Ntshav qab zib mellitus hu ua "plague" ntawm xyoo pua XXI. Yog li, kev noj tshuaj yog ib qho ntawm cov ntsiab lus tseem ceeb hauv kev kho tus mob. Kev npaj ntawm Pioglitazone cov lus qhia muaj cov ncauj lus qhia ntxaws ntxaws ntawm lawv siv.
Cov tshuaj tseem ceeb rau cov ntshav qab zib uas muaj cov tshuaj no yog Aktos, Pioglar, Diab-norm, Diaglitazone. Pioglitazone nws tus kheej yog dawb crystalline hmoov, uas muaj ntxhiab tsw.
Nws xyaum tsis yaj nyob hauv dej, tab sis nws yog diluted nyob rau hauv dimethylformamide. Raws li rau anhydrous ethanol, acetone thiab acetonitrile, cov tshuaj hauv lawv yog soluble me ntsis.
Pioglitazone yog ib feem ntawm chav kawm ntawm thiazolidinediones (glitazones); nws siv tau qhia rau txo cov ntshav qab zib. Txij li thaum hom mob ntshav qab zib hom thib ob yog tus cwj pwm los ntawm kev ua txhaum ntawm kev nkag siab ntawm lub cev lub cev rau cov tshuaj insulin, glitazones qhib cov receptors nyob hauv lawv lub nuclei. Yog li ntawd, cov ntaub so ntswg peripheral pib teb rau cov tshuaj hormone insulin.
Ntau tus neeg mob nug cov lus nug, nws puas tuaj yeem noj tshuaj uas muaj cov tshuaj pioglitazone hauv thawj hom kabmob? Glitazones yog cov tshuaj noj tshwj xeeb rau hom mob ntshav qab zib zaum ob. Lawv raug siv los ua cov tshuaj tseem ceeb, thiab ntxiv nrog metformin, sulfonamide lossis insulin. Cov neeg mob pib noj cov tshuaj yog tias kev tawm dag zog thiab kev noj zaub mov kom zoo tsis muaj qhov xav tau - cov ntshav qab zib ib txwm muaj.
Glitazones piv nrog rau lwm cov tshuaj muaj suab thaj txo cov tshuaj insulin kuj zoo dua. Lawv txo tus nqi ntawm cov roj ntsha hauv tib neeg cov ntshav thiab faib tawm cov ntaub so ntswg adipose los ntawm kev mob plab mus rau thaj av subcutaneous. Tsis tas li ntawd, cov tshuaj qis qis triglycerides.
Cov lus qhia rau kev siv tshuaj
Kev noj cov tshuaj yog qhia tsuas yog tom qab sab laj nrog tus kws kho mob uas tuaj koom, uas sau ntawv tshuaj kom raug, noj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob. Txheeb tus kheej ntawm kev siv cov tshuaj Pioglitazone, cov lus qhia rau cov tshuaj yuav tsum ua tib zoo kawm kom tsis txhob muaj kev cuam tshuam.
Cov tshuaj tau qhia rau kev siv yog tias thawj zaug tau pib yog li ntawm 15 txog 30 mg, thiab qhov siab tshaj plaws (hauv ib hnub) yog 45 mg. Yog tias koj sib xyaw nrog cov tshuaj nrog lwm cov tshuaj, cov tshuaj yuav tsum tsis pub dhau 30 mg. Pioglitazone yog qhia txog kev siv ib hnub ib zaug.
Thaum kho, koj yuav tsum tau txuas ntxiv ua raws kev noj haus thiab tawm dag zog. Nws yog ib qho tseem ceeb heev uas yuav tau kuaj xyuas hemoglobin qib hauv cov ntshav.
Pioglitazone yog qhia nrog kev saib xyuas tshwj xeeb rau cov neeg mob uas muaj kev o, thiab lub siab muaj cov enzymes ntau ntxiv. Nrog rau kev txhim kho ntawm hypoglycemia thaum lub sij hawm ua ke txoj kev kho yuav tsum muaj kev txo qis hauv cov tshuaj cov tshuaj insulin lossis sulfonamides. Yog hais tias tus neeg mob qau tawv nqaij, ua rau lub cev tsis zoo, tuaj yeem kho tau, yog li yuav tsum tau kho. Cov neeg mob uas muaj lub cev ntas khaub thuas anovulatory thaum lub sijhawm premenopausal yog qhov muaj feem yuav xeeb tub, yog li ntawd kev tiv thaiv yuav tsum siv.
