Gentamicin Sulfate yog cov tshuaj tua kab mob ntau yam uas muaj pov thawj nws tus kheej thiab feem ntau siv hauv thaj chaw ntawm cov tshuaj xws li:
- kev kuaj mob poj niam;
- dermatology;
- ophthalmology;
- lub paj hlwb;
- urology;
- tshuaj ntsws;
- otolaryngology;
- tshuaj mob ntsws.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Lub thoob ntiaj teb uas tsis yog lub npe ntawm cov tshuaj yog Gentamicin (hauv Latin - Gentamycin lossis Gentamycinum).
Gentamicin Sulfate yog ib hom tshuaj tua kab mob ntau yam.
ATX
Gentamicin nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj yog muab lub cev ib puag ncig-kho-tshuaj lom neeg (tshuaj) (JX1GB03). Tsab ntawv J txhais tau tias cov tshuaj yog tshuaj tua kabmob thiab siv tshuaj tua kab mob thiab siv rau kev kho mob hauv nruab nrab, cov tsiaj ntawv G thiab B txhais tau tias nws yog pawg ntawm aminoglycosides.
Qhov ATX code rau cov qhov muag pom yog S01AA11. Tsab ntawv S txhais tau hais tias cov tshuaj no yog siv rau kev kho mob hauv nruab nrog cev, thiab cov tsiaj ntawv AA qhia tau tias cov tshuaj tua kab mob no yog tsim rau siv tshuaj pleev thiab cuam tshuam rau cov metabolism.
Qhov ATX code ntawm Gentamicin nyob rau hauv daim ntawv ntawm tshuaj pleev yog D06AX07. Daim ntawv D txhais tau tias cov tshuaj yog npaj rau kev siv hauv tshuaj dermatology, thiab cov tsiaj ntawv AX - tias nws yog tshuaj tua kab mob hauv siab.
Tso cov ntawv thiab cov nyob ua ke
Gentamicin muaj 4 daim ntawv tso tawm:
- daws rau kev txhaj tshuaj;
- muag qhov muag;
- tshuaj pleev;
- aerosol.
Lub hauv paus ua haujlwm tseem ceeb hauv txhua 4 daim ntawv yog gentamicin sulfate. Cov tshuaj sib tov ntawm cov tshuaj txhaj suav nrog xws li cov ntu ntu xws li:
- sodium metabisulfite;
- disodium ntsev;
- dej rau kev txhaj tshuaj.
Cov tshuaj tau tawm hauv 2 ml ampoules, uas tau ntim hauv 5 pcs. hauv cov hlwv pob. Ib pob muaj 1 lossis 2 pob (5 lossis 10 ampoules) thiab cov lus qhia rau siv.
Kev sib txuam ntawm cov ntsiab muag:
- disodium ntsev;
- sodium tshuaj dawb;
- dej rau kev txhaj tshuaj.
Kev daws tau ntim rau hauv 1 ml hauv dropper cov hlab (1 ml muaj 3 mg ntawm qhov tshuaj nquag). 1 pob tuaj yeem ntim 1 lossis 2 pob roj hmab.
Cov neeg tau txais txiaj ntsig ntawm cov tshuaj pleev yog cov paraffins:
- tawv;
- kua;
- muag muag;
- dawb.
Cov tshuaj raug muag hauv cov raj ntawm 15 mg.
Gentamicin nyob rau hauv daim ntawv ntawm aerosol ua ib ntu pabcuam muaj cov khoom siv aerosol ua npuas ncauj thiab tau ntim rau hauv 140 g hauv tshwj xeeb aerosol fwj ntim nrog txau.
Pharmacological kev txiav txim
Gentamicin yog cov tshuaj tua kab mob uas siv los kho tshuaj (tawv nqaij) thiab muaj kabmob sab hauv. Cov tshuaj tua cov kab mob me, rhuav tshem lawv txoj haujlwm cuam tshuam. Cov tshuaj no tawm tsam cov kab mob xws li:
- staphylococci;
- streptococci (qee yam leeg);
- Ntxaug Yaj
- Salmonella
- Pseudomonas aeruginosa;
- enterobacter;
- Klebsiella;
- protea.
Cov tshuaj tsis ua haujlwm:
- treponema (tus neeg sawv cev ntawm tus mob syphilis);
- on neiseria (mob meningococcal);
- ntawm cov kab mob anaerobic;
- rau kab mob, fungi thiab protozoa.
