Noliprel Muv yog cov tshuaj uas ua ke nrog 2 nquag ua ke - perindopril arginine thiab indapamide. Raws li qhov kev txiav txim ua ke, nws muaj peev xwm ruaj khov los tiv thaiv cov ntshav tiv thaiv cov keeb kwm yav dhau los ntawm cov diuretic me ntsis. Cov tshuaj tsis yog tsim rau kev siv rau menyuam yaus thiab poj niam cev xeeb tub.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Perindopril + Indapamide.
Noliprel Muv yog cov tshuaj uas ua ke nrog 2 nquag ua ke - perindopril arginine thiab indapamide.
ATX
C09BA04.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb biconvex nrog zaj duab xis txheej saum npoo. Chav tsev ntawm cov tshuaj muaj arginine lossis tert-butylamine ntsev, 10 mg ntawm perindopril thiab 2.5 mg ntawm indapamide. Cov pawg ntawm cov khoom siv ntxiv suav nrog:
- dehydrogenated silica colloidal;
- mis nyuj qab zib;
- sodium carboxymethyl hmoov txhuv nplej siab;
- maltodextrin;
- magnesium stearate.
Cov zaj duab xis sab nraud ntawm lub ntsiav tshuaj muaj macrogol 6000, titanium dioxide, glycerol, magnesium stearate thiab hypromellose.
Pharmacological kev txiav txim
Cov tshuaj muaj qhov ua kom hypotensive thiab diuretic rau ntawm lub cev. Cov tshuaj sib xyaw ua ke pab rau kev tshem tawm cov leeg mob hlwb (ACE). Pharmacological cov yam ntxwv ntawm cov tshuaj tau tiav vim yog tus tib neeg cov cawv ntawm txhua yam tshuaj uas cuam tshuam. Kev sib xyaw ntawm indapamide thiab perindopril nce cov nyhuv antihypertensive.
Raws li qhov txiaj ntsig ntawm diuretic nyhuv ntawm cov tshuaj, tus neeg mob ntshav siab poob qis.
Perindopril tertbutylamine ntsev inhibits kev hloov ntawm angiotensin Kuv mus rau hauv hom II angiotensin los ntawm inhibiting kinase II (ACE). Qhov tom kawg yog sab nraud peptidase, uas koom nrog kev rhuav tshem cov vasodilating bradykinin mus rau heptapeptide, ib qho ua kom tsis tuaj yeem tiv taus. ACE inhibits qhov hloov pauv ntawm hom I angitensin tshuaj sib txuas rau hauv vasoconstrictor daim ntawv.
Indapamide belongs rau chav kawm ntawm sulfonamides. Cov chaw muag tshuaj zoo ib yam li cov tshuab ntawm kev txiav txim ntawm thiazide diuretics. Vim tias thaiv qhov reabsorption ntawm sodium lwg me me hauv lub glomerulus ntawm lub raum, qhov feem cuam ntawm chlorine thiab sodium ions nce, thiab kev nthuav tawm ntawm magnesium thiab potassium txo. Muaj kev nce ntxiv ntawm diuresis. Raws li qhov tso tawm ntawm lub diuretic, ntshav siab poob qis.
Cov Tshuaj Pharmacokinetics
Thaum noj ntawm qhov ncauj, lub ntsiav tshuaj tau tawg tawm los ntawm txoj hnyuv esterases. Perindopril thiab indapamide raug tso tawm rau hauv txoj hnyuv me me, qhov chaw ntawm cov tshuaj lom neeg yog nqus los ntawm villi tshwj xeeb. Thaum lawv nkag mus rau hauv lub txaj vascular, ob lub tebchaw nquag mus txog cov ntshav siab ntau kawg hauv ib teev.
Thaum perindopril nkag rau hauv cov hlab ntshav, nws tawg rau perindoprilat los ntawm 27%, uas muaj cov nyhuv antihypertensive thiab tiv thaiv kev tsim cov angiotensin II. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev noj haus qeeb qeeb rau kev pauv ntawm perindopril. Cov khoom lag luam metabolic ncav cuag lub siab tshaj plaws ntshav plasma tsis pub dhau 3-4 teev. Ib nrab-lub neej ntawm perindopril yog 60 feeb. Cov tshuaj lom neeg cov tshuaj tawm tom qab tso zis.
