Insulin P: tus nqi thiab chaw tsim khoom, sib txawv

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Niaj hnub no, ntshav qab zib tsis yog ib qho mob tsis tshua muaj tshwm sim thiab cov laj thawj ntawm nws cov tsos tsis yog ib txwm pom nyob hauv kev tshuaj ntsuam tsis zoo. Feem ntau, tus kab mob no pib tawm ntawm lub neej tom qab txoj kev ua neej tsis muaj zog, kev ntxhov siab tas mus li, kev coj tsis zoo thiab kev noj zaub mov tsis zoo.

Tab sis nyob rau hauv txhua rooj plaub, mob ntshav qab zib xav tau kev kho mob, txij li nws txoj kev hloov pauv coj mus rau kev txhim kho ntawm ntau yam kev phom sij. Cov teebmeem no suav nrog kev ua kom tsis pom kev, ua mob, muaj teeb meem nrog lub plawv hlab plawv, tawg, nephropathy thiab polyneuropathy.

Yog tias tus txiav tsis ua cov tshuaj insulin nyob rau hauv cov ntshav qab zib, tom qab ntawd cov khoom neeg tsim muaj cov tshuaj tua kabmob yog muab rau nws. Ib qho tshuaj zoo tshaj plaws ntawm cov pab pawg no yog Insulin R. Tab sis nws yog dab tsi, nws cov nyhuv thiab yuav siv nws li cas?

Rinsulin P: tso tawm daim ntawv thiab cov yam ntxwv ntawm pharmacological

Cov tshuaj yog cov tshuaj lom neeg uas ua rau tib neeg siv tau los ntawm kev siv DNA thev naus laus zis. Cov cuab yeej txuas rau cov receptors ntawm sab nraud cell daim nyias nyias, tsim cov insulin-receptor complex uas ua kom cov txheej txheem uas tshwm sim hauv cov hlwb, suav nrog kev tsim cov hlau lead ua.

Qhov kev txo qis hauv cov ntshav qab zib tau tiav los ntawm kev nce ntxiv hauv kev thauj cov ntshav hauv nruab nrab ntawm cov hlwb, nws txoj kev nqus thiab kev nqus los ntawm cov ntaub so ntswg. Kev loj hlob ntawm glycogenogenesis, lipogenesis kuj tshwm sim thiab tus nqi ntawm cov piam thaj los ntawm lub siab poob qis.

Raws li txoj cai, lub sijhawm ntawm cov nyhuv ntawm insulin npaj yog txiav txim siab los ntawm tus nqi ntawm kev nqus, nyob ntawm ntau yam (thaj tsam thiab txoj kev ntawm kev tswj hwm, koob tshuaj). Yog li, qhov profile ntawm qhov kev txiav txim yuav txawv nyob hauv txhua tus neeg mob. Tab sis qhov ib txwm, tom qab kev tswj hwm subcutaneous, Rinsulin P ua tom qab ib nrab teev, thiab cov txiaj ntsig siab tshaj plaws tau tiav tom qab 1-3 teev thiab kav ntev txog 8 teev.

GEROFARM-BIO OJSC insulin tus tsim R tsim cov tshuaj hauv peb daim ntawv:

  1. Ib qho kev daws teeb meem (10 IU / ml) rau kev txhaj tshuaj ntawm 3 ml ntawm cov tshuaj hauv cov iav cartridges nrog cov roj hmab plungers.
  2. 5 daim cartridges hauv blister sawb ntim ua ntawm ntawv ci thiab PVC.
  3. Ib lub cartridge sib xyaw ua ke nyob rau hauv ntau cov koob txhaj tshuaj uas siv cov yas, muab tso rau hauv lub thawv ntawv thawv.

Kev ua tiav ntawm kev nqus thiab pib ntawm kev ua ntawm tib neeg kev ua yeeb yam luv luv yog txiav txim siab los ntawm thaj chaw, thaj chaw, txoj haujlwm ntawm kev tswj hwm thiab kev kub siab ntawm cov tshuaj muaj zog. Cov tshuaj tsis raug xa tawm zoo thoob plaws cov ntaub so ntswg; nws tsis nkag rau hauv niam mis thiab tso rau hauv qhov chaw tiv thaiv.

Nws yog rhuav tshem los ntawm insulinase tsuas yog mob raum thiab siab. Cov tshuaj siv tawm hauv 30-80% ntawm ob lub raum. T1 / 2 yog 2-3 feeb.