Cov Tshuaj Pharmacokinetics
Kev muaj txiaj ntsig zoo tshaj plaws ntawm lub cev yog muab los ntawm kev txhaj tshuaj rau cov leeg thiab intramuscular. Nrog kev txhaj tshuaj intramuscular, qhov siab tshaj plaws ntshav plasma concentration tom qab 30-60 feeb. Cov tshuaj yog txiav txim nyob rau hauv cov ntshav rau 12 teev. Ntxiv rau cov ntshav ntshav, Gentamicin nkag mus sai thiab tau txhais tau zoo hauv cov ntaub so ntswg ntawm lub ntsws, ob lub raum thiab mob siab, lub cev, ntxiv rau hauv hnoos qeev thiab kua dej xws li:
- synovial;
- pleural;
- peritoneal.
Qhov qis tshaj plaws ntawm cov tshuaj muaj nyob hauv cov kua tsib thiab cerebrospinal kua.
Cov tshuaj tsis tuaj yeem tsim nyob hauv lub cev: ntau dua 90% ntawm cov tshuaj siv tawm hauv lub raum. Tus nqi ntawm qhov ua tau zoo yog nce raws tus neeg mob lub hnub nyoog thiab kev tsim muaj peev xwm ntawm qhov muaj peev txheej. Hauv cov neeg mob cov neeg laus uas muaj lub raum zoo, lub sijhawm ib nrab ntawm kev siv tshuaj yog 2-3 teev, hauv cov menyuam hnub nyoog 1 lub lis piam mus txog rau 6 hlis - 3-3,5 teev, nce txog 1 lub lis piam - 5.5 teev, yog tias tus menyuam hnyav dua 2 kg , thiab ntau dua 8 teev, yog tias nws qhov hnyav tsawg dua 2 kg.
Ib nrab-lub neej tuaj yeem nrawm nrog:
- anemia
- kom sov siab;
- kub nyhiab heev.
Nrog rau cov kab mob hauv lub raum, ib nrab ntawm lub neej ntawm Gentamicin yog ntev thiab nws txoj kev tshem tawm yuav ua tsis tiav, uas yuav ua rau kev txuam nrog cov tshuaj hauv lub cev thiab qhov tshwm sim ntawm kev cuam tshuam dhau.
Nws siv rau dab tsi?
Cov tshuaj yog tawm rau kis kab mob thiab kis mob:
- Mob txeeb zig. Xws li:
- pyelonephritis;
- txoj hlab zis;
- cystitis
- prostatitis.
- Kev nqus tau pa tsawg. Xws li:
- pleurisy;
- mob ntsws
- mob ntsws;
- empyema;
- lub ntsws ua qog.
- Plab plab. Xws li:
- mob peritonitis;
- cholangitis;
- mob hnoos qhuav.
- Cov pob txha thiab pob qij txha.
- Daim tawv nqaij integument. Xws li:
- mob rwj;
- kub hnyiab;
- furunculosis;
- seborrheic dermatitis;
- pob txuv
- paronychia;
- pyoderma;
- mob caj dab.
- Lub qhov muag. Xws li:
- mob txuas;
- blepharitis;
- keratitis.
- Nruab nrab hauv lub paj hlwb, nrog rau cov mob hlwb thiab vermiculitis.
Gentamicin tseem siv rau cov sepsis raws li kev phais mob thiab kab mob septicemia.
Cov Yuav Tsum Muaj
Cov tshuaj tsis tau sau tseg yog tus neeg mob:
- tsis zam cov tshuaj tua kab mob ntawm pawg antiglycoside lossis lwm cov khoom siv uas tsim cov tshuaj;
- kev txom nyem los ntawm neuritis ntawm auditory paj;
- mob nrog azotemia, uremia;
- muaj mob raum lossis siab mob hnyav;
- yog nyob rau lub xeev kev xeeb tub;
- yog ib tus niam laus;
- mob nrog myasthenia;
- muaj mob los ntawm tus kab mob Parkinson;
- muaj cov kab mob ntawm cov khoom siv vestibular (kiv taub hau, tinnitus);
- nyob rau hauv 3 xyoos.
Nrog saib xyuas
Cov tshuaj no yog siv nrog kev ceev faj, yog tias muaj keeb kwm muaj qhov qhia txog lub siab rau kev ua xua, nrog rau yog tias tus neeg mob muaj mob:
- botulism;
- hypocalcemia;
- lub cev qhuav dej.
Yuav ua li cas noj gentamicin sulfate?