Cov khoom lag luam metabolic nce mus txog qhov siab tshaj plaws ntshav plasma tsis pub dhau 3-4 teev, thiab ib nrab-lub neej yog 60 feeb.
Indapamide khi rau albumin los ntawm 79% thiab vim yog qhov tsim ntawm cov nyom tau muab faib thoob cov ntaub so ntswg. Kev tshem tawm ib nrab-lub neej nyob rau nruab nrab kav ntev li 14 txog 24 teev. Nrog kev rov ua dua, kev ua kom muaj zog ntawm cov tshuaj yeeb dej caw tsis pom. 70% ntawm indapamide nyob rau hauv daim ntawv ntawm cov khoom lag luam tawm hauv lub cev tawm ntawm lub raum, 22% - nrog quav.
Kev ntsuas rau siv
Cov tshuaj yog npaj los txo cov ntshav siab nyob rau hauv qhov muaj qhov tseem ceeb tawg nyob rau hauv cov neeg mob uas xav tau kev kho mob tshuaj nrog indapamide ntawm koob tshuaj 2.5 mg thiab 10 mg perindopril.
Cov Yuav Tsum Muaj
Cov tshuaj tsis nyob hauv cov teeb meem hauv qab no:
- kev tswj hwm kev sib txig sib luag ntawm cov tshuaj uas nce QT ntu, thiab cov tshuaj muaj lithium thiab potassium ions, tawm tsam keeb kwm ntawm hyperkalemia;
- ua kom lub cev tsis haum rau cov tshuaj uas tsim cov tshuaj;
- cov kab mob muaj keeb kwm ntawm lactose intolerance, galactosemia, lactase deficiency, malabsorption ntawm monosaccharides;
- kev tshem tawm creatinine (Cl tsawg dua 60 ml / min) - mob raum tsis ua haujlwm;
- mob plawv tsis ua hauj lwm hauv qhov theem decompensation;
- tsis tau muaj 18 xyoo.
Kev ceev faj yuav tsum tau siv thaum noj Noliprel nyob rau ntawm qhov muaj cov txheej txheem pathological hauv cov ntaub so ntswg sib txuas (lupus erythematosus, sclerodermaem), kev tsim txom los ntawm cov ntshav hauv plab, mob plawv, hyperuricemia.
Yuav noj Noliprel Bi li cas
Cov ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj, 1 daim ib hnub ib zaug. Nws raug nquahu kom haus cov tshuaj thaum sawv ntxov ua ntej noj tshais, vim hais tias kev noj kom tsawg dua qhov kev nqus thiab txo qis kev noj qab haus huv ntawm cov khoom siv nquag.
Yuav kho tus mob ntshav qab zib hom 2 li cas
Cov tshuaj tsis cuam tshuam rau cov tshuaj hormonal tso pa tawm ntawm lub cev pancreatic beta hlwb thiab tsis hloov pauv cov suab thaj hauv cov ntshav ntshav, yog li ntawd, cov neeg mob uas tsis muaj cov tshuaj insulin-mob ntshav qab zib mellitus tsis xav tau hloov kho koob tshuaj.
Phiv los ntawm noliprel bi
Cov kev mob tshwm sim los tiv thaiv keeb kwm ntawm kev noj tshuaj tsis raug cai los yog nyob rau ntawm qhov raug ntxiv ntawm cov nqaij mos raug rau cov txheej txheem yam ntxwv.
Kev kho mob txoj hnyuv
Cov kev tsis zoo tshwm sim hauv cov zom zaub yog qhov txawv ntawm:
- qhov ncauj qhuav
- saj tsis meej;
- mob epigastric;
- tsis qab los noj mov;
- ntuav, raws plab, raws plab thiab quav tawv.
Muaj qee zaus, pom tshwm sim ntawm pancreatitis, cholestatic jaundice tiv thaiv keeb kwm ntawm hyperbilirubinemia, angioedema ntawm txoj hnyuv.
Hematopoietic plab hnyuv siab raum
Hauv cov ntshav thiab lymph, txo qis ntawm tus naj npawb thiab qhov tsis txaus siab ntawm kev tsim cov platelets, neutrophils thiab leukocytes tuaj yeem pom. Nrog cov tsis muaj cov qe ntshav liab txaus, ua rau ntshav tsis muaj ntshav ntawm aplastic thiab hemolytic yam tshwm sim. Cov tsos ntawm agrenulocytosis yog tau. Hauv qee qhov tshwj xeeb: cov neeg mob hemodialysis, lub sijhawm rov kho dua tom qab lub raum hloov pauv - ACE inhibitors provoke kev txhim kho kev mob ntshav liab.
