlab ntsa thiab lwm yam zoo li pathologies.
Endocrine system
Kev txhim kho ntawm tus mob syndrome ntawm hyper- lossis txo qis ntawm ADH. Hauv cov txiv neej, kab mob gynecomastia yuav tshwm sim.
Ntawm ib sab ntawm daim siab thiab cov hnyuv
Ib qho kev nce ntawm enzyme kev ua si, nrog rau kev nce ntxiv hauv cov concentration ntawm conjugated bilirubin hauv cov ntshav. Jaundice yuav tsis tshua muaj tshwm sim vim cov neeg tawv ncauj. Kab mob siab hom tuag taus yog qhov tsawg kawg.
Los ntawm daim siab thiab mob biliary, mob daj ntseg yuav tshwm sim.
Los ntawm ib sab ntawm cov metabolism
Kev noj tshuaj yuav tuaj yeem ua rau muaj kev nce siab ntxiv ntawm cov potassium ions hauv cov ntshav ntshav. Tsis tshua muaj qhov tsis tshua muaj qab los noj mov mus txog qhov tsis nco qab.
Kev ua xua
Kev phom sij phiv tshuaj muaj qee zaum kuj tshwm sim. Qhov kev pheej hmoo ntawm lawv tsim tom qab muv stings nce.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Koj yuav tsum ceev faj nyob rau hauv tus txheej txheem ntawm tsav tsheb thiab tswj cov txheej txheem nyuaj. Nrog lub suab nyiam ua syncope, koj yuav tsum tso cov haujlwm no pov tseg.
Cov lus qhia tshwj xeeb
Kev ceev faj yuav tsum tau siv ntau qhov ntau.
Siv rau lub sijhawm qub
Nws yog qhov tsim nyog los txo cov tshuaj lossis kho cov neeg laus hauv tsev kho mob.
Nws yog qhov tsim nyog los txo cov tshuaj lossis kho cov neeg laus hauv tsev kho mob.
Txiag tej menyuam
Nws yog txwv tsis pub muab rau menyuam yaus.
Siv thaum cev xeeb tub thiab lactation
Tsis pom zoo thaum cev xeeb tub. Yog tias kev xeeb tub tau tshwm sim, tom qab ntawd koj yuav tsum hloov cov tshuaj nrog kev nyab xeeb dua tam sim ntawd, txwv tsis pub cov kab mob hauv qab no yuav tshwm sim:
- kev puas tsuaj rau lub raum ntawm ib tug menyuam;
- embryo oxygen starvation;
- siab poob;
- underdevelopment ntawm cranial cov pob txha;
- fusion ntawm cov nqua;
- underdevelopment ntawm lub ntsws.
Tsis pom zoo thaum cev xeeb tub.
Rau lub sijhawm ntawm kev kho mob, kev pub mis niam yog qhov txwv tsis pub siv.
Noj ntau dhau ntawm Dilaprel
Nyob rau hauv cov ntaub ntawv ntawm overdose, sab tsos mob yog pom.
Kev cuam tshuam nrog lwm yam tshuaj
Contraindicated kev sib txuas ua ke
Siv tib txhij nrog Aliskiren analogues txwv tsis pub rau cov neeg mob ntshav qab zib thiab lub raum tsis ua haujlwm. Nws tsis pom zoo kom siv cov tshuaj tiv thaiv zoo ib yam li qub - angiotensin-2 inhibitors.
Tsis pom zoo kev sib txuas ua ke
Koj tuaj yeem siv tsis tau cov tshuaj uas muaj ntsev ntsev, potassium-khaws cia diuretics.
Koj yuav tsum tsis txhob ua ke nrog cov tshuaj nrog Telmisartan cov ntsiab lus.
