Captopril-FPO yog ib qho tshuaj tiv thaiv kabmob vim muaj cov nyhuv vasodilating. Cov txiaj ntsig kho tau yog vim yog inhibition ntawm ACE thiab tsis ncaj qha inhibition ntawm kev tawg ntawm bradykinin. Cov tshuaj tiv thaiv kev tsim cov tshuaj angiotensin 2. Raws li kev nthuav dav ntawm cov hlab ntsha tseem ceeb thiab cov hlab ntsha, cov ntshav ncig hauv thaj tsam ischemia kho kom zoo dua qub, cov neeg mob kho lub keeb kwm ntawm pathologies ntawm cov hlab plawv ntawm ntau lub hauv paus pib. Cov tshuaj yuav tsum tau coj nruj me ntsis raws li cov lus qhia ntawm tus kws kho mob tuaj koom.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Captopril.
Captopril-FPO yog ib qho tshuaj tiv thaiv kabmob vim muaj cov nyhuv vasodilating.
ATX
C09AA01.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb nrog ib daim nplaum zas, muaj 25 lossis 50 mg ntawm cov tshuaj nquag - captopril. Txhawm rau kom nqus thiab bioavailability thaum lub sijhawm kev tsim khoom, cov khoom sib txuas nrog ntxiv rau cov nquag nquag:
- microcrystalline cellulose;
- pob kws nplej siab;
- mis nyuj qab zib;
- magnesium stearate;
- aerosil.
Cov chav kuaj tshuaj yuav muaj tus yam ntxwv tsis hnov tsw. Cov ntsiav tshuaj tau muab ntim rau hauv blister pob ntawm 5-10 pieces.
Pharmacological kev txiav txim
Cov tshuaj yog rau cov chav kawm ntawm cov tshuaj tiv thaiv kev tiv thaiv, qhov ua haujlwm ntawm uas ua raws li kev thaiv ntawm cov tshuaj angiotensin hloov kho enzyme (ACE). Raws li kev kho mob kom zoo, kev hloov pauv ntawm angiotensin I rau Daim Ntawv II qis qis dua, uas ua rau vasoconstriction - ib qho kev sib hloov ntawm cov leeg ntshav endothelium. Nrog qhov nqaim ntawm lub lumen ntawm lub nkoj ntawm qhov tawm tsam ntawm keeb kwm ib txwm ntawm lub cev ntshav, ntshav nce siab. Cov tshuaj txwv tsis pub spasm, yog li nres qhov rhuav tshem ntawm bradykinin, ib qho enzyme uas ceev cov hlab ntsha.
Captopril FPO qeeb qeeb rau kev txhim kho lub plawv nres.
Raws li qhov tshwm sim, cov hlab ntsha nthuav dav thiab lub siab poob qis rau li qub, muab tias qhov ntim ntawm cov ntshav tau txaus los sau lub txaj leeg. ACE inhibitor vim lub siab ceev hluav taws xob muaj cov yeeb yam nram no:
- txo qhov tsis kam nyob rau hauv cov hlab ntsws thiab hlab ntsha chaw nres nkoj;
- nce vascular tsis kam mus rau loads, txo qhov kev pheej hmoo ntawm kev sib tawg ntawm cov ntshav ntws phab ntsa;
- tiv thaiv kev ua txhaum ntawm kev ua haujlwm ntawm cov leeg ntswj, uas yog los ntawm ntshav siab (BP);
- Kev maj mam txo qis kev txhim kho lub plawv dhia;
- txo qhov kev haum xeeb ntawm sodium ntawm cov ntshav plasma tiv thaiv keeb kwm yav dhau los ntawm daim ntawv mob plawv tsis ua haujlwm;
- txhim kho txoj hlab ntshav khiav ua haujlwm thiab microcirculation hauv thaj chaw ischemic.
Cov tshuaj tiv thaiv kom tsis txhob platelet adhesion.
Cov Tshuaj Pharmacokinetics
Tom qab qhov ncauj tswj hwm, captopril yog 75% nqus tau rau hauv phab ntsa ntawm jejunum. Nrog rau cov pluas mov sib xyaw, kev nqus yog txo los ntawm 35-40%. Qhov nquag nquag mus txog qhov siab tshaj hauv cov ntshav hauv 30-90 feeb. Qhov qib ntawm khi rau ntshav ntshav albumin thaum nws nkag mus rau hauv cov ntshav ntawm txoj hlab ntshav qis - 25-30%. Nyob rau hauv daim ntawv ntawm qhov ua tau zoo, cov tshuaj yog metabolized hauv hepatocytes nrog kev tsim cov khoom ntawm biotransformation uas tsis muaj kev cuam tshuam txog tshuaj.
