Cov tshuaj ntsiav thiab cov ntsiav tshuaj Amikacin tsis yog cov ntawv uas tsis yog nyob ntawm cov tshuaj npaj rau kev kho mob ntawm kev sib kis.
Cov ntawv tso tawm thiab muaj pes tsawg leeg
Cov tshuaj muaj 2 hom:
- Ib qho kev daws teeb meem yog npaj rau kev tswj hwm lossis intravenous. Nws yog pob tshab, me ntsis xim lossis tsis muaj kob. Nws yog muag hauv iav ampoules, ntim hauv hlwv cov hlwv qhwv thiab pob ntawv ntawm cardboard. Ib qho ampoule muaj 500 mg lossis 1 g ntawm cov nquag tivthaiv.
- Lub hmoov npaj rau kev txhim kho hauv cov kua. Nws yog pleev xim dawb los yog ze rau dawb, nws muaj peev xwm nqus tau noo noo. Muag hauv 10 ml vials tso rau hauv cartons.
Cov tshuaj yeeb tshuaj yog tsim ua ob daim ntawv: ib qho kev daws teeb meem rau kev siv tshuaj intramuscular lossis tshuaj pleev ib ce thiab hmoov rau kev tso tawm hauv cov kua.
Tus nquag ua hauj lwm yog amikacin (hauv sulfate daim ntawv). Cov tshuaj tsis muaj lwm yam tshuaj uas cuam tshuam tau.
Cov tshuaj ntxiv ntawm cov tshuaj yog cov khoom xyaw xws li sodium citrate rau kev txhaj tshuaj, sodium disulfite, dilute sulfuric acid, dej rau kev txhaj tshuaj.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Lub npe tshuaj thoob ntiaj teb nonproprietary ntawm cov tshuaj yog Amikacin.
ATX
ATX Code - J01GB06
Pharmacological kev txiav txim
Nws yog cov tshuaj tiv thaiv kab mob, tus neeg sawv cev ntawm pawg aminoglycoside. Nws muaj cov nyhuv bactericidal rau qee cov gram-zoo, as Well as aerobic gram-cov kab mob tsis zoo. Nws qhia cov kev ua sim nruab nrab tiv thaiv streptococci. Txhim kho cov kab mob bactericidal ntawm benzylpenicillin tawm tsam cov quav quav tso quav.
Anaerobic pathogens tiv taus amikacin.
Cov Tshuaj Pharmacokinetics
Cov koob tshuaj uas muaj cov tshuaj tua kab mob tau pom nyob hauv cov ntshav rau 10-12 teev tom qab i / m lossis iv kev tswj hwm. Nrog cov plasma protein, cov tshuaj khi rau 4-11%.
Amikacin nkag mus rau hauv tag nrho cov ntaub so ntswg, cov kua dej ua ke thiab mus rau hauv cov hlwb. Cov ntshav siab heev muaj nyob hauv cov zis thiab cov nruab nrog muaj cov ntshav txaus - mob siab, ob lub raum, tus po, ntsws, myocardium. Cov roj ntsha me me muaj ntau hauv cov kua tsib, mis niam, tso zis zais pa, tso kua mis, cov hnoos qeev, hnoos qeev, cov leeg, pob txha, thiab cov roj muaj roj. Amikacin kis tau los ntawm qhov tso ntshav, kuaj hauv ntshav ntawm tus menyuam hauv plab thiab kua dej.
Kev Ntsuas Amikacin
Khaws tshuaj kho mob rau kev kho mob ntawm cov mob sib kis thiab mob. Cov tshuaj yeeb yaj kiab yog siv rau hauv cov teeb meem uas cov neeg ua hauj lwm ua rau tus kab mob yog cov kab mob gram-negative (tiv thaiv gentamicin, kanamycin, sisomycin) lossis symbioses ntawm gram-negative thiab gram-positive microorganisms.
