Amitriptyline Nycomed yog ib tus tswvcuab ntawm tricyclic antidepressant pawg. Cov tshuaj yog cov qeb qis tus nqi, uas yog qhov tseem ceeb, vim tias feem ntau lub sijhawm kho yog ntau lub lis piam lossis ob hlis.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Amitriptyline.
Amitriptyline Nycomed yog ib tus tswvcuab ntawm tricyclic antidepressant pawg.
ATX
N06AA09.
Tso cov ntawv thiab cov nyob ua ke
Cov khoom yog nyob rau hauv daim ntawv ntawm ntsiav tshuaj. Qhov no yog qhov kev npaj ib-ntu, muaj 1 yam khoom uas muaj sia - amitriptyline. Cov ntsiav tshuaj muaj lub plhaub, vim tias theem ntawm kev txhoj puab heev ntawm cov tshuaj nyob rau ntawm cov qog ua kua ntawm lub plab zom mov. Qhov kub siab ntawm cov tshuaj nquag: 10 lossis 25 mg (hauv 1 ntsiav tshuaj). Cov tshuaj tiv thaiv kev ntxhov siab muaj ntau tus naj npawb ntawm cov tshuaj tiv thaiv uas siv los ua kom tau qhov xav tau ntawm cov tshuaj:
- magnesium stearate;
- microcrystalline cellulose;
- silica;
- talc;
- lactose monohydrate.
- hmoov txhuv nplej siab.
Amitriptyline yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated, vim tias qib ntawm kev txhoj puab heev ntawm cov tshuaj rau ntawm cov qog ua kua ntawm lub plab zom mov txo.
Lub plhaub thaiv ntawm cov khoom no kuj yog multicomponent:
- macrogol;
- dimethicone;
- propylene glycol;
- titanium dioxide;
- hypromellose;
- talcum hmoov.
Cov ntsiav tshuaj muaj nyob hauv lub raj mis uas tuav 50 pcs.
Pharmacological kev txiav txim
Lub hauv paus ntsiab lus ntawm kev txiav txim ntawm tricyclic antidepressants yog ua raws li kev txwv tsis pub muaj kev ntes cov monoamines, uas yog sawv cev los ntawm norepinephrine, dopamine thiab serotonin. Cov tshuaj no yog lub luag haujlwm rau lub siab ntawm kev xyiv fab.
Cov tshuaj, zoo li lwm yam txhais tau tias ntawm tricyclic antidepressant pawg, muaj qhov cuam tshuam tseem ceeb - ntau ntawm cov kev mob tshwm sim uas tshwm sim thaum kho. Qhov no yog vim tsis xaiv qhov kev cai ntawm kev ua. Yog li ntawd, cov tshuaj tsis tsuas cuam tshuam rau kev ntes ntawm monoamines, tab sis kuj inhibits lwm cov kev hloov pauv biochemical.
Amitriptyline ua ke los ua ntau txoj haujlwm. Nws lub cuab yeej tseem ceeb yog tshuaj tiv thaiv kab mob. Tsis tas li ntawd, cov tshuaj muab cov sedative, anxiolytic, hypnotic effect. Qhov no txhais tau hais tias thaum kho tsis yog tsuas yog tus neeg mob lub siab lub ntsws yog ib txwm zoo li qub, tab sis tseem pw tsaug zog tau rov qab, kev ntxhov siab ploj.
Amitriptyline muab cov ua kom loog tsaug zog zoo, vim tias tus neeg mob rov pw tsaug zog.
Vim yog lub peev xwm los tiv thaiv qhov reuptake ntawm monoamines, ib qho kev nce siab hauv lawv cov kev xav hauv synaptic cleft ntawm lub hauv nruab nrab cov hlab ntsha tau sau tseg. Tsis tas li ntawd, cov nquag ua haujlwm ntawm Amitriptyline Nycomed block M1- thiab M2-muscarinic cholinergic receptors, histamine receptors, thiab tib lub sijhawm, alpha1-adrenergic receptors. Qhov txiaj ntsig zoo ntawm kev kho mob nrog cov tshuaj tiv thaiv kab mob no tau sau tseg vim muaj qhov sib txuas ntawm cov neurotransmitters uas muaj nyob hauv qhov sib txuas ntawm lub hlwb thiab lub xeev kev xav.
