Cov twj yog npaj rau kev kho mob ntshav qab zib hom 2. Cov tshuaj nquag ua rau cov muaj hlwb ua kom yuag tuaj yeem tsim cov insulin ntau dua rau cov ntshav qab zib.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Gliclazide.
Mob ntshav qab zib MV yog tsim rau kev kho mob hom 2 ntshav qab zib.
ATX
A10BB09.
Tso cov ntawv thiab cov nyob ua ke
Muaj nyob hauv ntsiav tshuaj daim ntawv:
- 15 pcs., Tau ntim rau hauv cov hlwv rau 2 lossis 4 pcs. nrog cov lus qhia rau kev siv ntim hauv thawv ntawv thawv;
- 30 pcs., Zoo li ntim ntawm 1 lossis 2 blisters ib ntim.
1 ntsiav tshuaj muaj 60 mg ntawm cov tshuaj nquag - gliclazide.
Ntu Cheebtsam:
- hypromellose 100 cP;
- anhydrous colloidal silicon dioxide;
- maltodextrin;
- magnesium stearate;
- lactose monohydrate.
Diabeton MV yog muaj nyob hauv ntsiav tshuaj daim ntawv.
Pharmacological kev txiav txim
Kev siv tshuaj hypoglycemic.
Cov tshuaj nquag yog sulfonylurea derivative. Piv nrog cov piv txwv, nws muaj nitrogen nrog endocyclic daim ntawv cog lus hauv heterocyclic nplhaib. Vim qhov kev ua ntawm gliclazide nyob rau hauv cov ntshav, qhov feem ntau ntawm cov piam thaj tsawg dua, thiab insulin secretion yog tsa los ntawm beta hlwb ntawm cov islets ntawm Langerhans.
Cov tshuaj muaj zog ntawm C-peptide thiab cov tshuaj insulin tom qab muaj kev kub ntxhov ntxiv li 2 xyoos tom qab kev kho mob.
Kev ua kom tau ntawm cov piam thaj hauv ntshav qab zib hom 2, thaum noj tshuaj, pab kho qhov ua kom tiav thaum kawg ntawm cov tshuaj insulin thiab ua kom nws cov qib thib ob zoo. Kev zais cia nce ntxiv nrog cov piam thaj.
Cov tshuaj muaj zog ntawm C-peptide thiab cov tshuaj insulin tom qab muaj kev kub ntxhov ntxiv li 2 xyoos tom qab kev kho mob.
Nws muaj cov nyhuv hemovascular. Cov tshuaj nquag cuam tshuam rau cov txheej txheem uas pab txhawb kev txhim kho cov teeb meem hauv ntshav qab zib, xws li:
- txo qis hauv kev ua hauj lwm ntawm thromboxane B2 thiab beta-thromboglobulin ua kom cov platelets;
- ua tsis tiav kev cuam tshuam ntawm kev coj thiab ua kom tiav ntawm cov khoom sib dhos.
Txhawb nqa nce kev ua si ntawm cov nqaij mos plasminogen activator thiab kev rov kho dua fibrinolytic kev ua haujlwm ntawm vascular endothelium.
Cov Tshuaj Pharmacokinetics
Kev ua tiav kev nqus ntawm cov tshuaj nquag tshwm sim tom qab noj tshuaj, tsis hais noj mov. Muaj maj mam nce ntxiv nyob rau hauv cov ntshav siab tshaj thawj 6 teev. Kev saib xyuas ntawm lub tiaj toj siab yog 6-12 teev. Tsawg tus neeg tsis kam txais.
Txog li 95% ntawm cov tshuaj nquag khi rau cov ntshav plasma. Qhov ntim ntawm kev faib tawm yog 30 litres. Noj 1 ntsiav tshuaj ib hnub ua rau kev saib xyuas qhov tsim nyog ntawm gliclazide hauv cov ntshav rau ntau tshaj ib hnub.
Kev mob plab zom mov feem ntau tshwm sim nyob hauv daim siab.
