Liprimar 10 yog ib tus neeg sawv cev hluavtaws uas muaj cov nyhuv lipid-txo qis. Cov tshuaj yog tsim nyog txaus kom txo tau cov roj cholesterol thiab qis lipoproteins. Raws li qhov tshwm sim, qhov tshwm sim ntawm kev tsim cov atherosclerotic plaques ntawm cov phab ntsa ntawm cov hlab ntsha poob qis, cov qeb ntawm triglycerides tsawg dua thiab cov rog rog hauv lub cev txhim kho. Lub hauv paus ntawm cov txheej txheem ntawm kev ua yog atorvastatin, uas yog tsim nyog los tshem tawm hypercholesterolemia.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Atorvastatin.
Liprimar 10 yog qhov tsim nyog los ua kom txaus cov roj (cholesterol) thiab qis lipoproteins.
ATX
C10AA05.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob hauv cov ntsiav tshuaj enteric-coated. Chav tsev tshuaj muaj 10 mg ntawm atorvastatin calcium uas yog cov khoom ua haujlwm nquag. Rau qhov ceev ntawm kev nqus thiab nce bioavailability, lub ntsiav tshuaj muaj cov tshuaj ntxiv:
- microcrystalline cellulose;
- magnesium stearate;
- mis nyuj qab zib;
- hyprolose;
- croscarmellose sodium;
- calcium carbonate.
Cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog microcrystalline cellulose, magnesium stearate, mis qab zib, hyprolose, croscarmellose sodium, calcium carbonate.
Cov qog ua cov zaj duab xis muaj cov ciab candelilla, hypromellose, polyethylene glycol, talc, emulsion simethicone, titanium dioxide. Ntawm cov ntsiav tshuaj dawb ntawm cov duab elliptical, cov duab kos "PD 155" thiab cov koob tshuaj ntawm cov tshuaj nquag tau siv.
Pharmacological kev txiav txim
Liprimar belongs rau chav kawm ntawm lipid-txo cov tshuaj. Cov tshuaj nquag ntawm atorvastatin yog cov kev xaiv cov khoom thaiv ntawm HMG-CoA reductase, qhov tseem ceeb enzyme tsim nyog rau kev hloov pauv ntawm 3-hydroxy-3-methylglutaryl coenzyme rau hauv mevalonate.
Thaum muaj ib hom mob tshwm sim rau hypercholesterolemia (cov roj (cholesterol) ntau ntxiv, cov roj ntshav sib xyaw ua ke), cov tshuaj tseem ceeb Liprimara yuav pab txo cov ntshav plasma tag nrho cov roj (Ch), apolipoprotein B, VLDL thiab LDL (lipoproteins tsawg ceev) thiab triglycerides. Atorvastatin ua rau muaj qhov siab ntxiv ntawm lipoprotein (HDL).
Qhov kev ua haujlwm ntawm kev ua yog vim yog kev tsuj ntawm kev ua haujlwm ntawm HMG-CoA reductase thiab kev txwv tsis pub muaj kev tsim cov cholesterol hauv hepatocytes.
Atorvastatin muaj peev xwm nce tus naj npawb ntawm qhov tsis tshua muaj lipoprotein receptors nyob rau sab nraud ntawm daim siab ua kua qaub, uas ua rau kom muaj kev nce siab ntau ntxiv thiab rhuav tshem ntawm LDL.
Cov tshuaj muaj peev xwm nce tus naj npawb ntawm cov qis lipoprotein receptors nyob rau sab nraud ntawm daim siab ua kua cell membrane.
Lub chaw nquag nquag txo qhov kev sib txuas ntawm LDL cov roj (cholesterol) thiab cov lipoproteins uas muaj teeb meem, vim qhov ntawd muaj ntau ntxiv rau qhov kev ua ntawm LDL receptors. Hauv cov neeg mob nrog homozygous cov kab mob siab hypercholesterolemia tiv taus qhov kev txiav txim ntawm lipid-txo cov tshuaj, LDL units yog txo. Kev kho mob nyhuv yog pom nyob rau hauv 2 lub lis piam tom qab pib kev kho mob. Qhov siab tshaj plaws tau sau tseg tom qab ib hlis ntawm kev kho mob nrog Liprimar.
Cov Tshuaj Pharmacokinetics
Tom qab kev tswj hwm ntawm qhov ncauj, cov ntsiav tshuaj tsis yaj nyob rau hauv kev ua ntawm hydrochloric acid hauv plab, ntog mus rau qhov ze ntawm jejunum. Hauv seem no ntawm txoj hnyuv zom zaub mov, cov qog zaj duab xis yauv ua lub cev.
