Qhov kev txhawb nqa ntawm pancreatic ntawm lawv tus kheej cov insulin ntau lawm ua thawj qhov kev ntsuas ntawm cov tshuaj tiv thaiv kab mob. Hauv pab pawg no - sulfonylurea series npaj (Maninil, Diabeton, Amaryl) thiab av nplaum.
Cov tshuaj niaj hnub NovoNorm, yog ib tus neeg sawv cev hypoglycemic nrog lub peev xwm ua tau sai, nws kuj yog nyob hauv chav kawm kawg. Nws yuav tsum tau siv kom zoo, thiab cov ntsiav tshuaj tsis haum rau txhua tus neeg mob ntshav qab zib nrog tus mob thib 2, yog li nws yuav tsum tau ua kom paub txog cov lus qhia (tsawg kawg nrog nws qhov kev hloov kho).
Kev sib xyaw thiab kev noj tshuaj
NovoNorma, cov duab uas tau nthuav tawm hauv ntu no, muaj cov khoom ua haujlwm zoo ntawm repaglinide, ntxiv nrog cellulose, pob kws nplej siab, potassium polacryline, glycerin, povidone, calcium hydrogen phosphate, magnesium stearate, iron oxide, poloxamer, meglumine, dyes.
Cov tshuaj muaj peev xwm raug txheeb xyuas los ntawm nws cov duab (puag ncig cov ntsiav tshuaj convex), xim (daj ntawm 1 mg thiab xim av, nrog lub pinkish zas ntawm 2 mg) thiab engraved logo ntawm lub tuam txhab - Novo Nordisk. Ntim cov ntsiav tshuaj hauv blisters rau 15 pcs.
Hauv ib lub thawv ntawm cov phaj zoo li no tuaj yeem yog txij li ob txog rau rau. Ntawm Novonorm, tus nqi yog ib qho ntawm cov peev nyiaj ntau rau cov tshuaj tiv thaiv kab mob: 177 rubles. rau 30 ntsiav tshuaj. Ib qho tshuaj yog muab tawm los. Lub tuam txhab Dutch tau txiav txim lub txee lub neej ntawm repaglinide tsis pub dhau 5 xyoos Cov tshuaj tsis tas yuav tshwj xeeb rau kev cia khoom.
Kws Tshuaj
Lub hauv paus tsim tshuaj repaglinide yog lub zog txhawb ntawm kev ua tiav cov tshuaj insulin ntau lawm. Ua kom muaj zog ua haujlwm ntawm cov txiav, cov tshuaj sai sai sai ua rau glycemia. Nws lub peev xwm cuam tshuam ncaj qha rau cov lej ua haujlwm b-hlwb ua lub luag haujlwm rau hormone synthesis.
Tom qab noj cov ntsiav tshuaj, repaglinide nyob rau hauv lub plasma hauv ntshav qab zib accumulates hauv ib nrab ib teev. Qhov no tso cai rau koj los tswj cov glycemia thaum kev nkag mus tom ntej thiab kev ua zaub mov. Sai li qhov kev thauj khoom ntawm lub plab zom mov txo, cov tshuaj ntawm cov tshuaj tsawg zuj zus, qhov tsawg kawg nkaus yog kho tau 4 teev tom qab cov tshuaj nkag mus rau hauv lub zom zaub mov.
Qhov kev nyab xeeb ntawm cov tshuaj tau raug sim hauv qhov chaw soj ntsuam. Qhov koob tshuaj-txo qhov txo qis hauv glycemic tau sau tseg nrog kev siv 0.5-4 mg NovoNorm. Cov txiaj ntsig pom tseeb qhov ua tau ntawm preprandial (15-30 feeb ua ntej noj mov) tau txais ntawm cov tshuaj.
Cov Tshuaj Pharmacokinetics
Repaglinide nquag nqus tawm ntawm lub plab hnyuv plab. Qhov siab tshaj plaws ntshav suav tau pom ib teev tom qab noj thiab tom qab ntawd lawv txo qis sai li sai tau nrog kev txiav txim txog kev noj qab haus huv ntawm 63% nrog kev sib pauv ntawm 11%.
NovoNorm yog tshem tawm hauv 4-6 teev nrog ib nrab-lub neej ntawm ntawm ib teev. Cov tshuaj yog metabolized kiag li, tab sis nws cov khoom noj khoom haus hauv lub cev tsis ua haujlwm. Ib qho tsis tseem ceeb ntawm qhov quav tau siv pom nyob hauv cov zis thiab quav - txog li 8% thiab 2%, feem. Qhov tseem ceeb ntim ntawm metabolites yog tshem tawm nrog bile.
