Fenofibrate yog ib qho tshuaj lom neeg sib txuas nrog cov nyhuv hypoglycemic. Hauv qee cov tshuaj. Cov tshuaj yog npaj los kho hyperlipidemia thiab hypercholesterolemia. Nws yog siv los tiv thaiv kev tiv thaiv los tiv thaiv kev tsim cov plua plav hauv plaques lossis atherosclerotic hloov pauv ntawm phab ntsa vascular.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Hauv Latin - Fenofibrate.
Lub npe lag luam yog Tricor.
Fenofibrate yog ib qho tshuaj lom neeg sib txuas nrog cov nyhuv hypoglycemic.
ATX
C10AB05.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm nyias daim nyias nyias ntsiav tshuaj. Ib chav ntawm kev npaj muaj 145, 160 lossis 180 mg ntawm micronized fenofibrate nyob rau hauv daim ntawv ntawm nanoparticles. Raws li cov khoom siv ntxiv tau siv:
- mis nyuj qab zib;
- microcrystalline cellulose;
- crospovidone;
- hypromellose;
- dehydrogenated silicon dioxide colloidal;
- sucrose;
- lauryl sulfate thiab docusate sodium;
- magnesium stearate.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm nyias daim nyias nyias ntsiav tshuaj.
Lub plhaub sab nraud muaj talc, xanthan ntawm cov pos hniav, titanium dioxide, polyvinyl cawv thiab socithin kua. Cov tshuaj dawb muaj lub ntsej muag zoo nkauj nrog lub ntsej muag ntawm ob sab ntawm daim ntawv tshuaj, qhia thawj thawj tsab ntawv ntawm cov tshuaj nquag thiab muab tshuaj.
Mechanism ntawm kev ua
Fenofibrate ntsiav tshuaj belongs rau cov pab pawg neeg ntawm hypoglycemic tus neeg sawv cev thiab yog ib qho kev sib txuas ntawm fibroic acid. Cov tshuaj no muaj peev xwm cuam tshuam rau theem ntawm lipids hauv lub cev.
Cov yam ntxwv ntawm kws tshuaj yog vim kev ua haujlwm ntawm RAPP-alpha (ib qho tshuaj lom los ntawm peroxisis proliferator). Raws li qhov tshwm sim hauv kev ua kom lub zog, cov txheej txheem kev zom zaub mov ntawm qhov tawg ntawm cov rog thiab qhov ua kom tsis muaj qhov plasma lipoproteins (LDL) tsawg dua. Kev tsim cov apoproteins AI thiab AH yog kho kom zoo dua, vim tias qib uas muaj cov lipoproteins ntau (HDL) tau nce li ntawm 10-30% thiab lipoprotein lipase yog ua kom.
Vim tias txum tim rov qab los ntawm cov roj metabolism hauv kev ua txhaum cai ntawm kev tsim ntawm VLDL, fenofibrate compound ua kom muaj qhov tsis pom ntawm LDL, txo qhov tsawg ntawm cov roj ntsha ntawm cov lipoproteins uas tsis muaj qhov me me.
Cov qib LDL nce rau hauv cov neeg mob uas muaj kev pheej hmoo txhim kho mob rau cov ntshav hlab plawv.
Cov tshuaj pabcuam pab txhawm rau txo cov cholesterol los ntawm 20-25% thiab triglycerides los ntawm 40-55%. Nyob rau hauv muaj hypercholesterolemia, qib ntawm LDL-txuam nrog cov cholesterol txo qis mus rau 35%, thaum hyperuricemia thiab atherosclerosis txo qis hauv kev saib xyuas ntawm uric acid hauv cov ntshav los ntawm 25%.
Cov Tshuaj Pharmacokinetics
Thaum noj ntawm qhov ncauj, micronized compound ntawm fenofibrate yog nqus rau qhov chaw ze ntawm txoj hnyuv me siv microvilli, los ntawm qhov chaw uas nws tau nqus rau hauv cov hlab ntshav. Thaum nws nkag mus rau hauv txoj hnyuv, cov tshuaj nquag tam sim ntawd decomposes rau fenofibroic acid los ntawm hydrolysis nrog esterases. Cov khoom lwj ua kom tiav mus txog cov ntshav siab tshaj plaws nyob rau hauv 2-4 teev. Noj ntawm tus nqi ntawm kev nqus thiab bioavailability tsis cuam tshuam vim nanoparticles.