Cov kev thaiv tsis zoo thiab cov tshwm sim
Ua ntej siv cov tshuaj raws Pioglitazone, koj yuav tsum sab laj nrog koj tus kws kho mob. Cov tshuaj no muaj ntau qhov kev tiv thaiv: ib tug neeg tsis kam ua rau Pioglitazone, hom 1 mob ntshav qab zib mellitus, mob ntshav qab zib ketoacidosis (kev tsis txaus siab los ntawm cov metabolism ua cov tshuaj vim tsis muaj cov tshuaj insulin), nplooj siab pathology ntawm qhov mob siab.
Qeb ntawm ALT (alanine aminotransferase) yog 2,5 npaug ntau dua li ib txwm, uas yuav qhia tau qhov kev txhim kho ntawm ntau yam kab mob loj, lub hnub nyoog txog 18 xyoo (qhov tseem ceeb ntawm cov tshuaj hauv cov neeg mob hnub nyoog tsis tau txiav txim siab), lub sijhawm ntawm kev xeeb tub thiab kev pub niam mis.
Yog tias Pioglitazone siv tsis raug lossis rau lwm qhov laj thawj, tus neeg mob yuav muaj cov kev mob tshwm sim hauv qab no:
- hypoglycemia - txo cov ntshav ntshav ntshav kom ceev;
- o, thiab kev sib txuam nrog cov tshuaj insulin nce kev pheej hmoo ntawm o tuaj txog 15.3%;
- anemia - ntshav tsawg nyob rau hauv tib neeg cov ntshav;
- txo qis hauv bilirubin qib;
- txo qis hauv alanine aminotransferase (ALT) - kev ua tsis taus pa hypogenic;
- txos aspartate aminotransferase (AST) - ib qho enzyme uas yog lub luag haujlwm rau cov synthesis ntawm cov amino acids;
- txo hauv alkaline phosphatase (ALP) - ib qho enzyme uas zom phosphates los ntawm cov protein, alkaloids, thiab lwm yam.;
- txo qis gamma glutamyl transferase.
Ntxiv mus, kev sib xyaw ua ke npaj muaj sulfonamide derivatives, metformin, insulin, ua rau cov ntshav qog ntshav qab zib.
Tsis tas li, thaum siv, cov txiaj ntsig ntawm kev txo cov txiaj ntsig ntawm kev tiv thaiv qhov ncauj tuaj yeem tawm.
Kev txheeb xyuas, qhov zoo thiab qhov tsis zoo
Kev tshuaj xyuas ntawm ntau tus neeg mob uas tau siv Aktos, Pioglar thiab lwm yam tshuaj, feem ntau zoo. Ntawm qhov zoo, nws muaj peev xwm hais txog qhov ua tau zoo ntawm kev txo qis tshuaj insulin ntawm tag nrho cov tshuaj txo qis ntshav uas noj ntawm qhov ncauj.
Tab sis muaj qee qhov tsis zoo ntawm glitazones, uas tau pom nyob hauv cov hauv qab no: lawv qis dua cov tshuaj uas muaj cov tshuaj metformin thiab sulfonylurea, hemoglobin poob qis los ntawm 0.5-1.5%, thaum siv, qhov nruab nrab qhov hnyav nce ntawm 1-3 kg yog pom vim muaj cov txuam nrog cov rog thiab kua dej ceev cia rau hauv lub cev.
Yog li, ua ntej noj cov tshuaj glitazones, koj yuav tsum tau sab laj nrog tus kws kho mob thiab nyeem cov kev tshuaj xyuas ntawm cov neeg mob uas twb tau noj lawv.