Nws raug nquahu kom siv Amikacin rau kev kis kab mob ntawm daim tawv nqaij, lub hauv nruab nrog hlab ntsha hauv plab, plab hnyuv siab, lub ntsws ua pa, pob qij txha, thiab pob txha:
- mob ntsws, mob o lossis mob ntsws, lwm yam mob ntsws;
- mob peritonitis thiab lwm yam kev mob ntawm lub plab hauv plab;
- urethritis, cystitis, pyelonephritis;
- septic endocarditis;
- mob rau daim phiaj;
- sepsis
- biliary kis mob;
- siab ua paug, mob txhab, hlawv roj thiab lwm yam mob ntawm daim tawv nqaij;
- mob postoperative thiab mob txhab;
- kab mob ntawm lub qhov ntswg thiab caj pas;
- osteomyelitis.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub sau ntawv rau Amikacin nrog:
- kev tsis qaug rau cov tshuaj ntawm cov tshuaj;
- yav dhau los pom hypersensitivity rau aminoglycosides;
- neuritis ntawm auditory hlab ntsha;
- cev xeeb tub
- lub raum ua rau mob tsis zoo, nyuaj los ntawm uremia (lom los ntawm cov khoom ntawm cov protein metabolism) thiab azotemia (lom los ntawm nitrogen-muaj cov ntsiab lus).
Cov neeg uas mob tus kab mob botulism, myasthenia gravis, lub cev qhuav dej, parkinsonism, thiab lub raum khiav tsis zoo yuav tsum tau ceev faj thaum siv amikacin. Qhov no kuj siv rau cov menyuam mos, cov menyuam mos ua ntej, cov pojniam laus, cov laus.
Yuav ua li cas noj amikacin?
Siv tshuaj rau cov tshuaj intramuscularly thiab intravenously (nqus dej lossis dej ntws). Cov neeg laus tau qhia kom tswj hwm 10 txog 15 mg rau ib kg ntawm lub cev qhov hnyav. Qhov koob qhia ntawd yog siv txhua hnub, tsim rau 2 lossis 3 koob tshuaj. Yog tias muaj teeb meem lub raum khiav tsis zoo, yuav tsum hloov ib koob.
Thawj koob tshuaj rau cov me nyuam yug ntxov thiab yug tshiab yog 10 mg / kg. Tom qab ntawd, nws txo qis rau 7.5 mg / kg, thov txhua 12 teev.
Ib qho tshuaj tua kab mob sab muaj peev xwm muab tshuaj rau ib leeg.
Lub sijhawm tiv thaiv yog nyob ntawm tus txheej txheem ntawm kev siv tshuaj (ntawm 3 txog 7 hnub rau i / v, txij li 7 txog 10 hnub rau i / m).
Yuav ua li cas thiab yuav ua li cas yug?
Cov txheej txheem ntawm dilution ntawm hmoov yog nyob ntawm tus txheej txheem ntawm kev coj:
- rau v / m - cov ntsiab lus ntawm lub vial yog diluted nyob rau hauv 4-5 ml dej rau kev txhaj tshuaj;
- rau kua nrog iv - cov ntsiab lus ntawm lub vial yog yaj rau hauv 200 ml ntawm 0.9% sodium chloride tov lossis 5% dextrose tov;
- rau cov dav hlau iv txhaj tshuaj - 0.9% sodium chloride tov, 5% dextrose tov lossis dej rau txhaj (ntawm 4 txog 5 ml) ntxiv rau cov ntsiab lus ntawm lub vial.
Nws yog ib qho tseem ceeb kom paub meej tias cov ntsiab lus ntawm amikacin hauv kev daws rau kev tswj hwm kev tso dej tsis pub tshaj 5 mg / ml.
Nws puas tuaj yeem noj tshuaj rau ntshav qab zib?
Thaum hais txog tshuaj insulin-tiv thaiv ntshav qab zib hom 1, Amikacin yog qhov ceeb toom. Thaum xaiv cov txheej txheem kho, nws tsim nyog xaiv tus neeg mob lub sijhawm.
Phiv los ntawm Amikacin
Zoo li lwm yam tshuaj, Amikacin tuaj yeem ua rau kev txhim kho ntawm cov kev phiv tshuaj.
