Lisinopril Ratiopharm muaj cov nyhuv vasodilating vim yog kev tsuj tawm ntawm kev ua ke ntawm cov tshuaj angiotensin II. Raws li kev ua tiav ntawm kev kho kom zoo, muaj txiaj ntsig zoo ntawm cov tshuaj ntawm ischemic cov ntaub so ntswg qhov chaw tau pom. Cov tshuaj tso cai rau koj los tsim cov kev tiv thaiv ntawm cov leeg ntshav endothelium thiab cov hlab ntaws ua kom nce ntxiv thaum txoj kev loj hlob ntawm txoj kev mob ntshav siab. Yog li, cov tshuaj no yog siv los ntawm cov kws kho plawv kho mob ntshav siab, mob plawv sai thiab mob plawv.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Lisinopril.
Cov tshuaj tso cai rau koj los tsim cov kev tiv thaiv ntawm cov leeg ntshav endothelium thiab cov hlab ntaws ua kom nce ntxiv thaum txoj kev loj hlob ntawm txoj kev mob ntshav siab.
ATX
C09AA03.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau kev siv qhov ncauj.
Ntsiav tshuaj
Nyob ntawm seb ntau npaum li cas ntawm cov nquag tivthaiv - lisinopril, ntsiav tshuaj sib txawv hauv kev siv xim:
- 5 mg yog xim dawb;
- 10 mg - lub teeb liab;
- 20 mg - liab dawb.
Txhawm rau txhawm rau txhim kho cov chaw muag tshuaj tsis haum, cov ntsiav tshuaj tseem ceeb muaj cov khoom siv ntxiv:
- magnesium stearate;
- calcium hydrogen phosphate;
- pregelatinized hmoov txhuv nplej siab;
- mannitol;
- croscarmellose sodium.
Ncos
Daim ntawv tsis muaj.
Pharmacological kev txiav txim
Lisinopril ua rau cov kev ua haujlwm ntawm cov angiotensin hloov mus ua enzyme (ACE). Raws li qhov tshwm sim, cov theem ntawm angiotensin II txo qis, nqaim lumen ntawm cov hlab thiab txo cov synthesis ntawm aldosterone. Kev nquag tshuaj lom neeg ntawm cov tshuaj tiv thaiv kev puas tsuaj ntawm bradykinin, peptide nrog cov vasopressor nyhuv.
Lisinopril txo qis qib ntawm angiotensin II, uas nqaim qhov lumen ntawm lub nkoj.
Tawm tsam keeb kwm yav dhau los ntawm vasodilation, muaj qhov txo qis ntawm cov ntshav siab, tiv thaiv nyob rau hauv cov hlab ntsha peripheral. Lub load ntawm lub myocardium yog txo. Nrog kev siv sijhawm ntev ntawm Lisinopril, kev tawm tsam ntawm cov leeg ntshav endothelium thiab mob plawv kom nce ntau ntxiv, microcirculatory ncig hauv thaj chaw nrog ischemia txhim kho. Cov tshuaj yaj yeeb pab txo qis kev pheej hmoo ntawm kev txhim kho sab laug ventricular tsis ua haujlwm.
Cov Tshuaj Pharmacokinetics
Thaum noj ntawm qhov ncauj, cov ntshav ntawm lisinopril nce mus txog nws qhov siab tshaj plaws tom qab 6-7 teev. Kev noj cov zaub mov thaum sib luag tsis cuam tshuam rau qhov nqus thiab bioavailability ntawm cov nquag tivthaiv. Lisinopril, thaum nws nkag rau hauv cov hlab ntshav, tsis ua ib qho kev sib txuam nrog cov ntshav plasma protein thiab tsis yauv hloov pauv hauv daim siab. Yog li ntawd, cov tshuaj nquag tawm hauv lub cev tawm ntawm lub raum nrog cov qauv qub. Qhov kev tshem tawm ib nrab-lub neej mus txog 12.6 teev.
Kev ntsuas rau siv
Cov tshuaj yog siv hauv qhov kev xyaum kho mob los kho:
- mob plawv tsis ua hauj lwm nrog sab laug ventricular ejection feem tsawg dua 30%;
- ntshav siab;
- mob myocardial infarction rau cov neeg mob yam tsis mob raum.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub noj cov tshuaj hauv cov teebmeem hauv qab no:
- tsis ua hauj lwm ntawm cov nqaij ua rau cov tshuaj sib txuam ntawm cov tshuaj;
- stenosis ntawm cov hlab ntsha ntawm ob lub raum;
- cov neeg mob raum muaj mob creatinine tshem tawm hauv qab 30 ml / min;
- mitral valve stenosis thiab aorta;
- systolic cov ntshav siab ntawm 100 hli Hg thiab qis dua;
- hemodynamics tsis khov kho tawm tsam keeb kwm ntawm ib qho mob ceev ntawm lub plawv tawg;
- poj niam cev xeeb tub thiab lactating;
- hyperaldosteronism;
- kev kho kom rov qab zoo tom qab lub raum hloov ntshav.
