Metformin Canon yog qhov tshuaj hypoglycemic ntawm cov khoom siv hluavtaws los ntawm cov pab pawg biguanide. Nws yog siv los kho ntshav qab zib thiab rog dhau los ntawm kev ua tsis taus pa lipid thiab carbohydrate.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Metformin.
Lub npe hauv Latin yog Metformin.
Metformin Canon yog siv rau kev kho mob ntshav qab zib thiab rog los ntawm kev ua rau lub cev tsis muaj roj thiab cov metabolism.
ATX
A10BA02.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj. Muaj cov ntsiav tshuaj uas muaj 500 mg, 850 mg thiab 1000 mg ntawm metformin.
Cov ntsiav tshuaj nrog qhov ntau npaum ntawm 500 mg yog puag ncig, thiab cov ntsiav tshuaj nrog tshuaj ntau npaum 850 mg thiab 1000 mg (Metformin ntev) yog oval.
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj.
Muaj pes tsawg leeg ntsiav tshuaj:
- Metformin hydrochloride.
- Polyethylene glycol (macrogol).
- Povidone.
- Talc.
- Sodium stearyl fumarate.
- Sodium carboxymethyl hmoov txhuv nplej siab.
- Pregelatinized hmoov txhuv nplej siab.
- Opadry II dawb (zaj yeeb yaj kiab-tsim kev ncua).
- Titanium dioxide.
- Cawv polyvinyl.
Pharmacological kev txiav txim
Metformin inhibits gluconeogenesis, kev sib txuas ntawm cov khoom siv roj dawb, nrog rau cov txheej txheem ntawm lipolysis (rog tsis ua haujlwm) thiab rog oxidation. Nyob rau tib lub sijhawm, kev noj ntawm cov piam thaj hauv lub cev yog ua kom los ntawm kev nce siab ntawm cov kab mob ntawm cov cell mus rau insulin.
Cov tshuaj normalizes cov ntsiab lus ntawm triglycerides thiab roj nyob rau hauv cov ntshav. Muaj qhov maj mam poob hauv qhov hnyav hauv cov neeg mob rog.
Cov tshuaj tau pom zoo nyob rau hauv muaj mob thrombosis, vim nws muaj cov nyhuv fibrinolytic. Metformin pab tshem tawm cov ntshav txhaws hauv cov hlab ntshav.
Cov tshuaj tau pom zoo nyob rau hauv muaj mob thrombosis, vim nws muaj cov nyhuv fibrinolytic.
Cov Tshuaj Pharmacokinetics
Thaum noj ntawm qhov ncauj, cov tshuaj maj mam nqus tawm ntawm cov hnyuv. Metformin kev nqus yog 50%. Bioavailability tsis tshaj li 60%. Cov tshuaj mus txog nws qhov siab tshaj plaws hauv ntshav hauv 2-2.5 teev.
Metformin tsis muaj zog khi rau cov ntshav albumin, tab sis nkag sai sai rau cov kua nruab nrog cev. Nws yog tawm hauv lub cev los ntawm lub raum feem ntau tsis hloov. Lub sijhawm zam yog 8-12 teev.
Nws yog dab tsi rau?
Cov tshuaj yog tawm rau cov laus thiab cov menyuam yaus hnub nyoog 10 xyoo los ntawm kev rog dhau los thiab hom 2 mob ntshav qab zib mellitus (tsis-insulin-tsis tos leej twg). Cov tshuaj yuav siv tau ob qho tib si thawj thiab theem nrab txhais tau tias (ua ke nrog insulin).
Lwm qhov kev qhia rau kev siv yog:
- Kab mob siab hepatosis (mob siab ua pob). Ib tug kab mob uas cov mob hepatocytes (mob siab hauv hlwb) hloov mus ua lipid cov nqaij.
- Polycystic lub zes qe menyuam. Qhov kab ke no feem ntau nrog los ntawm kev tiv thaiv insulin ntau zog. Muaj kev tsim cov tshuaj no ntau dhau thiab qhov kev nce siab ntawm cov piam thaj hauv cov ntshav.