Cov nyhuv ntawm cov tshuaj ntau dua rau cov neeg mob ntshav qab zib thiab txhua tus neeg uas muaj teeb meem lub raumCov. Tom qab 5 hnub ntawm kev noj NovoNorm hauv ib koob 3 p. / Hnub. 2 mg rau hauv cov ntaub ntawv tsis zoo ntawm lub raum ua haujlwm AUC thiab TЅ ob npaug.
Menyuam yaus ntshav qab zib tsis koom ua ke hauv kev sim. Cov kev tshawb nrhiav tsiaj tsis tau qhia tawm teratogenic cov teebmeem hauv repaglinide, tab sis pom tias muaj kev muaj me nyuam. Thaum siab siab ntawm cov tshuaj, malformations ntawm nas me nyuam tau pom, cov tshuaj kuj nkag rau hauv niam cov kua mis ntawm cov pojniam.
Cov Khoom Qhia
Cov tshuaj yog ua ke nrog cov tshuaj tiv thaiv kev tiv thaiv nrog rau lwm qhov kev ua ntawm kev ua - metformin, thiazolidinediones, yog li nws kuj tuaj yeem siv rau hauv txoj kev kho mob.
Cov Txheej Txheem Muab Kho rau Repaglinide
Ntxiv nrog rau qhov ua kom tsis haum rau cov khoom xyaw ntawm cov mis, repaglignide tsis qhia:
- Nrog hom 1 ntshav qab zib thiab C-peptide mob ntshav qab zib tsis zoo;
- Hauv lub xeev muaj ketoacidosis uas mob ntshav qab zib (txawm tias tsis xeev tsis nco qab);
- Cov poj niam cev xeeb tub thiab lactating;
- Tus mob ntshav qab zib uas muaj mob rau daim siab hnyav;
- Nrog rau thaum uas tig mus siv ntawm gemfibrozil.
Kev pom zoo rau kev siv
Tus kws kho mob xaiv cov koob tshuaj ntawm tus kheej, coj mus rau hauv qhov txiaj ntsig ntawm kev sim, theem ntawm tus kab mob, concomitant pathologies, hnub nyoog, thiab lub cev teb rau tshuaj. Txhua ob lub lis piam, nws soj ntsuam qhov ua tau zoo ntawm cov qauv raug xaiv kom meej meej qhov koob tshuaj, kev tshuaj xyuas lub hom phiaj yog muab los ntawm glycated hemoglobin.
Kev tshuaj xyuas yog tsim nyog los txo qis glycemia ntawm qhov siab tshaj plaws pom zoo (thawj qhov tsis ua haujlwm) thiab txhawm rau txhawm rau tsis muaj kev tawm tsam txaus tom qab qee lub sijhawm siv cov tshuaj (theem ob tsis ua haujlwm).
Txog NovoNorma, cov lus qhia rau kev siv pom zoo kom pib ib koob ntawm 0.5 mg. Rau ib nrab ib hlis nws yog twb tau los soj ntsuam qhov tshwm sim ntawm lub cev thiab kev ua titration. Yog tias NovoNorm ntshav qab zib tau hloov mus los ntawm lwm tus neeg sawv cev hypoglycemic, tom qab ntawd cov koob tshuaj yuav tsum nyob hauv 1 mg.
Kev kho txoj kev kho mob cuam tshuam nrog kev siv cov tshuaj repaglinide txog 4 mg / hnub. 15-30 feeb ua ntej noj mov. Koj yuav tsum haus ib lub ntsiav tshuaj ua ntej txhua pluas noj, vim tias cov tshuaj ntawm cov tshuaj hauv lub plab zom mov tau luv. Qhov ntau kawg ntawm cov tshuaj yog 16 mg / hnub Cov ntsiav tshuaj tau faib rau hauv ob mus rau peb zaug.
Nrog cov kev kho mob nyuaj nrog cov tshuaj metformin lossis thiazolidinediones, qhov pib ntawm cov tshuaj reaglinide tsis pub dhau 0.5 mg, qhov ntau npaum ntawm lwm cov tshuaj tawm tsis hloov.
Tsis muaj ntaub ntawv qhia txog kev nyab xeeb thiab ua haujlwm ntawm NovoNorm rau menyuam yaus.
Noj ntau dhau thiab tsis zoo lub siab
Rau cov laj thawj tshawb fawb, rau 6 lub lis piam, repaglinide tau muab rau cov neeg tuaj yeem pab dawb hauv ib qho nyiaj ntawm 4-20 mg / hnub. thaum ua ntawv thov plaub zaug. Kev mob ntshav qab zib tsawg nyob rau hauv cov xwm txheej ntawm kev sim tau tswj hwm los ntawm cov ntsiab lus hauv caloric ntawm kev noj zaub mov noj, yog li ntawd, tsis muaj kev phiv dab tsi.