Nrog saib xyuas
Nws raug nquahu kom yauv mus kho mob hauv kev kho mob hauv chaw kho mob raws li kev saib xyuas nruj ntawm tus kws kho mob hauv cov xwm txheej hauv qab no:
- hypovolemia;
- cov ntshav sodium tsawg dua 130 mmol / l;
- ntshav siab (BP);
- concurrent administration ntawm diuretics, tshwj xeeb tshaj yog lub siab ntau npaum;
- lub plawv tsis khov;
- mob raum
- high-koob vasodilator txoj kev kho;
- cov neeg mob laus dua 70 xyoo.
Yuav ua li cas noj lisinopril ratiopharm?
Lub sijhawm tiv thaiv yog 6 lub lis piam. Cov neeg mob uas lub plawv tsis ua haujlwm yuav tsum noj Lisinopril tsis tu ncua. Koom tes nrog Nitroglycerin tso cai.
Dab tsi lub siab kuv yuav tsum coj?
Cov tshuaj yog tawm rau cov neeg mob uas muaj ntshav siab ntau dua li 120/80 hli RT. Kos duab. Thaum lub siab qis thaum lub sij hawm systole - tsawg dua 120 hli RT. Kos duab. ua ntej pib kho nrog ACE inhibitor lossis thaum thawj 3 hnub ntawm kev kho, tsuas yog 2.5 mg ntawm cov tshuaj yuav tsum noj. Yog tias qhov ntsuas systolic rau ntau dua 60 feeb tsis nce siab tshaj 90 hli Hg. Art., Koj yuav tsum tsis kam lees noj tshuaj.
Noj cov tshuaj rau ntshav qab zib
Ntshav qab zib mellitus tsis tas yuav tsum tau kho ntawm ntau npaum kev hloov ntawm cov tshuaj ACE inhibitor.
Tawg taw qhov siab
Cov neeg mob ntshav siab yuav tsum noj 5 mg ntawm tshuaj thaum sawv ntxov rau 3 lub lis piam. Nrog rau theem zoo ntawm lub siab thev, koj tuaj yeem nce ntxiv rau txhua hnub rau 10-20 mg ntawm cov tshuaj. Lub sijhawm nruab nrab ntawm nce ntxiv qhov ntau npaum yuav tsum yog tsawg kawg 21 hnub. Kev tso cai ntau tshaj plaws hauv ib hnub yog 40 mg ntawm tshuaj. Cov ntsiav tshuaj yuav tsum noj ib hnub ib zaug.
Ntshav qab zib mellitus tsis tas yuav tsum tau kho ntawm ntau npaum kev hloov ntawm cov tshuaj ACE inhibitor.
Lub plawv tsis ua hauj lwm ntau npaum
Cov neeg mob plawv tsis ua hauj lwm noj cov tshuaj ib txhij nrog lub diuretics Digitalis. Yog li, cov koob tshuaj nyob rau theem pib ntawm kev kho mob yog 2.5 mg thaum sawv ntxov. Qhov kev saib xyuas cov tshuaj noj yog tsim nrog qhov nce ntawm 2.5 mg txhua 2-4 lub lis piam. Tus qauv muab tshuaj yog los ntawm 5 txog 20 mg, nyob ntawm theem qib ntawm kev zam rau ib koob tshuaj ib hnub. Qhov siab tshaj plaws yog 35 mg.
Mob myocardial infarction
Kev siv tshuaj kho mob tau kho nyob rau hauv nruab hnub los ntawm lub sijhawm pib thawj cov tsos mob ntawm lub plawv nres. Kev kho mob tsuas yog tso cai yog tias lub raum ruaj khov thiab systolic siab siab dua 100 hli Hg. Kos duab. Lisinopril yog ua ke nrog cov tshuaj thrombolytic, beta-adrenergic blockers, nitrates thiab cov ntshav-tshuaj. Thawj koob tshuaj yog 5 mg, tom qab 24 teev nrog rau cov neeg mob kom ruaj khov, qhov koob tshuaj tau nce siab txog qhov tau tso cai ntau tshaj - 10 mg.
Sab sij huam
Cov kev xav tsis zoo raug pom vim kev siv tshuaj tsis haum lossis ib tus neeg lub cev cov tshuaj tiv thaiv mus rau cov tshuaj ntawm cov tshuaj.
