Trazhenta yog qhov tshuaj hypoglycemic rau kev siv sab hauv. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov xim kaj, puag ncig ntsiav tshuaj. Cov ntsiav tshuaj siv khov kho muaj ob sab convex thiab beveled npoo. Cov cim ntawm cov chaw tsim khoom yog cim ntawm ib sab, thiab cim "D5" raug kos rau sab saud.
Cov lus qhia tau hais tias lub ntsiab tseem ceeb ntawm txhua cov ntsiav tshuaj ntawm Trazhenta yog linagliptin, uas muaj nyob hauv ib qho ntim ntawm 5 mg. Lwm cov ntsiab lus yog:
- 2.7 mg magnesium stearate.
- 18 mg pregelatinized hmoov txhuv nplej siab.
- 130.9 mg ntawm mannitol.
- 5.4 mg ntawm copovidone.
- 18 mg pob kws hmoov txhuv nplej siab.
- Cov sib xyaw ua ke ntawm lub plhaub zoo nkauj muaj xws li liab opadra (02F34337) 5 mg.
Cov tshuaj Trazent tau ntim rau hauv cov xaim qhwv txhuas, 7 ntsiav tshuaj txhua. Cov blisters, nyeg, yog nyob hauv cov thawv ntawv thawv ntawm 2, 4 lossis 8 daim. Yog hais tias lub hlwv tuav 10 ntsiav tshuaj, tom qab ntawd hauv ib pob yuav muaj 3 daim.
Pharmacological kev txiav txim ntawm cov tshuaj
Lub ntsiab cuam tshuam tseem ceeb ntawm cov tshuaj yog ib qho inhibitor ntawm enzyme dipeptidyl peptidase-4 (DPP-4). Qhov tshuaj yeeb dej caw no muaj qhov ua kom mob loj ntxiv rau cov tshuaj hormones incretin (GLP-1 thiab GUI), uas tsim nyog rau tib neeg lub cev los tswj cov qib qab zib kom raug.
Tam sim ntawd tom qab noj mov hauv lub cev, qhov kev xav ntawm ob hom tshuaj hormones. Yog hais tias cov piam thaj hauv cov ntshav tsis sib thooj lossis dhau me ntsis dhau lawm, cov tshuaj hormones no tsim tawm ntawm cov tshuaj insulin thiab nws txoj kev tso pa los ntawm parenchyma. Qhov tshuaj hormones GLP-1, ntxiv rau, kuj tseem txo qis tsim cov piam thaj los ntawm nplooj siab.
Kev ncaj qha rau cov tshuaj nws tus kheej thiab nws cov analogues nce tus naj npawb ntawm incretins los ntawm lawv lub xub ntiag thiab, ua rau lawv, pab txhawb lawv txoj haujlwm mus ntev.
Hauv kev tshuaj xyuas ntawm Trazhent, ib qho tuaj yeem pom cov lus hais tias cov tshuaj provokes kev nce ntxiv nyob rau hauv cov piam thaj ntawm insulin thiab txo qis ntau lawm ntawm glucagon. Vim li no, cov ntshav ua kom ntshav qab zib tau li qub.
Kev taw qhia rau siv thiab cov lus qhia
Lub trazent raug pom zoo rau kev siv rau cov neeg mob uas kuaj pom tus mob ntshav qab zib hom 2, ntxiv rau:
- Nov yog qhov tshuaj zoo tshaj plaws rau cov neeg mob uas tsis muaj glycemic tswj tsis tau, uas tuaj yeem tshwm sim los ntawm kev ua haujlwm ntawm lub cev lossis kev noj haus.
- Ib qho tshuaj mus rau thaum tus neeg mob lub raum tsis ua haujlwm, nyob rau hauv uas metformin txwv tsis pub noj lossis qhov tsis haum rau metformin los ntawm lub cev.
- Trazent tuaj yeem raug siv los ua ke nrog thiazolidinedione, sulfonylurea derivatives, nrog metformin. Los yog tom qab ntawd, thaum kho nrog cov tshuaj no, kev ua kis las, kev noj zaub mov kom zoo tsis coj qhov tshwm sim raug.