- Hyperlipidemia. Tus kab mob yog cim los ntawm cov ntsiab lus ntawm lipids thiab lipoproteins hauv cov ntshav.
Qhov qhia rau siv yog fatty hepatosis.
Cov Yuav Tsum Muaj
Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv hauv qab no:
- kev tsis qaug rau metformin lossis excipients;
- mob dias taub;
- mob ntshav qab zib ketosis;
- mob siab daim siab pathology;
- lub raum tsis ua haujlwm;
- zawv plab lossis ntuav heev;
- cov kab mob kis hnyav;
- hypoxia;
- ua npaws;
- sepsis
- anaphylactic kev poob siab;
- myocardial infarction;
- ua pa lossis lub plawv tsis ua haujlwm;
- kev quav cawv;
- lactic acidosis;
- calories tsis txaus;
- cov me nyuam qis dua 10 xyoo.
Nrog saib xyuas
Thaum lub hnub nyoog ntau dua 60, muaj qhov pheej hmoo siab ntawm kev tsim kab mob lactic acidosis. Yog li, cov neeg laus cov neeg mob tau sau tseg cov tshuaj nrog ceev faj.
Yuav ua li cas noj Metformin Canon?
Cov tshuaj yog npaj rau kev siv qhov ncauj.
Ua ntej lossis tom qab noj mov?
Txhawm rau kom txo cov txiaj ntsig tsis zoo ntawm metformin ntawm lub plab, cov ntsiav tshuaj raug pom zoo kom noj nrog zaub mov lossis tam sim ntawd.
Noj cov tshuaj rau ntshav qab zib
Ua raws li cov lus qhia, cov neeg laus nrog kho mob monotherapy tau muab sau rau 1000-1500 mg ntawm qhov tshuaj ib hnub. Yog tias tsim nyog, qhov tshuaj txhua hnub yog maj mam nce mus txog 2000 mg. Qhov siab tshaj plaws niaj hnub noj yog 3000 mg ntawm metformin. Qhov koob tshuaj txhua hnub tuaj yeem faib ua 2-3 koob.
Thaum ua ke nrog cov tshuaj insulin, qhov tshuaj ntawm Metformin yog 1000-1500 mg ib hnub. Thaum siv tshuaj kho, yuav tsum tau txhaj tshuaj kho cov tshuaj insulin.
Yuav noj rau qhov poob phaus li cas?
Txog kev kho mob rog, qhov ua rau uas yog insulin tsis kam, cov tshuaj yog kws kho nyob rau hauv thawj zaug ntawm 500 mg ib zaug. Qhov koob tshuaj tau nce rau 2000 mg rau ib hnub, ntxiv 500 mg txhua lub lis piam.
Metformin pab txo qhov hnyav thaum ua ke nrog kev noj zaub mov kom raug.
Metformin pab txo qhov hnyav thaum ua ke nrog kev noj zaub mov kom raug. Tab sis kev noj zaub mov nruj tsis tuaj yeem ua rau vim muaj qhov pheej hmoo ntawm cov ntshav qog ntshav qab zib.
Kev phiv tshuaj ntawm Metformin Canon
Thaum noj cov tshuaj no, phiv los ntawm ntau yam plab hnyuv siab raum tuaj yeem pom, tab sis feem ntau, mob lub plab zom mov.
Kev kho mob txoj hnyuv
Los ntawm cov kab mob plab yog pom:
- xeev siab thiab ntuav
- saj ntawm hlau nyob rau hauv lub qhov ncauj;
- tsis qab los noj mov;
- anorexia;
- mob hauv plab thiab hnyuv;
- zawv plab
- kev siv roj ntau ntxiv.
Los ntawm ib sab ntawm cov metabolism
Ntxim rau cov metabolism:
- lactic acidosis;
- B12 tsis muaj peev xwm (tsis hnov qab cov vitamin zom tau).