Nruab nrab hauv lub paj hlwb
Nrog kev ua txhaum ntawm lub hauv nruab nrab lub paj hlwb, qhov tshwm sim ntawm:
- xob vwj;
- mob taub hau;
- paresthesia;
- Kiv taub hau
- kev tsaug zog kev ntxhov siab thiab ploj ntawm txoj kev xav.
Hauv qee qhov tshwj xeeb, 1 tus neeg mob ntawm 10,000 tus neeg mob yuav muaj kev kub ntxhov thiab tsis nco qab.
Cov kev mob tshwm sim hauv lub qhov muag tau pom los ntawm qhov txo qis ntawm qhov pom ntawm lub pob ntseg, thaum hnov lus tsis zoo yog ua kom pom kev ua suab nrov hauv pob ntseg.
Los ntawm cov kab mob zis
Muaj qee zaus, lub raum tsis ua hauj lwm thiab mob erectile kawg.
Los ntawm lub tshuab ua pa
Tawm tsam cov keeb kwm yav dhau los ntawm kev siv tshuaj kho mob, ACE inhibitors tuaj yeem tsim hnoos qhuav, ua tsis taus pa, bronchospasm, txhaws ntswg thiab mob ntsws oosinophilic.
Kev ua xua
Muaj tus ua tau tawm pob khaus, erythema thiab khaus ntawm daim tawv nqaij. Qee qhov xwm txheej, mob hlwb ntawm lub ntsej muag thiab mob kawg, Quincke's edema, urticaria, vasculitis. Tshwj xeeb tshaj yog nyob rau hauv muaj ib tug predisposition rau anaphylactoid kev tsis haum. Nyob rau hauv muaj mob ntawm loogus erythematosus, soj ntsuam daim duab ntawm tus kab mob worsens. Hauv kev xyaum kho mob, cov xwm txheej ntawm cov roj ntsha ua rau lub cev thiab cov kab mob sib kis ntawm cov roj ntsha subcutaneous.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis cuam tshuam rau lub peev xwm mloog thiab tsis txo qhov nrawm ntawm qhov tshuaj tiv thaiv, tab sis vim muaj kev pheej hmoo ntawm cov kev mob tshwm sim hauv lub hauv nruab nrab cov hlab ntsha, yuav tsum saib xyuas thaum ua haujlwm nrog cov khoom siv nyuaj, kev ua kis las, tsav tsheb.
Cov lus qhia tshwj xeeb
Noj cov tshuaj sib xyaw tsis tiv thaiv kev txhim kho hypokalemia, nrog rau cov neeg mob raum tsis ua haujlwm thiab ntshav qab zib. Hauv qhov xwm txheej no, kev saib xyuas tsis tu ncua ntawm kev saib xyuas cov poov tshuaj hauv plasma yog qhov yuav tsum tau ua.
Thaum kho, txo qis sodium nyob rau hauv lub cev yog ua tau vim muaj kev loj hlob ntawm hypotension. Txoj kev pheej hmoo ntawm hyponatremia nce nrog ob tog stenosis ntawm cov hlab ntsha ntawm ob lub raum, yog li nyob rau hauv cov rooj plaub no nws yuav tsum tau qhia rau tus kws kho mob txog lub cev qhuav dej, ntuav thiab raws plab. Kev txo qis hauv cov ntshav siab tsis tiv thaiv kev tswj hwm ntawm Noliprel ntxiv.
Siv rau lub sijhawm qub
Cov neeg mob uas muaj hnub nyoog 65 xyoos uas lub raum tsis ua haujlwm tsis tas yuav tsum hloov qhov koob ntxiv. Hauv lwm qhov teeb meem, qhov ntau thiab cov sijhawm ntawm kev kho mob raug kho nyob ntawm seb muaj hnub nyoog, hnyav li cas thiab tub los ntxhais ntawm tus neeg mob.
Ntawv pub rau noliprel bi rau menyuam yaus
Vim tias tsis muaj cov ntaub ntawv hais txog cov txiaj ntsig ntawm cov tshuaj yeeb dej caw ntawm kev loj hlob thiab kev loj hlob ntawm menyuam yaus thiab thaum tiav hluas, cov tshuaj txwv tsis pub rau cov menyuam yaus hnub nyoog qis dua 18 xyoo siv.