Kev kho mob txoj hnyuv
Cov tshuaj tsis zoo rau cov tshuaj hauv cov plab zom mov yog pom raws li hauv qab no:
- cem quav, raws plab;
- gag tsis kam;
- tsis qab los noj mov
- hloov pauv thaum saj;
- cholestatic jaundice, provoked los ntawm kev txhim kho ntawm hyperbilirubinemia.
Hematopoietic plab hnyuv siab raum
Hemolytic anemia tau pom nyob hauv cov neeg mob uas muaj piam thaj-6-phosphate dehydrogenase tsis txaus. Nrog kev txwv tsis pub ntawm cov hlwb pob txha hematopoiesis, muaj pes tsawg ntawm cov qe ntshav txo qis.
Nruab nrab hauv lub paj hlwb
Kev puas tsuaj ntawm qhov cuab yeej siv nruab nrab thiab lub hauv lub paj hlwb yog tus cwj pwm pom los ntawm:
- mob taub hau;
- mob nkees ntev;
- Kiv taub hau
- ploj ntawm kev qhia thiab sib npaug hauv qhov chaw;
- lub suab nrov hauv pob ntseg;
- tsis meej pem thiab tsis nco qab;
- paresthesia;
- mob leeg;
- ploj ntawm kev tswj hwm: txoj kev loj hlob ntawm kev nyuaj siab, poob siab;
- polyneuropathy.
Cov tshuaj yuav ua rau mob plab.
Los ntawm lub tshuab ua pa
Hauv qee kis, muaj mob caj pas thiab pom cov ntsws qhuav.
Ntawm feem ntawm daim tawv nqaij thiab cov nqaij mos
Qee qhov xwm txheej, kev txhim kho urticaria, tawm pob, ua mob Stevens-Johnson syndrome, erythema, muaj zog photosensitivity, exacerbation ntawm psoriasis yog ua tau. Cov plaub hau yuav poob rau hauv lub taub hau.
Los ntawm cov hlab plawv system
Muaj kev pheej hmoo ntawm kev tsim orthostatic hypotension thiab bradycardia, kev hnov ntawm tshav kub.
Ntawm ib feem ntawm lub raum thiab urogenital system
Kev puas tsuaj uas tsis tuaj yeem ua rau lub raum khiav tsis zoo, ua rau lub raum tsis ua haujlwm, tso zis ntxiv.
Los ntawm ib sab ntawm cov metabolism
Hauv qee kis, hypernatremia lossis hyperkalemia tshwm sim.
Cov lus qhia tshwj xeeb
Nrog rau kev siv lisinopril thiab kev lim ntshav thaum siv cov lipoproteins uas tsis muaj ntau, muaj kev pheej hmoo ntawm anaphylactic kev poob siab.
Nrog rau kev siv lisinopril thiab kev lim ntshav thaum siv cov lipoproteins uas tsis muaj ntau, muaj kev pheej hmoo ntawm anaphylactic kev poob siab.
Hauv cov neeg mob predisposed mus rau kev txhim kho kev ua xua, kev mob hlwb yuav tshwm sim. Yog hais tias o ntawm lub ntsej muag thiab daim di ncauj tau sau tseg, antihistamines yuav tsum tau noj. Nrog rau kev cuam tshuam ntawm cov hlab pas tiv thaiv keeb kwm yav dhau los ntawm kev o ntawm tus nplaig thiab glottis, kev kho mob thaum muaj xwm txheej ceev yog yuav tsum tau txhaj tshuaj Epinephrine subcutaneously 0.5 mg lossis 0.1 mg txhaj tshuaj. Nrog rau o ntawm lub larynx, nws yog ib qhov tsim nyog los saib xyuas cov electrocardiogram thiab ntshav siab.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Thaum kho nrog Lisinopril, nws yog ib qho tsim nyog los tswj cov txiaj ntsig ntawm cov ntshav siab, vim tias nyob ntawm tus neeg yam ntxwv ntawm tus neeg mob, kev txhim kho ntawm cov leeg ntshav hypotension yog ua tau. Raws li kev txo qis ntshav siab, muaj qhov ua txhaum cai ntawm kev muaj peev xwm tswj hwm cov khoom siv nyuaj thiab tsav tsheb.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj tsis raug tso cai rau cov poj niam cev xeeb tub vim tias tsis muaj cov ntaub ntawv ntawm cov nyhuv ntawm cov tshuaj sib txuas ntawm ACE inhibitor rau txoj kev loj hlob ntawm tus me nyuam hauv plab. Thaum lub sij hawm kawm preclinical, lub peev xwm ntawm lub tshuaj nquag ua kom nkag mus rau qhov kev tso quav tso tawm. Hauv thawj lub hlis ntawm kev loj hlob ntawm tus me nyuam hauv plab, cov tshuaj muaj peev xwm ua rau muaj kev loj hlob ntawm kev txhim kho ntawm daim di ncauj.