Cov ntsiav tshuaj tawg tawm, cov as-ham thiab tshuaj pib nqus los ntawm microvilli tshwj xeeb.
Atorvastatin nkag mus rau hauv cov hlab ntshav los ntawm cov hnyuv phab ntsa, qhov twg nws nce mus txog qhov ntshav siab tshaj plaws nyob rau hauv 1-2 teev. Rau cov poj niam, qhov concentration ntawm cov tshuaj nquag yog 20% siab dua txiv neej.
Bioavailability ncav cuag 14-30%. Qhov qes qis yog vim parietal metabolism ntawm atorvastatin nyob rau hauv cov qog ua kua ntawm txoj hnyuv thiab hloov hauv cov qog hlwb los ntawm isoenzyme ntawm cytochrome CYP3A4. Cov tshuaj yeeb dej caw khi rau albumin los ntawm 98%, uas yog vim li cas hemodialysis ua tsis tau zoo. Qhov kev tshem tawm ib nrab-lub neej ncav 14 teev. Cov nyhuv kho tau ntev ntev rau 20-30 teev. Atorvastatin tawm hauv lub cev maj mam dhau los ntawm cov kab mob tso zis - tsuas yog 2% ntawm qhov koob tshuaj pom nyob rau hauv cov zis tom qab siv ib zaug.
Kev ntsuas rau siv
Cov tshuaj yog siv hauv kev kho mob los kho:
- thawj hypercholesterolemia ntawm keeb kwm thiab tsis muaj keeb;
- txhawb theem endogenous ntawm triglycerides tiv taus kev kho kev noj haus;
- hereditary homozygous hypercholesterolemia muaj txiaj ntsig ntawm kev noj zaub mov kom tsawg thiab lwm txoj kev siv tshuaj tsis raug ntawm kev kho mob;
- ua ke hom hyperlipidemia.
Cov tshuaj no tau sau tseg ua kev ntsuas ntawm kev tiv thaiv kab mob plawv rau cov neeg mob thaum tsis muaj cov cim ntawm kev mob plawv, tab sis nrog kev pheej hmoo: lub hnub nyoog laus, cov cwj pwm tsis zoo, ntshav siab, ntshav qab zib mellitus. Cov pab pawg muaj kev phom sij suav nrog cov neeg uas muaj qhov tsis txaus siab rau hypercholesterolemia thiab nrog rau theem qis ntawm HDL.
Cov tshuaj yog tshuaj raws li kev tiv thaiv kab mob rau cov kab mob plawv.
Cov tshuaj yog siv los ua qhov txuas rau kev kho mob rau kev txhim kho ntawm dysbetalipoproteinemia. Liprimar yog siv ua txoj hauv kev los tiv thaiv kev txhim kho ntawm cov kev mob tshwm sim hauv cov neeg mob myocardial ischemia kom txo qis kev pheej hmoo ntawm kev tuag, mob plawv, mob hlab ntsha tawg thiab tsev kho mob rau angina pectoris.
Cov Yuav Tsum Muaj
Cov tshuaj tsis raug sau rau kev ua rau muaj kev cuam tshuam ntau ntxiv ntawm cov ntaub so ntswg mus rau cov txheej txheem yam ntxwv ntawm Liprimar, zoo li muaj qee yam hauv qab no:
- daim siab mob siab;
- cov menyuam yaus hnub nyoog qis dua 18 xyoo;
- nce ntshav kev ua si ntawm hepatic transaminases ntau dua 3 zaug.
Ceev faj yuav tsum tau siv thaum kev haus dej cawv.
Yuav ua li cas noj Liprimar 10
Cov ntsiav tshuaj tau sau rau kev tswj hwm qhov ncauj, tsis hais lub sijhawm nruab hnub lossis noj mov. Kev siv tshuaj kho mob yog nqa tawm tsuas yog nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov hypocholesterolemic, yuag yuag yuag tiv thaiv tsis txaus ntseeg txog keeb kwm yav dhau los ntawm pathological rog, qoj ib ce. Yog tias qhov nce hauv cov roj (cholesterol) los ntawm qhov pib mob, ua ntej siv Liprimar, koj yuav tsum sim ua kom tshem tawm cov txheej txheem tseem ceeb ntawm cov kab mob. Thaum lub sij hawm kho tag nrho cov tshuaj, koj yuav tsum ua raws li kev noj haus tshwj xeeb.