Siv thaum cev xeeb tub thiab lactation
Kev noj cov tshuaj hauv II thiab III lub sijhawm ntawm kev txhim kho embryonic tuaj yeem ua rau kev tso tsis raug ntawm lub raum thiab pob txha ntawm pob txha taub hau, oligohydramnios, thiab tseem yuav muaj kev pheej hmoo ntawm txoj hlab ntshav hypotension thiab lub raum tsis ua haujlwm hauv cov menyuam mos. Yog li, kev siv Noliprel hauv cov poj niam cev xeeb tub yog txwv tsis pub.
Thaum kho, nres mis.
Daim ntawv thov rau lub raum khiav tsis zoo
Nrog creatinine tshem tawm saum toj 60 ml / min, nws yog qhov yuav tsum tau soj ntsuam tas li theem ntawm creatinine thiab potassium ions hauv ntshav.
Siv rau lub siab ua haujlwm tsis zoo
Cov tshuaj yog txwv rau kev siv hauv cov neeg mob uas muaj lub siab tsis ua haujlwm siab.
Noj tshuaj ntau ntawm Noliprel Bi
Nrog ib zaug hno koob tshuaj, qhov kev soj ntsuam daim duab ntawm kev noj tshuaj tshaj yog pom:
- txoj kev mob siab rau txo cov ntshav siab, nrog ntuav thiab xeev siab;
- mob leeg;
- Kiv taub hau
- oliguria nrog txoj kev loj hlob ntawm anuria;
- ua txhaum ntawm dej-ntsev tshuav;
- tsis meej pem, tsis muaj zog.
Tus neeg mob xav tau kev kho mob tam sim ntawv tsom rau tiv thaiv kom tsis txhob nqus ntxiv ntawm cov tshuaj. Hauv tsev kho mob, tus neeg mob tau ntxuav nrog lub plab ntawm lub plab, cov pa roj carbon activated yog tus kws kho. Nrog txoj kev ua kom ntshav nce siab, tus neeg mob hloov mus rau ib qho chaw tav toj thiab txhais ceg tau tsa. Nrog rau txoj kev loj hlob ntawm hypovolemia, 0.9% sodium chloride tov yog muab tshuaj kom ncaj.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau kev tswj hwm tib lub sij hawm ntawm cov tshuaj tiv thaiv tshuaj tiv thaiv thiab tshuaj tua kab mob, nws muaj peev xwm nce cov nyhuv antihypertensive, uas ua rau muaj peev xwm ntxiv ntawm kev tiv thaiv orthostatic hypotension. Glucocorticosteroids thiab tetracosactides ua rau dej thiab sodium tuav, txo cov nyhuv diuretic. Raws li qhov tshwm sim, kev nce ntshav hauv ntshav nce siab. Txhais tau rau kev siv tshuaj loog ntau ntxiv qhov txo qis hauv ntshav hauv cov hlab ntsha.
Nrog saib xyuas
Ceev faj kom paub thaum sau ntawv rau cov neeg hauv qab no hauv kev sib luag:
- Cov tshuaj nonsteroidal anti-inflammatory, acetylsalicylic acid nrog tshuaj rau ib hnub ntau dua 3000 mg. Muaj ib qho kev txo qis hauv cov nyhuv antihypertensive, tawm tsam uas lub raum tsis ua haujlwm thiab cov ntshav dej hyperkalemia pib.
- Cyclosporin. Txoj kev pheej hmoo ntawm nce creatinine ntau ntau yam tsis muaj kev hloov pauv ntawm cyclosporine nrog cov dej ib txwm muaj nce ntxiv.
- Baclofen tuaj yeem txhim kho txoj kev kho kom zoo ntawm cov tshuaj, yog li thaum nws tau noj tshuaj, nws yog ib qho tsim nyog los soj ntsuam cov ntshav siab thiab lub raum. Yog tias tsim nyog, kev noj tshuaj ntau dua ntawm ob qho tshuaj yuav raug kho.