Thaum sau ntawv rau Lisinopril thaum pub mis, koj yuav tsum nres kev pub mis rau menyuam thiab hloov mus rau khoom noj khoom haus nrog cov khoom sib xyaw.
Tshuaj Lisinopril Ratiopharm rau menyuam yaus
Cov tshuaj no yog txwv rau cov menyuam yaus thiab cov hluas hauv qab 18 xyoo.
Cov tshuaj no yog txwv rau cov menyuam yaus thiab cov hluas hauv qab 18 xyoo.
Siv rau lub sijhawm qub
Rau cov neeg mob laus, cov tshuaj noj tau muab kho tau yog nce raws li cov creatinine tshem tawm. Qhov tom kawg yog xam los ntawm cov qauv Cockroft:
| Rau txiv neej | (140 - hnub nyoog) × qhov hnyav (kg) /0.814 × cov ntshav creatinine qib (μmol / L) |
| Cov poj niam | Qhov tshwm sim tau khoo nrog 0.85. |
Noj ntau dhau
Kev siv ntau dhau ntawm cov tshuaj tuaj yeem ua rau kev txhim kho cov tsos mob ntawm kev siv ntau tshaj:
- ib qho kev poob qis hauv cov ntshav siab;
- cardiogenic poob siab;
- tsis nco qab, kiv taub hau;
- bradycardia.
Tus neeg mob yuav tsum tau pauv mus rau chav saib xyuas mob hnyav, qhov chaw tswj hwm cov tshuaj electrolytes thiab creatinine raug tswj hwm. Yog tias cov ntsiav tshuaj tau noj nyob hauv 3-4 teev dhau los, tom qab ntawd tus neeg mob yuav tsum tau noj tshuaj kom nqus tshuaj, yaug lub plab ntawm lub plab. Lisinopril tuaj yeem tshem tawm los ntawm hemodialysis.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog lub sijhawm sib tw ntawm Lisinopril ntsiav tshuaj nrog rau lwm cov tshuaj, cov tshuaj tiv thaiv tau pom hauv qab no:
- Cov tshuaj pleev tsis haum thiab cov tshuaj uas tsis yog tshuaj steroidal ua rau muaj peev xwm txo kev siab ntsws.
- Baclofen txhim kho kho cov nyhuv ntawm lisinopril. Vim tias qhov no, txoj kev txhim kho ntawm txoj hlab ntsha hypotension yog tau.
- Cov tshuaj tiv thaiv antihypertensive, sympathomimetics, Amifostin txhim kho kev ua kom zoo ntawm cov tshuaj, uas ua rau txoj kev txhim kho tau ntawm txoj kev mob ntshav hypotension.
- Kev npaj rau kev ua kom loog, kev noj tshuaj tsaug zog thiab tshuaj tiv thaiv ua rau kom ntshav nce siab.
- Immunosuppressants, cytostatic thiab anticancer tshuaj tiv thaiv kev pheej hmoo ntawm leukopenia.
- Qhov ncauj tshuaj hypoglycemic nyob hauv thawj lub lis piam ntawm txoj kev kho txoj kev tuaj yeem txhim kho cov nyhuv antihypertensive ntawm lisinopril.
- Antacids txo cov bioavailability ntawm cov khoom xyaw nquag.
Amifostine pab txoj kev kho kom zoo rau cov tshuaj, uas ua rau kom muaj kev txhim kho ntawm txoj kev mob ntshav hypotension.
Sodium chloride-based cov tshuaj ua rau lub zog kho tsis zoo ntawm cov tshuaj thiab ua rau muaj kev loj hlob ntawm cov tsos mob ntawm lub plawv nres.
Cawv tau zoo
ACE inhibitor muaj peev xwm nce cov tshuaj lom quav cawv ntawm ethyl cawv rau hepatocytes, cov ntaub so ntswg ntawm cov hlab plawv thiab leeg hlwb. Yog li ntawd, nyob rau lub sijhawm tiv thaiv kev tiv thaiv, koj yuav tsum tsis txhob haus cawv.