Ntau tshaj li 95% ntawm captopril tawm hauv lub cev nrog kev pab los ntawm ob lub raum, nrog 50% tau tawm hauv nws cov qauv qub.
Ib nrab-lub neej yog tsawg dua 3 teev. Lub sijhawm nce ntxiv tawm tsam keeb kwm ntawm lub raum tsis ua haujlwm los ntawm 1-29 teev, nyob ntawm seb tus mob hnyav npaum li cas. Ntau tshaj li 95% ntawm captopril tawm hauv lub cev nrog kev pab los ntawm ob lub raum, nrog 50% tau tawm hauv nws cov qauv qub.
Dab tsi pab
Cov tshuaj yog siv hauv kev kho mob rau kev kho thiab tiv thaiv ntawm cov txheej txheem hauv qab no:
- ntshav siab los qis, suav nrog kev kho cov ntshav siab;
- ua ib feem ntawm txoj kev kho mob kom zoo rau kev tshem tawm cov kev mob plawv ntev;
- kev tsis sib haum xeeb ntawm kev ua haujlwm ntawm sab laug ventricle tom qab lub plawv nres, muab tus neeg mob ruaj khov;
- kev puas tsuaj rau glomerular apparatus thiab lub plawv rov qab plab parenchyma hauv ntshav qab zib hom 1.
Cov Yuav Tsum Muaj
Cov tshuaj no yog txwv rau kev siv los ntawm tib neeg nrog ib tus neeg tsis kam ua rau captopril thiab lwm cov ntsiab lus uas tsim cov tshuaj. Vim tias muaj cov lactose monohydrate, Captopril tsis pom zoo rau siv rau hauv cov neeg tsis tuaj yeem mob monosaccharide malabsorption, tsis muaj kam lossis lactase tsis txaus.
Tsuas tshuaj
Qhov ntau npaum li cas yog tsim los ntawm ib leeg tus kheej los ntawm tus kws kho plawv, uas tso siab rau kev ntsuas thiab qhov hnyav ntawm cov kab mob pathology. Cov tshuaj yog npaj rau cov neeg laus laus dua 18 xyoo. Qhov pom zoo kom pib noj yog 12,5 mg 2 zaug ib hnub.
Nrog rau cov ntshav qab zib nephropathy
Txog kev tiv thaiv thiab kho nephropathy tiv thaiv keeb kwm ntawm kev mob ntshav qab zib insulin, nws yog ib qho tsim nyog yuav tau noj los ntawm 75 txog 100 mg ntawm cov tshuaj ib hnub.
Hauv lub plawv tsis ua haujlwm
Txhaws lub plawv tsis ua haujlwm yuav tsum siv 25 mg 3 zaug hauv ib hnub nyob rau thawj theem ntawm kev kho mob. Nrog ib qho ntshav lossis ntshav qis, nrog rau cov neeg mob hypovolemia thiab cov dej qab ntsev tsawg nyob hauv cov ntshav, nws raug nquahu kom txo cov tshuaj kom tsawg li 6.25-12.5 mg nrog kev tswj hwm ntau zaus txog 3 zaug hauv ib hnub. Raws li kev saib xyuas kho, 3 zaug hauv ib hnub yuav tsum tau noj 12,5 lossis 25 mg, nyob ntawm theem ntawm kev zam rau cov tshuaj.
Hauv qab lub siab
Txhawm rau tswj cov ntshav ntawm cov mob me lossis mob hnyav thaum pib kho, 25 mg yuav tsum noj 2-3 zaug ib hnub. Nrog tus kws kho mob teb kom tsawg, ib koob tshuaj yuav tsum tau nce rau 50 mg xwb yog tias nws zoo haum. Qhov siab tshaj plaws pub siv rau ib hnub yog 150 mg.
Yog tias cov ntsuas ntshav siab xav tau tsis tiav hauv 14-21 hnub ntawm kev kho mob, thiazide diuretics ntxiv rau kev noj tshuaj rau captopril-FPO monotherapy. Cov tshuaj tiv thaiv ntawm lub cev raug pom rau 1-2 lub lis piam. Txhawm rau tshem tawm cov txheej txheem mob pathological, koj tuaj yeem nce ntxiv rau qhov ntau npaum li 100-150 mg nrog kev tswj hwm ntau zaus txog 2-3 zaug hauv ib hnub.
