Amoxiclav 312 mg sib xyaw ua ke 250 mg ntawm semisynthetic amoxicillin thiab 62 mg ntawm beta-lactamase inhibitor. Qhov ntxiv ntawm clavulanic acid rau amoxicillin tso cai los nthuav cov spectrum ntawm kev ua tshuaj tua kab mob. Cov tshuaj tua kab mob yog siv hauv cov kis mob, nrog tus mob tshwm sim. Cov tshuaj yuav pab tshem tawm cov kab mob microflora thiab nws cov khoom lag luam metabolic.
ATX
J01CR02.
Amoxiclav 312 mg sib xyaw ua ke 250 mg ntawm semisynthetic amoxicillin thiab 62 mg ntawm beta-lactamase inhibitor.
Tso cov ntawv thiab cov nyob ua ke
Daim ntawv ntau ntau ntawm cov tshuaj visually yog lub hmoov dawb npaj rau kev npaj ncua kev kawm. Raws li lub tebchaw nquag, kev sib xyaw ua ke ntawm 250 mg ntawm amoxicillin trihydrate (lossis 500 mg) thiab 62 mg ntawm clavulanic acid hauv daim ntawv ntawm cov ntsev ntsev (125 mg) yog siv. Txhawm rau txhawm rau txhim kho palatability thiab txhim kho kev nyab xeeb, cov tshuaj nquag tau ntxiv nrog cov khoom hauv qab no:
- colloidal dehydrated silica;
- Tsiaj qus Cherry Flavor
- benzoate, carboxycellulose thiab sodium saccharin;
- microcrystalline cellulose;
- xanthan ntawm cov pos hniav;
- mannitol.
Cov tshuaj tua kab mob yog siv hauv cov kis mob.
Cov tshuaj yog muaj nyob hauv khob iav. Thaum diluting hmoov nrog dej rwg, ib qho kev ua tiav tiav yog tau, uas yog homogeneous sib xyaw nrog ib qho dawb lossis daj zas.
Pharmacological kev txiav txim
Cov tshuaj yog cov tshuaj tua kabmob, tua cov kab mob ntawm cov kab mob me me. Cov txheej txheem ntawm kev ua yog raws li cov tshuaj tua kab mob ntawm amoxicillin, ib qho khoom sib txuas ua ke los ntawm pawg neeg penicillin. Tus neeg sawv cev Beta-lactam inhibits qhov kev ua si enzymatic ntawm cov tshuaj uas lub luag haujlwm rau cov synthesis ntawm peptidoglycan. Qhov kev sib xyaw no yog qhov tsim nyog rau kev sib txuas lus ib leeg thiab ntxiv dag zog rau daim nyias nyias ntawm lub cev kis tau. Thaum nws raug rhuav tshem, lub plhaub sab nraud pov tseg lawm, thiab cov kab mob hauv lub cev tuag hauv qab ntawm osmotic siab.
Tib lub sijhawm, amoxicillin tsis ua haujlwm tawm tsam cov kab mob me me uas tsim cov beta-lactamases. Cov Enzymes rhuav tshem cov tshuaj tua kab mob ib nrab, yog li cov ntsev ntsev ntawm clavulanic acid tau ntxiv rau cov tshuaj los tiv thaiv nws. Nws inhibits kev ua haujlwm ntawm beta-lactamases, thaum amoxicillin ua rau kev tuag ntawm cov kab mob. Ua tsaug rau qhov kev sib xyaw ua ke no, tus neeg sawv cev tiv thaiv kab mob tau txuas ntxiv ntawm qhov kev txiav txim.
Cov Tshuaj Pharmacokinetics
Thaum siv txoj kev tshem tawm kev hais lus, ob qho kev sib xyaw ua ke raug tso tawm nyob rau hauv qhov kev txiav txim ntawm esterases nyob rau hauv txoj hnyuv thiab tau nqus rau hauv phab ntsa ntawm cov hnyuv me. Thaum lawv nkag rau hauv cov hlab ntshav, semisynthetic penicillin thiab beta-lactam ncav cuag cov ntshav siab tshaj plaws nyob rau hauv ib teev. Ob qho sib txuas ua ke tsis khi rau cov protein plasma. Nrog albumin, cov ntaub ntawv nyuaj tsuas yog 18-20% ntawm cov tshuaj nquag.
Thaum lawv nkag rau hauv cov hlab ntshav, semisynthetic penicillin thiab beta-lactam ncav cuag cov ntshav siab tshaj plaws nyob rau hauv ib teev.