Kev siv tshuaj kho mob nrog Liprimar 10 yog nqa tawm tsuas yog nrog qhov tsis muaj txiaj ntsig ntawm kev noj ntshav hypocholesterolemic.
Kev siv tshuaj rau txhua hnub yog 10-80 mg rau kev siv ib zaug thiab raug kho nyob ntawm kev ua haujlwm ntawm LDL-C thiab ntawm kev ua tiav ntawm kev kho kom zoo.
Qhov siab tshaj plaws tau pub rau noj yog 80 mg.
Thaum kho nrog Liprimar, nws yog qhov yuav tsum tau soj ntsuam cov ntshav plasma concentration ntawm lipids txhua 2-4 lub lis piam, tom qab ntawd koj yuav tsum sab laj nrog koj tus kws kho mob txog kev hloov pauv ntawm kev siv tshuaj.
Txhawm rau tshem tawm cov tshuaj sib xyaw ua ke ntawm hyperlipidemia, nws yog ib qho tsim nyog yuav tsum noj 10 mg ib hnub ib zaug, thaum homozygous kab mob hypercholesterolemia yuav tsum muaj kev kho mob siab tshaj plaws ntawm 80 mg. Hauv rooj plaub tom kawg, cov roj (cholesterol) siab tau txo qis txog 20-45%.
Noj cov tshuaj rau ntshav qab zib
Cov neeg mob ntshav qab zib yuav tsum ceev faj thaum muaj hypercholesterolemia tshwm sim. Cov tib neeg zoo li no yog qhov pheej hmoo txhim kho cov kev mob plawv coronary. Liprimar yog siv los ua qhov ntsuas tawm ntawm kev tiv thaiv myocardial infarction. Qhov ntau npaum li cas yog txiav txim los ntawm tus kws kho mob mus kawm nyob ntawm seb muaj qib roj (cholesterol).
Cov neeg mob ntshav qab zib yuav tsum ceev faj thaum muaj hypercholesterolemia tshwm sim.
Yog nws tau mus faib ib nrab
Tsis muaj kev pheej hmoo rau ntawm cov ntsiav tshuaj, uas txhais tau tias qhov tsis yooj yim ntawm kev faib cov tshuaj ntau npaum.
Phiv los ntawm Liprimara 10
Nrog rau kev siv tsis raug ntawm cov tshuaj, cov kev mob tshwm sim tuaj yeem tshwm sim hauv kev sib txawv hauv zos.
Kev kho mob txoj hnyuv
Tej zaum qhov tsos mob ntawm ntuav, raws plab, mob nyob rau hauv thaj chaw epigastric, cem quav thiab flatulence. Muaj qee zaus, kev kho mob nrog Liprimar tuaj yeem ua rau mob anorexia, kev kho mob hauv txoj hlab ntsws, kab mob siab thiab mob daj ntseg.
Hematopoietic plab hnyuv siab raum
Tsawg tsawg zaus, mob hlwb pob txha mob tshwm sim, nrog nws ua ke nrog thrombocytopenia.
Liprimar 10 yuav ua rau insomnia.
Nruab nrab hauv lub paj hlwb
Cov kev xav tsis zoo nrog kev puas tsuaj rau cov leeg hlwb uas tau pom tias:
- insomnia
- dav dav malaise;
- asthenic syndrome;
- mob taub hau thiab kiv taub hau;
- txo thiab ua tiav poob ntawm rhiab;
- peripheral poob siab mob hlwb neuropathy;
- amnesia.
Los ntawm cov kab mob zis
Hauv cov txiv neej, kev ua kom tsis yog mob erectile thiab tso zis cia.
Los ntawm lub tshuab ua pa
Dyspnea tuaj yeem tshwm sim.
Kev ua xua
Nrog tus cwj pwm ua kom pom tus mob tsis haum, tawm pob rau ntawm daim tawv nqaij, liab, khaus, exudative erythema, necrosis ntawm subcutaneous rog txheej yuav tshwm sim. Hauv cov xwm txheej loj, Quincke's edema thiab anaphylactic shock poob siab.
Prem ntawm cov tshuaj nyob rau hauv nqe lus nug tuaj yeem ua rau pom qhov tsos mob ntawm daim tawv nqaij.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis cuam tshuam rau cov dej num uas yuav tsum tau teb ceev thiab siab. Thaum kho nrog tshuaj, tsav tsheb thiab tswj cov khoom siv kho vajtse nyuaj tso cai.