Lwm qhov zoo ntawm cov tshuaj yog cov nyhuv qeeb. Qhov txiaj ntsig zoo tsis tiav tom qab tau tiav tam sim ntawd, tab sis tom qab kev saib xyuas los ntawm cov khoom muaj txiaj ntsig hauv cov ntshav ntshav tau nce mus txog qhov tsis muaj qhov sib npaug. Ib qho ntxiv, thaum nce mus txog ib qib twg (nws txawv nyob ntawm qhov koob tshuaj), cov teebmeem kev xav ntawm lub hlwb tseem ua kom pom. Txawm li cas los xij, qhov tshwm sim yog ib txwm ua rau tiv thaiv keeb kwm ntawm ib qho kev nce ntxiv hauv kev ua kom tau ntawm qhov tseem ceeb ntawm cov khoom tseem ceeb ntawm amitriptyline - nortriptyline.
Nrog rau qhov nce ntxiv thiab txo qis dua hauv thaj, cov khoom ntawm cov tshuaj hloov me ntsis. Yog li, thaum mus txog ib qib twg, cov haujlwm ntawm nortriptyline poob qis, ua haujlwm ntawm amitriptyline nce. Txawm li cas los xij, qee zaum sau tseg hauv cov tshuaj tiv thaiv kev ntxhov siab tau sau tseg. Vim li no, koj tsis tuaj yeem noj cov tshuaj ntawm koj tus kheej, vim tias nws yog ib qho tseem ceeb uas yuav tsum xaiv txoj kev kho uas tsim nyog coj los xav txog tus yam ntxwv ntawm lub cev. Nws yuav tsum tau yug los rau hauv lub siab tias kev noj tshuaj me me yuav tsis muab qhov tshwm sim xav tau.
Nrog amitriptyline, koj tuaj yeem tswj koj lub plawv dhia. Qhov no yog vim muaj cov nyhuv antiarrhythmic ntawm cov tshuaj.
Cov tshuaj hauv cov lus nug tseem ua tau zoo ntawm kev ua txhaum ntawm CCC txoj haujlwm. Piv txwv, nws tuaj yeem siv los tswj lub plawv dhia. Qhov no yog vim muaj cov nyhuv antiarrhythmic ntawm cov tshuaj. Thaum muab tshuaj rau hauv cov tshuaj kho mob, qhov txo qis hauv kev siv ntawm cov txheej txheem ventricular conduction txheej txheem tau sau tseg.
Cov Tshuaj Pharmacokinetics
Amitriptyline yog tus cwj pwm los ntawm kev nqus sai. Tom qab 2-6 teev, qhov siab tshaj plaws ntawm kev ua ntawm cov khoom no tau mus txog. Nws yog qhov txawv los ntawm ib nrab ntawm qhov nruab nrab ntawm bioavailability (50%). Tab sis cov lus khi rau ntshav cov protein yog siab - 95%. Muab hais tias cov tshuaj muab qhov tshwm sim uas xav tau tom qab tau mus txog qhov sib npaug ntawm lub siab ua haujlwm hauv lub cev, qhov txiaj ntsig zoo yuav tsum tsis txhob xav tias ntxov dhau 1 lub lis piam tom qab. Qhov no yog vim qhov tseeb hais tias xws li ib lub sijhawm dhau los yuav tsum ua kom tiav cov kev mob tseem ceeb hauv qab uas cov tsos mob ntawm pathology pib ploj.
Cov tshuaj ua haujlwm nquag yog metabolized hauv lub siab. Ua ntej, lub ntsiab sib txuas, nortriptyline, raug tso tawm. Tom qab ntawd, ob qho tib si amitriptyline thiab nws cov metabolite nquag tau hydroxylated, tom qab ntawd los ntawm kev tso tawm ntawm cov muaj zog yam tsawg. Ib nrab-lub neej ntawm cov tshuaj nws txawv 9 mus rau 46 teev, uas cuam tshuam los ntawm lub xeev lub cev, nyob ntawm lwm cov pathologies.
