Insulin glulisin yog tshuaj noj rau kev kho mob los ntawm cov ntshav qab zib uas tsis yog insulin los yog tsis muaj kev tiv thaiv ntshav qab zib. Nws yog qhia rau hauv lub cev tsuas yog nrog kev pabcuam ntawm kev txhaj tshuaj. Ua tau zoo tswj glycemic ntsuas.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN - Apidra.
Insulin glulisin yog tshuaj noj rau kev kho mob los ntawm cov ntshav qab zib uas tsis yog insulin los yog tsis muaj kev tiv thaiv ntshav qab zib.
ATX
ATX encoding - A10AV06.
Lub npe Kev Lag Luam
Muaj nyob hauv cov npe kev lag luam Apidra thiab Apidra SoloStar.
Pharmacological kev txiav txim
Cov tshuaj yog qhov ua kom rov zoo li qub ntawm tib neeg cov tshuaj insulin. Lub zog ntawm kev nqis tes ua zoo ib yam li cov tshuaj hormones uas tsim los ntawm kev noj qab haus huv txiav zoo. Glulisin ua tau nrawm dua thiab muaj lub sijhawm ntev.
Tom qab qhia rau hauv lub cev (subcutaneously), qhov tshuaj hormones pib tswj cov metabolism hauv kev ua kom yuag.
Cov tshuaj txo cov concentration ntawm cov ntshav qab zib, txhawb nws txoj kev nqus los ntawm cov ntaub so ntswg, tshwj xeeb tshaj yog cov leeg pob txha thiab cov nqaij mos adipose. Nws inhibits qhov tsim los ntawm cov piam thaj hauv cov nqaij hauv lub siab. Tsub kom muaj protein ntau sib txuas.
Cov kev tshawb fawb soj ntsuam pom tias glulisin, siv 2 feeb ua ntej noj mov, muab tib qho kev tswj cov piam thaj hauv ntshav li tib neeg cov tshuaj insulin, qhia rau hauv lub cev ib nrab teev ua ntej noj mov.
Kev ua haujlwm ntawm insulin tsis hloov pauv ntawm cov neeg sib txawv ntawm ntau haiv neeg.
Cov Tshuaj Pharmacokinetics
Tom qab subcutaneous tswj hwm ntawm cov tshuaj, qhov siab tshaj plaws nyob rau hauv cov ntshav tau mus txog tom qab 55 feeb. Qhov nruab nrab lub sijhawm nyob ntawm qhov tshuaj nyob hauv cov hlab ntshav yog 161 feeb. Nrog subcutaneous thawj coj ntawm cov tshuaj mus rau thaj av ntawm thaj chaw ntawm sab xub ntiag phab ntsa lossis xub pwg, kev nqus tau sai dua nrog kev qhia ntawm cov tshuaj rau hauv tus ncej puab. Bioavailability yog li ntawm 70%. Qhov kev tshem tawm ib nrab-lub neej yog kwv yees li 18 feeb.
Tom qab kev tswj hwm subcutaneous, glulisin yog tawm sai sai dua li cov tib neeg muaj insulin. Nrog rau lub raum puas, qhov ceev ntawm qhov pib ntawm cov txiaj ntsig xav tau yog tswj. Cov ntaub ntawv hais txog kev hloov pauv ntawm cov teeb meem pharmacological ntawm insulin hauv cov neeg laus tsis tau ua haujlwm txaus.
Kev ntsuas rau siv
Glulisin qhia rau cov ntshav qab zib xav tau insulin thiab ntshav qab zib hom 2.
Glulisin qhia rau cov ntshav qab zib xav tau insulin thiab ntshav qab zib hom 2.
Cov Yuav Tsum Muaj
Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hypoglycemia thiab hypersensitivity rau Apidra.
Yuav ua li cas noj insulin glulisin?
Nws yog noj subcutaneously 0-15 feeb ua ntej noj mov. Qhov kev txhaj tshuaj yog tsim nyob rau hauv lub plab, ncej puab, xub pwg. Tom qab txhaj tshuaj, thaj chaw txhaj tshuaj yuav tsum tsis txhob zaws. Koj tsis tuaj yeem sib xyaw ntau hom tshuaj insulin nyob rau hauv tib lub koob txhaj, txawm hais tias tus neeg mob yuav tau txais cov tshuaj insulins sib txawv. Kev thim rov qab ntawm cov tshuaj ua ntej nws cov kev tswj hwm tsis pom zoo.
