Cov tshuaj tiv thaiv antihypertensive Losacor yog siv rau hauv kev kho mob ntshav siab thiab rau kev tiv thaiv cov mob vascular hloov hauv cov neeg mob uas muaj kev pheej hmoo. Ntau cov kev txheeb xyuas zoo txog cov tshuaj yog vim muaj cov tshuaj muaj txiaj ntsig thiab tus nqi tsim nyog.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Losartan (hauv Latin - Lozartanum).
Lub npe thoob ntiaj teb uas tsis yog tus tswv ntawm cov tshuaj Losacor yog Losartan.
ATX
C09CA01.
Tso cov ntawv thiab cov nyob ua ke
Ntawm kev muag, cov tshuaj yog nyob rau hauv daim ntawv foos. Txhua lub ntsiav tshuaj muaj 12,5 mg ntawm losartan potassium, uas ua lub hauv paus (cov tshuaj ua kom muaj zog) ntawm cov tshuaj. Muaj pes tsawg leeg:
- pob kws nplej siab;
- pregelatinized hmoov txhuv nplej siab;
- microcrystalline cellulose;
- magnesium stearate;
- anhydrous aerosil (colloidal silicon dioxide);
- cellulose (kev sib xyaw ntawm cov cellulose thiab lactose monohydrate).
Cov tshuaj ntsiav tshuaj suav nrog quinolone zas xim daj, titanium dioxide, propylene glycol, talc thiab hypromellose.
Hauv ib lub phaj contour ntawm 7, 10 lossis 14 ntsiav tshuaj. Hauv pob ntawv thawv ntawm 1, 2, 3, 6 lossis 9 contour paib.
Cov tshuaj ntsiav tshuaj suav nrog quinolone zas xim daj, titanium dioxide, propylene glycol, talc thiab hypromellose.
Pharmacological kev txiav txim
Cov tshuaj muaj cov txiaj ntsig hypotensive thiab yog antagonist ntawm angiotensin 2, uas khi rau ntau cov ntaub so ntswg receptors thiab muaj ntau txoj haujlwm los ntawm qhov pom ntawm cov kab mob kev kho mob, suav nrog kev tso tawm thiab vasoconstriction ntawm aldosterone thiab kev ua kom zoo ntawm cov leeg nqaij ntawm tes txoj kev loj hlob.
Tsis tas li ntawd, cov tshuaj txo cov ntshav siab, tiv thaiv kom tsis txhob muaj dej thiab ntsev tuav hauv lub cev, thiab tseem ua rau muaj kev tawm dag zog hauv kev ua haujlwm hauv cov neeg mob lub plawv (mob plawv tsis ua haujlwm ntev).
Cov Tshuaj Pharmacokinetics
Losartan yog qhov nqus tau zoo tom qab kev tswj hwm qhov ncauj. Qhov khoom ntawd tso rau "thawj zaj" los ntawm nplooj siab.
Raws li qhov tshwm sim ntawm cov txheej txheem no, cov tshuaj tiv thaiv metabolite (carboxylated) thiab tus naj npawb ntawm lub cev tsis muaj zog yog tsim. Cov txheej txheem muaj cov kev suav txog ntawm kev thauj mus los ntawm 33%. Nws lub siab plasma ntau tshaj yog nce mus txog 1 teev tom qab noj. Khoom noj khoom haus tsis muaj kev cuam tshuam loj heev rau cov ntaub ntawv pharmacokinetic ntawm cov tshuaj tiv thaiv kabmob ntshav.
Losartan cov ntawv cog lus muaj zog nrog cov plasma protein (txog li 99%). Li ntawm 14% ntawm cov koob tshuaj tiv thaiv yog hloov mus rau hom kev siv tshuaj metabolite.
Cov tshuaj yog dhau los ntawm lub raum thiab hnyuv.
Kev ntsuas rau siv
Cov ntsiav tshuaj tuaj yeem raug kho rau cov neeg mob nyob rau hauv cov mob zoo li no:
- nyob rau hauv muaj cov leeg arterial tawg;
- txhawm rau txo cov kev pheej hmoo ntawm kev tuag thiab kev qias neeg nyob rau hauv cov neeg mob uas muaj kev pheej hmoo (sab laug ventricular hypertrophy, hlab ntsha tawg);
- kev kho mob ntawm cov proteinuria thiab hypercreatinemia (nrog rau qhov sib piv ntawm creatinine thiab albumin ntawm cov zis ntau dua 300 mg / g) hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus thiab nrog kev mob ntshav siab;
- CHF nyob rau hauv qhov tsis muaj cov nyhuv ntawm kev kho nrog ACE inhibitors;
- kev tiv thaiv ntawm vascular cov teeb meem hauv kev phais.