Dab tsi yog xaj tshuaj
Nws raug nquahu kom siv cov tshuaj rau ntau lub hlwb kev xav, hauv kev tshwj xeeb:
- ntau yam kev nyuaj siab, nrog rau kev pw tsaug zog, ntxhov siab, thaum lub tshuaj hauv cov lus nug yog siv los ua kev ntsuas tseem ceeb;
- raws li ib feem ntawm cov kev kho mob nyuaj, tshuaj tiv thaiv kev ntxhov siab yog sau tseg hauv ntau qhov teeb meem: kev coj cwj pwm, kev ntshai, kev puas siab ntsws, kev ua tsis tiav ntawm cov zais zis (enuresis nrog kev tshwm sim thaum hmo ntuj), anorexia, bulimia.
Cov Yuav Tsum Muaj
Muaj ntau txoj kev txwv ntawm kev siv cov tshuaj no:
- cov tshuaj tiv thaiv ib qho tsis zoo rau ib qho twg hauv cov lus (tsis nquag thiab tsis muaj zog);
- myocardial infarction, nrog rau keeb kwm ntawm;
- mob hnyav ethanol lom;
- pathological mob nrog los ntawm kev tsis hnov qab;
- lom nrog tshuaj (tshuaj tiv thaiv kab mob hlwb, hlwb hlwb lossis hypnotics);
- arrhythmia;
- lub kaum ntse ntse-kaw glaucoma;
- ua txhaum ntawm intraventricular, atrioventricular conduction;
- kev mob hauv lub cev muaj feem nrog lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome;
- ntau cov synthesis hauv cov hlwb hauv cov nqaij ntawm lub caj pas ntawm prostate, uas ua rau txoj kev nqaim ntawm lub lumen ntawm qhov zis;
- tuag tes tuag taw txoj hnyuv ntawm kev;
- kev noj cov poov tshuaj tsawg;
- bradycardia.
Nrog saib xyuas
Tus txheeb ze contraindications:
- ntshav siab;
- pathological mob nrog rau kev hloov hauv cov muaj pes tsawg leeg thiab cov yam ntxwv ntawm cov ntshav;
- nce siab intraocular siab thiab lwm yam kab mob ntawm cov plab hnyuv siab raum ntawm lub zeem muag;
- ib qho pathology nrog urinary tuav tseg;
- cramps
- mob schizophrenia
- qaug dab peg
- kev puas siab puas ntsws bipolar;
- ua txhaum ntawm cov thyroid caj pas (hypothyroidism).
Yuav noj Amitriptyline Nycomed li cas
Kev xaiv ntawm txoj kev kho mob yog coj tawm mus rau hauv tus account hom kab mob. Coj mus rau hauv lub hnub nyoog, kev loj hlob ntawm kev loj hlob ntawm pathology, lub xub ntiag ntawm kev txwv ntawm kev siv Amitriptyline Nycomed. Cov ntsiav tshuaj yuav tsum tsis txhob zom. Qhia cov tshuaj tom qab noj mov.
Cov sijhawm tshuaj noj rau cov laus
Txoj kev kho yuav tsum pib nrog ib koob tshuaj 50-75 mg. Tom qab ntawd nws tau nce ntxiv, yog tias tsim nyog, los ntawm 25-50 mg. Qhov nyiaj no npaum li cas ib zaug ua ntej mus pw lossis faib ua 2 zaug. Txawm li cas los xij, koj tsis tuaj yeem dhau qhov kev siv txhua hnub ntawm 200 mg. Lub sijhawm kawm - 6 lub hlis.
Amitriptyline Nycomed muab tshuaj rau cov menyuam
Muab cov enuresis: 25 mg ib zaug rau cov neeg mob hnub nyoog 7 txog 12 xyoos, tshaj 12 xyoos - 50 mg. Nws raug nquahu kom noj nyiaj ua ntej mus pw.
Noj cov tshuaj rau ntshav qab zib
Cov tshuaj hauv cov lus nug cuam tshuam rau cov nyhuv tso tawm los ntawm insulin, thiab tseem tuaj yeem ua rau kev hloov pauv hauv cov piam thaj. Vim li no, feem ntau, yuav tsum tau txhaj tshuaj kom haum. Tus nqi ntawm cov tshuaj tau sau tseg ib tus zuj zus.