Ua ntej siv, koj yuav tsum kuaj xyuas lub raj mis. Nws yog qhov tsim nyog kom sau cov tshuaj rau hauv cov koob txhaj tshuaj tsuas yog tias qhov kev daws teeb meem yog pob tshab thiab tsis muaj cov khoom tawg.
Cov cai hais txog siv rab koob xaum hluav taws xob
Tib tus cwj mem yuav tsum tsuas yog siv los ntawm ib tus neeg mob. Yog tias nws raug puas, nws tsis raug tso cai siv nws. Ua ntej siv tus cwj mem, ua tib zoo saib xyuas daim cartridge. Nws tuaj yeem siv nkaus xwb thaum daws tau qhov tseeb thiab tsis muaj kev cuam tshuam. Tus cwj mem khoob yuav tsum tau muab pov tseg raws li tsev neeg pov tseg.
Cov tshuaj tau muab tshuaj subcutaneously 0-15 feeb ua ntej noj mov. Qhov kev txhaj tshuaj yog tsim nyob rau hauv lub plab, ncej puab, xub pwg. Tom qab txhaj tshuaj, thaj chaw txhaj tshuaj yuav tsum tsis txhob zaws.
Tom qab hle lub hau, nws pom zoo kom kuaj xyuas daim ntawv lo thiab cov tshuaj. Tom qab ntawd ua tib zoo muab lub taub hau tso rau hauv cov xias. Hauv cov cuab yeej tshiab, qhov ntsuas pom tau qhia "8". Hauv lwm cov ntawv thov, nws yuav tsum tau teeb rov qab rau qhov ntsuas "2". Nias lub khawm dispenser txhua txoj kev.
Tuav lub kov kom sawv, tshem tawm cov cua npuas los ntawm npuaj. Yog tias txhua yam ua tiav zoo, qhov poob me me yuav tso tawm sab ntawm lub taub hau. Cov cuab yeej tso cai rau koj teeb tsa qhov ntau npaum li ntawm 2 txog 40 ib pawg. Qhov no tuaj yeem ua tiav los ntawm kev hloov cov dispenser. Rau them nqi, lub dispenser khawm tau pom zoo kom rub kom deb npaum li nws yuav mus.
Ntxig lub koob txhaj rau hauv daim ntaub subcutaneous. Tom qab ntawd nias lub pob txhua txoj kev. Ua ntej tshem tawm rab koob, nws yuav tsum tuav li 10 vib nas this. Tom qab txhaj tshuaj, tshem tawm thiab pov tseg cov koob. Cov teev qhia ntau npaum li cas kwv yees li ntawm insulin nyob rau hauv cov koob txhaj tshuaj.
Yog hais tias tus xwj xaum hluav taws xob tsis ua haujlwm, ces yuav muab cov kua tov los ntawm daim cartridge mus rau hauv cov phwj.
Cov kev mob tshwm sim ntawm insulin glulisin
Feem ntau cov kev mob tshwm sim ntawm cov tshuaj insulin yog cov ntshav qog ntshav qab zib. Nws tuaj yeem tshwm sim vim kev siv cov koob tshuaj ntau ntawm cov tshuaj. Cov tsos mob ntawm kev poob qis hauv cov ntshav qab zib pib maj mam tshwm sim:
- hws txias;
- pallor thiab txias ntawm daim tawv nqaij;
- txoj kev xav zoo nkaus li kev qaug zog;
- arousal
- kev cuam tshuam nrog kev pom;
- tshee hnyo
- kev ntxhov siab loj heev;
- tsis meej pem, nyuaj mloog zoo;
- muaj zog hnov ntawm mob mob taub hau;
- lub plawv dhia.
Kev muaj ntshav qab zib ntau ntau yuav nce ntxiv. Qhov no yog lub neej hem, vim nws ua rau muaj kev cuam tshuam loj heev ntawm lub hlwb, thiab nyob rau hauv cov mob hnyav - tuag.
Ntawm ib sab ntawm daim tawv nqaij
Ntawm qhov chaw txhaj tshuaj, nws khaus thiab o tuaj yeem tshwm sim. Qhov tshuaj tiv thaiv no yog hloov dhau mus, thiab koj tsis tas yuav noj tshuaj kom tshem tawm. Tej zaum muaj kev txhim kho lipodystrophy hauv cov poj niam ntawm qhov chaw txhaj tshuaj. Qhov no tshwm sim yog tias nws tau nkag mus rau hauv tib qho chaw. Txhawm rau tiv thaiv qhov no los ntawm tshwm sim, thaj chaw txhaj tshuaj yuav tsum tau sib hloov.
