Ib qho ntawm cov neeg sawv cev ntawm pawg loj ntawm sulfonylurea derivatives (PSM) yog qhov kev npaj ntawm qhov ncauj Glurenorm. Nws cov tshuaj nquag, glycidone, muaj cov nyhuv hypoglycemic, yog qhia rau hom ntshav qab zib hom 2. Txawm hais tias nws qhov kev txiav txim siab qis dua, Glurenorm ua tau zoo ib yam nkaus li nws pawg analogues. Cov tshuaj tsis xyaum ua tsis tawm los ntawm ob lub raum, yog li ntawd nws tau dav siv nyob rau hauv cov ntshav qab zib mob hlwb nrog kev kho mob raum tsis ua haujlwm. Glurenorm raug tso tawm los ntawm Greek kev faib tawm ntawm lub tuam txhab tshuaj German Beringer Ingelheim.
Glurenorm txoj cai ntawm kev ua haujlwm
Glurenorm koom nrog tiam 2 tiam ntawm PSM. Cov tshuaj muaj tag nrho cov pharmacological yam ntxwv ntawm cov pab pawg ntawm cov kab mob hypoglycemic:
- Qhov kev txiav txim siab tseem ceeb yog kev txiav txim siab. Glycvidone, lub zog tshuaj ntawm Glurenorm ntsiav tshuaj, khi rau pancreatic cell receptors thiab stimulates insulin synthesis hauv lawv. Kev nce siab ntawm cov tshuaj no nyob rau hauv cov ntshav pab kom kov yeej cov tshuaj insulin, thiab pab tshem tawm cov piam thaj hauv cov hlab ntshav.
- Ib qho kev ua ntxiv yog kev lom zem ntxiv. Glurenorm ua rau insulin rhiab heev, txo qhov tso ntshav qab zib mus rau hauv cov ntshav los ntawm lub siab. Ntshav qab zib Hom 2 yog tus cwj pwm txawv txav hauv daim siab lipid ntawm cov ntshav. Glurenorm pab ua kom cov cev no tsis thooj li qub, txwv tsis pub thrombosis.
Cov ntsiav tshuaj ua rau theem 2 ntawm kev tsim tshuaj insulin, yog li thawj zaug tom qab noj qab zib tuaj yeem nce ntxiv. Raws li cov lus qhia, cov nyhuv ntawm cov tshuaj pib tom qab txog ib teev, cov nyhuv siab tshaj plaws, lossis qhov siab tshaj plaws, raug pom tom qab 2.5 teev. Lub sijhawm tag nrho ntawm qhov kev txiav txim ncav txog 12 teev.
Txhua lub sijhawm niaj hnub PSM, suav nrog Glurenorm, muaj qhov tsis zoo: lawv txhawb lub zog ntawm cov tshuaj insulin, tsis hais txog qib ntawm cov piam thaj hauv cov hlab ntsha ntawm cov ntshav qab zib, uas yog, nws ua haujlwm nrog hyperglycemia thiab qab zib li qub. Yog tias cov piam thaj hauv ntshav tsawg dua xa mus rau cov ntshav ntau dua li ib txwm, lossis yog tias nws tau siv rau cov leeg ua haujlwm, ntshav qab zib pib. Raws li kev ntsuam xyuas ntawm tus mob ntshav qab zib, nws qhov kev pheej hmoo yog qhov tshwj xeeb tshaj plaws thaum lub sijhawm cov tshuaj tiv thaiv thiab nrog kev ntxhov siab ntev.
Pharmacokinetics ntawm cov tshuaj
Hom loj tshaj plaws ntawm cov neeg mob uas muaj ntshav qab zib hom 2 yog cov neeg laus. Lawv tsiag ntawv los ntawm lub cev txo qis hauv kev ua haujlwm hauv lub raum. Yog tias ntshav qab zib yog decompensated, cov neeg mob muaj qhov pheej hmoo ntawm nephropathy, thiab tom qab ntawd ua rau lub raum tsis ua haujlwm. Yuav luag txhua qhov kev tiv thaiv hypoglycemic yog tawm los ntawm lub raum, yog tias lawv tsis muaj txhij txhua, cov tshuaj txuam nrog rau cov tshuaj hauv lub cev pib, uas ua rau cov ntshav qis heev.