Ntau npaum li cas yog siv tau
Cov cuab yeej muab cov nyhuv hauv ob peb lub lis piam. Nws pib ua haujlwm thaum thawj teev tom qab pib kho. Cov nyhuv tshwm sim kav rau 1-2 hnub.
Yuav ua li cas rho Amitriptyline Nycomed kom raug
Txhawm rau kom tsis txhob tshem tawm cov tsos mob, nws raug nquahu kom maj mam txo cov koob tshuaj.
Sab sij huam
Nws yuav tsum tau yug los hauv lub siab tias cov tshuaj hauv nqe lus nug ua rau pom kev zoo ntawm muaj kev tsis zoo ntau.
Kev kho mob txoj hnyuv
Xeev siab, qhuav ua qog ua paug, hloov pauv ntawm tus qauv quav (ua quav). Los ntawm lub plab zom mov, cov tsos mob hauv qab no feem ntau tshwm sim: tsis xis nyob hauv lub qhov ncauj, o, caries. Tsawg dua, raws plab, ntuav, o ntawm tus nplaig, kab mob siab, daj ntseg, txhaws tsis voos.
Hematopoietic plab hnyuv siab raum
Hlauj pob txha tsis zoo muaj nuj nqi, tus lej ntawm cov kab mob pathological uas muaj kev hloov pauv ntawm cov muaj pes tsawg leeg thiab cov khoom hauv cov ntshav.
Nruab nrab hauv lub paj hlwb
Kev tsis muaj zog ntau yam, nkees nkees, tshee tshee ntawm tes taw, mob taub hau thiab kiv taub hau, hnov mob, hais lus, saj.
Los ntawm ib sab ntawm cov metabolism
Hloov pauv hauv qhov qab los: nce ntxiv, txo qis. Raws li qhov tshwm sim, lub cev hnyav nce lossis txo qis.
Kev ua xua
Vasculitis, urticaria, uas yog qhia los ntawm khaus, tawm pob.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Thaum kho, koj yuav tsum tsis kam tsav tsheb, vim tias cov tshuaj pab txhawb kev ua haujlwm ntawm lub paj hlwb tsis zoo, cuam tshuam rau cov plab hnyuv siab raum ntawm lub zeem muag thiab hnov, thiab ua rau lub siab tsis zoo.
Cov lus qhia tshwj xeeb
Kev kho mob pib nrog tswj ntshav siab.
Thaum hloov chaw ntawm lub cev, kev saib xyuas yuav tsum ua, kev coj ua ntse tsis tuaj yeem ua.
Cov neeg mob hnub nyoog tshaj 50 xyoos muaj feem ntau yuav muaj kev pheej hmoo ntawm pob txha lov.
Qee zaum nws yuav tsim nyog los tswj kev suav cov ntshav.
Cov kev xav tua tus kheej mus txog thaum lub caij sib xyaw pabcuam yuav pab txo cov tsos mob ntawm lub hlwb tsis zoo.
Hauv cov tub ntxhais hluas (txog 24 xyoos), kev pheej hmoo ntawm kev tua tus kheej nrog kev kho mob nrog Amitriptyline Nycomed nce.
Ua ntej ua cov haujlwm ntau, cov txheej txheem kho hniav, koj yuav tsum tsis txhob noj cov tshuaj no.
Siv thaum cev xeeb tub thiab lactation
Tsis raug muab teev tseg.
Siv rau lub sijhawm qub
Nws raug pom zoo los siv tshuaj tiv thaiv kab mob rau hauv nqe lus nug, tab sis ceev faj yuav tsum tau siv. Koj yuav tsum pib cov chav kawm ntawm kev kho mob nrog 25-30 mg (ib hnub ib zaug). Nce qhov ntau ntawm cov tshuaj yuav tsum yog 1 zaug txhua 2 hnub. Qhov nyiaj pab ntau tshaj txhua hnub yog 100 mg.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv cov neeg mob uas muaj cov kab mob ntawm cov khoom nruab nrog cev no, qhov kev tshem tawm ntawm lub cev nquag ntawm Amitriptyline Nycomed los ntawm lub cev tau qeeb qeeb. Tsis muaj kev txwv nruj heev rau kev noj cov tshuaj.
Siv rau lub siab ua haujlwm tsis zoo
Tso cai siv nrog nrog ceev faj. Nrog daim siab ua haujlwm tsis txaus siab, lub koob tshuaj yog txo.