Kev ua xua
Muaj tsawg kawg uas qhov tshuaj muaj peev xwm ua rau muaj kev tsis haum tshuaj.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nrog hypoglycemia, nws yog txwv tsis pub tsav tsheb los yog tsav txoj hauv kev.
Cov lus qhia tshwj xeeb
Hloov chaw ntawm tus neeg mob rau ib hom tshuaj insulin tshiab yog ua tiav los ntawm kev saib xyuas mob nkeeg nkaus xwb. Qee qhov xwm txheej, kev kho mob ntshav qab zib tej zaum yuav tsum tau ua. Thaum hloov lub cev kev qoj ib ce, koj yuav tsum kho lub koob tshuaj kom haum.
Siv rau lub sijhawm qub
Cov tshuaj yuav siv tau thaum muaj hnub nyoog laus. Koob tshuaj yuav tsis haum yog li ntawd.
Txiag tej menyuam
Hom insulin no tuaj yeem kho rau cov menyuam yaus txij thaum muaj hnub nyoog rau xyoo.
Siv thaum cev xeeb tub thiab lactation
Tsuas muaj pov thawj tsawg txog kev siv cov tshuaj no thaum xeeb tub thiab pub niam mis. Kev tshawb nrhiav tsiaj ntawm cov tshuaj tsis tau qhia txog txhua tus neeg hauv lub cev xeeb tub.
Thaum muab tshuaj rau cov tshuaj no rau cov poj niam cev xeeb tub, kev ceev faj yuav tsum yog siv. Nws yog ib qho tsim nyog yuav tsum ua tib zoo ntsuas ntsuas ntshav qabzib.
Cov neeg mob ntshav qab zib muaj mob ntshav qab zib yuav tsum tau soj ntsuam cov ntshav qab zib kom qis. Hauv thawj peb lub hlis, cov kab mob yuav tsum tau poob qis dua me ntsis. Seb cov insulin kis mus rau leej niam mis yog tsis paub.
Daim ntawv thov rau lub raum khiav tsis zoo
Tsis txhob hloov cov tshuaj thiab cov tshuaj kho rau lub raum puas.
Siv rau lub siab ua haujlwm tsis zoo
Cov kev tshawb fawb soj ntsuam hauv cov neeg mob uas muaj lub cev tsis ua haujlwm tsis muaj teeb meem tsis tau ua
Glulisin insulin overdose
Nrog kev tshaj li ntawm kev noj tshuaj ntau dhau, hypoglycemia txhim kho sai sai, thiab nws cov degree yuav txawv - ntawm me me mus rau mob hnyav.
Kev mob ntshav qog ntshav me me yog nres qhov siv cov piam thaj lossis zaub mov qab zib. Nws raug nquahu kom cov neeg mob ib txwm nqa khoom qab zib, ncuav qab zib, kua txiv qab zib, lossis tsuas yog muaj cov piam thaj ua kom huv nrog lawv.
Nrog kev tshaj li ntawm kev noj tshuaj ntau dhau, hypoglycemia txhim kho sai sai, thiab nws cov degree yuav txawv - ntawm me me mus rau mob hnyav.
Nrog ib tus neeg mob ntshav nce siab ntau ntau, ib tug neeg poob qab lawm. Glucagon lossis dextrose raug muab rau hauv kev pabcuam ua ntej. Yog tias tsis muaj qhov tshuaj tiv thaiv rau kev tswj hwm ntawm glucagon, tom qab ntawd tib qho kev txhaj tshuaj dua. Tom qab nws rov qab nco qab, koj yuav tsum muab tshuaj rau tus neeg mob qab zib.
Kev cuam tshuam nrog lwm yam tshuaj
Qee yam tshuaj yuav cuam tshuam rau cov metabolism hauv qabzib. Qhov no yuav tsum tau hloov cov tshuaj insulin. Cov tshuaj yeeb tshuaj hauv qab no ua rau kom qhov teebmeem hypoglycemic ntawm Apidra:
- piam thaj txo cov tshuaj noj ntawm qhov ncauj;
- ACE inhibitors;
- Disopyramids;
- fibrates;
- Fluoxetine;
- monoamine oxidase inhibiting tshuaj yeeb;
- Pentoxifylline;
- Propoxyphene;
- salicylic acid thiab nws cov derivatives;
- sulfonamides.