Cov lus qhia rau kev siv tshuaj

Cov tshuaj yog qhia rau txhua yam ntshav qab zib mellitus, nyob rau hauv rooj plaub ntawm tag nrho lossis ib nrab tsis kam rau cov piam thaj txo cov ntsiav tshuaj. Nws kuj tseem siv thaum muaj xwm txheej ceev hauv cov neeg mob ntshav qab zib tiv thaiv keeb kwm yav dhau los ntawm kev decompensation ntawm carbohydrate metabolism thiab tus kabmob sib kis. Txawm li cas los xij, cov tshuaj tsis raug sau rau cov ntshav qab zib thiab ib tug neeg tsis kam rau nws lub Cheebtsam.

Cov tshuaj yog npaj rau iv, v / m, s / c tswj hwm. Cov kab ke ntawm kev tswj hwm thiab kev noj tshuaj yog tshuaj los ntawm tus neeg endocrinologist raws li tus yam ntxwv ntawm tus neeg mob. Qhov nruab nrab ntawm cov tshuaj yog 0.5-1 IU / kg ntawm qhov hnyav.

Kev siv tshuaj insulin luv luv yog muab rau hauv 30 feeb. ua ntej noj cov khoom noj carbohydrate. Tab sis ua ntej, koj yuav tsum tos kom txog thaum ntsuas kub ntawm lub txim ncua mus txog tsawg kawg 15 degrees.

Xws li kev kho mob monotherapy, cov tshuaj insulin raug tswj 3 mus rau 6 zaug hauv ib hnub. Yog tias qhov koob tshuaj txhua hnub yog ntau dua 0.6 IU / kg, tom qab ntawd koj yuav tsum nkag mus rau ob lossis ntau qhov kev txhaj tshuaj hauv qhov chaw sib txawv.

Raws li txoj cai, tus neeg sawv cev yog txhaj sc rau hauv phab ntsa plab. Tab sis kev txhaj tshuaj tuaj yeem ua rau hauv lub xub pwg, pob tw thiab ncej puab.

Ua ntu zus, thaj chaw txhaj tshuaj yuav tsum raug hloov pauv, uas yuav tiv thaiv cov tsos ntawm lipodystrophy. Xws li s / c tswj hwm cov tshuaj hormones, koj yuav tsum ua tib zoo xyuas kom meej tias cov kua tsis nkag rau hauv cov hlab ntshav. Tsis tas li, tom qab kev txhaj tshuaj, qhov chaw txhaj tshuaj tsis tuaj yeem raug muab zaws.

Hauv / hauv thiab / m kev tswj hwm yog ua tau tsuas yog nyob hauv kev saib xyuas mob. Daim cartridges tsuas yog siv yog tias cov kua muaj xim pob tshab tsis muaj impurities, yog li ntawd, thaum muaj nag lossis daus tshwm, cov tshuaj yuav tsum tsis txhob siv.

Nws yog tsim nyog kom nco ntsoov tias daim cartridges muaj cov cuab yeej tshwj xeeb uas tsis pub sib xyaw ntawm lawv cov ntsiab lus nrog lwm hom insulin. Tab sis nrog txoj kev sau daim ntawv kom raug ntawm cov xaum xaum qhwv lawv tuaj yeem rov siv dua.

Tom qab tso ntxig tag, rab koob yuav tsum tau txuas nrog nws sab nraud thiab pov tseg. Yog li, kev tiv thaiv xau tuaj yeem tiv thaiv, kev tuaj yeem tuaj yeem ua kom zoo, thiab huab cua tsis tuaj yeem nkag mus ntawm rab koob thiab ua rau txhaws.

Thaum siv cov koob tshuaj ntau ntau lub koob txhaj, ua ntej siv thawj zaug, tshem cov kua xaum xoos tawm hauv lub tub yees thiab tos kom txog thaum nws tau txais chav sov. Txawm li cas los xij, yog tias cov kua tau khov lossis dhau los ua huab, ces nws siv tsis tau.

Lwm txoj cai tseem yuav tsum tau saib xyuas:

  • koob tsis tuaj yeem siv rov qab;
  • Qhov tshuaj insulin R uas qhov xaum xaum xaum yog txhawm rau tsuas yog siv rau tus kheej, thaum lub koob txhaj tshuaj tsis tuaj yeem sau rov qab;
  • cov koob txhaj tshuaj siv yuav tsum tsis pub tso rau hauv tub yees;
  • txhawm rau txhawm rau tiv thaiv xaum xaum ntawm lub teeb, nco ntsoov npog nws nrog lub hau.