Txoj kev tiv thaiv kom tsis txhob siv tshuaj
Cov lus piav qhia rau cov tshuaj kom meej meej hais tias Trazhenta tsis pom zoo rau kev siv:
- thaum cev xeeb tub;
- nrog ntshav qab zib hom 1;
- thaum lactation;
- tsis txhob sau cov tshuaj rau cov menyuam hnub nyoog qis dua 18 xyoo;
- cov neeg uas hypersensitive rau qee yam ntawm Trazhenta;
- cov neeg muaj ketoacidosis los ntawm ntshav qab zib.
Txoj kev ntawm daim ntawv thov
Cov koob tshuaj pom zoo rau cov neeg mob cov neeg laus yog 5 mg, cov tshuaj yuav tsum noj 3 zaug hauv ib hnub, cov lus qhia tau qhia meej qhov no. Yog tias cov tshuaj tshwm sim ua ke nrog metformin, tom qab ntawd cov koob tshuaj ntawm yav tom ntej tseem tsis hloov.
Ib txoj kev mob rau cov neeg mob uas lub raum lub raum tsis ua haujlwm yuav tsis tas muaj kev hloov kho ntau npaum li cas.
Pharmacokinetic cov kev tshawb fawb qhia tias Trazent yuav tuaj yeem yuav tsum yoog kom haum rau daim siab ua haujlwm. Txawm li cas los xij, kev paub txog kev siv tshuaj los ntawm cov neeg mob zoo li no tseem tsis tau poob.
Qhov kev hloov no tsis yog rau cov neeg laus cov neeg laus. Tab sis rau ib pawg neeg tom qab 80 xyoo, cov kws kho mob tsis pom zoo kom noj cov tshuaj no, vim tias tsis muaj kev paub txog kev siv tshuaj thaum muaj hnub nyoog no.
Tau nyab xeeb npaum li cas Trazenta rau me nyuam yaus thiab cov tub ntxhais hluas tseem tsis tau tsim.
Yog tias tus neeg mob uas niaj hnub noj cov tshuaj no rau ib qho laj thawj tsis nco qab noj tshuaj, tom qab ntawd cov ntsiav tshuaj yuav tsum tau noj sai li sai tau. Tab sis tsis txhob txhaj ob koob. Koj tuaj yeem noj cov tshuaj txhua lub sijhawm, tsis hais los ntawm cov zaub mov.
Dab tsi tuaj yeem siv ntau dhau ntawm cov tshuaj ua rau?
Raws li kev tshawb fawb txog kev kho mob ntau (rau cov neeg mob siab tuaj yeem caw), nws yog qhov tseeb tias ib zaug ntau dhau ntawm cov tshuaj hauv cov nyiaj ntawm 120 ntsiav tshuaj (600 mg) tsis ua mob rau cov neeg noj qab haus huv.
Niaj hnub no, tsis muaj cov neeg mob haus dej ntau dhau nrog cov tshuaj no tau sau tseg txhua lub sijhawm. Yog lawm, yog tias ib tus neeg noj tshuaj ntau ntawm Trazhenta, nws yuav tsum tshem tawm cov ntsiab lus ntawm nws lub plab, ua rau ntuav thiab tawm dej. Tom qab ntawd, nws tsis raug mob rau sab laj nrog tus kws kho mob.
Nws yog tau tias tus kws tshaj lij yuav pom cov kev ua txhaum cai thiab sau ntawv kho mob kom tsim nyog.
Kev siv cov tshuaj thaum cev xeeb tub thiab lactation
Kev siv ntawm Trazenti los ntawm cov poj niam thaum lub sijhawm lub sijhawm yug tus menyuam tseem tsis tau kawm. Txawm li cas los xij, kev tshawb xyuas tsiaj ntawm cov tshuaj pom tias tsis muaj cov cim ntawm kev muaj menyuam yaus. Dua li qhov no, thaum cev xeeb tub, cov kws kho mob pom zoo kom tsis txhob siv cov tshuaj no.
Cov ntaub ntawv tau los ntawm pharmacodynamic kev tshuaj ntsuam xyuas ntawm cov tsiaj pom tias tau txais txiaj ntsig ntawm linagliptin lossis nws cov khoom sib xyaw hauv cov kua mis ntawm tus poj niam laus.
Yog li, cov nyhuv ntawm cov tshuaj rau cov menyuam tshiab uas tau noj niam mis tsis pub cais tawm.