Amoxicillin yauv raug biotransformation nyob rau hauv hepatocytes rau tsawg dua li clavulanic acid. Cov tshuaj yeeb dej caw tawm sab nraud los ntawm lub raum los ntawm kev pom kev txhaws hauv nws daim ntawv qub. Ib qhov nqi ntawm clavulanate tawm hauv lub cev hauv daim ntawv ntawm cov khoom lag luam metabolic nrog quav. Ib nrab-lub neej yog nyob ntev txog 60-90 feeb.
Kev ntsuas rau siv
Cov tshuaj yog siv rau cov kab mob tshwm sim los ntawm kev tsis tuaj yeem loj hlob ntawm cov kab mob pathogenic:
- kis kab mob ntawm cov pa hauv siab thiab cov kabmob ENT: pharyngeal abscess, kev kis mob ntawm hlab ntsha o thiab hlab ntsha txhaws, mob otitis media, tonsillitis, sinusitis;
- inflammatory kab mob ntawm lub ntsws thiab bronchi (mob ntsws, mob ntsws);
- kev sib kis ntawm kev txhab ntawm kev txhab, kev puas tsuaj rau cov pob txha mos (osteomyelitis), kis mob ntawm cov nqaij mos;
- kis kab mob (alveolitis);
- kev puas tsuaj rau txoj hlab plab thiab lub zais zis;
- gynecological thiab sib deev sib kis kabmob (kab mob gonorrhea thiab mob chlamydia).
Cov tshuaj yeeb yaj kiab raug tso cai rau kev siv los tiv thaiv kev mob nrawm tom qab, dhau los ntawm qhov muaj tus kab mob, lossis rau kev kho pob txuv provoked los ntawm kev loj hlob ntawm staphylococcus.
Cov Yuav Tsum Muaj
Ib qho tshuaj tua kab mob tau txwv rau cov tib neeg uas tsis haum siab rau cephalosporins, beta-lactams thiab pawg penicillin. Koj tsis tuaj yeem sau cov tshuaj rau cov neeg mob cholestatic jaundice thiab mob siab mob siab uas tau tawm tsam los ntawm kev noj cov tshuaj amoxicillin thiab clavulanate. Ib qho tshuaj yog contraindicated rau lymphocytic leukemia los yog mononucleosis ntawm ib qho kev kis mob.
Nrog saib xyuas
Nws yog ib qho tsim nyog yuav tau soj ntsuam cov mob nyob rau hauv lub xub ntiag ntawm daim siab ua haujlwm lossis lub raum ua haujlwm tsis zoo. Yog tias muaj qhov tso quav xoob nrog impurities ntawm cov ntshav, nws yog qhov yuav tsum tau ua kev soj ntsuam los txiav txim siab qhov ua rau los ntshav. Yog tias zawv plab muaj feem xyuam nrog pseudomembranous enterocolitis, kev siv tshuaj tua kab mob yuav tsum tau nres tam sim ntawd.
Yuav noj Amoxiclav 312 li cas
Txhawm rau npaj qhov kev ncua, nws yog qhov tsim nyog kom yaj hmoov hauv cov dej rhaub ntawm chav tsev kub. Nws raug nquahu kom noj cov tshuaj ntawm qhov ncauj nrog zaub mov lossis tom qab noj mov. Lub sijhawm tiv thaiv ntawm kev kho yuav tsum tsis pub ntau tshaj 2 lub lis piam, vim tias muaj kev pheej hmoo ntawm kev txhim kho microflora cov kab mob rau Amoxiclav.
Nws yog ib qho tsim nyog yuav tau soj ntsuam xyuas lub sijhawm thaum muaj kab mob siab.
Rau cov laus
Rau cov neeg mob cov neeg laus, cov tshuaj txhua hnub yog 5 ml lossis 312 mg ntawm cov tshuaj, muaj 250 mg ntawm semisynthetic amoxicillin thiab 62 mg ntawm clavulanic acid. Ib qho kev ncua ntawv twg los nrog 5 ml noj tshuaj lossis tus kav dej. Cov tshuaj tau coj ib hnub ib zaug.