Nruab nrab hauv lub paj hlwb
Ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb yuav tshwm sim:
- tsaug zog
- mob taub hau
- apnea
Muaj qee kis, cov tshuaj muaj cov nyhuv neurotoxic, tshwm sim hauv cov leeg mob, txhawm rau qaug, qaug zog ntawm tes taw.
Los ntawm cov kab mob zis
Thaum kho nrog amikacin, yuav tshwm sim ntawm nephrotoxicity, xws li oliguria, microhematuria, proteinuria.
Kev ua xua
Nrog hypersensitivity rau cov tshuaj hauv cov tshuaj, kev fab tshuaj tshwm sim hauv qab no tuaj yeem tshwm sim:
- hyperemia ntawm daim tawv nqaij;
- Quincke's edema;
- daim tawv nqaij ua pob;
- npaws
- khaus
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nrog rau kev txhim kho cov kev mob tshwm sim los ntawm lub hauv nruab nrab hauv lub cev, nws yog qhov zoo dua rau qhov tsis kam tswj cov txheej txheem.
Cov lus qhia tshwj xeeb
Ua ntej siv cov tshuaj, nws yog qhov yuav tsum txiav txim siab qhov rhiab ntawm cov kab mob kis. Ua li no, siv disks nrog 30 μg ntawm amikacin.
Nws yog qhov tsim nyog kom paub meej tias cov ntsiab lus ntshav ntawm amikacin tsis tshaj 25 exceedg / ml.
Thaum lub sij hawm kho, nws yog ib qho tsim nyog los saib xyuas lub luag haujlwm ntawm lub pob ntseg hnov, hlab ntsws thiab lub tshuab ntxig. Nws raug nquahu kom ua qhov no ib hlis ib zaug.
Yog tias qhov ntsuas qhov ntsuas tsis txaus, txo qhov koob tshuaj lossis ncua kev noj tshuaj.
Thaum lub cev tsis zoo ua haujlwm lub ntsej muag, siv sijhawm ntev lossis siv ntau dua ntawm cov tshuaj, nephrotoxicity yuav tshwm sim.
Nrog kev sib kis thiab mob ntawm cov kab mob ntawm lub tso zis, yuav tsum muaj kua dej ntau dua.
Qhov tsis muaj qhov tshwm sim zoo yuav qhia tias muaj kev tawm tsam ntawm cov kab mob me. Hauv qhov no, Amikacin tshem tawm, txoj kev kho tsim nyog yog nqa tawm.
Siv rau lub sijhawm qub
Rau cov neeg laus dua, Amikacin yog qhov muaj kev ceev faj.
Txiag tej menyuam
Kev kho mob ntawm cov menyuam mos thaum ntxov yuav pib noj ib zaug ntawm 10 mg / kg. Tom qab ntawd cov tshuaj raug muab rau 7,5 mg / kg rau txhua txhua 18-24 teev.
Thawj koob tshuaj rau cov neeg mob txij li 0 txog 6 xyoo yog 10 mg / kg. Tom qab ntawd cov tshuaj raug muab txhua 12 teev nyob rau 7,5 mg / kg. Kev kho mob kav ntev li 7 txog 10 hnub.
Siv thaum cev xeeb tub thiab lactation
Amikacin tsis raug xaj rau cov neeg mob cev xeeb tub.
Siv cov tshuaj thaum pub mis niam pub, yog tias muaj cov cim tseem ceeb.
Noj ntau dhau
Yog tias dhau ntawm kev noj haus ntau dhau, lom tshwm sim tuaj yeem tsim: ataxia, nqhis dej, kiv taub hau, hnov lus tsis zoo, tso zis tsis nco qab, ntuav, xeev siab, tsis qab los noj mov, hnov lus thiab ua pa nyuaj.
Txhawm rau tshem tawm cov kev cuam tshuam ntawm kev tshaj tawm, peritoneal lim ntshav thiab hemodialysis tuaj yeem siv tau. Nws tseem tuaj yeem siv tshuaj tua kab mob anticholinesterase, siv tshuab ua pa, ua pa ntsev ntsev.