Analogs
Hloov kho txoj kev kho mob yog ua tiav los ntawm kev saib xyuas ntawm tus kws kho mob nyob hauv qhov tsis muaj qhov tsim nyog hypotensive nrog kev koom tes ntawm ib qho ntawm cov tshuaj hauv qab no:
- Dapril;
- Aurolyza;
- Vitopril;
- Diroton;
- Zonixem;
- Amapin-L;
- Amlipin.
Nyiaj so koobtsheej tej yam mob Lisinopril Ratiopharm los ntawm cov chaw muag tshuaj
Ntsiav tshuaj tuaj yeem nqus tau los ntawm lub hwj tshuaj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Kev noj tshuaj tsis muaj cov lus qhia kho mob ncaj qha tuaj yeem ua rau poob ntshav nce siab, uas tuaj yeem ua rau kev txhim kho bradycardia, ploj ntawm kev nco qab, lub plawv tsis ua haujlwm, tsis nco qab, tuag. Rau kev nyab xeeb rau cov neeg mob, cov tshuaj tsis raug muag tom khw muag tshuaj.
Nqi
Tus nqi nruab nrab ntawm cov tshuaj yog kwv yees li 250 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj tau khaws cia ntawm qhov kub tsawg dua + 25 ° C hauv ib qho chaw sib cais los ntawm kev ua ntawm lub hnub.
Hnub tas sij hawm
4 xyoos
Cov Chaw Tsim Tshuaj Lisinopril Ratiopharm
Merkle GmbH, Lub Tebchaws Yelemees.
Kev txheeb xyuas rau Lisinopril Ratiopharm
Nrog kev soj ntsuam kom zoo ntawm cov lus pom zoo ntawm cov kws tshaj lij, nws muaj peev xwm kom tau txais cov nyhuv tshuaj uas tsim nyog.
Cov kws kho mob
Anton Rozhdestvensky, urologist, Yekaterinburg
Cov tshuaj no zoo tiv thaiv los ntawm cov neeg mob. Nws ua rau ntsuas qhov ntsuas lub zog ruaj khov, pheej yig dua Diroton. Nyob rau tib lub sijhawm, Kuv tsis hais kom siv tshuaj diuretics zoo nrog rau nws. Lisinopril tsis cuam tshuam rau erectile muaj nuj nqi. Cov ntsiav tshuaj yuav tsum tau noj thaum sawv ntxov 1 zaug hauv ib hnub. Siab tswj tau 24 teev.
Vitaliy Zafiraki, kws kho plawv, Vladivostok
Cov tshuaj tsis haum rau kev kho mob monotherapy. Kuv sau ntawv rau cov neeg mob koom nrog kev muab tshuaj zoo rau qis. Ntxiv mus, lub sijhawm kho, kev ntsuas kev ua tib zoo saib ntawm lub raum lub raum yog yuav tsum ua. Cov tshuaj tau dhau qhov kev sim tshuaj uas tsim nyog thiab raug tso cai rau kev siv los ntawm cov neeg mob ntshav siab.
Amlipin yog ib qho tshuaj noj ntawm cov tshuaj.
Cov neeg mob
Barbara Miloslavskaya, 25 xyoo, Irkutsk
Nrog kev ywj siab xaiv cov tshuaj rau cov siab, tsis muaj dab tsi pab. Kuv tau mus rau hauv tsev kho mob ntshav qab zib, qhov twg ib qho tshuaj kim kim tau sau tseg rau kev kub siab. Tus kws kho mob tau hais kom hloov cov tshuaj no nrog cov tshuaj Lisinopril-Ratiopharm. Kuv noj nws rau 5 xyoos ntawm 10 mg ib hnub twg. Lub siab rov qab mus rau 140-150 / 90 hli Hg. Kos duab. thiab tsis tau sawv ntxiv lawm. This BP suits kuv. Yog tias koj tsis noj tshuaj ntsiav, tom qab ntawd mus rau yav tsaus ntuj, lub siab tawm tuaj thiab koj kev noj qab haus huv yuav mob ntxiv.
Immanuel Bondarenko, 36 xyoo, St.
Tus kws kho mob tau sau 5 cov lisinopril rau ib hnub. Kuv coj nws thaum sawv ntxov nruj raws li cov lus qhia tib lub sijhawm.Cov chaw kho mob ceeb toom tias cov ntsiav tshuaj tsis yog npaj rau kev ua nrawm. Cov kev kho mob siv tau tsim tawm, thiab tom qab ib hlis ntawd lub siab tsis siab tshaj 130-140 / 90 hli Hg. Kos duab. Yav dhau los, 150-160 / 110 mmHg tau pom. Kos duab. Yog li, Kuv tawm ntawm qhov kev soj ntsuam zoo.Kuv tsis tau pom muaj cov kev mob tshwm sim.