Tsuas tshuaj Amoxiclav 312 rau menyuam yaus
Cov menyuam mos hnub nyoog txog 90 hnub raug qhia kom laij raws qhov hnyav nyob ntawm lub cev: 30 mg rau 1 kg ntawm lub cev qhov hnyav ib hnub. Qhov ncua kev kawm ntawv no yog muab ncua nrog 12 teev 2 zaug ib hnub. Cov menyuam loj dua raug qhia kom noj 20 lossis 40 mg rau ib hlis twg ntawm lub cev hnyav. Hauv qhov no, lub sijhawm nruab nrab ntawm cov koob tshuaj yog txo kom tsawg 8 teev.
Rau ib tus menyuam qhov hnyav dua 40 kg, qhov ntau tshaj yog pub tau rau ib hnub yog 2.4 mg ntawm amoxicillin thiab 0.6 g ntawm clavulanate. Cov qauv koob tshuaj nws txawv ntawm 20 + 5 mg / kg lub cev qhov hnyav (amoxicillin + clavulanic acid) txog 60 + 15 mg rau 1 kg ntawm lub cev hnyav. Cov menyuam yaus tshaj 40 kg tau qhia kom muab tshuaj rau cov neeg laus.
Noj cov tshuaj rau ntshav qab zib
Cov neeg mob ntshav qab zib tsis tas yuav ntxiv hloov pauv rau cov tshuaj kom zoo. Qhov no yog vim tsis muaj cov tshuaj tua kab mob los cuam tshuam rau kev ua haujlwm ntawm pancreatic beta hlwb, thiab theem ntawm cov insulin lossis cov piam thaj hauv ntshav plasma.
Cov neeg mob ntshav qab zib tsis tas yuav ntxiv hloov pauv rau cov tshuaj kom zoo.
Sab sij huam
Qhov tshwm sim ntawm kev mob tshwm sim yog vim cov tshuaj noj tsis raug cai los yog muaj qhov tsis haum rau Amoxiclav tshuaj tiv thaiv kab mob. Cov kev nquag tshwm sim suav nrog kev tshwm sim ntawm kev saib xyuas tau zoo dua lossis kev kis mob fungal. Hauv qee qhov tshwj xeeb, muaj kev pheej hmoo ntawm kev txhim kho alopecia, kom txo qis qhov zoo li ntawm qhov pom ntawm cov kev saib xyuas plaub hau thiab tu cev yog qhov tsim nyog rau lub hau.
Kev kho mob txoj hnyuv
Cov kev tsis zoo tshwm sim hauv cov zom zaub yog qhov txawv txav ntawm cov tsos mob hauv qab no:
- mob mob intraperitoneal;
- kev ntxhov siab hauv lub siab;
- txhim kho cov kev ua si enzymatic ntawm AST thiab ALT - hepatic aminotransferases;
- o ntawm daim siab;
- cov tshuaj tua kab mob sib kis;
- ntuav, xeev siab, raws plab;
- tsis qab los.
Hauv qee qhov tshwj xeeb, muaj kev pheej hmoo ntawm cholestatic jaundice vim muaj kev nce ntxiv hauv cov concentration ntawm bilirubin.
Hematopoietic plab hnyuv siab raum
Nrog kev puas tsuaj rau cov pob txha mob hematopoiesis, kev hloov pauv hauv qhov ntsuas ntawm cov qog ntshav thiab cov nuj nqis ntawm cov teeb meem tsim los ntawm ntshav yuav tshwm sim:
- txo qis hauv cov neeg platelets, qe ntshav liab, qe ntshav dawb thiab neutrophils;
- eosinophilia;
- pancytopenia;
- thim rov qab agranulocytosis.
Txo cov lej ntawm cov ntshav liab tuaj yeem ua rau muaj kev loj hlob ntawm hemolytic anemia.
Txo cov lej ntawm cov ntshav liab tuaj yeem ua rau muaj kev loj hlob ntawm hemolytic anemia.
Nruab nrab hauv lub paj hlwb
Kev phiv los ntawm cov leeg ntshav muaj nrog rau qhov zoo li ntawm:
- Kiv taub hau
- mob leeg;
- nce neuromuscular excitability;
- kev xav ntawm kev ntxhov siab, ntxhov siab, kev poob siab;
- tsis zoo ntawm kev pw tsaug zog lossis insomnia;
- mob taub hau.
Cov neeg mob uas lub raum tsis zoo ua rau lub cev muaj feem ntau ua rau qaug dab peg thaum siv cov tshuaj hauv qhov ntau dua.
Los ntawm cov kab mob zis
Cov teeb meem hauv lub tso zis tuaj yeem xav txog daim ntawv ntawm crystalluria thiab interstitial nephritis.
