Txog rau hnub tim, cov tuam txhab muag tshuaj tsim ntau cov tshuaj insulin rau cov neeg mob ntshav qab zib, npaj rau kev txhaj tshuaj. Cov tshuaj sib txawv no tuaj yeem muaj npe txawv, zoo thiab nqi. Ib ntawm lawv yog cov tshuaj Humulin.
Cov Tshuaj Hauv Tshuaj
Cov tshuaj insulin yog qhov DNA tso tawm cov tshuaj tiv thaiv ntawm cov tshuaj hormones los ntawm tib neeg lub cev. Qhov sib txawv ntawm Humalog thiab insulin ntuj yog qhov sib txawv ntawm amino acid sib lawv liag ntawm txoj haujlwm 29 thiab 28 ntawm insulin B saw. Cov nyhuv tseem ceeb nws muaj yog kev tswj ntawm cov metabolism hauv qabzib
Humalog kuj muaj cov nyhuv anabolic. Hauv cov leeg nqaij, qhov ntau ntawm cov muaj cov roj acids, glycogen thiab glycerol nce, cov protein ntau nce, qib ntawm kev siv cov amino acids ntau ntxiv, tab sis qhov ntau ntawm glycogenolysis, gluconeogenesis, thiab tso tawm ntawm cov amino acids txo.
Hauv lub cev ntawm cov neeg mob ntshav qab zib ntawm ob hom vim kev siv ntawm Humalog, qhov hnyav ntawm hyperglycemia uas tshwm tom qab noj mov tau txo kom ntau dua nrog kev hwm rau kev siv cov tshuaj lom neeg lub cev.
Rau cov neeg mob uas tau txais hom mob insulin ib txhij nrog rau lub sijhawm luv luv, koj yuav tsum xaiv cov tshuaj ntawm ob hom tshuaj insulin kom ua tiav cov piam thaj hauv ib hnub.
Zoo sib xws rau lwm cov tshuaj insulin, cov sijhawm ntawm cov nyhuv ntawm cov tshuaj Humalog sib txawv hauv cov neeg mob sib txawv lossis txawv sijhawm nyob hauv ib tus neeg mob. Cov chaw muag tshuaj ntawm Humalog hauv cov menyuam yaus ua rau nws cov khoom siv tshuaj rau hauv cov laus.
Hauv cov neeg mob uas muaj ntshav qab zib hom 2 thiab noj ntau ntau ntawm sulfonylurea derivatives, kev siv ntawm Humalog ua rau muaj kev poob qis hauv glycated hemoglobin ntau ntau. Thaum Humalog siv ob hom ntshav qab zib, muaj qhov poob qis hauv lub qog ntshav qab zib tsawg thaum hmo ntuj.
Cov tshuaj tiv thaiv glucodynamic ua rau Humalog tsis cuam tshuam nrog qhov tsis muaj peev xwm ntawm hepatic thiab lub raum. Lub polarity ntawm cov tshuaj tau tsim rau tib neeg cov tshuaj insulin, txawm li cas los xij, cov nyhuv ntawm cov tshuaj tshwm sim sai dua thiab kav sijhawm tsawg dua.
Qhov tshwm sim ntawm Humalog yog qhov ua rau nws cov nyhuv pib sai (hauv li ntawm 15 feeb) vim muaj qhov nqus ntawm qhov tseem ceeb, uas ua rau nws tuaj yeem qhia nws ua ntej noj mov (hauv 1-15 feeb), thaum insulin zoo tib yam, uas muaj lub sijhawm luv luv, tuaj yeem ua haujlwm hauv 30 -45 feeb ua ntej noj mov.
Cov Tshuaj Pharmacokinetics
Nrog kev txhaj tshuaj subcutaneous, qhov nqus ntawm lyspro insulin tshwm sim sai sai, nws Cmax tiav tom qab 1-2 teev. Vd ntawm cov tshuaj insulin nyob rau hauv kev sib xyaw ntawm cov tshuaj thiab cov tib neeg insulin zoo ib yam, lawv thaj tsam li ntawm 0.26 txog 0.36 litres ib kg.
Cov Khoom Qhia
Daim ntawv tiv thaiv ntshav qab zib hom tshuaj tiv thaiv ntshav qab zib: ib tug neeg tsis kam mus rau lwm yam tshuaj insulin; postprandial hyperglycemia, uas tsis tuaj yeem kho los ntawm lwm cov tshuaj insulin.
Daim ntawv uas tsis muaj cov tshuaj insulin-tiv thaiv cov ntshav qab zib: kev tawm tsam cov tshuaj tiv thaiv ntshav qab zib noj ntawm qhov ncauj (malabsorption ntawm lwm cov tshuaj insulin, postprandial hyperglycemia, tsis yog tuaj yeem kho); kev phais mob thiab cov kev mob cuam tshuam (uas ua rau mob ntshav qab zib ua tiav).
Thov
Dosage Humalog yog txiav txim siab ib tus zuj zus. Humalog nyob rau hauv daim ntawv ntawm vials yog muab ob qho tib si subcutaneously thiab intravenously thiab intramuscularly. Lub humalogue nyob rau hauv daim ntawv ntawm cartridges tsuas yog subcutaneous. Kev txhaj tshuaj yog nqa tawm 1-15 feeb ua ntej noj mov.