Thaum nws nkag mus rau hauv txoj hnyuv, cov tshuaj nquag tam sim ntawd decomposes rau fenofibroic acid los ntawm hydrolysis nrog esterases.
Hauv cov hlab ntshav, cov nquag sib xyaw ua ke khi rau ntshav albumin los ntawm 99%. Cov tshuaj tsis koom nrog microsomal metabolism. Ib nrab-lub neej nyob ntev txog 20 teev. Hauv kev sim tshuaj kho mob, tsis muaj ib qho kev ua txhaum dab tsi nrog ob qho tib si lossis nrog rau kev tswj hwm ntev ntawm cov tshuaj. Hemodialysis tsis muaj txiaj ntsig. Cov tshuaj tau tawm hauv cov qauv fenofibroic acid kiag li 6 hnub dhau los ntawm cov kab mob tso zis.
Kev ntsuas rau siv
Cov tshuaj yog kws kho nyob hauv qhov muaj cov roj (cholesterol) siab thiab nrog hom hypertriglyceridemia. Pab kev mob caj dab. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov tshuaj yog npaj rau kev kho mob ntawm keeb kwm yav dhau los ntawm kev siv tshuaj tsawg, kev tawm dag zog thiab lwm yam cuam tshuam nrog poob phaus. Tshwj xeeb tshaj yog nyob rau ntawm muaj kev pheej hmoo yam (ntshav siab, tus cwj pwm tsis zoo) nrog dyslipidemia.
Cov tshuaj yog siv los tshem tawm cov hyperlipoproteinemia theem nrab tsuas yog thaum tswj hwm lipoprotein qhov siab ntawm qib siab tiv thaiv keeb kwm ntawm kev kho tau zoo ntawm cov txheej txheem tseem ceeb.
Dyslipidemia nyob rau hauv ntshav qab zib mellitus yuav yog tom kawg.
Cov Yuav Tsum Muaj
Cov tshuaj tsis tau sau tseg vim yog ua tiav contraindications:
- ua kom lub cev tsis haum rau fenofibrate thiab lwm yam kev teeb tsa ntawm cov tshuaj;
- daim siab mob
- mob raum tsis zoo;
- cov kab mob ua rau cov leeg galactosemia thiab fructosemia, cov tsis muaj cov lactase thiab sucrose, kev tsis haum ntawm cov piam thaj thiab galactose;
- keeb kwm muaj keeb kab mob leeg;
- rhiab rau lub teeb thaum kho nrog Ketoprofen lossis lwm yam fibrates;
- pathological txheej txheem nyob rau hauv lub gallbladder.
Cov neeg uas muaj kev phiv tshuaj anaphylactoid rau cov txiv laum huab xeeb thiab txiv laum huab xeeb yuav tsum tsis txhob noj cov tshuaj.
Nrog saib xyuas
Ceev faj yuav tsum siv lub raum thiab hepatic tsis txaus, haus dej cawv tawm, kab mob leeg mob, hypothyroidism.
Yuav ua li cas noj Fenofibrate
Cov ntsiav tshuaj tau noj yam tsis muaj kev zom. Cov neeg mob laus yuav tsum noj 145 mg ntawm ib hnub ib zaug. Thaum hloov pauv los ntawm qhov ntau npaum ntawm 165, 180 mg rau qhov kev siv tshuaj txhua hnub ntawm 145 mg, yuav tsum tau kho qhov ntau ntxiv ntawm qhov kev niaj hnub tsis tas yuav.
Nws raug nquahu kom noj cov tshuaj rau lub sijhawm ntev tiv thaiv keeb kwm ntawm kev tsim kho kev noj haus. Cov hauj lwm zoo ntawm kev kho yuav tsum raug soj ntsuam tas li los ntawm tus kws kho mob nyob ntawm seb cov ntshiab lipid cov ntsiab lus li cas.
Cov ntsiav tshuaj tau noj yam tsis muaj kev zom.
Noj cov tshuaj rau ntshav qab zib
Ua ntej noj Fenofibrate, nws yog ib qho tsim nyog yuav tsum tshem tawm cov theem nrab hypercholesterolemia tawm tsam keeb kwm ntawm tsis muaj tshuaj insulin-tiv thaiv hom 2 mob ntshav qab zib mellitus. Tom qab, cov tshuaj siv rau hauv cov txheej txheem tshuaj.