Cov tshuaj uas twb tau siv yuav tsum khaws cia ntawm qhov kub txog 15 txog 25 degrees rau tsis pub dhau 28 hnub. Tsis tas li, koj yuav tsum tsis txhob cia cov cuab yeej ua kom sov lossis tiv thaiv tshav ntuj ncaj qha.

Yog hais tias muaj ntshav ntau dhau nyob rau hauv cov ntshav, cov concentration ntawm cov piam thaj tuaj yeem ua rau tsawg. Kev kho mob ntawm hypoglycemia muaj nyob rau hauv kev noj cov khoom noj uas muaj carbohydrate lossis cov dej qab zib. Yog li, cov ntshav qab zib yuav tsum muaj qab zib lossis kua txiv nrog lawv txhua lub sijhawm.

Nrog rau qhov mob ntshav nce siab ntau, thaum uas tus kab mob ntshav qab zib tsis nco qab lawm, nws tau txhaj tshuaj qabzib (40%) los yog glucagon.

Tom qab ib tus neeg rov qab nco qab, nws yuav tsum tau noj cov zaub mov carbohydrate, uas yuav tiv thaiv qhov kev txhim kho ntawm kev tawm tsam zaum ob.

Kev Phom Sij thiab Kev Phom Yeeb

Cov kev mob tshwm sim yog qhov ua tsis tau ntawm cov metabolism hauv cov metabolism. Yog li, kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob tau nqis los rau qhov tseeb tias tom qab ua haujlwm tswj hwm Rinsulin P, mob ntshav qab zib tsawg tuaj yeem pib txhim kho. Qhov no tshwm sim los ntawm malaise, blanching ntawm daim tawv nqaij, mob taub hau, palpitations, tshee tshee, tshaib plab, hyperhidrosis, kiv taub hau, thiab nyob rau hauv mob hnyav, hypoglycemic coma tsim muaj ntshav qab zib mellitus.

Kev ua xua tsis haum, xws li Quincke's edema, ua pob rau ntawm tawv nqaij kuj tseem ua tau. Anaphylactic kev poob siab, uas tuaj yeem ua rau tuag taus, qee zaus muaj kev txhim kho.

Los ntawm cov tshuaj tiv thaiv hauv zos, khaus, o thiab hyperemia hauv thaj chaw txhaj tshuaj feem ntau tshwm sim. Thiab nyob rau hauv cov ntaub ntawv ntawm lub sijhawm ntev kev kho mob insulin, lipodystrophy tshwm ntawm qhov chaw txhaj tshuaj.

Lwm yam kev phiv tshuaj suav nrog kev o thiab qhov muag pom. Tab sis feem ntau cov tsos mob no ploj mus thaum kho.

Muaj ntau tus lej ntawm cov tshuaj uas cuam tshuam rau cov tshuaj insulin. Yog li, kev kho mob hais tias cov ntshav qab zib kom txo qis ntawm cov tshuaj insulin yuav muaj zog yog tias nws siv nrog kev sib xyaw ua ke hauv qab no:

  1. cov ntsiav tshuaj hypoglycemic;
  2. ethanol;
  3. ACE / MAO / carbonic anhydrase inhibitors;
  4. lithium npaj;
  5. tsis xaiv-block-blockers;
  6. Fenfluramine;
  7. Bromocriptine;
  8. Cyclophosphamide;
  9. salicylates;
  10. Mebendazole thiab ntau dua.

Nicotine, glucagon, phenytoin, somatropin, morphine, estrogens, tshuaj tiv thaiv qhov ncauj, diazoxide thiab corticosteroids txo cov nyhuv hypoglycemic. Cov thyroid hormones uas muaj iodine, CCB, thiazide diuretics, Epinephrine, Clonidine, Heparin, Danazole, tricyclic antidepressants thiab sympathomimetics kuj ua rau cov nyhuv suab thaj txo qis.

Siv cov B-blockers tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib. Lanreotide lossis Octreotide thiab cawv muaj peev xwm nce lossis txo qis yuav tsum muaj cov insulin ntau ntxiv.

Nws yog kiag li tsis sib xws los sib xyaw ua ke rau tib neeg insulin nrog tshuaj zoo sib xws thiab tsiaj.

