Glimecomb hais txog cov tshuaj uas siv rau ntshav qab zib hom 2.
Lub cuab yeej muaj qhov ua ke nrog hypoglycemic cov cuab yeej.
Tom qab noj cov tshuaj, ib qho kev ua tsis zoo ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob tau sau tseg.
Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab daim ntawv tso tawm
Cov tshuaj tshwj xeeb hais txog cov neeg sawv cev hypoglycemic coj noj ntawm qhov ncauj. Cov cuab yeej muaj kev sib koom ua ke. Ntxiv nrog rau cov nyhuv qab zib-qis, Glimecomb muaj cov nyhuv ua pancreatic. Hauv qee kis, cov tshuaj muaj cov nyhuv ntxiv.
Kev npaj muaj Metformin hydrochloride nyob rau hauv ib qho nyiaj ntawm 500 mg thiab Gliclazide - 40 mg, thiab ntxiv rau cov neeg tsis muaj txiaj ntsig sorbitol thiab croscarmellose sodium. Txo me me, magnesium stearate thiab povidone muaj nyob hauv cov tshuaj.
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav cylindrical hauv dawb, qab zib lossis daj ntxoov. Rau cov ntsiav tshuaj, marbling yog tau. Tshuaj tua kab mob muaj qhov pheej hmoo thiab ib qho bevel.
Glimecomb raug muag hauv 10 ntsiav tshuaj hauv qhov hlwv blister. Ib pob muaj 6 pob.
Cov chaw muag tshuaj thiab tshuaj pharmacokinetics
Glimecomb yog ib hom tshuaj uas ua ke nrog cov tshuaj hypoglycemic ntawm biguanide pawg thiab sulfonylurea derivatives.
Tus neeg sawv cev yog tus cwj pwm los ntawm pancreatic thiab ntxiv cov teebmeem ntxiv.
Gliclazide yog ib yam khoom tseem ceeb ntawm cov tshuaj. Nws yog sulfonylurea derivative.
Cov tshuaj pab rau:
- nquag insulin ntau lawm;
- txo hauv cov piam thaj hauv ntshav;
- txo cov platelet adhesion, uas txwv tsis pub tsim cov ntshav txhaws hauv cov hlab;
- normalization ntawm vascular permeability.
Gliclazide inhibits qhov tshwm sim ntawm microthrombosis. Thaum lub caij nyoog siv cov tshuaj hauv cov neeg mob ntshav qab zib nephropathy, qhov kev txo qis ntawm cov proteinuria (muaj cov protein nyob hauv cov zis) tau pom.
Gliclazide cuam tshuam qhov hnyav ntawm tus neeg mob noj cov tshuaj. Nrog rau cov khoom noj kom haum rau cov neeg mob ntshav qab zib noj Glimecomb, poob ceeb thawj yog sau tseg.
Metformin, uas yog ib feem ntawm cov tshuaj, yog hais txog cov pab pawg biguanide. Cov tshuaj yuav pab txo cov piam thaj hauv cov ntshav, pab ua kom txoj kev nqus ntawm cov piam thaj hauv plab thiab cov hnyuv. Metformin pab ceev cov txheej txheem ntawm kev siv cov kua nplaum los ntawm cov nqaij hauv lub cev.
Cov tshuaj txo cov roj cholesterol, cov lipoproteins tsawg ua kom qis. Hauv qhov no, Metformin tsis cuam tshuam rau theem ntawm lipoproteins ntawm ntau qhov sib txawv. Zoo li Glyclazide, txo qhov hnyav ntawm tus neeg mob. Nws tsis muaj dab tsi tshwm sim thaum tsis muaj insulin hauv cov ntshav. Tsis pab ua rau pom ntawm hypoglycemic kev tshwm sim. Gliclazide thiab metformin sib txawv nqus thiab ua rau tus neeg mob siab. Gliclazide yog tus cwj pwm los ntawm kev nqus ntau dua li ntawm Metformin.