Txhawm rau kom tshem tawm cov kev kub siab, nws yog ib qho tsim nyog yuav tsum muab cov tshuaj tso rau hauv tus nplaig nrog qhov ntau ntawm 6.25-50 mg.
Txhawm rau kom tshem tawm cov kev kub siab, nws yog ib qho tsim nyog yuav tsum muab cov tshuaj tso rau hauv tus nplaig nrog qhov ntau ntawm 6.25-50 mg. Txoj kev kho kom zoo yog pom tom qab 15-30 feeb.
Nrog myocardial infarction
Cov tshuaj tau sau tawm rau 3 hnub tom qab myocardial infarction. Qhov hno thaum pib ntawm kev siv tshuaj yog 6.25 mg rau ib hnub. Nrog rau qhov tshwm sim zoo ntawm lub cev rau cov tshuaj, qhov nce ntxiv ntawm ib hnub rau 12,5 mg nrog rau zaus ntawm kev tswj hwm txog 3 zaug hauv ib hnub yog tso cai. Hauv ob peb lub lis piam, qhov muab ntxiv rau qhov ntau tshaj plaws tau zam.
Yuav noj Captopril-FPO li cas
Cov ntsiav tshuaj tau noj ntawm lub plab khoob 60 feeb ua ntej noj mov, vim tias cov zaub mov qeeb lossis cuam tshuam nrog kev ib txwm nqus ntawm cov tshuaj.
Nyob hauv qab nplaig lossis dej haus
Sublingual captopril tsuas yog siv los txhawm rau kho lub zog kho. Kev txo ntshav siab sai yog qhov tsim nyog thaum muaj kev kub ntxhov.
Ntev li cas?
Nrog kev tswj hwm sublingual, cov nyhuv hypotensive yog pom 15-30 feeb tom qab cov ntsiav tshuaj yaj yaj hauv qab tus nplaig. Thaum noj, qhov siab tshaj plaws ua tau zoo tshaj plaws tau ua tiav tsis dhau 3-6 teev, thaum pib - tom qab 1-2 teev.
Kuv haus tau pes tsawg zaus
Tshaj tawm ntawm kev thov - 2-3 zaug hauv ib hnub.
Sab sij huam
Cov kev xav tsis zoo tsim tawm los ntawm kev siv tshuaj tsis haum. Thaum lawv tshwm sim, pom zoo kom txo koob tshuaj.
Kev kho mob txoj hnyuv
Phiv nyob rau hauv cov hnyuv manifest li:
- xeev siab
- tsis qab los noj mov;
- saj tsis meej;
- mob plab;
- nce enzymatic kev ua si ntawm hepatic transaminases;
- hyperbilirubinemia;
- raws plab, cem quav;
- kev txhim kho ntawm cov rog rog ua rau daim siab.
Cov teeb meem tsawg, stagnation ntawm cov kua tsib yog ua tau. Muaj kev cais tawm cov teeb meem kev o ntawm cov txiav.
Hematopoietic plab hnyuv siab raum
Kev ua txhaum ntawm cov pob txha mob hematopoiesis yog qhov tsis tshua sau tseg:
- anemia
- txo qis hauv tus naj npawb ntawm neutrophils;
- txo hauv platelet tsim.
Hauv cov neeg mob uas muaj cov kab mob autoimmune, agranulocytosis yuav tshwm sim.
Nruab nrab hauv lub paj hlwb
Nrog rau kev puas tsuaj ntawm cov leeg poob siab, muaj kev pheej hmoo ntawm kiv taub hau, mob taub hau, mob nkees, mob caj dab. Kev nkhaus yuav tsis pom zoo.
Los ntawm cov kab mob zis
Qee qhov xwm txheej, cov protein tuaj yeem tawm hauv cov zis, cov ntsiab lus ntawm uric acid thiab creatinine nyob rau hauv cov ntshav ntshav nce siab, acidosis tshwm sim.
Los ntawm lub tshuab ua pa
Cov tsos ntawm hnoos qhuav yog tau.