Cov lus qhia tshwj xeeb

Tawm tsam keeb kwm ntawm kev siv tshuaj insulin, nws yog ib qho tseem ceeb uas yuav tsum tau soj ntsuam glycemia ntsuas tas li. Tseeb, ntxiv rau kev noj ntau dhau, qee cov kab mob, hloov tshuaj, nce lub cev kev ua si, zawv plab, qhov hloov pauv ntawm thaj chaw txhaj tshuaj thiab txawm tias noj tsis raws cai tuaj yeem ua rau txo qis dua cov suab thaj.

Tsis tas li ntawd, kev cuam tshuam kev tswj hwm ntawm cov tshuaj insulin thiab cov tshuaj noj tsis yog tuaj yeem ua rau hyperglycemia hauv cov neeg mob ntshav qab zib hom 1. Thaum tsis muaj kev kho, ketoacidosis lub neej txoj sia yuav pib.

Yog tias muaj kev ua txhaum nyob rau hauv kev ua haujlwm ntawm lub raum, mob siab, lub qog thyroid, hypopituitarism, Addison's kab mob thiab thaum muaj hnub nyoog laus dua, nws yog qhov tsim nyog yuav tau kho cov koob tshuaj insulin. Tsis tas li, kev hloov pauv ntawm cov tshuaj ntxiv yuav tsim nyog thaum hloov pauv kev noj zaub mov thiab ua kom lub cev muaj zog.

Qhov xav tau ntawm insulin nce nyob rau hauv qhov muaj cov kab mob sib kis, tshwj xeeb tshaj yog cov cuam tshuam nrog kub taub hau. Nws yog tsim nyog sau cia tias thaum lub sij hawm hloov los ntawm ib hom tshuaj insulin mus rau lwm tus, koj yuav tsum ua tib zoo saib xyuas cov ntshav qab zib.

Tus nqi ntawm Rinsulin R ranges ntawm 448 txog 1124 rubles.

Ntxiv nrog rau Insulin P, muaj ib qho tshuaj Rinsulin NPH. Tab sis yuav ua li cas cov nyiaj no txawv?

Tshuaj yaug NPH

Cov tshuaj tseem yog tib neeg cov tshuaj insulin tau los ntawm kev siv DNA thev naus laus zis thev naus laus zis. Txawm li cas los xij, hauv kev sib piv nrog Insulin P, nws tsis muaj luv luv, tab sis muaj cov nyhuv nrab. Ob qhov tshuaj no tuaj yeem ua ke.

Raws li txoj cai, tom qab kev tswj hwm sc, qhov kev ua haujlwm ntawm insulin pib hauv 1.5 teev. Qhov txiaj ntsig zoo tshaj plaws tau tiav tom qab 4-12 teev thiab kav ib hnub.

Qhov kev ncua muaj cov xim dawb, thiab thaum sawv ntawm hauv qab ntawm lub raj mis, ib hom dej nag lossis daus, uas, thaum shaken, rov kho dua. Cov tshuaj nquag ntawm cov tshuaj yog cov tshuaj insulin-isophan.

Ua ntu pab tau siv:

  • distilled dej;
  • kev cog lus sulfate;
  • sodium hydrogen phosphate dihydrate;
  • glycerol;
  • metacresol;
  • crystalline phenol.

Qhov kev ncua yog muaj nyob rau hauv lub khob cartridges ntawm 3 ml txhua, muab tso rau hauv cardboard contour ntim. Tsis tas li, cov khoom lag luam tuaj yeem raug yuav hauv cov iav cartridges mounted hauv ntau koob txhaj tshuaj rau ntau txoj kev txhaj tshuaj ntawm Rinastra.

Cov chaw muag tshuaj thiab kev cim rau kev siv tshuaj yog tib yam li kev siv Rinsulin R. Kev noj tshuaj ntau npaum li cas tau txiav txim siab los ntawm tus kws kho mob tshwj xeeb.

Qhov nruab nrab qhov tshuaj ntawm cov tshuaj yog 0.5-1 IU / kg ntawm lub cev hnyav. Tab sis kev tswj hwm cov dej khov yog contraindicated.

Cov lus qhia rau kev siv Rinsulin NPH hais txog kev phiv, kev siv ntau tshaj ntawm cov yam ntxwv thiab kev siv tsis txawv ntawm qhov kev cim ntawm qhov luv ntawm tib neeg lub cev insulin.

Tus nqi ntawm kev ncua yog los ntawm 417 txog 477 rubles. Daim vis dis aus hauv tsab xov xwm no yuav pab koj kawm paub tswj hwm cov tshuaj insulin.

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