Sab sij huam
Cov kev mob tshwm sim los ntawm kev siv tshuaj tsis haum lossis thaum kis tus kab mob sab nraud: lwm yam kab mob ntawm cov plab hnyuv siab raum thiab lub nruab nrog cev, muaj kev cuam tshuam ntawm cov txheej txheem pathological, ib leeg nqaij raug rau fenofibrate.
Kev kho mob txoj hnyuv
Epigastric mob, ntuav, thiab raws plab heev. Tus neeg mob tau mob pancreatitis tau tshaj tawm.
Hematopoietic plab hnyuv siab raum
Cov teeb meem vascular muaj xws li cov leeg ntshav muaj zog. Tsawg tsawg zaus, qhov nce ntawm leukocytes thiab theem ntawm hemoglobin nyob rau hauv cov ntshav yog tau.
Nruab nrab hauv lub paj hlwb
Erectile kawg ua haujlwm thiab mob taub hau tuaj yeem tshwm sim nrog kev phiv tshuaj rau ntawm cov leeg hlwb.
Los ntawm cov leeg musculoskeletal
Muaj qee zaus, kis mob leeg mob, mob caj dab, tsis muaj zog thiab mob leeg nqaij, thiab muaj kev pheej hmoo ntawm kev tsim cov leeg mob necrosis.
Los ntawm genitourinary system
Tsis muaj cov kev hloov pauv tsis zoo hauv qhov kev ua haujlwm ntawm txoj kev tso zis.
Kev ua xua
Feem ntau, ua pob rau ntawm daim tawv nqaij, ua kom lub ntsej muag (hnov tau lub teeb pom kev zoo), khaus lossis khaus ntawm qhov mob me mus rau mob hnyav tau tshwm sim. Muaj qee zaus, plaub hau ploj, qhov pom ntawm erythema, hlwv los yog nodules ntawm cov nqaij sib txuas hauv qab ntawm ultraviolet hluav taws xob tau pom.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Txais tos ntawm Fenofibrate tsis cuam tshuam rau kev xav, lub cev thiab lub hlwb tsis zoo, yog li ntawd, thaum lub sijhawm kho lipid-txo qis, tsav tsheb thiab ua haujlwm nrog cov khoom siv nyuaj tau tso cai.
Lub sijhawm thaum noj cov tshuaj, tsav tsheb thiab ua haujlwm nrog cov twj siv tau yooj yim raug tso cai.
Cov lus qhia tshwj xeeb
Qib ntawm kev kho mob nyhuv yog txheeb xyuas ntawm lub hauv paus ntawm kev ntsuas ntawm lipid cov ntsiab lus: ntshiab LDL, cov roj cholesterol thiab triglycerides. Yog tias tsis muaj tshuaj tiv thaiv ntawm lub cev mus rau cov tshuaj tsis pub dhau 3 lub hlis ntawm txoj kev kho, nws yog qhov yuav tsum tau sab laj nrog tus kws kho mob txog kev teem sijhawm kho lwm yam.
Qhov tshwm sim ntawm theem siab hyperlipidemia tom qab noj tshuaj estrogens, tshuaj hormones thiab tshuaj sib deev raws li poj niam txiv neej pw ua ke yuav cuam tshuam nrog kev nce qib hauv estrogen. Cov qib Fibrinogen tsawg dua.
Kev nce ntawm hepatocytic transaminases nyob rau hauv Feem ntau yog ib ntus asymptomatic. Thawj 12 lub hlis ntawm kev kho mob hauv qhov xwm txheej no nws raug nquahu kom kuaj mob rau theem ntawm hepatic aminotransferases txhua 3 lub hlis. Nrog rau qhov kev nce siab ntawm kev txav ntawm transaminases los ntawm 3 lossis ntau zaus, nws yog qhov tsim nyog kom tsis txhob noj Fenofibrate.
Thaum lub sijhawm kev kho mob, qhov tshwm sim ntawm kev txhim kho ntawm pancreatitis tau sau tseg. Ntawm qhov ua tau rau mob o, muaj:
- cholelithiasis, nrog mob cholestasis;
- tsis tshua muaj txiaj ntsig ntawm cov tshuaj rau mob ntshav siab hypertriglyceridemia;
- qhov tsim kom muaj kev loog nyob rau hauv lub kem.
Hauv lub sijhawm ntawm kev kho mob nrog tshuaj, tus kab mob ntawm kev txhim kho ntawm pancreatitis tau sau tseg.