Kev cuam tshuam nrog lwm yam tshuaj
Amikacin cuam tshuam nrog cov tshuaj hauv qab no:
- nrog cephalosporins, benzylpenicillin, carbenicillin - muaj kev nce ntxiv hauv cov nyhuv ntawm amikacin thiab cov tshuaj uas tau teev tseg lawm;
- nrog rau cov tshuaj diuretic (tshwj xeeb tshaj yog furosemide), penicillins, NSAIDs, cephalosporins, sulfonamides - nce neuro- thiab nephrotoxicity;
- nrog curare zoo li txhais tau tias - cov leeg nce ntxiv;
- nrog indomethacin (nrog rau kev tswj hwm hauv tsoomfwv) - kev txhim kho ntawm cov nyhuv tsis haum rau cov tshuaj tua kab mob aminoglycosides;
- nrog polymyxin B, vancomycin, nalidixic acid, cisplatin - muaj kev pheej hmoo ntawm nephro- thiab ototoxicity;
- nrog rau cov tshuaj tiv thaiv myasthenic - txo qis hauv qhov txiaj ntsig ntawm cov tshuaj aforementioned;
- nrog methoxyflurane, capreomycin, parenteral polymyxins thiab lwm yam tshuaj uas muaj cov txiaj ntsig zoo ib yam - kev pheej hmoo ntawm lub ntsws ua pa tuaj.
Nws yuav tsum nco ntsoov tias Amikacin yog tshuaj tsis haum nrog rau cov neeg sawv cev hauv qab no: heparin, capreomycin, hydrochlorothiazide, potassium chloride, erythromycin, amphotericin B, nitrofurantoin, penicillins, cephalosporins, vitamins C thiab B.
Cawv tau zoo
Tsis txhob haus cawv thaum noj tshuaj nrog Amikacin. Qhov kev sib xyaw ua ke no nce lub nra rau ntawm daim siab, ua rau txhim kho kev phiv tshuaj.
Analogs
Cov qauv sib txig sib xyaw rau cov nquag sib xyaw:
- Amikabol;
- Amikacin Ferein;
- Amikacin Vial;
- Amikacin sulfate;
- Amicositis;
- Amikin;
- Seleomycin;
- Lycacin;
- Hemacin;
- Fercycline.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kev yuav tshuaj Amikacin, koj yuav tsum tau yuav tshuaj xaj.
Nqi
Tus nqi ntawm cov tshuaj yog nyob ntawm tus naj npawb ntawm ampoules (lub raj mis) hauv ib pob, lub tsev muag tshuaj ntawm npoo thiab lwm yam. Tus nqi siab tshaj plaws ntawm Amikacin hauv Russia yog 2500-2600 rubles. ib pob ntawm 50 vials ntawm hmoov.
Cia rau cov neeg mob rau cov tshuaj
Cov hmoov thiab cov tshuaj tau muab khaws cia rau hauv qhov chaw qhuav thiab tsaus, ntawm qhov chaw ntawm cov menyuam yaus. Qhov ntsuas kub thaum cia cov tshuaj tso cai sib txawv ntawm + 5 ... + 25 ° C.
Hnub tas sij hawm
Amikacin khaws nws cov khoom rau 36 lub hlis.
Chaw tsim tshuaj paus
Cov chaw tsim tshuaj nyob rau yeeb tshuaj yog Kraspharm OJSC, nyob hauv thaj chaw Krasnoyarsk.
Xyuas
Yana, 31 xyoo, Perm: "Thaum kuv tus ntxhais pom pom muaj tus kab mob hnyuv, peb yuav Amikacin ua hmoov. Cov kws kho mob tau hais tias kom npaj cov tshuaj raws li cov lus qhia thiab txhaj tshuaj rau hauv. Cov kev kho mob mus zoo, tsis muaj kev phiv tshuaj."
Olga, hnub nyoog 27 xyoo, Ufa: “Kuv tau pib siv Amikacin thaum kuv tau hnoos ntsws. Kuv tau txhaj tshuaj txhua txhua hnub rau 5 hnub. tsev tshuaj txee. "