Ntawm ib sab ntawm daim tawv nqaij
Daim tawv nqaij ua pob liab liab, khaus, thiab lwm yam kev ua xua nyob hauv zos yog ua tau.
Endocrine system
Qhov kev tshwm sim tshwm sim los ntawm cov ntshav hauv ntshav qis dhau - cov ntshav qog ntshav qab zib.
Kev ua xua
Nrog rau ib tus neeg tsis kam rau cov kev nquag, muaj:
- ua pob
- khaus tawv nqaij;
- urticaria;
- daim tawv liab
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Tsis ntxim rau kev saib xyuas. Txawm li cas los xij, vim qhov pheej hmoo ntawm kev txhim kho hypoglycemia, kev ceev faj yuav tsum tau siv thaum tsav tsheb.
Cov lus qhia tshwj xeeb
Ua ntej kev ua haujlwm thiab kev ntsuam xyuas uas siv cov tshuaj radiopaque, cov tshuaj kho mob raug muab tso tseg. Kev tshem tawm cov tshuaj yog nqa tawm 2 hnub ua ntej kev kuaj mob thiab tom qab ntawd rov pib dua tom qab 2 hnub.
Ua ntej kev phais mob, kev noj tshuaj raug muab tso tseg.
Siv thaum cev xeeb tub thiab lactation
Txij li cov tshuaj yeeb dej caw hla mus rau ntawm qhov txwv tsis pub, poj niam cev xeeb tub tsis pom zoo kom siv cov tshuaj no. Cov kev tshawb fawb uas ntseeg tau ntawm cov teebmeem teratogenic ntawm metformin tsis tau ua. Qee zaum cov kws kho mob sau cov tshuaj no rau poj niam cev xeeb tub yog tias tsim nyog.
Kev pub niam mis thaum kho mob yog qhov pom zoo kom tsum.
Tshuaj Ntawv Metformin Canon rau Cov Menyuam
Cov tshuaj no raug tso cai rau coj mus rau menyuam yaus muaj hnub nyoog tshaj 10 xyoo nyob hauv kev saib xyuas ntawm kws kho mob.
Siv rau lub sijhawm qub
Cov tshuaj tsis pom zoo rau cov laus (tom qab 60 xyoo) vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis.
Daim ntawv thov rau lub raum khiav tsis zoo
Contraindicated.
Siv rau lub siab ua haujlwm tsis zoo
Nws yog qhov txwv tsis pub lees txais.
Tshaj ntawm Metformin Canon
Thaum noj cov tshuaj hauv qhov siab kawg, kev txhim kho ntawm:
- xeev siab thiab ntuav
- zawv plab
- tsawg lub cev kub;
- mob plab;
- Kiv taub hau
- tsaus muag
- coma
Kev cuam tshuam nrog lwm yam tshuaj
Cov tshuaj yog ua nrog ceev faj nrog cov tshuaj hauv qab no:
- Danazole (tus neeg sawv cev hyperglycemic).
- Chlorpromazine.
- Cov tshuaj tiv thaiv.
- Derivatives ntawm sulfonylureas.
- NSAIDs.
- Oxytetracycline.
- ACE thiab MAO inhibitors.
- Chaw kaw neeg.
- Cov tshuaj hormones (nrog rau tshuaj tiv thaiv kom txhob muaj menyuam).
- Diuretics (los ntawm pab pawg ntawm thiazide lossis voj diuretics).
- Derivatives ntawm nicotinic acid thiab phenothiazine.
- Glucagon.
- Cimetidine.
Yog tias kev sib xyaw ua ke yog tsim nyog, tus kws kho mob kho cov koob tshuaj thiab tswj hwm qhov qab zib thiab lactic acid hauv cov ntshav.
Cawv tau zoo
Cov khoom no muaj qhov tsis zoo nrog haus cawv. Cov cawv yuav ua rau muaj kev phom sij ntawm cov nqaij hypoxia, cov kab mob lactic acidosis thiab lwm yam kev phiv.