Cov lus qhia tshwj xeeb
Thaum kho nrog Liprimar txhua 6 lub lis piam, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam kev kuaj mob lub siab thiab ntsuas ntawm ALT, AST. Yog tias qhov kev ua ntawm aminotransferases siab dua qhov kev txwv sab sauv ntawm qhov ib txwm muaj ntau dua 3 zaug, nws yuav tsum tau sab laj tus kws kho mob txog kev txo tshuaj ntau npaum.
Vim yog txoj kev kho hypocholesterolemic, hauv qee kis, qhov tsos ntawm cov leeg mob tiv thaiv keeb kwm ntawm myopathy tau pom. Nyob rau tib lub sijhawm, kev tshawb nrhiav kuaj pom pom 10 npaug ntawm kev ua haujlwm ntawm creatine phosphokinase piv nrog cov cai.
Yog tias tus neeg mob tau mob tsis muaj zog thiab mob hauv cov leeg ntawm cov leeg pob txha, nws yog qhov yuav tsum tau tsum tsis txhob noj cov tshuaj no.
Muaj qee zaus, rhabdomyolysis tsim - necrotic puas rau cov leeg nqaij, nrog mob raum tsis ua haujlwm.
Kev siv cov tshuaj yuav tsum nres nrog kev txo qis ntshav siab.
Cov hlwv pob zeb tsis ua haujlwm yog lub txim rau myoglobinuria. Txhawm rau txo txoj kev pheej hmoo ntawm rhabdomyolysis, koj yuav tsum tsum tsis txhob noj cov tshuaj nyob rau hauv rooj plaub no:
- thaum kev phais mob nrog lub tiaj dav;
- kev kis mob hnyav rau lub raum;
- txoj kev txo qis ntshav siab;
- neeg kho tshuab kev poob plig;
- mob leeg.
Tus neeg mob yuav tsum ceeb toom rau qhov kev pheej hmoo ntawm rhabdomyolysis. Nrog kev pom zoo rau kev kho mob, tus neeg mob muaj lub luag haujlwm yuav tsum nrhiav kev pab kho mob kom zoo rau cov leeg tsis muaj zog thiab cov tsos mob ntawm qhov tsis hnov mob, nrog rau ua npaws thiab qaug zog.
Muab tshuaj Liprimar rau 10 tus menyuam
Cov yeeb tshuaj tsis pub siv rau hauv kev kho mob hauv hlwb.
Cawv tau zoo
Cov tshuaj yuav tsum tsis txhob tov nrog cov khoom muaj cawv. Ethyl cawv txwv tsis pub cov hauv nruab nrab cov hlab ntsha, hlab ntsha thiab ntshav khov mus rau hauv lub cev, thiab yog li ntawd cov nyhuv hypocholesterolemic ntawm kev siv Liprimar yog txo qis. Qhov tshwm sim ntawm kev tsim cov atherosclerotic plaques ntawm cov phab ntsa ntawm cov hlab ntsha nce ntxiv.
Cov tshuaj yuav tsum tsis txhob tov nrog cov khoom muaj cawv.
Noj Ntau Lawm Liprimar 10
Thaum kev overdose tshwm sim, cov kev mob tshwm sim loj heev. Ib qho tshwj xeeb cov tshuaj tiv thaiv tsis tau txhim kho, yog li ntawd, thaum mus pw hauv tsev kho mob, kev kho mob cov tsos mob yog nqa tawm.
Kev cuam tshuam nrog lwm yam tshuaj
Cimetidine, Phenazone, Azithromycin, antacids, Terfenadine, Warfarin, Amlodipine tsis cuam tshuam rau qhov kev siv pharmacokinetic ntawm Liprimar thiab tsis cuam tshuam nrog atorvastatin.
Kev sib xyaw tsis pom zoo
Vim tias qhov kev pheej hmoo ntawm cov neuromuscular pathologies, cov kab ke khiav ua ke ntawm Liprimar tsis pom zoo nrog:
- cov tshuaj tua kab mob cyclosporin;
- nicotinic acid derivatives;
- Erythromycin;
- antifungal tshuaj;
- fibrates.
Tsis pom zoo tswj hwm Liprimar thiab Erythromycin tsis pom zoo.
Cov tshuaj sib xyaw ua ke tuaj yeem ua rau myopathy.
Nrog saib xyuas
Nws raug nquahu kom xyuam xim thaum siv Liprimar nrog lwm cov khw muag tshuaj:
- Atorvastatin muaj peev xwm nce AUC ntawm qhov ncauj tiv thaiv kom tsis txhob muaj 20-30%, nyob ntawm seb cov tshuaj hormones muaj nyob hauv qhov kev npaj.