Yog tias nyob hauv tsev muaj cov cim qhia tias muaj kev noj ntau dhau hauv daim ntawv ntawm kev tawm hws ntau, tshee tshee, mob taub hau thiab poob ntawm kev sib koom tes, nws yog qhov yuav tsum tau muab cov khoom noj rau cov neeg raug tsim txom nrog cov ntsiab lus ntawm cov carbohydrates ceev. Yog tias tus mob hnyav thiab tus neeg mob tsis nco qab, nws tau txhaj nrog suab thaj thiab raug xa mus rau tsev kho mob.
Kev mob ntshav qab zib yog ib yam mob txaus ntshai tshaj plaws rau ntawm lub sijhawm tsis tau pom. Qhov ntau zaus ntawm nws qhov kev cuam tshuam yog cuam tshuam nrog kev ua neej ntawm cov ntshav qab zib: kev noj zaub mov noj, qib nqaij thiab txoj kev xav, kev noj tshuaj thiab tshuaj siv. Qhov txheeb cais ntawm cov rooj plaub zoo li no yooj yim nthuav tawm hauv lub rooj.
| Organs thiab tshuab | Hom mob tshwm sim | Qhov tshwm sim |
| Kev tiv thaiv kab mob | kev fab tshuaj | tsawg heev |
| Kev paub kev zom zaub mov | ntshav qog | tsis qhia npe |
| Lub zeem muag | kev sib hloov pauv | qee zaum |
| Lub plawv thiab cov hlab ntshav | kev mob plawv | nquag |
| Kev kho mob txoj hnyuv | kev mob epigastric, tso quav dhau ntawm lub suab tsis sib xws, dyspeptic cuam tshuam | nquag tsawg tsawg |
| Tawv | kev tiv thaiv tsis haum | tsis qhia npe |
| Kev zom | daim siab ua tsis tiav, enzyme kev loj hlob | tsawg heev |
Zam kev rau qhov tsis xav ua dhau los yuav ua rau muaj kev nce ntxiv hauv koob tshuaj, kom muaj kab mob, kis mob, haus dej cawv, qaug zog, mob ntshav qab zib uas ua haujlwm hnyav yuav tsum tau nce siab ntxiv.
Kuv yuav tuaj yeem hloov NovoNorm li cas
Txog NovoNorm, cov tshuaj tiv thaiv analogues raug xaiv raws li cov txheej txheem thoob ntiaj teb rau kev faib tawm cov tshuaj ATS (cov cev nqaij daim tawv, kev kho mob thiab tshuaj cais). Repaglinide nyob rau hauv nws cov muaj pes tsawg leeg muaj 2 cov tshuaj ntxiv - Repodiab thiab Insvada.
Raws li qhov ntsuas thiab txoj kev siv, repaglinides zoo ib yam:
- Guarem;
- Baeta;
- Victoza;
- Lycosum;
- Forsyga;
- Saxenda;
- Jardins
- Ua tub rog.
Amaril, Bagomet, Glibenclamide, Glibomet, Glyukofazh, Glurenorm, Glyclazid, Diabeton, Diaformin, Metformin, Maninil, Ongliza, Siofor, Yanumet, Yanuviya thiab ntau lwm tus yog nyob ze ntawm qib 3 ATC code (qhov sib txawv yog qhov sib txawv, tab sis cov cim tau sib xws).
Hauv kev sib txawv ntawm cov tshuaj niaj hnub hypoglycemic, kev kho cov kws kho mob yeej ib txwm tsis paub txog lawv tus kheej, thiab nws tsis tsim nyog rau cov neeg mob ntshav qab zib los sim cov tshuaj uas tsis muaj kev kawm kho mob. Cov ncauj lus hauv tsab xov xwm tsuas yog nthuav tawm dav dav xwb.
Tshuaj Ntsuam Xyuas
Txog NovoNorm kev tshuaj xyuas ntawm cov kws kho mob thiab cov ntshav qab zib feem ntau yog qhov zoo. Cov tshuaj yog tsim tawm hauv tebchaws Denmark ntawm NovoNordisk lub tuam txhab, qhov chaw ntawm kev nyab xeeb ntawm tshuaj yog tshuaj xyuas ua ntej.
Cov lus qhia tswv yim rau kev tswj hwm tus mob ntshav qab zib hom 2 - hauv TV qhia "Ntsiav tshuaj" - ntawm daim yeeb yaj kiab no.