Analogs
Cov tshuaj yeeb yaj kiab nrov ntawm cov khoom no muaj xws li Glucophage (Merck Sante, Fabkis), Formmetin (Pharmstandard, Russia), Siofor (Berlin-Chemie, Fabkis). Cov tshuaj no muaj tib lub zog qub - metformin hydrochloride.
Cov tshuaj xws li Metformin Teva thiab Metformin Richter yog tshuaj tua kab mob generics. Lawv zoo tib yam rau Metformin Canon nyob rau hauv muaj pes tsawg leeg thiab ua, tab sis yog tsim los ntawm lwm cov tuam ntxhab.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Cov tshuaj no rau npe B thiab raug faib tawm ncaj qha los ntawm cov tshuaj noj.
Nqe rau Metformin Canon
Tus nqi ntawm cov tshuaj hauv Lavxias yog 130-200 rubles. rau 30 ntsiav tshuaj.
Cov kua nplaum yog ib qho ntawm cov qauv sib txig sib luag ntawm cov khoom no.
Cia rau cov neeg mob rau cov tshuaj
Khaws cov tshuaj ntawm qhov kub tsis tshaj 25 ° C.
Hnub tas sij hawm
Cov tshuaj no haum rau 3 xyoos.
Chaw tsim tshuaj paus
Lub chaw tsim khoom ntawm cov cuab yeej no yog CJSC Kanofarma Ntau Lawm, NPO FarmVilar (Russia).
Kev txheeb xyuas ntawm Metformin Canon
Cov kws kho mob
Konstantin, hnub nyoog 42 xyoos, St. Petersburg
Kuv tau ua haujlwm li endocrinologist rau ntau dua 10 xyoo. Cov tshuaj no yog sau rau cov neeg mob ntshav qab zib thiab rog rog. Nws pab ua kom cov metabolism hauv thiab cov ntshav qabzib feem ntau. Kuv tsis tshua pom muaj kev phiv ntau hauv kuv xyaum.
Irina, 35 xyoo, Krasnodar
Metformin yog ib tus neeg sawv cev hypoglycemic zoo hauv kev kho mob ntshav qab zib hom 2. Kuv cov neeg mob zam cov tshuaj no zoo. Tom qab ib hlis tom qab noj cov ntshav qab zib cov tee. Txhawm rau kom tsis txhob mob plab, Kuv pom zoo kom tsis txhob noj cov tshuaj ntawm qhov khoob plab.
Cov neeg mob
Valentin, 56 xyoo, Belorechensk
Kuv tau kawm txog cov tshuaj xws li Metformin, Siofor, Glucofage los ntawm endocrinologist. Nws pom zoo kom lawv mus tua ntshav qab zib. Metformin cov txiaj ntsig zoo hauv kev sib piv nrog nws cov analogues yog nws tus nqi tsawg. Cov tshuaj tau pab thiab tsis ua rau muaj kev phiv.
Alexander, 43 xyoo, Volgograd
Kuv haus cov tshuaj no rau kev tiv thaiv mob ntshav qab zib. Cov ntshav qab zib tau pib sawv, thiab kws kho mob tau hais tawm Metformin. Kuv tsis pom muaj qhov tshwm sim tsis zoo thaum kho.
Poob phaus
Ekaterina, 27 xyoo, Moscow
Tom qab yug menyuam tas, kuv tau pib zoo sai. Kuv tsis tuaj yeem ua raws li cov khoom noj kom ntev ntev, yog li kuv txiav txim siab sim Metformin kom tsis qab los noj mov. Cov tshuaj tau pab tshem ntawm 5 kg hauv ib hlis. Tshaib plab dulled, thiab kuv tsis tuaj yeem siv.
Arina, 33 xyoo, Irkutsk
Kuv pib noj cov tshuaj no rau kev pom zoo los ntawm kws kho mob. Cov tshuaj txo cov ntshav qab los noj mov thiab nqhis cov khoom qab zib. Thaum lub hli ntawm kev nkag mus, kuv qhov hnyav dua li 4 kg, uas kuv zoo siab. Tsis muaj kev mob tshwm sim.