Kev sib xyaw tsis pom zoo
Thaum noj cov khoom siv lithium nrog rau Noliprel Bi-Forte, kev tshuaj kws tshuaj tsis suav nrog. Nrog kev siv tshuaj ib txhij, lub plasma concentration ntawm lithium ib ntus nce ntxiv thiab qhov kev pheej hmoo ntawm kev ua kom muaj zog ntxiv tuaj.
Cawv tau zoo
Nws yog txwv tsis pub haus cawv thaum lub sij hawm siv tshuaj yaj yeeb. Kev haus cawv Ethyl txhim kho cov mob lub siab thiab ua rau lub zog kho tsis haum tshuaj, txhim kho cov nyhuv inhibitory nyob rau ntawm cov leeg hlwb thiab kab mob siab.
Analogs
Cov kev hloov pauv nrog qhov zoo sib xws cov kev ua muaj xws li:
- Ko-perineva;
- Noliprel A;
- Noliprel A-Forte;
- tib lub sijhawm noj Perindopril thiab Indapamide, uas yog muag pheej yig dua li cov generics.
Koj tuaj yeem hloov mus rau lwm cov tshuaj tom qab sib tham kev kho mob.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Muag los ntawm cov tshuaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Kev muag dawb yog txwv vim muaj kev pheej hmoo ntawm kev noj ntau dhau thiab phiv thaum noj yam tsis muaj kev kho mob ncaj qha.
Nqe rau noliprel bi
Tus nqi nruab nrab ntawm cov tshuaj yog 540 rubles., Hauv Ukraine - 221 UAH.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cia hauv qhov kub thiab + 15 ... + 25 ° C.
Hnub tas sij hawm
36 hli.
Chaw tsim tshuaj paus
Kev Tshuaj Ntsuam (Lab) Servier Kev Lag Luam, Fab Kis.
Kev txheeb xyuas txog Noliprel Bi
Hauv Is Taws Nem cov kev sib tham muaj kev tshuaj xyuas zoo ntawm cov kws muag tshuaj thiab cov neeg mob txog cov tshuaj.
Kev kho plawv
Olga Dzhikhareva, kws kho plawv, Moscow
Kuv xav txog cov tshuaj antihypertensive coj los ua ib qho tshuaj kho tau zoo. Cov tshuaj ib txwm txos txo cov ntshav siab ua tsaug rau indapamide uas muaj cov nyhuv diuretic. Cov tshuaj tau sau ntawv tawm rau cov neeg mob 1 zaug hauv ib hnub thaum sawv ntxov. Lub chav kawm ntawm kev kho mob yog tsim los ntawm cov tib neeg.
Svetlana Kartashova, kws kho plawv, Ryazan
Cov tshuaj zoo rau thawj cov tshuaj tiv thaiv kab mob nrog rau kev kho tom qab ntawm cov tshuaj ntau dua. Cov tshuaj pab ua kom txo cov leeg ventricular hypertrophy thiab txhim kho kev ywj pheej ntawm daim siab mob plawv thiab phab ntsa vascular. Nov yog qhov tshuaj qub rau kev kho mob tawg.
Cov neeg mob
Anastasia Yashkina, 37 xyoo, Lipetsk
Cov tshuaj tau muab tawm rau cov ntshav siab. Lub siab tsis yog qhov siab tshaj plaws, yog li thaum xub thawj kuv tsis tau mus ntsib kws kho mob. Thaum kub siab tshaj qhov kev mob siab tshwm sim, lub siab nce mus rau 230/150. Muab tso rau hauv tsev kho mob. Xaj Noliprel Bi-Fort ntsiav tshuaj. Tom qab 14 hnub ntawm kev nquag, lub siab rov ua kom zoo li qub. Tsis muaj qhov ua xua, cov ntsiav tshuaj tuaj rau hauv lub cev. Lub siab ruaj khov rau 3 xyoos.
Sergey Barankin, 26 xyoo, Irkutsk
Ib xyoo dhau los, qhov siab tau nce mus rau 170/130. Nws nrhiav kev pab kho mob - tus kws kho mob tau sau 10 mg ntawm Noliprel thiab hais kom noj 1 lub tshuaj thaum sawv ntxov ntawm lub plab khoob. Thaum xub thawj, Kuv mloog zoo li kuv tsis xis nyob thiab tawm hws. Kuv txiav txim siab mus noj ib nrab ntsiav tshuaj. Tus mob thiab lub siab rov qab ua qhov qub. Cov naj npawb tau nce mus txog 130/80.