Kev mob plab zom mov feem ntau tshwm sim nyob hauv daim siab. Tsis muaj cov metabolites hauv lub plasma ntshav. Cov kab mob Metabolites tsuas yog tawm hauv lub raum, tsawg dua 1% - hloov pauv. Qhov kev tshem tawm ib nrab-lub neej yog 12-20 teev.
Kev ntsuas rau siv
Cov tshuaj yog tshuaj rau lub koom haum saib xyuas qhov ncauj hauv cov kis hauv qab no:
- nyob rau hauv qhov muaj ntawm hom 2 mob ntshav qab zib mellitus nrog kev ua kom tau qis ntawm kev thov zaub mov noj, kev ua kom lub cev thiab poob phaus;
- rau kev tiv thaiv ntawm cov teeb meem: kev sib ntxiv glycemic soj ntsuam cov kev mob ntawm cov neeg mob kom txo tau qhov kev pheej hmoo ntawm micro- (retinopathy, nephropathy) thiab macrovascular cov teeb meem (mob stroke, myocardial infarction).
Tus mob ntshav qab zib MV tau sau tseg nyob rau hauv lub xub ntiag ntawm hom 2 mob ntshav qab zib mellitus nrog kev ua kom tau qis ntawm kev thov zaub mov noj, ua kom lub cev thiab yuag poob.
Cov Yuav Tsum Muaj
Cov tshuaj tsis tuaj yeem sau tseg hauv cov teeb meem hauv qab no:
- ua kom txo tau qhov mob gliclazide thiab lwm yam tshuaj ntawm cov tshuaj, suav nrog rau sulfonamides;
- ntshav qab zib hom 1;
- noj miconazole;
- cev xeeb tub thiab lactation;
- mob ntshav qab zib precoma thiab coma;
- hepatic los yog lub raum tsis ua haujlwm;
- mob ketoacidosis.
Cov tshuaj tseem yog contraindicated hauv cov menyuam yaus.
Nws tsis pom zoo rau siv rau hauv cov neeg mob uas muaj qabzib-galactose malabsorption, galactosemia, ua mob rau lactose tsis haum.
Nrog saib xyuas
Ceev faj cov tshuaj yog siv rau:
- kev quav cawv;
- pituitary lossis adrenal, lub raum lossis daim siab ua haujlwm;
- tsis muaj cov piam thaj-6-phosphate dehydrogenase;
- cov kab mob plawv loj;
- Lub caij nyoog ntev siv glucocorticosteroids;
- Noj tsis tau lossis noj tsis xwm yeem;
- laus lawm.
Yuav Ua Li Cas Noj Kiab Mob MV?
Qhov koob tshuaj txhua hnub yog 0.5-2 ntsiav tshuaj 1 zaug hauv ib hnub. Cov ntsiav tshuaj yog nqos tag nrho yam tsis muaj kev zom thiab ntxo.
Cov ntsiav tshuaj yog nqos tag nrho yam tsis muaj kev zom thiab ntxo.
Cov kev nco txais tsis tau them nyiaj rau qhov nce ntxiv hauv kev txais tos hauv qab no.
Cov koob tshuaj yog txiav txim los ntawm tus kws kho mob nyob ntawm qib HbA1c thiab qib ntshav qab zib.
Kev kho thiab tiv thaiv mob ntshav qab zib
Pib kho nrog a ntsiav tshuaj. Yog tias tswj tau tsim nyog, tom qab ntawd cov koob tshuaj no tau txaus rau kev kho kho. Yog tias glycemic tswj tsis txaus, qhov kev muab tshuaj yuav raug nce ntxiv los ntawm 30 mg tom qab tsawg kawg 1 lub hlis ntawm kev noj cov tshuaj ntawm cov tshuaj uas tau siv yav tas los, tshwj rau cov neeg mob uas cov ntshav qabzib tsis tau txo tom qab 2 lub lis piam kev kho mob. Txog rau tom kawg, qhov koob tshuaj tau nce 14 hnub tom qab pib ua haujlwm.