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Glurenorm yog ib qho tshuaj zoo tshaj plaws rau lub raum. Cov lus qhia rau kev siv qhia tau hais tias nws nrawm thiab nqus tau tag nrho los ntawm txoj hnyuv, thiab tom qab ntawd maj mam tawg los ntawm daim siab ua rau lub cev tsis muaj zog lossis ua haujlwm tsis muaj zog. Feem coob ntawm lawv, 95%, yog nrog nrog cov quav. Ob lub raum cia li 5% ntawm cov tshuaj metabolites. Rau kev sib piv, 50% ntawm glibenclamide (Maninil), 65% ntawm glyclazide (Mob ntshav qab zib), 60% ntawm glimepiride (Amaryl) raug tso tawm nrog cov zis. Vim tias cov yam ntxwv no, Glurenorm tau suav tias yog tshuaj rau kev xaiv rau tus neeg mob ntshav qab zib hom 2 nrog kev ua kom lub raum ntshav txo qis.
Kev ntsuas rau nkag
Cov lus qhia pom zoo rau kev kho mob nrog Glurenorm tsuas yog paub tseeb tias cov mob ntshav qab zib hom 2, suav nrog cov neeg mob ntshav qab zib thiab cov neeg laus ib nrab.
Cov kev tshawb fawb tau ua pov thawj lub siab-txo qis ua tau zoo ntawm kev siv tshuaj Glyurenorm. Thaum kws kho mob tam sim ntawd tom qab kuaj ntshav qab zib nyob rau hauv ib koob tshuaj txhua hnub txog li 120 mg rau cov neeg mob ntshav qab zib, qhov nruab nrab txo qis glycated hemoglobin dhau 12 lub lis piam yog 2.1%. Hauv cov pawg uas noj glycidone thiab nws pawg analogue glibenclamide, kwv yees li ntawm tib tus neeg mob ua tiav cov mob ntshav qab zib mellitus them nyiaj, uas qhia tau hais tias qhov ua tau zoo ntawm cov tshuaj no.
Thaum Glurenorm tsis tuaj yeem haus
Cov lus qhia rau kev siv txwv tsis pub noj Glurenorm rau cov ntshav qab zib hauv cov mob hauv qab no:
- Yog tias tus neeg mob tsis muaj cov qe ntshav. Qhov ua rau tuaj yeem ua rau pancreatic rov qab lossis hom ntshav qab zib 1.
- Hauv cov kab mob rau daim siab hnyav, kab mob siab rau lub cev, glycidone tuaj yeem hloov kho tsis txaus thiab nthuav tawm hauv lub cev, uas ua rau muaj ntau dhau.
- Nrog hyperglycemia, hnyav hnyav los ntawm ketoacidosis thiab nws cov teeb meem - precoma thiab coma.
- Yog tias tus neeg mob tau mob siab rau glycvidone lossis lwm yam PSM.
- Nrog hypoglycemia, cov tshuaj yuav tsis tuaj yeem haus cawv kom txog thaum qab zib yog qhov qub.
- Hauv cov mob uas muaj mob hnyav (mob hnyav, raug mob, phais mob), glurenorm yog hloov kho cov tshuaj insulin ib ntus.
- Thaum cev xeeb tub thiab thaum lub sijhawm muaj kab mob siab B, cov tshuaj yog nruj me ntsis txwv tsis pub, txij li glycidone nkag mus rau cov ntshav ntawm tus menyuam thiab cuam tshuam tsis zoo rau nws txoj kev loj hlob.
Thaum ua npaws, cov ntshav qab zib ntawm lub cev nce. Txoj kev kho kom zoo yog feem ntau nrog hypoglycemia. Lub sijhawm no, koj yuav tsum tau coj tshuaj Glurenorm nrog kev ceev faj, feem ntau ntsuas glycemia.
Nyeem kab lus - siab thiab tsis kub nyob hauv ntshav qab zib
Hormonal cuam tshuam cov xeeb ceem ntawm cov thyroid kab mob tuaj yeem hloov cov kev ua ntawm insulin. Cov neeg mob zoo li no tau qhia cov tshuaj uas tsis ua rau mob ntshav qab zib - metformin, glyptins, acarbose.
Kev siv ntawm cov tshuaj Glurenorm hauv kev quav cawv yog fraught nrog loj intoxication, kev xav tsis meej nyob rau hauv glycemia.
Nkag Tawm Cov Cai
Glurenorm muaj nyob hauv ib qhov tshuaj npaum li 30 mg xwb. Cov ntsiav tshuaj muaj qhov pheej hmoo, vim li ntawd lawv tuaj yeem faib kom tau txais ib nrab koob.