Ntawm ib sab ntawm daim tawv nqaij
Cov tawv nqaij tshwm sim tshwm sim raws li ua pob liab liab lossis khaus khaus. Hauv cov neeg mob predisposed mus rau kev loj hlob ntawm kev tsis haum tshuaj, Stevens-Johnson mob, urticaria, los yog tiv tauj dermatitis yuav tshwm sim.
Los ntawm genitourinary system
Hauv cov txiv neej, lub mis o lossis kev txhim kho ntawm erectile kawg yog ua tau.
Kev ua xua
Kev ua xua tshwm sim nyob rau hauv daim ntawv ntawm cov tawv nqaij kev tiv thaiv, bronchospasm nrog kev ua tsis taus pa, Quincke's edema, anaphylactic poob siab, ntshiab ntshav, thiab muaj cov tshuaj tiv thaiv kab mob hauv cov ntshav.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis cuam tshuam rau kev ua haujlwm ntawm kev ua kom lub cev muaj zog, lub hlwb thiab lub cev ntawm tus neeg mob. Yog li no, thaum lub caij kho nrog Captopril, tsis tas yuav txwv lub sijhawm tsav tsheb lossis ua haujlwm nrog cov txheej txheem nyuaj.
Cov lus qhia tshwj xeeb
Ceev faj yog qhia thaum noj cov nram no:
- stenosis ntawm cov hlab ntsha ntawm ob lub raum;
- kab mob plawv;
- cerebrovascular kev sib tsoo;
- hais cov kab mob autoimmune;
- kev tsim txom los ntawm cov ntshav tsim;
- ntshav qab zib mellitus;
- kev rov txhim kho lub sijhawm tom qab lub raum hloov;
- aortic stenosis;
- kev noj zaub mov kom tsawg sodium
- hnub nyoog siab heev;
- qis ntim ntawm cov ntshav ncig, lub cev qhuav dej.
Thaum lub sij hawm kho cov tshuaj, nws yog ib qho tsim nyog ceeb toom rau cov neeg ua haujlwm hauv chaw kuaj ntshav txog qhov tshwm sim uas yuav tshwm sim ntawm cov txiaj ntsig tsis zoo thaum ntsuas cov zis rau qhov muaj acetone.
Siv thaum cev xeeb tub thiab lactation
Kev siv cov tshuaj nyob rau hauv II thiab III trimesters ntawm kev loj hlob ntawm embryonic qhia tau hais tias fetotoxicity, vim hais tias ntawm qhov kev tso ntawm cov plab hnyuv siab raum nyob rau hauv lub fetus tej zaum yuav ntxhov. Qhov ntxim nyiam ua ntej ntawm kev yug menyuam ntxov. Cov poj niam cev xeeb tub yog txwv tsis pub siv cov tshuaj no.
Captopril ua rau nrog rau cov kua mis, yog li ntawd, thaum lub sijhawm lactation, nws yog ib qho tsim nyog yuav tsum tsis txhob lactation.
Cawv tau zoo
Cov tshuaj yog nruj me ntsis txwv tsis pub siv rau hauv kev haus dej cawv, thiab yog li ntawd, thaum lub sijhawm kawm kho cov tshuaj, koj yuav tsum tsis txhob haus cawv lossis haus cawv uas muaj cov tshuaj cawv. Kev haus dej cawv ethyl txo cov nyhuv antihypertensive, ua rau cov ntshav txhaws ntau ntxiv vim qhov teeb meem ntawm cov ntshav platelet thiab ntau ntxiv ua kom lub cev qhuav dej.
Noj ntau dhau
Nyob rau hauv cov ntaub ntawv ntawm cov tshuaj overdose, ib tug ntse poob nyob rau hauv cov ntshav siab yog ua tau. Raws li cov txiaj ntsig ntawm txoj hlab ntsha hypotension, ib tus neeg tuaj yeem tsis nco qab, poob rau hauv coma lossis tsis nco qab, thiab raug ntes plawv yog muaj peev xwm. Nrog kev tsim txom me ntsis ntawm cov tshuaj, lub taub hau pib yoov, qhov kub hauv cov ceg qis dua.
Txhawm rau cov ntshav siab li qub, nws yog qhov yuav tsum tau yuam tus neeg mob kom pw ntawm nws sab tom qab thiab tsa nws ob txhais ceg. Hauv cov chaw kho mob, nyob hauv qhov chaw kho, cov kev mob tshwm sim.