Tej kev sib txuam uas xav tau ceev faj
Koj yuav tsum ceev faj thaum siv tshuaj nrog:
- lithium cov ntsev;
- tricyclic cov tshuaj tiv thaiv kab mob;
- cytostatics;
- tshuaj loog (thov rau sab saum toj lossis rau kev siv dav dav);
- pw tsaug zog tshuaj;
- vasopressor sympathomimetic tshuaj (Dobutamine, Epinephrine, thiab lwm yam.)
- kev npaj kub;
- ib qho tshuaj hypoglycemic (qhov kev pheej hmoo ntawm kev tsim ua rau lub xeev tsis nco qab nce ntxiv);
- non-steroidal anti-inflammatory tshuaj tiv thaiv.
Koj yuav tsum ceev faj thaum siv cov tshuaj nrog cov tshuaj tsaug zog.
Cawv tau zoo
Nws yog qhov txwv tsis pub coj nrog ethanol.
Analogs
Cov tshuaj yeeb yaj kiab muaj xws li:
- Pob Tsuas;
- Pyramids;
- Huab Tais;
- Ramipril;
- Amprilan.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Koj tuaj yeem yuav tau tom khw muag tshuaj tsuas yog tomqab siv tshuaj tas los ntawm kws khomob.
Koj tuaj yeem yuav tau tom khw muag tshuaj tsuas yog tomqab siv tshuaj tas los ntawm kws khomob.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Qee cov chaw muag tshuaj muaj lawv cov neeg yuav khoom ntawm Dilaprel tsis yuav nqa cov ntawv kho mob. Cov kev ua no yog ua txhaum txoj cai. Cov neeg mob uas noj cov tshuaj raws txoj kev txaus ntshai no lawv tus kheej.
Nqe ntawm Dilaprel
Tus nqi ntawm kev ntim yog li 200 rubles.
Cia rau cov neeg mob rau cov tshuaj
Khaws rau hauv qhov chaw tsaus thiab txias, kom deb ntawm cov me nyuam.
Hnub tas sij hawm
Tsim nyog siv nyob rau hauv 24 lub hlis txij li hnub ntawm kev tsim khoom.
Chaw tsim tshuaj paus
Nws yog tsim ntawm Lavxias kev lag luam "Vertex".
Kev txheeb xyuas ntawm Dilaprel
Ivan, 50 xyoo, Kolomna: "Nrog kev pab los ntawm Dilaprel, nws muaj peev xwm ua kom lub cev tiv thaiv kev mob tshwm sim ntawm txoj hlab ntshav siab. Muaj cov teeb meem mob ntshav siab thaum lub sijhawm luv siab nce mus txog ib puag ncig 180. Qhov hnov tau hnyav heev. Tsuas yog kev pab los ntawm Dilaprel nws muaj peev xwm ua kom nws qis dua qub. cov kev kho mob tsis tau ceeb toom cov kev mob tshwm sim. "
Svetlana, hnub nyoog 49 xyoo, Moscow: "Lawv tau muab cov tshuaj no rau kev kho mob ntshav siab.Kev ntshai ntawm cov kws kho mob ceeb toom tias ib qho kab mob uas tsis tau kho kiag tuaj yeem ua rau myocardial infarction lossis mob stroke. Yog li ntawd, nws yooj yim pom zoo los siv yeeb tshuaj uas muaj zog. Txawm hais tias qhov tseeb tias cov lus qhia tau qhia ntau ntau ntawm cov kev phiv, lawv tsis yog. "
Olga, hnub nyoog 58 xyoo, St. Petersburg: "Kuv tau noj tshuaj raws li kws kho mob tau hais kom tiv thaiv kev pheej hmoo ntawm lub plawv nres. Kuv raug mob ntshav siab tau ntev thiab ntau yam tshuaj tau siv los kho nws. Cov tshuaj tau raug kho los txhim kho txoj kev kho mob. Kuv tuaj yeem tiv taus cov tshuaj zoo thiab ua raws txhua tus kws kho mob tau teem tseg." Cov.