Cov tshuaj tau qaug dej qaug cawv tam sim ntawd ua ntej noj mov, lossis thaum pib. Hauv qhov no, los ntawm qhov kawg ntawm pluas noj lossis tsis ntev tom qab nws, qhov tshuaj insulin yuav nce ntxiv li ntawm 40%, uas yuav ua rau poob qab zib. Qhov kev poob qis hauv cov kua dej txuas ntxiv thaum siv Glyurenorm yog ze rau lub cev kev tsim kho, yog li ntawd, qhov pheej hmoo ntawm cov ntshav qog ntshav qis yuav tsawg. Cov lus qhia pom zoo kom pib nrog ib nrab ntsiav tshuaj thaum noj tshais. Tom qab ntawd cov koob tshuaj tau maj mam nce mus txog thaum them nyiaj rau ntshav qab zib tiav. Lub sijhawm nruab nrab ntawm kev hloov kho tshuaj yuav tsum yog tsawg kawg 3 hnub.
| Tshuaj muab tshuaj | Ntsiav tshuaj | mg | Txais tos lub sijhawm |
| Pib noj | 0,5 | 15 | yav sawv ntxov |
| Pib noj thaum hloov pauv los ntawm lwm PSM | 0,5-1 | 15-30 | yav sawv ntxov |
| Noj ntau npaum | 2-4 | 60-120 | 60 mg tuaj yeem noj ib zaug thaum noj tshais, muab ib qhov loj muab faib 2-3 zaug. |
| Tsuas pub npaum | 6 | 180 | 3 koob tshuaj, noj ntau tshaj plaws sawv ntxov. Hauv feem ntau cov neeg mob, qhov ua hauj lwm ntev-glucose txo qis ntawm glycidone tsis ua kom loj hlob ntawm qhov koob tshuaj saum toj no 120 mg. |
Tsis txhob hla khoom noj tom qab siv cov tshuaj. Cov khoom lag luam yuav tsum muaj cov carbohydrates, nyiam nrog tsis tshua muaj glycemic Performance indexCov. Kev siv Glenrenorm tsis thim cov kev noj haus ua ntej thiab tawm dag zog. Nrog rau kev tswj tsis tau noj cov zaub mov carbohydrates thiab cov haujlwm tsawg, cov tshuaj yuav tsis tuaj yeem them nyiaj rau cov ntshav qab zib hauv feem coob ntawm cov neeg mob.
Kev Txais ntawm Glyurenorm nrog nephropathy
Glurenorm kev hloov kho rau lub raum tsis tas yuav tsum tau ua. Txij li cov glycidone feem ntau ua rau yoov tawm ntawm ob lub raum, cov ntshav qab zib nrog nephropathy tsis ua rau muaj kev pheej hmoo ntawm hypoglycemia, zoo li nrog lwm cov tshuaj noj.
Cov ntaub ntawv sim qhia tau hais tias dhau 4 lub lim tiam ntawm kev siv tshuaj, proteinuria poob qis nrog kev txhim kho tswj ntshav qab zib mellitus, thiab cov zis rov qab txhim kho kom zoo dua qub. Raws li kev txheeb xyuas, Glurenorm yog tshuaj txawm tias tom qab hloov raum.
Siv rau kab mob siab
Cov kev qhia txwv tsis pub noj Glurenorm hauv kev mob siab tsis ua haujlwm. Txawm li cas los xij, muaj pov thawj tias glycidone metabolism hauv cov kab mob siab yog feem ntau tau khaws cia, thaum hloov kev ua haujlwm ntawm lub cev tsis tshwm sim, thiab qhov zaus ntawm cov kev mob tshwm sim tsis nce ntxiv. Yog li, kev teem caij Glyurenorm rau cov neeg mob zoo li no yog ua tau tom qab kuaj kom zoo.
Kev sib txuas ua ke
Hauv cov lus qhia rau Glyurenorm, cov tshuaj tso cai raug coj tsuas yog nrog metformin. Raws li kev txheeb xyuas, cov tshuaj kuj mus tau zoo nrog acarbose, DPP-4 inhibitors, insulin. Txhawm rau txhawm rau tiv thaiv ntau dhau, Glyrenorm yog txwv tsis pub haus tib lub sijhawm uas lwm tus PSM.