Qhov siab tshuaj ntau tshaj txhua hnub yog 120 mg.
Pib kho nrog a ntsiav tshuaj.
Rau cov neeg mob uas muaj kev pheej hmoo tias yuav ua rau lub qog ntshav qab zib, qhov tsawg kawg nkaus (0.5 ntsiav tshuaj) yog tau sau tseg.
Txog kev tiv thaiv cov mob ntshav qab zib muaj teeb meem, cov koob tshuaj yuav maj mam nce mus rau 120 mg / hnub. Kev noj tshuaj yog nrog lub cev ua si thiab kev noj haus kom txog rau qib HbA1c tau mus txog. Thaum kho, lwm yam tshuaj hypoglycemic tuaj yeem siv:
- Cov tshuaj insulin
- alpha glucosidase inhibitor;
- thiazolidinedione derivative;
- Metformin.
Kev noj cov tshuaj nrog rau kev noj haus.
Daim ntawv thov lub cev
Tus neeg tawm lub cev xav tau cov chav kawm insulin rau nce hnyav. Hauv kev ua kis las no, nws yog nrov vim qhov tseeb tias:
- muag dawb hauv khw muag tshuaj;
- tsis ua kev puas tsuaj rau kev noj qab haus huv;
- muaj cov nyhuv ntawm lub cev me me.
Kev siv cov tshuaj yuav tsum tau ua ke nrog kev sib tw ntawm cov neeg ncaws pob. Nws yog qhov zoo dua rau kev ci lossis ncu. Cov tshuaj no tau noj ntawm lub plab tas li ib nrab teev ua ntej noj mov. Tsis txhob noj zaub mov thaum kawm thiab ± 1 teev ua ntej thiab tom qab.
Cov tshuaj raug coj 3 zaug hauv ib hnub. Qhov koob tshuaj tau txiav txim los ntawm qhov ntau ntawm cov kis las. Kev ua kom nce mus rau hauv overeating, tk. yuav txo cov piam thaj kom yuav tsum tau them nyiaj ua cov zaub mov muaj calorie ntau.
Tus neeg tawm lub cev xav tau cov chav kawm insulin rau nce hnyav.
Sab sij huam
Thaum siv gliclazide, zoo li lwm yam tshuaj sulfonylurea, cov tshuaj tuaj yeem ua rau mob ntshav qab zib thaum dhia zaub mov noj lossis tsis xwm yeem. Cov tsos mob hauv qab no yog sau tseg:
- bradycardia;
- pa ua tsis taus pa;
- zoo nkaus li tsis paub pab;
- ploj ntawm kev nco qab nrog lub peev xwm loj hlob ntawm coma nrog txoj kev pheej hmoo ntawm kev tuag;
- Kiv taub hau
- cramps
- kev nkees;
- tsis muaj zog
- paresis;
- tshee hnyo
- poob ntawm kev tswj tus kheej;
- tsis pom kev thiab hais lus;
- aphasia;
- Kev Nyuaj Siab
- tsawg tus neeg saib xyuas qis;
- tsis meej pem txog txoj kev nco qab;
- arousal
- kev chim siab;
- xeev siab thiab ntuav
- kev pw tsaug zog;
- nce siab ntawm kev tshaib kev nqhis;
- mob taub hau.
Cov tshuaj tiv thaiv adrenergic tseem tau sau tseg:
- angina pectoris;
- arrhythmia;
- Ntxhov siab vim
- tachycardia;
- palpitations
- ntshav siab;
- tawv nqaij nplaum;
- hyperhidrosis.
Kev kuaj pom tau pom tias kev ua txhaum ntawm daim siab ua haujlwm nrog kev txhim kho ntawm cholestasis yog ua tau.
Cov cim ntawm tus kab mob tso tseg qhov kev haus ntawm cov carbohydrates. Noj cov khoom qab zib yog qhov ua tsis tau txiaj ntsig. Nws tsis pom zoo kom noj lwm yam sulfonylurea derivatives.