Kev ua xua
Hauv cov neeg mob predisposed rau kev txhim kho kev ua xua, kev txhim kho ntawm:
- urticaria;
- erythema, suav nrog Stevens-Johnson kab mob lossis Lyell syndrome;
- anaphylactic kev poob siab;
- o ntawm lub suab pa, pharynx, tus nplaig;
- angioedema ntawm txoj hnyuv;
- pustulosis;
- khaus thiab tawv nqaij.
Cov lus qhia tshwj xeeb
Nrog rau qhov kev nce ntxiv ntawm cov ntshav amoxicillin thaum tso zis mus rau kev tsom xam dav dav, nws yog ib qho tsim nyog yuav tsum nco ntsoov txog qhov tshwm sim muaj qhov tshwm sim tsis pom qhov tsis zoo rau qhov muaj cov piam thaj hauv zis. Hauv qhov no, kev tshuaj ntsuam xyuas pom tseeb raug pom zoo raws li txoj kev kuaj mob tseeb.
Txhawm rau tiv thaiv kev kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos uas tawm tsam muaj pob txuv, nws yog ib qho tsim nyog yuav tsum tau siv ntxiv rau cov khoom siv tu cev.
Cawv tau zoo
Thaum kho kab mob, tsis txhob haus cawv. Ethanol tuaj yeem txo cov nyhuv antimicrobial ntawm Amoxiclav, muaj qhov tsis zoo rau lub siab ua haujlwm.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tua kabmob tsis muaj kev cuam tshuam rau kev muaj peev xwm ntawm kev xav, kev paub txog lub luag haujlwm thiab kev ceev lub cev. Yog li no, nyob rau hauv chav ua haujlwm ntawm kev kho tshuaj, tsis tas yuav txo lub sijhawm ua haujlwm nrog kev siv tshuab lossis tsav tsheb. Thaum muaj qhov tsis zoo tshwm sim los ntawm cov leeg hlwb tshwm sim, yuav tsum muaj kev tiv thaiv kev nyab xeeb.
Thaum cev xeeb tub, cov tshuaj tsis siv, vim tias nws muaj qhov pheej hmoo siab ntawm qhov tshwm sim tsis haum rau txoj hnyuv hauv lub cev.
Siv thaum cev xeeb tub thiab lactation
Thaum cev xeeb tub, cov tshuaj tsis siv, vim tias nws muaj qhov pheej hmoo siab ntawm qhov tshwm sim tsis haum rau txoj hnyuv hauv lub cev. Kev pub niam mis rau menyuam yog tias tsis muaj mob ua npaws thiab mob kis rau tus menyuam. Nyob rau ntawm qhov muaj mob candidiasis lossis qhov siab tsis haum, nws yog qhov yuav tsum hloov xa tus menyuam mus rau khoom noj khoom haus dag.
Noj ntau dhau
Hauv kev sim ua ntej thiab kev xyaum tom qab muag, tsis muaj cov neeg tuag thiab tshwm sim tsis zoo uas ua rau muaj kev hem thawj rau tus neeg mob lub neej. Thaum siv tshuaj tua kab mob, cov tsos mob hauv qab no tej zaum yuav tshwm sim:
- kev zom plab zom mov;
- mob plab;
- pw tsis tsaug zog;
- Kiv taub hau
- mob leeg;
- poob ntawm txoj kev xav hauv siab;
- ntuav
Thaum daim duab ntawm kev noj ntau dhau tshwm, yuav tsum tau mus pw hauv tsev kho mob thiab muaj tsos mob.
Kev cuam tshuam nrog lwm yam tshuaj
Thaum siv Amoxiclav nrog aminoglycosides, ib lub laxative, Probenecid thiab antacids, tus nqi ntawm cov tshuaj tua kab mob tsawg dua, thaum vitamin C ua rau nws nqus sai.
Diuretic thiab tsis siv tshuaj steroidal los tiv thaiv cov tshuaj, Allopurinol yog cov tshuaj uas tua cov tubular tso zis ntawm cov zis hauv lub raum. Yog li ntawd, cov tshuaj tua kab mob txo tus nqi tsawg, vim tias cov ntshav plasma concentration ntawm semisynthetic penicillin ntau ntxiv. Allopurinol txuas ntxiv nce qhov zoo li ntawm exanthema.