Rau cov neeg mob uas muaj hnub nyoog 14 xyoos nrog cov kab mob ntawm lub tso zis, txoj kev kho mob yog 0.4 mg thiab raug siv 2-3 zaug ib hnub intramuscularly, nrog cov mob hnyav thiab sepsis, cov tshuaj tau txhaj 3-4 zaug hauv ib hnub, 0.8-1 mg. Qhov kev siv ntau tshaj yuav tsum tsis pub tshaj 5 mg ib hnub. Lub sijhawm tiv thaiv yog 7-10 hnub. Hauv cov xwm txheej loj, hauv 2-3 hnub dhau los, Gentamicin raug muab tshuaj rau hauv qhov quav, tom qab ntawd tus neeg mob hloov mus rau kev txhaj tshuaj intramuscular.
Rau kev tswj hwm kev siv tshuaj, tsuas yog cov tshuaj tiv thaiv tau npaj hauv ampoules yog siv; rau kev txhaj tshuaj rau cov leeg, cov tshuaj tau npaj ua ntej kev tswj hwm, yaj lub hmoov nrog dej rau kev txhaj tshuaj.
Gentamicin tuaj yeem raug coj los ua kev nqus tshuaj los kho kab mob ua pa.
Purulent o ntawm daim tawv nqaij, cov hauv paus plaub hau, mob ntsws thiab lwm yam kab mob ntawm daim tawv qhuav yog kho nrog tshuaj pleev. Ua ntej, cov cheeb tsam cuam tshuam tau kho nrog kev daws ntawm Furacilin kom tshem tawm cov paug thiab cov paug tawm, thiab tom qab ntawd txheej txheej pleev pleev ib leeg raug thov 2-3 zaug hauv ib hnub rau 7-10 hnub (ntaub qhwv tuaj yeem siv). Cov koob tshuaj pleev rau txhua hnub rau cov neeg laus yuav tsum tsis pub ntau tshaj 200 mg.
Aerosol yog siv los kho cov kab mob ntawm daim tawv nqaij, tab sis cov txheej txheem ntawm kev siv yog tib yam li rau cov tshuaj pleev. Aerosol yuav tsum tau muab tshuaj txau los ntawm ib qho deb li 10 cm ntawm daim tawv nqaij.
Cov kab mob qhov muag tau kho nrog tee, sau lawv rau hauv hnab looj tes sib luag 3-4 zaug hauv ib hnub.
Nws puas tuaj yeem noj tshuaj rau ntshav qab zib?
Ntshav qab zib mellitus tsis yog sib kis rau kev kho mob nrog Gentamicin.
Qhov tshwm sim los ntawm Gentamicin Sulfate
Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj tshwm sim thiab tuaj yeem tshwm sim hauv daim ntawv ntawm:
- kev tsaug zog, kiv taub hau, mob taub hau;
- tsis qab los noj mov, nce dej salivation, xeev siab, ntuav, poob phaus;
- mob leeg, sib ntswg, cramps, loog loog, paresthesia;
- muaj kev cuam tshuam nrog cov khoom siv vestibular;
- hnov;
- lub raum tsis ua haujlwm;
- kev puas tsuaj ntawm lub plab (oliguria, microhematuria, proteinuria);
- urticaria, ua npaws, khaus, tawv nqaij ua pob;
- qhov taw qhia qis ntawm leukocytes, platelets, potassium, magnesium thiab calcium hauv cov ntshav;
- txhawb kev kuaj ntshav siab kom nce siab.
Tsis tshua muaj neeg ua tau:
- mob hauv thaj tsam ntawm kev txhaj tshuaj intramuscular;
- phlebitis lossis thrombophlebitis hauv kev saib xyuas ntawm cov leeg ntshav;
- tubular necrosis;
- superinfection kev loj hlob;
- anaphylactic poob siab.
Cov lus qhia tshwj xeeb
- Hauv kev kho mob nrog Gentamicin, nws yog ib qhov tsim nyog los soj ntsuam lub luag haujlwm ntawm lub raum, vestibular thiab pob ntseg hnov.
- Nws yog ib qho tsim nyog yuav tsum soj ntsuam cov qib ntawm poov tshuaj, magnesium thiab calcium hauv cov ntshav.
- Rau cov neeg mob raum tsis ua hauj lwm zoo, kev tswj tus kheej creatinine tshem tawm yog tsim nyog.
- Tus neeg mob tau mob los ntawm mob hnyav los yog mob mus ntev ntawm cov kab mob ntawm lub tso zis (nyob rau theem ntawm exacerbation) yuav tsum siv dej ntau dua thaum kho nrog Gentamicin.
- Kev siv dej cawv thiab cawv muaj yees thaum lub sij hawm kho nrog Gentamicin yog txwv tsis pub.
- Vim hais tias cov tshuaj ua rau txo qis qis, kiv taub hau, txo qhov muag pom, nws yog qhov yuav tsum tso tseg cov tsav tsheb thaum lub sijhawm kho.