Qhov siab tshaj plaws ntawm Gliclazide hauv cov ntshav tau mus txog tom qab 3 teev txij li lub sijhawm ntawm kev noj tshuaj. Cov tshuaj no dhau los ntawm lub raum (70%) thiab cov hnyuv (12%). Qhov kev tshem tawm ib nrab-lub neej ncav 20 teev.
Lub peev txheej ntawm bioesailability ntawm Metformin yog 60%. Cov tshuaj nquag txuam nrog rau cov ntshav liab. Ib nrab-lub neej yog 6 teev. Kev rho tawm hauv lub cev tshwm sim los ntawm lub raum, nrog rau txoj hnyuv (30%).
Kev taw qhia thiab contraindications
Cov tshuaj yog pom zoo rau cov neeg mob ntshav qab zib nrog hom ntshav qab zib hom 2 yog tias:
- kev kho yav dhau los nrog kev noj haus thiab kev tawm dag zog tsis muaj lub cev tseem ceeb;
- muaj qhov xav tau los hloov kev kho ua ke dhau los siv kev siv Gliclazide nrog Metformin hauv cov neeg mob uas muaj cov ntshav qabzib nyob ruaj.
Cov tshuaj yog tus cwj pwm los ntawm cov kev qhia ntau yam ntawm contraindications, uas:
- muaj cov ntshav qab zib hom 1;
- tus kheej intolerance mus rau lub Cheebtsam ntawm cov tshuaj;
- lub raum tsis ua haujlwm;
- cev xeeb tub
- daim siab ua haujlwm;
- lactic acidosis;
- lub plawv tsis ua hauj lwm;
- mob dias taub;
- kev pub mis
- ntau yam kab mob;
- myocardial infarction;
- porphyrin kab mob;
- kuaj mob ntshav qab zib;
- kev phais yav dhau los;
- lub sijhawm ntawm tus neeg mob mus kuaj xoo hluav taws xob thiab kev soj ntsuam siv cov khoom siv radioisotopes nrog kev qhia txog iodine-cov tshuaj tsis zoo rau hauv lub cev (nws yog txwv tsis pub noj 2 hnub ua ntej thiab tom qab cov kev tshawb fawb no);
- kev raug mob hnyav;
- poob siab mob tiv thaiv keeb kwm ntawm kab mob hauv lub plawv thiab raum;
- ua pa tsis ua haujlwm;
- cawv intoxication;
- cov piam thaj hauv ntshav tsawg (hypoglycemia);
- mob raum tsis zoo;
- cawv ntev ntev;
- dav hlawv hauv lub cev;
- mas ua raws cov neeg mob hypocaloric noj;
- noj miconazole;
- mob ketoacidosis.
Cov lus qhia rau kev siv thiab cov lus qhia tshwj xeeb
Qhov ntau thiab tsawg ntawm cov tshuaj yog ib leeg rau txhua tus neeg mob. Nws raug nquahu kom noj 1-3 ntsiav tshuaj hauv ib hnub. Hauv cov hnub tom qab ntawm kev kho mob, qhov nce ntxiv ntawm koob tshuaj yog ua tau, raws li qhov ntsuas ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob thiab qhov ntsuas pom ntawm nws tus kab mob. Rau Glimecomb, kev muab tshuaj ntau tshaj plaws yog 5 ntsiav tshuaj ib hnub.
Cov tshuaj raug pom zoo kom noj thaum sawv ntxov thiab yav tsaus ntuj. Cov tshuaj yog noj thaum lub sijhawm lossis tom qab noj mov.
Cov cuab yeej tsis pom zoo rau cov neeg mob laus dua 60 xyoo, ua haujlwm lub cev tsis zoo. Nrog rau kev ua haujlwm nyuaj thiab noj Glimecomb hauv cov neeg laus, cov kab mob lactic acidosis yuav tshwm sim.