Hauv nws daim ntawv dawb huv, cov tshuaj tau muab 4-6 zaug hauv ib hnub, ua ke nrog cov tshuaj insulin nrog ib lub sijhawm ntev, peb zaug ib hnub. Qhov luaj li cas ntawm ib koob tsis tuaj yeem dhau 40 units. Humalog hauv vials tuaj yeem sib xyaw nrog cov tshuaj insulin nrog cov nyhuv ntev dua nyob hauv ib qho koob txhaj.
Lub pob txha taub hau tsis tsim rau tov Humalog nrog rau lwm yam tshuaj insulin npaj rau hauv nws thiab rau kev rov siv dua.
Qhov xav tau ntawm kev txo qis ntawm cov tshuaj insulin tuaj yeem tshwm sim thaum muaj kev cuam tshuam cov ntsiab lus ntawm cov khoom noj carbohydrates hauv cov khoom noj, cov teeb meem lub cev tseem ceeb, ntxiv kev noj tshuaj uas muaj cov nyhuv hypoglycemic - sulfonamides, tsis xaiv cov beta-blockers.
Sab sij huam
Cov nyhuv tseem ceeb ntawm cov tshuaj no ua rau cov kev mob tshwm sim hauv qab no: nce tawm hws, pw tsis tsaug zog, tsis xeev plab. Tsis tshua muaj xwm txheej, kev ua xua thiab lipodystrophy tuaj yeem tshwm sim.
Cev xeeb tub
Tam sim no, tsis muaj qhov tsis zoo uas tshwm sim ntawm Humalog rau kev mob ntawm tus poj niam cev xeeb tub thiab cov embryo tau pom. Tsis muaj kev tshawb fawb cuam tshuam tau tshwm sim.
Tus pojniam uas muaj hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov yuav npaj lossis lub sijhawm xeeb menyuam. Rau cov neeg mob ntshav qab zib, lactation qee zaum yuav tsum tau yoog cov tshuaj insulin lossis kev noj haus.
Noj ntau dhau
Qhov tshwm sim: ib qho kev poob qis hauv cov ntshav nyob hauv lub cev, uas nrog ua kom nkees, tawm hws, tawm ntawm lub plawv dhia sai, mob hauv lub taub hau, ntuav, tsis meej pem.
Kev Kho Mob: nyob rau hauv ib daim ntawv me me, hypoglycemia tuaj yeem nres los ntawm cov piam thaj sab hauv lossis lwm yam tshuaj los ntawm cov piam thaj pab pawg, lossis cov khoom uas muaj suab thaj.
Kev mob ntshav qab zib tsawg mus rau ib tus neeg kawm ntawv qib siab yuav kho tau los ntawm kev txhaj tshuaj los ntawm cov kab mob ntshav qab zib thiab ntxiv cov piam thaj hauv lub cev tom qab cov neeg mob tus mob yuav nyob ruaj khov.
Cov neeg mob uas tsis teb rov qab rau glucagon yog muab cov tshuaj pleev ntsej muag rau ntshav qab zib. Cov teeb meem tsis nco qab, glucagon yog muab tshuaj subcutaneously lossis intramuscularly. Thaum tsis muaj cov glucagon lossis qhov tshuaj tiv thaiv rau kev txhaj tshuaj ntawm cov tshuaj no, cov tshuaj ua haujlwm ntawm cov kua nplaum ntawm lub cev yuav tsum tau ua.
Tam sim ntawd tom qab tus neeg mob rov qab nco qab, nws yuav tsum noj cov khoom noj uas muaj carbohydrates. Tej zaum koj yuav tsum noj cov zaub mov carbohydrates nyob rau yav tom ntej, thiab koj kuj yuav tsum tau saib xyuas tus neeg mob, vim tias nws muaj kev pheej hmoo ntawm kev rov qab los ntawm hypoglycemia.
Cia
Cov ntawv qhia tshuaj yuav tsum muab ceev cia ntawm qhov kub ntawm +2 txog +5 (hauv tub yees). Cia kom khov yog qhov tsis lees txais. Lub laub lossis lub taub ntim uas twb tau pib yuav tsis pub ntev tshaj 28 hnub ntawm chav tsev kub. Koj yuav tsum tiv thaiv Humalog los ntawm tshav ntuj ncaj qha.
Nws tsis tsim nyog siv cov tshuaj daws teeb meem thaum nws muaj qhov huab tsos, zoo li tuab lossis xim, thiab nyob ntawm qhov muaj cov khoom me me hauv nws.
Kev sib txuam ntawm Pharmacological
Cov nyhuv hauv lub ntsej muag hypoglycemic yog txo qis thaum noj qhov ncauj tawm, tshuaj raws li cov thyroid hormones, beta2-adrenergic agonists, danazole, tricyclic antidepressants, thiazide-type diuretics, diazoxide, chlorprotixen, isoniazid, nicotinic acid, lithium carbonate, lithium carbonate.
Cov nyhuv hypoglycemic ntawm Humalog nce nrog beta-blockers, ethyl cawv thiab tshuaj uas muaj nws, fenfluramine, anabolic steroids, tetracyclines, guanethine, salicylates, tshuaj tiv thaiv hypoglycemic, sulfonamides, ACE inhibitors thiab MAO thiab octre.
Siv tshuaj Humalog yuav siv tau (raug tshuaj saib xyuas mob) hauv kev sib xyaw nrog tib neeg cov tshuaj insulin, uas tau ua kom ntev dua, lossis siv nrog cov tshuaj hypoglycemic hauv qhov ncauj, uas yog derivatives ntawm sulfonylurea.