Kev kho mob txoj hnyuv
Txo cov kev mob tshwm sim no, koj yuav tsum noj cov tshuaj thaum noj tshais. Cov no suav nrog:
- xeev siab thiab ntuav
- cem quav
- zawv plab
- mob plab.
Hematopoietic plab hnyuv siab raum
Tsis tshua pom muaj:
- granulocytopenia;
- leukopenia;
- thrombocytopenia
- anemia
Feem ntau yuav thim rov qab yog thaum tsis siv tshuaj txiav.
Mob ntshav qab zib MB tuaj yeem ua kom mob plab.
Nruab nrab hauv lub paj hlwb
Cov hauv qab no yog sau tseg:
- tsis hnov qhov pom ntawm ib puag ncig;
- kiv kiv heev.
Los ntawm cov kab mob zis
Tsis txheeb.
Ntawm ib feem ntawm cov plab hnyuv siab raum ntawm lub zeem muag
Pom kev tsis sib haum xeeb yog qhov ua tau nrog kev hloov pauv hauv qab zib cov ntshav. Feem ntau cov yam ntxwv ntawm thawj zaug rau kev kho mob.
Yog tias koj hloov koj cov piam thaj hauv ntshav thaum noj cov tshuaj, koj lub qhov muag yuav cuam tshuam.
Ntawm ib sab ntawm daim tawv nqaij
Saib:
- Stevens-Johnson mob;
- erythema;
- Quincke's edema;
- khaus
- lom epidermal necrolysis;
- ua pob, incl. maculopapullous;
- urticaria.
Ntawm ib sab ntawm daim siab thiab cov hnyuv
Cov hauv qab no yog sau tseg:
- mob siab nyob rau hauv raug tus mob;
- nce kev ua si ntawm daim siab enzymes (alkaline phosphatase. AST, ALT).
Cov kev kho mob nres thaum cholestatic jaundice tshwm sim.
Tsawg tsawg zaus, kab mob siab yuav tshwm sim thaum kho mob Diabeton MV.
Cov lus qhia tshwj xeeb
Cov tshuaj yog tawm rau cov neeg mob uas noj zaub mov carbohydrate-nplua nuj tas nrog noj tshais. Cov tsos mob ntawm kev ua ntshav qab zib yog pab los ntawm:
- ua kom tawm dag zog ntev;
- noj ntau cov tshuaj hypoglycemic nyob rau tib lub sijhawm;
- cov khoom noj tsis muaj calorie tsawg;
- haus cawv kom tsawg.
Cov phiajcim nres tsis thim rov qab. Nrog cov tsos mob hnyav, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob.
Txoj kev pheej hmoo ntawm hypoglycemia nce nrog:
- noj tshuaj tuag;
- lub raum thiab lub siab ua haujlwm tsis zoo;
- adrenal thiab pituitary tsis txaus;
- cov thyroid kab mob;
- tsis txaus ntawm tus nqi ntawm cov nyiaj carbohydrates coj thiab kev ua haujlwm ntawm lub cev;
- kev saib xyuas ib txhij ntawm ob peb tshuaj sib cuam tshuam;
- tus neeg mob tsis muaj peev xwm tswj hwm nws qhov mob;
- hloov kev noj haus, hla zaub mov noj, yoo mov, ua haujlwm tsis xwm yeem thiab noj tsis tau zaub mov.
Txoj kev pheej hmoo ntawm hypoglycemia nce nrog cov thyroid kab mob.
Cawv tau zoo
Thaum cov cawv yog kho nrog ceev faj. Haus dej cawv tuaj yeem ua rau mob glycemia.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov neeg mob tau qhia txog cov cim qhia tus mob hypoglycemia. Lawv yuav tsum ceev faj thaum nqis tes ua uas yuav tsum muaj kev xav thiab qhov siab ceev ntawm cov kev xav psychomotor, tshwj xeeb tshaj yog nyob rau theem pib ntawm kev kho.