Cev xeeb tub yog ib qho ntawm cov contraindications kom noj cov tshuaj no. Thaum cev xeeb tub tshwm sim, ntxiv rau ua ntej nws npaj, nws yog ib qho tsim nyog los hloov cov tshuaj nrog tshuaj insulin.
Kev pub niam mis kuj yog ib qho kev tsis sib haum vim yog lub siab nqus cov tshuaj ntawm cov tshuaj mus rau niam mis. Nws yog ib qho tsim nyog yuav tsum tshem tawm qhov kev pub noj rau lub sijhawm noj Glimecomb los ntawm leej niam lossis kom tsum tsis txhob noj cov tshuaj nws tus kheej thaum lactation.
Nrog kev ceev faj, nws yog qhov tsim nyog los noj cov tshuaj no rau cov neeg mob nrog:
- ua npaws;
- cov thyroid teeb meem;
- adrenal tsis txaus.
Cov tshuaj yog txwv rau cov neeg mob uas muaj kab mob hauv lub siab, nrog rau lub raum tsis zoo, nrog kev poob siab, lub cev qhuav dej thiab lwm yam kev tshwm sim loj.
Cov tshuaj no tsuas yog noj rau cov zaub mov uas tsis muaj calorie ntau nrog rau cov zaub mov uas muaj carbohydrate tsawg. Lub sijhawm ntxov ntawm kev kho, tswj cov ntshav qab zib yuav tsum muaj. Kev kho nrog cov tshuaj yog nqa tawm tsuas yog nyob rau hauv cov neeg mob uas tau txais kev noj haus tsis tu ncua.
Sulfonylureas, uas yog ib feem ntawm cov tshuaj, tuaj yeem ua rau mob ntshav qab zib. Nws tshwm sim nrog kev noj zaub mov hauv lub cev tsawg thiab ua si lub cev. Nws yog ib qho tsim nyog yuav tsum tau hloov kho qhov tshuaj tsis tu ncua, tshwj xeeb tshaj yog nyob rau cov neeg laus.
Kev mob ntshav siab ntshav qab zib tuaj yeem tshwm sim hauv cov neeg mob thaum noj:
- ethyl cawv;
- non-steroidal anti-inflammatory tshuaj tiv thaiv.
Kev yoo mov tseem yuav ua rau muaj kev pheej hmoo ntawm hypoglycemia hauv cov neeg mob, thiab cov tshuaj xws li reserpine nrog clonidine daim npog nws.
Thaum muaj kev phais mob hauv cov neeg mob, yog tias lawv kub hnyiab, raug mob, kis mob nrog kub taub hau, nrog rau myalgia, lactic acidosis, kev txiav tsis siv tshuaj tam sim ntawd.
Cov tshuaj yuav cuam tshuam kev tsav tsheb. Kev saib xyuas yuav tsum ua.
Nws yog qhov yuav tsum tau tsum tsis txhob noj Glimecomb 2 hnub ua ntej thiab tom qab nkag mus rau hauv tus neeg mob lub cev radiopaque tus neeg sawv cev nrog iodine.
Phiv thiab haus tshaj
Ntawm cov kev phiv uas tshwm sim vim kev siv tshuaj yeeb muaj peev xwm ua tau:
- ntshav qog ntshav nrog kev tawm hws, tsis muaj zog, kiv taub hau, tshaib plab, thiab tsaus muag;
- lactic acidosis nrog kev ua haujlwm tsis txaus, tsis muaj ntshav siab, ua kom tsis muaj zog, mob plab, myalgia;
- xeev siab
- anemia
- teeb meem tsis pom kev;
- urticaria;
- kev tsis haum vasculitis;
- zawv plab
- khaus
- hemolytic anemia;
- khaus
- erythropenia;
- hauv qee qhov tsawg, kab mob siab;
- daim siab ua hauj lwm.