Siv rau lub sijhawm qub
Gentamicin yuav tsum siv nrog ceev faj hauv cov neeg laus. Cov tshuaj muaj qhov ua rau lub ntsej muag tsis zoo thiab ua kom lub ntsej muag, lub raum ua haujlwm, thiab hauv cov neeg laus, cov kab ke no, raws li kev hloov pauv ntawm lub hnub nyoog, feem ntau twb ua haujlwm nrog tsis meej. Yog tias kev txiav txim siab tau txiav txim siab yuav tshuaj, tom qab ntawd thaum kho thiab qee lub sijhawm tom qab ua tiav, tus neeg mob yuav tsum soj ntsuam kom tshem tawm cov creatinine thiab pom los ntawm tus kws kho mob otolaryngologist.
Khaws cov tshuaj Gentamicin Sulfate rau Cov Menyuam
Rau cov menyuam yaus hnub nyoog qis dua 14 xyoos, kev tswj hwm tshuaj ntawm cov tshuaj yog raug qhia tsuas yog nyob rau kis tseem ceeb xav tau. Koob tshuaj ib zaug yog xam raws lub hnub nyoog thiab qhov hnyav ntawm tus menyuam: rau cov menyuam hnub nyoog 6 txog 14 xyoos - 3 mg / kg, los ntawm 1 txog 6 - 1.5 mg / kg, tsawg dua 1 xyoos - 1.5-2 mg / kg. Qhov koob tshuaj ntau tshaj plaws rau txhua tus neeg mob hnub nyoog qis dua 14 xyoos yuav tsum tsis pub tshaj 5 mg / kg. Cov tshuaj yog muab 2-3 zaug ib hnub rau 7-10 hnub.
Kho cov tawv nqaij hauv zos lossis qhov muag nrog aerosol, tshuaj pleev, lossis tshuaj pleev qhov muag yog qhov tsis tshua muaj kev phom sij thiab tuaj yeem kho rau cov neeg mob hnub nyoog qis dua 14 xyoos. Cov txheej txheem kho zoo tib yam li rau cov neeg laus. Qhov tshuaj txhua hnub ntawm cov tshuaj pleev yuav tsum tsis pub ntau tshaj 60 mg.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj yooj yim kis tawm ntawm cov kab mob thiab tso rau hauv niam mis, yog li ntawd, cov tshuaj tua kab mob txwv tsis pub rau cov poj niam cev xeeb tub thiab pub niam mis. Ib zaug hauv tus menyuam lub cev, cov tshuaj ua rau ua txhaum lub plab zom mov thiab tuaj yeem ua rau lub cim ntawm ototoxicity. Ib qho kev zam yog qhov xwm txheej uas yuav ua rau muaj txiaj ntsig zoo rau leej niam yuav dhau qhov kev phom sij rau tus menyuam.
Kev noj tshuaj ntawm Gentamicin Sulfate
Kev siv ntau tshaj tawm tuaj yeem tsuas yog tshwm sim los ntawm gentamicin txhaj tshuaj. Tshuaj pleev, qhov muag tawm thiab aerosol tsis muab cov nyhuv zoo li. Cov tsos mob ntawm kev haus ib ce muaj xws li:
- xeev siab thiab ntuav
- tsaug zog thiab mob taub hau;
- tawv nqaij ua pob, khaus;
- npaws
- lag ntseg ua tsis tau zoo;
- ua txhaum ntawm txoj haujlwm ntawm vestibular apparatus;
- lub raum tsis ua haujlwm;
- ua txhaum txheej txheem tso zis;
- Quincke's edema (tsis tshua muaj).
Cov kev kho mob cuam tshuam nrog kev tshem tawm tshuaj tam sim thiab ntxuav ntshav nrog hemodialysis lossis lim ntshav.
Kev cuam tshuam nrog lwm yam tshuaj
Tiav tsis tiav nrog gentamicin yog:
- Amphotericin;
- Heparin;
- Tshuaj tua kab mob beta-lactam.
Gentamicin txuam nrog ethacrylic acid thiab furosemide tuaj yeem txhim kho lub txiaj ntsig tsis zoo rau lub raum thiab pob ntseg tsis hnov lus.
Kev txhim kho ntawm kev ua pa ntawm kev ntes thiab ua rau cov leeg nqaij tuaj yeem ua rau tib lub sijhawm siv Gentamicin nrog cov tshuaj xws li:
- Decamethonium;
- Tubocurarine;
- Succinylcholine.