Tej zaum qhov kev loj hlob ntawm cov tshuaj lom los ntawm cov tshuaj ntawm cov leeg, ua rau rhabdomyolysis. Txoj kev pheej hmoo ntawm kev txhim kho tus kab mob thiab nws cov teeb meem cuam tshuam rau lub keeb kwm yav dhau los ntawm lub raum tsis ua haujlwm thiab txo qis ntawm cov albumin hauv ntshav. Nws yog ib qho tsim nyog yuav tsum ua qhov kev tshawb fawb los txheeb xyuas qhov ua rau muaj kev phom sij ntawm Fenofibrate ntawm cov leeg pob txha hauv kev tsis txaus siab ntawm qhov tsis muaj zog, mob leeg nqaij, mob leeg nqaij, mob plab, mob leeg, nce ntxiv hauv cov kev ua si ntawm creatine phosphokinase 5 zaug lossis ntau dua. Yog tias cov ntsuas pom hauv qhov muaj txiaj ntsig zoo, cov tshuaj noj raug tso tseg.
Nrog rau kev nce hauv creatinine qib ntawm ntau dua 50% ntawm cov cai, nws raug nquahu kom ncua kev kho mob Fenofibrate. Nrog kev siv tshuaj txuas ntxiv, nws raug nquahu kom cov creatinine concentration yuav soj ntsuam li 90 hnub.
Siv thaum cev xeeb tub thiab lactation
Hauv kev tshawb fawb hauv cov tsiaj, tsis muaj teebmeem teratogenic tau kuaj pom. Hauv kev tshawb fawb preclinical, kev mob toxicity rau leej niam lub cev thiab qhov kev pheej hmoo rau tus me nyuam hauv plab tau sau cia, yog li ntawd, kev noj cov tshuaj yog nqa tawm tsuas yog tias muaj txiaj ntsig zoo rau tus poj niam cev xeeb tub tshaj qhov kev pheej hmoo ntawm kev tsim muaj mob pob ntseg hauv menyuam.
Kev pub mis niam thaum kev kho mob tso tseg.
Fenofibrate Tshaj Tawm rau Cov Menyuam
Cov tshuaj tsis pom zoo rau cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo vim tias tsis muaj ntaub ntawv qhia txog cov nyhuv ntawm Fenofibrate ntawm kev loj hlob thiab kev loj hlob ntawm lub cev.
Siv rau lub sijhawm qub
Cov neeg laus dua 70 xyoo tsis tas yuav kho cov tshuaj ntau npaum li cas.
Noj ntau dhau
Muaj tsis muaj ib qho tshwm sim ntawm kev haus ib qho zuj zus vim yog siv tshuaj yeeb. Nws tsis muaj qhov tshwj xeeb dab kev tub rog ua ke. Yog li, yog tias tus neeg mob nrog rau ib tus kws kho mob siab rau ib zaug ntau zaug pib xav tias tsis xis nyob, thab plaub lossis phiv lwm yam tshwm sim, nws yuav tsum nrhiav kev pab kho mob. Nrog tsev kho mob, cov tsos mob tshwm sim ntawm kev siv ntau dhau yog tshem tawm.
Kev cuam tshuam nrog lwm yam tshuaj
Thaum muab cov fenofibrate nrog cov tshuaj anticoagulants rau kev tswj hwm qhov ncauj, qhov ua tau zoo ntawm cov tshuaj hauv nqe lus nug nce ntxiv. Nrog rau txoj kev cuam tshuam no, txoj kev pheej hmoo ntawm los ntshav ntau ntxiv vim kev hloov chaw ntawm cov tshuaj anticoagulant los ntawm cov ntshav protein.
Nrog kev siv hluav taws xob sib xyaw ua ke ntawm HMG-CoA reductase blockers, qhov kev pheej hmoo ntawm cov lus tshaj tawm tsis zoo rau cov leeg nqaij nce ntxiv, yog li yog tus neeg mob noj cov tshuaj statins, nws yog qhov yuav tsum tau thim cov tshuaj.
Cyclosporine pab txhawb kom lub raum ua kom tsis zoo rau lub raum, yog li thaum noj Fenofibrate, koj yuav tsum kuaj xyuas lub cev tas mus li. Yog tias tsim nyog, txoj kev tswj hwm ntawm cov tshuaj tiv thaiv hypolipidemic yog tso tseg.
Cawv tau zoo
Thaum kho nrog Fenofibrate, nws yog txwv tsis pub haus cawv. Kev haus dej cawv ethyl ua rau lub zog kho tsis zoo ntawm cov tshuaj, txhim kho cov tshuaj lom rau lub siab ua haujlwm, lub hauv nruab nrab cov hlab ntsha thiab ntshav khiav haujlwm.