Cov tshuaj no txo cov hypoglycemic kev ua si ntawm hom insulin no:
- GCS;
- Danazole;
- Diazoxide;
- tshuaj diuretic;
- Isoniazid;
- npaj - derivatives ntawm phenothiazine;
- Kev loj hlob hormone;
- cov thyroid hormones analogues;
- poj niam sib deev cov tshuaj hormones muaj nyob hauv qhov ncauj tiv thaiv kab mob;
- tshuaj uas inhibit tus protease.
Beta-adrenergic thaiv cov kab mob, clonidine hydrochloride, cov roj ntsha lithium npaj tuaj yeem txhim kho, los sis, hloov, tsis muaj zog cov kev ua ub no ntawm insulin. Kev siv Pentamidine ua ntej ua rau lub qog ntshav qab zib, thiab tom qab ntawd ib qho kev nce siab ntxiv hauv kev ua haujlwm ntawm cov ntshav qabzib.
Cov tshuaj insulin tsis tas yuav muab sib xyaw nrog lwm hom tshuaj no hauv tib lub koob txhaj. Tib yam siv rau infusion twj.
Cawv tau zoo
Haus cawv ntau yuav ua rau lub ntsej muag ntshav qab zib.
Analogs
Glulisin analogues suav nrog:
- Apidra
- Novorapid Flekspen;
- Epidera;
- tshuaj insulin isophane.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Apidra muaj qhov muag tshuaj. Tus mob ntshav qab zib tau txais cov tshuaj dawb.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Tsis yog.
Nqi
Tus nqi ntawm rab koob xev hluav taws xob yog kwv yees li 2 txhiab rubles.
Cia rau cov neeg mob rau cov tshuaj
Tsis tau qhib lub laub thiab cov vials yuav tsum cia hauv tub yees. Txwv tsis pub tshuaj insulin. Qhib cov vials thiab daim cartridges yog khaws cia hauv qhov kub tsis dhau + 25ºC.
Hnub tas sij hawm
Cov tshuaj no haum rau 2 xyoos. Txee lub neej nyob rau hauv lub raj mis qhib lossis lub taub ntim taub yog 4 lub lis piam, tom qab ntawd yuav tsum tau muab pov tseg.
Cov tshuaj no haum rau 2 xyoos. Txee lub neej nyob rau hauv lub raj mis qhib lossis lub taub ntim taub yog 4 lub lis piam, tom qab ntawd yuav tsum tau muab pov tseg.
Chaw tsim tshuaj paus
Nws yog tsim ntawm lub chaw lag luam Sanofi-Aventis Deutschland GmbH, Lub Tebchaws Yelemees.
Xyuas
Cov kws kho mob
Ivan, 50 xyoo, endocrinologist, Moscow: "Nrog kev pab los ntawm Apidra, nws muaj peev xwm los tswj cov kev qhia glycemia hauv cov neeg mob ntshav qab zib hom 1. Kuv xav kom koj txhaj tshuaj insulin tam sim ua ntej noj mov.
Svetlana, 49, kws kho mob ntshav qab zib, Izhevsk: "Glulisin yog ib qhov zoo tshaj plaws luv luv insulins. Cov neeg mob zam nws zoo, tab sis raug rau cov kev tsim tshuaj thiab cov kev tswj hwm. Hypoglycemia yog qhov tsis tshua muaj."
Cov neeg mob
Andrei, 45 xyoo, St. Petersburg: "Glulusin tsis ua rau cov piam thaj txo qis, uas yog qhov tseem ceeb rau kuv uas mob ntshav qab zib nrog" kev paub dhau los. Qhov chaw tom qab txhaj tshuaj tsis mob thiab tsis o. Tom qab noj mov, cov ntshav qabzib muaj qhov qub. "
Olga, hnub nyoog 50 xyoo, Tula: "Cov insulins qub ua rau kuv kiv taub hau, thiab qhov chaw txhaj tshuaj mob tas li. Glulizin tsis ua rau muaj cov tsos mob li no. Nws yooj yim siv koob txhaj tshuaj thiab qhov tseem ceeb tshaj, siv tau."
Lydia, hnub nyoog 58 xyoo, Rostov-on-Don: "Ua tsaug rau Glulizin, Kuv muaj ib qib qab zib tom qab noj mov tas. Kuv ua raws nraim li kev noj zaub mov noj thiab ua tib zoo suav cov tshuaj noj kom tsawg."