Cov tsos mob tshwm sim feem ntau ntawm kev noj ntau tshaj yog hypoglycemia thiab lactic acidosis. Cov tsos mob ob leeg yuav tsum tau mus kho tam sis ntawd hauv tsev kho mob. Hauv ob qho xwm txheej, cov tshuaj yog nres. Hauv thawj kis, tus neeg mob tau txais kev kho mob, kho mob ntshav kuaj ntshav.
Nrog rau cov ntshav qog ntshav qab zib thiab cov ntshav nruab nrab, nws txaus rau cov neeg mob coj kev tov ua suab thaj sab hauv. Hauv cov ntawv hnyav, cov piam thaj yog tswj hwm cov leeg ntawm cov neeg mob (40%). Lwm txoj hauv kev yuav yog glucagon, muab ob qho tib si ntawm intramuscularly thiab subcutaneously. Kev kho ntxiv yog siv nrog tus neeg mob noj cov khoom noj uas muaj carbohydrate-nplua nuj.
Kev sib cuam tshuam txog Yeeb Tshuaj thiab Analogs
Cov tshuaj cuam tshuam nrog lwm cov tshuaj raws li hauv qab no:
- cov nyhuv hypoglycemic yog qhov zoo dua thaum noj ua ke nrog enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine thiab lwm tus neeg sawv cev nrog cov nyhuv hypoglycemic;
- txo cov nyhuv hypoglycemic thaum noj ua ke nrog Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, nicotinic acid nyob rau hauv cov koob tshuaj loj, tshuaj estrogen, lithium ntsev, tshuaj tiv thaiv kab mob hauv qhov ncauj;
- concomitant siv nrog nifedipine qeeb ntawm kev tshem tawm ntawm metformin;
- Kev sib koom tes nrog kev sib koom tes nrog tshuaj cationic nce qhov siab tshaj plaws ntawm metformin hauv cov ntshav los ntawm 60%;
- tsub kom cov ntsiab lus ntawm metformin co-administration ntawm cov tshuaj nrog furosemide.
Glimecomb muaj analogues thiab cov lus ua tau:
- Glidiab;
- Glyformin;
- Glidiab MB;
- Gliformin Prolong;
- Hlau;
- Formmetin;
- Glyclazide MB;
- Diabetalong;
- Gliclazide-Akos.
Cov tshuaj yeeb yaj kiab qhia cov tsos mob thiab kho ntshav qab zib:
Kev xav ntawm cov kws tshaj lij thiab cov neeg mob
Los ntawm kev tshuaj xyuas cov neeg mob, nws tuaj yeem xaus lus tias Glimecomb txo cov ntshav qab zib kom zoo thiab muaj kev tiv thaiv zoo, txawm li cas los xij, cov kws kho mob hais kom nws ceev faj vim muaj ntau cov kev mob tshwm sim.
Glimecomb yog ib txoj kev kho zoo rau tus mob ntshav qab zib hom 2. Tab sis muab ntau yam contraindications rau nws, nws raug nquahu tias nws yuav tsum tau txiav txim nrog ceev faj rau ntau tus neeg mob. Tshwj xeeb cov neeg laus.
Anna Zheleznova, 45 xyoo, endocrinologist
Ib cov tshuaj zoo rau tswj ntshav qab zib. Kuv coj nws mus ib hlis, tsis muaj kev mob tshwm sim, txawm hais tias muaj ntau ntawm lawv hauv cov lus qhia. Txaus siab nrog tus nqi.
Hlub, 57 xyoo
Kuv tau raug kev txom nyem los ntawm hom 2 ntshav qab zib rau qee lub sijhawm. Kuv txais Glimecomb. Cov tshuaj zoo thiab tsis kim heev. Nws txo cov piam thaj zoo. Qhov loj tshaj plaws yog noj kom zoo thiab noj kom raug.
Alexandra, 51
Cov tshuaj uas tshwj xeeb yog faib los ntawm cov tshuaj. Nws tus nqi yog li ntawm 440-580 rubles. Tus nqi ntawm lwm cov khoom lag luam hauv tsev yog ntawm 82 txog 423 rubles.