Analogs
Analogues ntawm cov tshuaj suav nrog cov tshuaj nrog ib qho kev tsis sib xws ntawm kev txiav txim:
- Tricor
- Atorvacor;
- Kev Ntsiav Tshuaj lipantyl;
- Ciprofibrate;
- Ntsiav tshuaj Canon Fenofibrate;
- Livostor;
- Cuav;
- Trilipix.
Hloov mus rau lwm cov tshuaj yog ua tiav tom qab sab laj kev kho mob.
Cov nqe lus So Tsev Muag Tshuaj Fenofibrate
Cov tshuaj tsis raug muag yam tsis muaj daim ntawv yuav tshuaj ntawm Latin.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Vim tias qhov pheej hmoo ntawm rhabdomyolysis, qhov muag dawb ntawm fenofibrate yog txwv tsis pub.
Npaum licas
Rau cov ntsiav tshuaj ntawm 145 mg, 30 daim rau ib pob, tus nqi nruab nrab yog 482-541 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cov tshuaj ntawm qhov kub txog + 25 ° C hauv qhov chaw qhuav, nyob deb ntawm tshav ntuj.
Nws raug nquahu kom khaws cov tshuaj ntawm qhov kub txog + 25 ° C hauv qhov chaw qhuav, nyob deb ntawm tshav ntuj.
Hnub tas sij hawm
145 thiab 160 mg ntsiav tshuaj tuaj yeem khaws cia tau 3 xyoos, 180 mg rau 2 xyoos.
Fenofibrate Chaw Tsim Tshuaj
Plaub Thib Laboratories, Ireland.
Fenofibrate Xyuas
Muaj cov lus pom zoo los ntawm cov kws muag tshuaj thiab cov neeg mob.
Cov kws kho mob
Olga Zhikhareva, kws kho plawv, Moscow
Ua tau zoo nyob rau hauv kev sib ntaus tawm tsam siab triglycerides. Kuv pom zoo kom siv cov hom IIa, IIb, III thiab IV rau hyperlipoproteinemia. Hauv kev siv tshuaj, Kuv sau lub sijhawm tswj hwm thiab haus ntau npaum li cas ntawm ib tus neeg. Tsis muaj kev phiv pom. Nws tsis muaj suab hais txog kev txo cov roj (cholesterol).
Afanasy Prokhorov, neeg noj zaub mov zoo, Yekaterinburg
Nrog rau kev rog thiab cov roj (cholesterol) siab, fenofibroic acid pab zoo. Tshwj xeeb ntawm qis qis ntawm kev tawm dag zog thiab kev noj haus. Hauv lub sijhawm kho, Kuv pom zoo kom tso tseg tsis zoo thiab ua raws li kws kho mob cov lus pom zoo txhawm rau ua kom muaj txiaj ntsig zoo.
Cov neeg mob
Nazar Dmitriev, 34 xyoo, Magnitogorsk
Kev kho mob zoo Lipids tau 5.4.Nrog kev siv Fenofibrate tsis tu ncua, cov theem ntawm cov rog tsawg dua rau 1,32. Ciaj ciam yog 1.7. Tsis muaj kev phiv sau tseg.
Anton Makaevsky, 29 xyoos, St. Petersburg
Nws tau siv li ib xyoos hloov Torvacard vim yog cov ntsiab lus tsawg ntawm HDL. Tom qab 4-5 lub hlis ntawm kev noj, kev tawm tsam ntawm xeev siab thiab mob ntawm lub plab mog tau pib tshwm sim. Tom qab 8-9 lub hlis, lawv tau ua kev phais mob tawm kom tshem tawm cov kem plab. Viscous bile thiab pob zeb xoob tau pom. Tom qab lub lag luam, kev tawm tsam nres.
Mikhail Taizhsky, 53 xyoo, Irkutsk
Cov tshuaj noj kom haus cov leeg ntsa txha khov, tab sis kuv tsis tuaj yeem hais txog qhov kev txiav txim. Cov hlab ntsha tsis muaj kev xav li cas. Nrog kev pabcuam ntawm cov tshuaj, lub cev hnyav poob vim tias kev tshaib plab, tab sis daim tawv nqaij sagged muaj zog. Yuav tsum tau ua haujlwm rov qab. Kuv txaus siab rau lub txiaj ntsig.