Nws tsis pom zoo kom ua ke nrog Gentamicin nrog cov tshuaj hauv qab no:
- Viomycin;
- Vancomycin;
- Tobramycin;
- Streptomycin;
- Paromomycin;
- Amikacin;
- Kanamycin;
- Cephaloridin.
Analogs
Cov qauv ntawm cov tshuaj txhaj yog:
- Gentamicin Sandoz (Poland, Slovenia);
- Gentamicin-K (Slovenia);
- Gentamicin-Kev Noj Qab Haus Huv (Ukraine).
Cov tshuaj tiv thaiv qhov tshuaj nyob rau hauv daim ntawv ntawm lub qhov muag pom yog:
- Lwm Haiv Neeg (Belarus);
- Dexon (Is Nrias teb);
- Dexamethasons (Russia, Slovenia, Finland, Romania, Ukraine).
Cov tshuaj pleev cov tshuaj pleev Gentamicin yog:
- Candiderm (Is Nrias teb);
- Garamycin (Belgium);
- Celestroderm (Belgium, Russia).
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Raws li cov lus qhia, Gentamicin (tag nrho 4 daim ntawv), zoo ib yam li lwm yam tshuaj tua kab mob, yuav tsum muab tso rau hauv cov khw muag tshuaj nkaus xwb yog cov tshuaj noj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Ib qho twg ntawm 4 daim ntawv qhia txog kev tso tawm tshuaj tawm tau ntawm tus neeg muag tshuaj yam tsis tas muaj ntawv yuav.
Gentamicin Sulfate Nqe
Gentamicin belongs rau cov qeb ntawm cov tshuaj pheej pheej yig. Tus nqi nruab nrab ntawm 10 ampoules hauv chaw muag tshuaj Moscow yog 50 rubles., Tshuaj pleev thiab aerosol - 85-100 rubles., Qhov muag poob - 35 rubles. Hauv cov khw muag khoom online, tus nqi ntawm cov tshuaj yog 5 rubles. tsawg dua.
Cia rau cov neeg mob rau cov tshuaj
Tshuaj yuav tsum muab khaws cia kom deb ntawm cov menyuam yaus. Cia qhov kub thiab txias rau kev txhaj tshuaj thiab qhov muag yuav tsum yog + 15 ... + 25 ° С, rau aerosol thiab tshuaj pleev - + 8 ... + 15 ° С.
Tshuaj yuav tsum muab khaws cia kom deb ntawm cov menyuam yaus.
Hnub tas sij hawm
Txee lub neej ntawm qhov muag poob yog 3 xyoos, aerosol thiab tshuaj pleev - 2 xyoos, txhaj tshuaj tov - 1 xyoos. Qhov muag tawm tom qab qhib lub raj mis haum rau tsis pub dhau 1 hlis.
Chaw tsim tshuaj paus
Gentamicin raws li kev txhaj tshuaj tsim tawm:
- Lavxias
- Belarus
- Turkmenistan
- Uzbekistan
Gentamicin nyob rau hauv daim ntawv ntawm tshuaj pleev thiab qhov muag tawm yog tsim nyob rau hauv Belarus, nyob rau hauv daim ntawv ntawm aerosol - Bulgaria.
Kev tshuaj xyuas dua ntawm Gentamicin Sulfate
Maria, hnub nyoog 25 xyoo, Voronezh: “Tau ob peb lub lis piam dhau los, qee yam poob rau hauv lub qhov muag. Rau ib hnub, qhov muag tau mob, o (yuav luag kaw) thiab qhov mob tsis nco qab lawm. Tus kws kho mob qhia rau Gentamicin ua rau kuv tso. txhua txhua lwm hnub, thiab txog rau hnub thib 3 - lwm yam kev mob tshwm sim, tab sis kuv dripped tag nrho 7 hnub. "
Vladimir, hnub nyoog 40 xyoo, Kursk: “Kuv tau hlawv kuv txhais caj npab thaum ua haujlwm hnyav. Thaum yav tsaus ntuj pom lub ntsej muag tawm, ob peb hnub tom qab ntawd lub qhov txhab pib zoo thiab mob heev. qhov mob ntawd tsis tu lawm thiab pib kho nws zoo hlo. "
Andrei, hnub nyoog 38 xyoo, Moscow: "Tsaib no kuv tau mob ntsws. Kuv tsis tau pib kho tam sim ntawd, yog li thaum kuv mus tom tsev kho mob tus kab mob tau sib txawv los ntawm kev kub taub hau thiab hnoos heev. Gentamicin tau raug tshuaj sai. Lawv tau txhaj 4 zaug hauv ib hnub. Thiab ib hlis tom qab kuv tau raug rho tawm. "