- Atorvastatin nrog tshuaj 40 mg sib xyaw nrog 240 mg ntawm Diltiazem ua rau kev nce ntshav ntau ntxiv ntawm atorvastatin hauv cov ntshav. Thaum noj 200 mg ntawm Itraconazole nrog 20-40 mg ntawm Liprimar, ib qho kev nce ntxiv hauv AUC ntawm atorvastatin tau pom.
- Rifampicin txo qis ntshav ntshav ntawm atorvastatin.
- Colestipol ua rau kom txo qis hauv cov plasma qhov siab-txo cov tshuaj.
- Nrog rau kev kho ua ke nrog digoxin, qhov kev tsuam tsig ntawm tom kawg nce ntxiv 20%.
Cov kua txiv kua txiv tshem tawm kev ua ntawm cytochrome isoenzyme CYP3A4, uas yog vim li cas thaum haus ntau tshaj li 1.2 liv ntawm cov kua txiv qaub tauj ib hnub, cov ntshav plasma concentration ntawm atorvastatin ntau ntxiv. Cov txiaj ntsig zoo sib xws yog pom thaum noj CYP3A4 inhibitors (Ritonavir, Ketoconazole).
Liprimar yog txwv tsis pub siv rau 10 tus poj niam cev xeeb tub.
Siv thaum cev xeeb tub thiab lactation
Nws yog txwv tsis pub siv cov tshuaj rau cov poj niam cev xeeb tub, raws li muaj qhov kev pheej hmoo ntawm kev ua txhaum ntawm kev tso cov ntaub so ntswg kom zoo thiab lub plab hnyuv siab raum thaum pib txhim kho. Tsis muaj ntaub ntawv qhia txog lub peev xwm ntawm Liprimar txeem hematoplacental teeb meem.
Thaum lub sij hawm siv tshuaj kho, kev pub mis niam yuav tsum tsis ua mus ntxiv.
Analogs
Hloov chaw ntawm cov tshuaj uas muaj cov nyhuv zoo xws li:
- Atoris;
- Tulip;
- Vazator;
- Atorakord;
- Atorvastatin-SZ.
Kev hloov pauv yog nqa tawm tom qab kev sab laj kho mob.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj raug muag nruj me ntsis raws cov tshuaj noj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Tsis yog.
Nqe rau Liprimar 10
Tus nqi nruab nrab ntawm 10 mg ntsiav tshuaj yog 750-1000 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws yog qhov tsim nyog yuav tsum tau khaws cov tshuaj rau hauv qhov chaw uas muaj coefficient tsawg ntawm cov av noo ntawm qhov kub ntawm + 15 ... + 25 ° C.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus
Gedecke GmbH, Lub Tebchaws Yelemees.
Liprimar qhov analog - cov tshuaj Atoris yog muag hauv khw muag tshuaj nruj me ntsis raws li cov ntawv sau tshuaj.
Kev txheeb xyuas ntawm Liprimar 10
Elvira Ignatieva, 76 xyoo, Lipetsk
6 lub hlis dhau los, thaum kuaj ntshav dav dav, qhov nce siab ntawm 7,5 mmol tau nce lawm. Kuv muaj hlab plawv pathology, yog li ntawd, txhawm rau tiv thaiv cov teeb meem vascular, cov roj cholesterol yuav tsum raug txo sai sai hauv lub sijhawm luv. Tus kws kho mob sau Liprimar 40 mg txhua hnub. Tus nqi yog siab, tab sis tsim nyog los ntawm kev ua haujlwm. Cov kev tshuaj ntsuam kawg tau qhia tias txo cov roj (cholesterol) mus rau 6 mmol.
Kristina Molchanova, 24 xyoos, Yaroslavl
Niam Pog tau mob atherosclerosis ntawm cov hlab ntsha ntawm qhov qis qis dua thiab nws cov roj (cholesterol) thiab LDL yog nce. Ua ntej tsa Rosuvastatin, uas tsis haum. Tsis muaj kev hloov zoo. Tom qab Rosuvastatin, Liprimar tau raug sau tseg.Ua tsaug rau cov tshuaj, lipid kawg profile qhia pom kev txhim kho: cov roj cholesterol thiab lub cev hnyav poob qis, qhov tseem ceeb ntawm lipoproteins ntau ntom nce ntxiv.