Ua ke nrog rifampicin, txoj kev qaug zog ntawm cov tshuaj kho tau pom.
Tus neeg sawv cev tshuaj tua kab mob ua rau pom kev sib txuam tshuaj nrog disulfiram. Nws tsis raug nquahu kom coj cov tshuaj nrog methotrexate, txij li amoxicillin tsub kom muaj cov kuab lom rau tom kawg.
Tsawg tsawg zaus, kev nce qib hauv lub sijhawm prothrombin yog ua tau, vim tias nws yog qhov yuav tsum tau saib xyuas kev ceev faj thaum siv tshuaj tiv thaiv qhov ncauj.
Ua ke nrog Rifampicin, qhov ua kom tsis muaj zog ntawm cov tshuaj kho tau pom, zoo li ua ke nrog cov tshuaj tua kab mob nrog cov kab mob bacteriostatic lossis nrog sulfonamides.
Cov npe ntawm Amoxiclav 312
Amoxiclav nrog lub qes ua kom lub zog me me lossis nrog kev txhim kho kev mob tshwm sim tuaj yeem hloov nrog cov tshuaj hauv qab no:
- Augmentin;
- Panklav;
- Amoxiclav Quicktab;
- Flemoklav Solyutab.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj no tau faib tawm nruj me ntsis raws li ntawv kho mob.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Yog tias siv qhov tsis zoo, tshuaj tua kab mob tuaj yeem ua rau tsis muaj kev tiv thaiv kab mob microflora ntawm lub plab hnyuv, vim tias qhov twg dysbiosis thiab vitamin K tsis txaus feem ntau pib. Yog li ntawd, cov tshuaj tsuas yog muag nkaus xwb.
Nqi
Tus nqi nruab nrab ntawm kev ncua yog kwv yees li 150-200 rubles.
Cia li mob Amoxiclav 312
Lub hmoov rau kev npaj qhov kev ncua yuav tsum muab khaws cia rau hauv qhov chaw sib cais los ntawm kev nkag mus ntawm lub hnub ci ntawm qhov kub ntawm + 8 ... + 30 ° C. Qhov xaus kev ncua yuav tsum muab khaws cia rau hauv tub yees ntawm + 2 ... + 8 ° C.
Hnub tas sij hawm
3 xyoos
Amoxiclav 312 Xyuas
Ua tsaug rau cov lus pom zoo ntawm cov kws muag tshuaj thiab cov neeg mob, cov tshuaj tua kab mob tau tuaj yeem nce ib lub foothold hauv khw muag tshuaj.
Cov kws kho mob
Roman Bariev, cog hniav kws kho hniav, Irkutsk
Kuv nquag muab tshuaj rau hauv cov kev kho hniav rau kev kho mob ntawm alveoli, ua kom hniav sib txawv, thiab muab tso rau qhov quav. Kuv saib tsuas pom qhov ua tau zoo.
Ivan Semendyaev, urologist, St. Petersburg
Tus kab mob antibacterial zoo uas kuv siv rau kev kho mob ntawm pyelonephritis, ntev cystitis. Kev phiv rau hauv kev xyaum tsis muaj sau tseg. Nws ua haujlwm qeeb nrog kev mob prostatitis. Hauv qee kis, txoj kev kho kom zoo tsis pom.
Cov neeg mob
Vyacheslav Nikonov, 42 xyoo, Vladivostok
Cov tshuaj zoo. Lub caij ntuj no dhau los, Kuv tau pib ua qhov hnoos hnyav, qhov kub tau nce ntau. Tus kws kho mob kuaj tau mob tracheitis thiab tshuaj Amoxiclav. Qhov kev ncua pab kom tshem tawm cov kab mob. Kuv nyiam qhov tsis hnov tsw ntawm cov txiv ntoo qab thiab cov saj. Tsis zoo li cov ntsiav tshuaj, nws yooj yim dua rau kev ncua kev ncua. Tsis muaj teeb meem mob plab. Nws haus cov tshuaj tam sim ntawd tom qab noj mov.
Galina Alexandrova, 34 xyoo, Arkhangelsk
Kuv xav tias cov tshuaj yog tshuaj tua kab mob muaj zog, txij li nws tau pab tshem ntawm cov hlwb pob txha caj dab hauv lub caij ntuj no. Tus kab mob tau nrog mob taub hau heev thiab ua npaws. Txhawm rau zam teeb meem hnyuv, cov vitamins thiab probiotics tau raug kho.