Cov Yuav Tsum Muaj
Cov cuab yeej tsis yog siv rau daim siab ua kom mob siab (ntau dua 9 ntsiab lus hauv Child-Pugh), lactose tsis txaus siab, lactation, cev xeeb tub, muaj hnub nyoog rau cov hluas, nrog rau qhov ua kom yuag rau losartan thiab cov tshuaj ntxiv los ntawm cov tshuaj.
Nrog saib xyuas
Cov kab mob antihypertensive yog ua tib zoo txiav txim siab nrog BCC txo qis, mob ntshav qis, ua kom tsis muaj dej-electrolyte tshuav, hauv kev sib xyaw nrog digoxin, diuretics, warfarin, lithium carbonate, fluconazole, erythromycin thiab ntau lwm yam tshuaj.
Yuav ua li cas coj Losacor
Cov ntsiav tshuaj tuaj yeem noj tau tsis hais noj zaub mov, nqos tau thiab ntxuav kom huv nrog dej kom ntau. Zaus ntawm kev siv - 1 zaug ib hnub.
Arterial hypertension yog kho tau hauv qhov ntau npaum ntawm 50 mg / hnub.
Qee zaum koob tshuaj tuaj yeem nce ntxiv txog 100 mg ob zaug ib hnub. Qhov nyiaj ntau kawg yog 150 mg / hnub.
Txhawm rau tiv thaiv cov kab mob ntawm cov hlab plawv.
Nrog ntshav qab zib
Txhawm rau tiv thaiv lub raum hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus nrog concomitant proteinuria, koob tshuaj ntawm 50 mg / hnub yog kho.
Qhov ntau npaum ntawm cov tshuaj rau ntshav qab zib tuaj yeem nce ntxiv txog 100 mg rau ib hnub, suav txog qhov mob hnyav ntawm kev ua txhaum ntawm cov ntshav siab.
Qhov ntau npaum li cas tuaj yeem raug nce ntxiv rau 100 mg ib hnub twg, noj mus rau hauv tus account qhov hnyav tsis cuam tshuam ntshav siab.
Kev tshwm sim los ntawm Losacor
Feem ntau, cov tshuaj muaj peev xwm thev taus ntau yam. Qhov tshwm sim ntawm cov kev mob tshwm sim yog sib piv rau qhov no thaum siv cov placebo.
Kev kho mob txoj hnyuv
Qhov ua tau tshwm sim tsis zoo, tsis mob ncauj plab, txhawb kom ntuav. Tsawg tsawg zaus, kab mob siab.
Nruab nrab hauv lub paj hlwb
Muaj mob taub hau, pw tsaug zog, thiab kiv taub hau me me.
Ntawm ib sab ntawm daim tawv nqaij
Cov pob liab liab tshwm sim rau ntawm daim tawv nqaij.
Los ntawm cov hlab plawv system
Lub plawv dhia tseem ceeb yog ua tau.
Kev noj tshuaj yuav ua rau lub plawv dhia.
Los ntawm ib sab ntawm cov metabolism
Qee qhov tsis tshua muaj, lub cev qhuav dej thiab nce ntxiv ntawm qhov kev txiav txim ntawm creatinine lossis urea hauv cov ntshav ntshav tau pom.
Kev ua xua
Kev o o, xoo pob thiab khaus yog ua tau. Feem ntau tsis tshua muaj tshwm sim, Quincke's edema nthuav dav thiab cov leeg ntawm lub qhov ntswg, qhov ncauj thiab lwm qhov ntawm lub cev raug cuam tshuam.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Tsis tau muaj kev sim tshwj xeeb hais txog kev ntsuam xyuas cov txiaj ntsig ntawm cov tshuaj ntawm psychomotor cov tshuaj tiv thaiv thiab muaj peev xwm tsav tsheb.
Cov lus qhia tshwj xeeb
Hauv cov neeg mob nrog BCC txo qis, tsos mob hypotension tshwm sim. Xws li cov mob yuav tsum tau siv cov tshuaj qis dua.
Tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj kho mob, koj yuav tsum ua tib zoo saib xyuas qib ntawm cov kab mob potassium nyob rau hauv cov ntshav, tshwj xeeb tshaj yog nyob rau cov neeg laus thiab nrog lub raum tsis ua haujlwm.
Cov neeg hauv lub hnub nyoog laus tsis tas yuav tsum tau kho ib leeg ib leeg ntawm cov tshuaj hauv nqe lus nug.
Siv rau lub sijhawm qub
Pawg no ntawm cov neeg mob tsis tas yuav tsum tau kho kom haum rau ib tus neeg.
Txiag tej menyuam
Rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, cov tshuaj tsis raug txwv.
Siv thaum cev xeeb tub thiab lactation
Antihypertensive tshuaj yog contraindicated rau siv nyob rau hauv pab pawg neeg ntawm cov neeg mob.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv kev mob raum tsis ua hauj lwm, ib qho tshuaj tiv thaiv lub cev tiv thaiv kab mob tsis pom zoo.
Siv rau lub siab ua haujlwm tsis zoo
Thaum tsis muaj txhij txhua thiab lwm yam kev ua haujlwm tsis ua haujlwm hauv lub siab (suav nrog rau mob ntsws), qhov tsawg kawg yog muab tshuaj.
Tsau ntawm Losacor
Cov ntaub ntawv hais txog kev siv tshuaj ntau dhau ntawm cov tshuaj tiv thaiv kabmob ntshav tsawg tsawg.
Nrog tshaj ntawm Losacor, ntshav siab tuaj yeem txo qis.
Cov tsos mob: ib qho tseem ceeb txo nyob rau hauv cov ntshav siab, tachycardia. Hemodialysis tsis muaj txiaj ntsig.
Kev cuam tshuam nrog lwm yam tshuaj
Cov tshuaj tsub kom cov txiaj ntsig ntawm sympatholytics thiab beta-blockers.
Kev sib xyaw ua ke ntawm cov tshuaj nrog cov tshuaj diuretic tuaj yeem ua rau ntxiv cov nyhuv.
Fluconazole thiab rifampin txo cov ntshav plasma theem ntawm cov metabolite ntawm cov tshuaj nquag.
NSAIDs tuaj yeem txo cov nyhuv tshuaj tiv thaiv antihypertensive. Nrog rau kev siv ua ke ntawm cov tshuaj no, yuav tsum tau muab kev kho kom haum.
Losacor nce cov txiaj ntsig ntawm sympatholytics thiab beta-blockers.
Cawv tau zoo
Cov kws tshaj lij tsis pom zoo kom haus cawv thaum siv tshuaj tiv thaiv antihypertensive.
Analogs
Pheej yig thiab zoo hloov chaw rau kev siv tshuaj antihypertensive:
- Vasotens;
- Vasotens N;
- Losartan;
- Lozap;
- Xarten;
- Cantab;
- Edarby
- Angiakand;
- Hyposart;
- Sartavel.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Nws yog tsis yooj yim sua los yuav cov tshuaj yam tsis muaj tshuaj.
Nqe rau Losacor
Los ntawm 102 rub. rau 10 ntsiav tshuaj.
Cia rau cov neeg mob rau cov tshuaj
Nyob rau hauv ib qho chaw tiv thaiv los ntawm high humidity, ntawm ib sim kub.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus
Lub tuam txhab Bulgarian "Adifarm EAT".
Koj yuav tsum khaws cov tshuaj rau hauv qhov chaw tiv thaiv los ntawm qhov kub siab, nyob rau qhov kub nruab nrab.
Kev txheeb xyuas txog Losacore
Victoria Zherdelyaeva (kws kho plawv), hnub nyoog 42 xyoos. Ufa
Kho tau zoo. Nws cov nyhuv hypotensive yog pom thaum hnub thib ib. Ib qho tshuaj yog muab tshuaj feem ntau nrog txoj hlab ntshav siab. Nqis tus nqi. Ua ntej siv cov tshuaj, nco ntsoov sab laj nrog tus kws kho mob tshwj xeeb.
Valentina Struchkova, 23 xyoo, Moscow
Cov tshuaj yog kws kho rau kuv txiv los ntawm kws kho plawv rau kev tiv thaiv kab mob plawv. Kev txiav txim siab los ntawm cov txiaj ntsig ntawm kev tshuaj ntsuam uas nws nyuam qhuav dhau los hauv thaj av tsev kho mob, cov tshuaj "ua haujlwm."