Siv thaum cev xeeb tub thiab lactation
Cov ntaub ntawv hais txog kev siv cov tshuaj nquag thaum lub cev xeeb tub tsis muaj. Hauv kev sim tsiaj, tsis muaj kev cuam tshuam teratogenic.
Nrog lub cev xeeb tub tau npaj tseg thiab nws pib thaum kho, nws raug nquahu kom hloov cov tshuaj tiv thaiv qhov ncauj hypoglycemic nrog kev kho insulin.
Vim tias tsis muaj cov ntaub ntawv hais txog kev nqus ntawm cov khoom ua si nquag hauv niam mis, noj cov tshuaj thaum pub mis yog contraindicated.
Cov ntaub ntawv hais txog kev siv cov tshuaj nquag thaum lub cev xeeb tub tsis muaj.
Qhia tshuaj mob ntshav qab zib MV rau menyuam yaus
Tsis muaj ntaub ntawv qhia txog cov nyhuv ntawm cov tshuaj rau cov menyuam yaus hnub nyoog.
Siv rau lub sijhawm qub
Tsis pom zoo qhov kev txav zoo ntawm cov qauv pharmacokinetic rau cov neeg laus yog tsis pom.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv kev mob raum tsis ua haujlwm, insulin raug pom zoo. Hauv cov theem pib me thiab theem ntawm qhov kab mob pathology, cov koob tshuaj tsis hloov.
Siv rau lub siab ua haujlwm tsis zoo
Contraindicated nyob rau hauv mob siab heev tsis ua hauj lwm.
Hauv kev mob raum tsis ua haujlwm, insulin raug pom zoo.
Noj ntau dhau
Yog tias qhov koob tshuaj tau dhau qhov siab tshaj, Kev txo ntshav qog ntshav yuav tshwm sim. Yog tias cov tsos mob me ntsis ntawm tus kab mob no tshwm sim yam tsis muaj mob neurological thiab lub siab tsis nco qab, nce tus nqi ntawm cov zaub mov carbohydrate hauv cov zaub mov, hloov pauv kev noj haus thiab / lossis txo qhov koob.
Cov foos ntawm cov kev ua haujlwm hypoclycemic, uas yog los ntawm ntau cov kev mob puas siab puas ntsws, suav nrog mob ncauj plab thiab coma, uas yuav tsum tau mus pw hauv tsev kho mob sai.
Yog tias qhov mob ntshav qab zib tsis tsaug zog lossis nws pib tshwm sim, xav tias 20-30% kua nplaum nyob hauv ib qho ntawm 50 ml yog muab rau tus neeg mob kom ncaj. Txhawm rau tswj cov ntshav qab zib kom siab dua 1 g / l, ib qho tshuaj 10% dextrose yog muab rau noj. Txog 48 teev, tus neeg mob lub sijhawm yog saib xyuas, tom qab ntawd tus kws kho mob txiav txim siab txog kev xav tau kev soj ntsuam ntxiv.
Kev lim ntshav tsis muaj txiaj ntsig, vim hais tias cov tshuaj nquag ua haujlwm yog txuam nrog ntshav protein.
Yog tias qhov koob tshuaj tau dhau qhov siab tshaj, Kev txo ntshav qog ntshav yuav tshwm sim.
Kev cuam tshuam nrog lwm yam tshuaj
Nws yog ib qho tsim nyog yuav tsum coj mus rau hauv qhov kev sib xyaw ua ke ntawm cov tshuaj nrog tshuaj anticoagulants, txij li thaum coj los ua ke, cov nyhuv ntawm tom kawg tej zaum yuav ua kom zoo dua.
Contraindicated kev sib txuas ua ke
Miconazole tuaj yeem ua rau lub ntsej muag hypoglycemic thaum siv lub ntsej muag rau ntawm lub qhov ncauj mucosa thiab cov kev tswj hwm zoo.
Tsis pom zoo kev sib txuas ua ke
Cov no suav nrog:
- Phenylbutazone nrog cov tswj hwm kev tswj hwm vim muaj cov nyhuv hauv hypoglycemic ntau ntxiv. Nws yog qhov zoo dua los siv lwm cov tshuaj tiv thaiv kev o.