Muaj qee kis, cov kws kho mob yuav xav kom tsis pub mis niam yog tias tus mob niam yuav tsum tau noj Trazenti. Cov kev tshawb fawb ntawm cov nyhuv ntawm cov tshuaj rau tib neeg muaj peev xwm xeeb tub tsis tau ua. Cov kev sim ntawm cov tsiaj nyob hauv thaj chaw no tsis tau ua rau pom qhov tsis zoo; kev tshuaj xyuas los ntawm cov kws tshawb fawb kuj tseem tsis tau lees tias qhov phom sij ntawm cov tshuaj.
Sab sij huam
Tus lej ntawm cov kev mob tshwm sim tom qab noj Trazhenta zoo ib yam li tus naj npawb ntawm cov kev tsis zoo tom qab siv cov placebo.
Ntawm no yog cov kev coj ua uas tuaj yeem tshwm sim tom qab siv tshuaj Trazhenty:
- pancreatitis
- kev hnoos
- nasopharyngitis (ib tug mob kis);
- hypertriglyceridemia;
- rhiab rhiab rau qee qhov sib xyaw ntawm cov tshuaj.
Tseem Ceeb! Cheebtsam Trazenti tuaj yeem ua rau kiv taub hau. Yog li no, tom qab noj cov tshuaj, tsav tsheb tsis zoo yog tsis pom zoo!
Cov kev mob tshwm sim saum toj no feem ntau tshwm sim nrog kev sib koom ua ke ntawm kev siv Trazhenta thiab nws cov analogues nrog metformin thiab sulfonylurea derivatives.
Kev tswj hwm tib lub sijhawm ntawm pioglitazone thiab linagliptin tsim nyog pab txhawb qhov hnyav hauv lub cev, qhov tshwm sim ntawm pancreatitis, hyperlipidemia, nasopharyngitis, hnoos, thiab hauv qee cov neeg mob hypersensitivity los ntawm lub cev tiv thaiv kab mob.
Nrog rau kev siv ua ke nrog cov tshuaj nrog metformin thiab sulfonylurea derivatives, mob ntshav qab zib thaum cev xeeb tub, hnoos, mob pancreatitis, nasopharyngitis thiab mob siab rau qhov sib xyaw ntawm cov tshuaj tuaj yeem tshwm sim.
Txee lub neej thiab cov lus pom zoo
Cov lus qhia nrog rau cov tshuaj hais tias koj yuav tsum khaws cov tshuaj no ntawm qhov kub tsis pub tshaj 25 degrees thiab tsuas yog nyob hauv qhov chaw tsaus rau cov menyuam yaus siv tsis tau. Hnub tas sij hawm ntawm Trazenti yog 2.5 xyoo.
Cov kws kho mob tsis xaj sau Trazent rau cov neeg muaj ketoacidosis uas mob ntshav qab zib. Cov tshuaj yuav tsis tso cai rau mob ntshav qab zib hom 1. Qhov ntxim nyiam ntawm kev txhim kho hypoglycemia thaum noj Trazhenta yog sib npaug rau qhov uas tuaj yeem tshwm sim thaum siv cov placebo.
Kev tsim tawm ntawm sulfonylureas tuaj yeem ua rau mob ntshav qab zib, yog li ntawd, cov tshuaj no yuav tsum tau ua ke nrog linagliptin nrog kev ceev faj tshaj plaws. Yog tias tsim nyog, tus kws kho mob endocrinologist tuaj yeem txo qhov koob tshuaj sulfonylurea derivatives.
Txog hnub tim, tseem tseem tsis muaj cov ntaub ntawv txaus ntseeg ntawm cov kev tshawb fawb kho mob uas yuav qhia txog kev cuam tshuam ntawm Trazhenta nrog cov tshuaj hormone-insulin. Rau cov tib neeg kev txom nyem los ntawm lub raum tsis ua haujlwm, cov tshuaj tau tawm nrog rau lwm cov tshuaj hypoglycemic, thiab kev soj ntsuam tseem nyob zoo.
Qhov concentration ntawm cov piam thaj hauv cov hlab ntshav yog qhov zoo tshaj plaws txo thaum tus neeg mob noj Trazhenta lossis cov tshuaj zoo sib xws ua ntej noj mov.