Tus neeg mob noj cov tshuaj Pioglitazone, tus nqi uas yog nyob ntawm cov tshuaj, yuav tsum txiav txim siab seb yuav siv hom tshuaj twg. Tus nqi nruab nrab ntawm Pioglar ntsiav tshuaj (30 daim ntawm 30 mg ib qho) yog 1083 rubles, Actos (28 daim ntawm 30 mg ib qho) yog 3000 rubles. Hauv txoj cai, ib tus neeg nruab nrab-tus neeg muaj peev xwm them taus yuav cov tshuaj no. Lawv tus nqi siab yog vim qhov tseeb tias cov no yog cov tshuaj ntshuam muag, Pioglar yog tsim tawm hauv Is Nrias teb, Actos - hauv Ireland.
Pheej yig yog cov tshuaj tsim hauv Russia. Cov no suav nrog:
- Diab ntsuam;
- Astrozone;
- Diaglitazone.
Thaum ua ntawv thov, cov nyhuv hypoglycemic yuav muab. Diaglitazone, uas yog tus nqi ntawm 295 rubles, tuaj yeem yog qhov kev xaiv zoo rau cov tshuaj muaj nqi ntau dua. Astrozone thiab Diab-cai muaj yuav luag tib cov contraindications thiab phiv.
Diagnitazone tuaj yeem txo qis kev ua haujlwm ntawm kev siv qhov ncauj qhov ncauj, uas yuav tsum tau suav nrog.
Pioglitazone analogues
Vim ib tus neeg tsis kam txais thiab phiv, kev siv Pioglitazone yuav raug txwv. Yog li, tus kws kho mob sau ntawv rau lwm cov tshuaj uas muaj rosiglitazone.
Cov tshuaj no tseem muaj nyob hauv cov pab pawg ntawm thiazolidinediones (glitazones). Thaum siv nws, tib cov nyhuv yuav tawm dhau los ntawm pioglitazone, uas yog, kev txhawb nqa ntawm tes thiab ntaub so ntswg receptors kom tshem tawm cov tshuaj insulin.
Cov tshuaj tseem ceeb muaj rosiglitazone yog:
- Av ‡ Q
- Roglit.
Ua ntej siv lawv, koj yuav tsum sab laj nrog tus kws kho mob thiab nyeem cov lus qhia rau kev siv.
Kev npaj ua Biguanide txo qis cov tshuaj insulin. Metformin, uas yog ib feem ntawm cov khoom lag luam, txo qis tsim cov piam thaj los ntawm nplooj siab. Siv cov tshuaj no nrog kev ceev faj, vim tias biguanides cuam tshuam tsis zoo rau kev ua haujlwm ntawm lub plawv hauv cov neeg laus, qhov cuam tshuam tsis zoo rau kev ua haujlwm ntawm lub raum thiab kev loj hlob raws li cov kab mob lactic acidosis tuaj yeem tawm. Kev npaj nrog cov tshuaj nquag metformin suav nrog Bagomet, Glucofage, Metformin-BMS, NovoFormin, Siofor thiab lwm yam.
Kuj tseem txo qis cov ntshav qab zib Acarbose. Lub tshuab ntawm nws cov kev ua yog tsom rau inhibiting cov enzymes uas pab coj los ua kom muaj cov carbohydrates hauv cov hnyuv. Kev mob ntshav qab zib yog ua tau nrog kev siv tshuaj ntxiv thiab lwm yam tshuaj insulin. Txhawm rau tiv thaiv qhov tshwm sim ntawm kev phiv tshuaj nrog kem plab, nws zoo dua yog pib noj nrog cov koob tshuaj me me.
Hauv kev kho mob ntshav qab zib hom 2, tshuaj uas muaj pioglitazone lossis nws cov analogues, tsis hais Diaglitazone lossis Metformin, tuaj yeem siv. Txij li thaum cov tshuaj no muaj ntau qhov sib txuam ntawm qhov sib txuam thiab cov kev mob tshwm sim, nws tau pom zoo siv lawv tom qab sab laj txog ntshav qab zib. thiab nrog kws kho mob. Daim vis dis aus hauv tsab xov xwm no nthuav qhia txog kev sab laj txog