Kev cuam tshuam nrog lwm yam tshuaj
Kev siv loj sib luag ntawm captopril nrog rau lwm cov tshuaj yog pom nyob rau hauv cov tshuaj tiv thaiv hauv qab no:
- Cytostatic thiab immunosuppressive tshuaj, azathioprine tsub kom muaj kev pheej hmoo ntawm kev tsim leukopenia. Azathioprine provokes ib tug txo nyob rau hauv cov leeg pob txha hematopoiesis.
- Potassium-sparing diuretics thiab cov tshuaj uas tsis yog tshuaj steroidal tuaj yeem ua rau hyperkalemia. ACE inhibitor txo qhov kev cia siab ntawm aldosterone, vim tias muaj kev ncua sijhawm cov poov tshuaj ions.
- Nrog rau kev siv tib lub sijhawm nrog cov tshuaj diuretic, muaj zog hypotensive nyhuv yog pom. Raws li qhov tshwm sim, txoj kev txhim kho ntawm txoj kev mob ntshav ntawm txoj kev mob ntshav qis, hyperkalemia, thiab lub raum ua haujlwm tsis tuaj yeem. Tsis tas li, kev poob siab hauv cov ntshav siab yog pom nrog cov lus qhia ntawm cov nyiaj rau kev ua kom loog.
- Allopurinol ua rau kom muaj kev tsis haum tshuaj ntau thiab cov mob ntshav tsis haum.
- Acetylsalicylic acid, ibuprofen thiab indomethacin txo cov kev kho mob ntawm captopril.
- Captopril nce cov ntshav plasma concentration ntawm digoxin.
Cov tshuaj tua kab mob Cyclosporin tuaj yeem ua rau kev txhim kho ntawm oliguria thiab ua kom tsis muaj zog ntawm kev ua haujlwm ntawm lub raum.
Analogs
Captopril-FPO ntsiav tshuaj thaum tsis muaj qhov tsim nyog antihypertensive yuav hloov nrog cov tshuaj hauv qab no:
- Kapoten;
- Blockordil;
- Captopril Sandoz;
- Angiopril;
- Rilcapton;
- Captopril-STI;
- Captopril-Akos.
Cas yog captopril-FPO sib txawv ntawm captopril
Feem ntau, tsis zoo li cov tshuaj qub, muaj cov nyhuv hypotensive ntev dua thiab muaj cov txiaj ntsig kho kom zoo dua qub.
Kev so hauj lwm rau captopril-FPO los ntawm ib lub tsev muag tshuaj
Nws raug tso cai yuav khoom rau kev kho mob ncaj qha.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Raws li kev siv tsis raug, txoj kev txhim kho ntawm txoj hlab ntsha hypotension yog ua tau, yog li kev yuav khoom ntawm Captopril uas tsis muaj daim ntawv kho mob yog txwv tsis pub.
Nqe rau captopril-FPO
Tus nqi nruab nrab hauv cov khw muag tshuaj yog 128 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cov tshuaj rau hauv ib qho chaw sib cais los ntawm tshav ntuj, ntawm qhov kub tsis tshaj + 25 ° C
Hnub tas sij hawm
3 xyoos
Chaw Tsim Tshuaj Captopril-FPO
CJSC FP Obolenskoye, Russia.
Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob txog Captopril-FPO
Olga Kabanova, kws kho plawv, Moscow
Kuv pom tias Captopril thiab nws cov generics tsis ua haujlwm rau txhua tus neeg mob. Kuv tuaj yeem pom zoo ib cov tshuaj los txo cov ntshav siab hauv cov xwm txheej ceev. Koj tuaj yeem noj tshuaj rau 3 zaug hauv ib hnub. Muaj qee kis, cov neeg mob yws ntawm hnoos heev. Siv nrog ceev faj thaum muaj mob raum tsis ua haujlwm.
Ulyana Solovyova, 39 xyoo, Vladivostok
Kuv tawm hauv qhov kev tshuaj xyuas zoo. Ib ntsiav tshuaj dawb me me tau yooj yim muab faib ua 4 ntu ua tsaug rau cov lus qhia tshwj xeeb. Hauv kuv kis, tus kws kho mob pom zoo kom muab cov tshuaj tso rau hauv tus nplaig kom nrawm dua. Kws tshuaj txhawm rau kom txo qis kev kub ntxhov. Qhov kev txiav txim yog pom rau 5 feeb. Kuv tsis pom qhov cons, tsuas yog muaj qhov iab iab. Kuv tsis xav hloov cov tshuaj. Tsis muaj kev cuam tshuam.