Noj ntau dhau
Tshaj tawm amitriptyline tuaj yeem ua rau mob pob ntseg pob txha hnyav. Lwm cov kev phiv loj heev. Kev Kho Mob: lub plab yog ntxuav kom txo cov tshuaj lom ntawm cov tshuaj, sorbents yog tshuaj, yog tias tsim nyog, cholinesterase inhibitors tau txais kev tswj hwm, lub siab tsis txaus yuav tsum ua, thiab dej-electrolyte tshuav yog tswj.
Kev cuam tshuam nrog lwm yam tshuaj
Kev txwv tsis pub lub hauv nruab nrab cov hlab ntsha tau txhim kho nrog kev sib txuam nrog cov tshuaj hauv cov lus nug thiab tshuaj tiv thaiv kev tiv thaiv, sedatives, hypnotics, tshuaj loog, tshuaj loog analgesics.
Ua ke nrog Amitriptyline, MAO inhibitors tsis siv. Nws yog qhov tsis tsim nyog los muab nws nrog Adrenaline, Ephedrine, Dopamine, Noradrenaline, Phenylephedrine.
Cawv tau zoo
Cawv muaj dej cawv thiab cov tshuaj tiv thaiv kab mob hauv cov lus nug tsis tau koom ua ke.
Analogs
Cov tshuaj zoo siv tsis hloov ntawm Amitriptyline Nycomed:
- Anafranil;
- Melipramine;
- Ladisan;
- Doxepin thiab lwm tus
Dab tsi yog qhov txawv ntawm Amitriptyline thiab Amitriptyline Nycomed
Cov tshuaj muaj npe nrog Nycomed hauv lub npe tsis yog tsim nyob rau hauv daim ntawv ntawm tov. Nws tuaj yeem muas tsuas yog hauv cov ntsiav tshuaj. Amitriptyline muaj ntau hom: khov, kua (txhaj). Npaj cov pawg no yog nyob rau hauv tib nqe. Yuav txawv nyob hauv tus nqi ntawm cov khoom xyaw dhia.
Nyiaj so koobtsheej tej yam mob Amitriptyline Nycomed los ntawm lub tsev muag tshuaj
Cov tshuaj yog ib qho tshuaj xaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Tsis yog.
Nqe rau Amitriptyline Nycomed
Tus nqi nruab nrab yog 60 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov menyuam yaus yuav tsum tau kaw lawv cov khoom siv. Pom zoo cia cov khoom mob: + 15 ... + 25 ° С.
Hnub tas sij hawm
Cov tshuaj cia nws lub cev rau 5 xyoo txij li hnub tso tawm.
Chaw Tsim Tshuaj Tsim Amitriptyline Nycomed
Takeda Pharma A / S, Tebchaws Denmark.
Kev txheeb xyuas txog Amitriptyline Nycomed
Neeg puas hlwb
Chukhrov V.V., kws kho mob hlwb, hnub nyoog 49 xyoo, Chelyabinsk
Cov tshuaj dhau los lawm, cov tshuaj tshiab dua tshiab tam sim no tau tshwm sim los ntawm qhov tsis tshua muaj feem cuam tshuam rau kev kho.
Kochev V.O., Kws kho mob hlwb, hnub nyoog 34 xyoo, Stavropol
Tshuaj tua kab mob zoo ntxiv, ntxiv rau kev kho mob taub hau nrog psychosomatics. Tej zaum yuav ua rau qeeb hauv kev tso zis txoj kev.
Cov neeg mob
Larisa, 34 xyoo, Barnaul
Kuv coj 10 ntsiav tshuaj mg. Kev kho mob tau tshwm sim tom qab 3 lub lis piam, uas ntev. Tab sis, thaum kawg, kev nyuaj siab tau kov yeej.
Marina, 41 xyoo, Moscow
Siv cov tshuaj no. Tsuas yog siv tau ntev heev kuv tsis tuaj yeem tuav tau. Ua ntej, tus kws kho mob tau ceeb toom tias qhov tshwm sim zoo tshwm sim nyob rau hauv thawj lub hlis tom qab pib kev kawm. Thib ob, phiv los ntawm cov tshuaj no tsis tau tso cai kho ntxiv.