- Ethanol, uas ua rau txhim kho hypoglycemia txog kev loj hlob ntawm kev tsis nco qab. Tsis kam lees yog qhov tsim nyog tsis yog los ntawm kev haus cawv, tab sis kuj yog los ntawm cov tshuaj muaj cov khoom no.
- Danazole - pab txhawm rau txhim kho kev mloog ntxiv ntawm cov piam thaj hauv cov ntshav.
Danazole - pab txhawm rau txhim kho kev mloog ntxiv ntawm cov piam thaj hauv cov ntshav.
Tej kev sib txuam uas xav tau ceev faj
Qhov no suav nrog kev sib xyaw nrog cov tshuaj nrog qee cov tshuaj. Ua rau muaj kev pheej hmoo ntawm hypoglycemia:
- beta-blockers;
- lwm cov kab mob hypoglycemic: Insulin, Acarbose, GLP-1 agonists, thiazolidinidione, Metformin, dipeptidyl peptidase-4 inhibitors;
- Fluconazole;
- MAO thiab ACE inhibitors;
- histamine H2 receptor blockers;
- sulfonamides;
- NSAIDs
- Clarithromycin
Ua rau kom cov ntshav qabzib:
- Chlorpromazine hauv siab npaum li cas;
- glucocorticosteroids;
- Terbutaline, Salbutamol, Ritodrin nrog kev tswj hwm ntawm cov leeg.
Maninil yog ib qho tshuaj noj ntawm cov tshuaj Diabeton MV.
Cov npe ntawm Diabeton MV
Cov no suav nrog:
- Maninil;
- Gliclazide MV;
- Glidiab;
- Glucophage;
- Diabefarm MV.
Cov kev hloov pauv tom qab sab laj nrog kws kho mob.
Qhov twg yog qhov zoo dua: Diabeton lossis Diabeton MV?
Diabeton MV txawv ntawm Diabeton hauv tus nqi ntawm kev tso tawm ntawm cov tshuaj nquag. "MV" yog kev hloov kho tso tawm.
Lub sijhawm ntawm glycoside nqus nyob rau hauv Diabeton yog tsis pub ntau tshaj 2-3 teev. Tsuas tshuaj - 80 mg.
CF tau noj 1 zaug nyob rau ib hnub, nws ua tsis hnyav, qhov kev pheej hmoo ntawm hypoglycemia yog tsawg heev.
Diabeton MV txawv ntawm Diabeton hauv tus nqi ntawm kev tso tawm ntawm cov tshuaj nquag.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj (Diabeton MR hauv Latin) yog daim ntawv yuav tshuaj.
Nqe rau Ntshav Qab Zib MV
Tus nqi nruab nrab yog 350 rubles.
Cia rau cov neeg mob rau cov tshuaj
Hauv qhov chaw tsis muaj kev nkag siab rau cov menyuam yaus, ntawm qhov kub uas tsis muaj siab tshaj + 25 ° C.
Hnub tas sij hawm
2 xyoos
Chaw tsim tshuaj paus
- "Lub chaw soj nstuam Servier Kev Lag Luam", Fab Kis.
- Serdix LLC, Russia.
Kev xyuas txog mob ntshav qab zib MV
Cov kws kho mob
Shishkina E.I., Moscow
Qhov kev ua tau zoo yog siab. Tsis pom cov kev mob tshwm sim. Nws pib ua kom sai. Tshuaj zoo mob ntshav qab zib.
Lawj xeeb
Diana, 55 xyoo, Samara
Tus kws kho mob tau sau 60 ml / ib hnub, tab sis thaum sawv ntxov cov piam thaj ntawm qab zib yog 10-13. Nrog rau qhov kev nce ntxiv rau cov koob tshuaj rau 1.5 ntsiav tshuaj, qib thaum sawv ntxov poob mus rau 6 hli. Cov haujlwm qoj ib ce me me ntxiv rau kev noj haus tseem yuav pab tau.