Qhov tshwm sim, overdose txim
Qhov ntau zaus ntawm qhov tsis xav tau thaum noj cov tshuaj Glurenorm:
| Zaus% | Thaj tsam ua txhaum | Sab sij huam |
| ntau tshaj 1 | Kev kho mob txoj hnyuv | Kev zom plab zom mov, mob plab, ntuav, tsis qab los. |
| los ntawm 0.1 txog 1 | Tawv | Ua xua khaus, erythema, eczema. |
| Kev tswj hwm leeg | Mob taub hau, cuam tshuam ib ntus, kiv taub hau. | |
| mus txog 0.1 | Ntshav | Tsawg cov platelet suav. |
Hauv cov xwm txheej cais, muaj kev ua txhaum ntawm outflow ntawm bile, urticaria, txo qis hauv qib ntawm leukocytes thiab granulocytes hauv cov ntshav.
Thaum tus neeg noj haus ntau dhau, txoj kev pheej hmoo ntawm lub qog ntshav qab zib muaj ntau. Tshem tawm nws los ntawm qhov ncauj lossis tso ntshav qabzib. Tom qab cov piam thaj normalization, nws tuaj yeem rov poob ib zaug dua kom txog thaum cov tshuaj tawm hauv lub cev tawm.
Yeeb tshuaj sib cuam tshuam
Cov nyhuv ntawm Glenrenorm yuav hloov nrog kev kho mob kom zoo nrog lwm cov tshuaj:
- qhov ncauj tiv thaiv tsis zoo, tshuaj tiv thaiv CNS, tshuaj steroid thiab cov thyroid hormones, nicotinic acid, chlorpromazine tsis muaj zog nws cov nyhuv;
- qee cov NSAIDs, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob (acenocoumarol, warfarin), thiazide diuretics, beta-blockers, ethanol txhim kho cov nyhuv ntawm cov tshuaj.
Cov lus qhia tshwj xeeb
Thaum noj Glyurenorm, kev ua raws li kev pom zoo rau kev kho mob rau qhov ua haujlwm ntawm kev noj haus cov zaub mov ua kom txaus yog yuav tsum ua. Kev tswj lub cev qhov hnyav, ua raws li cov kev qhia noj zaub mov zoo, kev kuaj lub raum tsis ua haujlwm yog qhov tsim nyog.
Thaum muaj kev mob tshwm sim, koj yuav tsum tau sab laj tus kws kho mob sai sai los daws qhov teeb meem ntawm qhov yuav tsum tau hloov cov tshuaj.
Hauv kev ua si uas yuav tsum muaj kev saib xyuas ntau tshaj plaws (tsav tsheb, ua haujlwm nrog cov txheej txheem, ntawm qhov siab, thiab lwm yam), koj yuav tsum ua tib zoo tsis txhob nco thawj cov tsos mob ntawm tus mob ntshav qab zib tsawg. Txoj kev pheej hmoo ntawm cov piam thaj poob qis dua nyob rau lub sijhawm muaj ntau dua cov tshuaj ntau ntxiv.
Nqe thiab Glurenorm hloov chaw
Tus nqi ntawm ib pob nrog 60 ntsiav tshuaj ntawm Glyurenorm yog li 450 rubles. Cov tshuaj glycidon tsis suav nrog hauv cov npe tseem ceeb tshuaj, yog li nws yuav tsis tuaj yeem tau txais nws dawb.
Ib qho tiav ua tiav nrog tib yam khoom muaj tshuaj hauv Lavxias tseem tsis tau muaj. Tam sim no qhov kev sau npe tam sim no tau npaj rau cov tshuaj Yuglin, tus tsim tshuaj paus ntawm Pharmasynthesis. Cov roj ntsha sib luag ntawm Yuglin thiab Glyurenorm twb tau paub tseeb lawm, yog li ntawd, tsis ntev nws yuav cia siab kom tshwm sim ntawm muag.
Hauv cov neeg mob ntshav qab zib nrog lub raum zoo, ib qho PSM tuaj yeem hloov Glurenorm. Lawv yog qhov dav dav, yog li nws yooj yim los xaiv cov tshuaj pheej yig. Tus nqi ntawm kev kho mob pib los ntawm 200 rubles.
Hauv raum tsis ua haujlwm, linagliptin yog qhov pom zoo. Qhov cov tshuaj nquag muaj nyob hauv qhov kev npaj ntawm Trazhent thiab Gentadueto. Tus nqi ntawm cov ntsiav tshuaj hauv ib hlis ntawm kev kho mob yog los ntawm 1600 rubles.
