Comboglyz Prolong yog ib hom tshuaj hypoglycemic. Nws siv los ntawm cov neeg mob uas muaj ntshav qab zib hom 2, thaum kev noj zaub mov kom tsawg thiab kev tawm dag zog tsis tuaj yeem kho cov piam thaj li qub.
Mob ntshav qab zib mellitus yog ib qho mob hnyav heev uas yuav tsum tau saib xyuas tshwj xeeb. Yog hais tias tus kab mob no tawm mus rau lub caij nyoog, nws yuav nkag mus rau tag nrho "pawg" ntawm cov teeb meem, los ntawm retinopathy mus rau gangrene, kev daws ntawm uas tsuas yog txiav tawm ntawm cov nqua.
Kev tswj ntshav qab zib kom ua tau zoo suav nrog plaub yam tseem ceeb: kev noj zaub mov zoo, ua kom ib ce muaj zog, soj ntsuam cov suab thaj kom ntau, kev siv tshuaj kho (los yog kho tshuaj insulin rau hom ntshav qab zib hom 1).
Ntxiv mus, kev siv cov tshuaj yuav tsum raug coj nrog txhua qhov hnyav thiab kev ceev faj: txhua qhov tshuaj tau nws cov contraindications, thiab tseem tuaj yeem cuam tshuam tus neeg mob lub cev ntawm ntau txoj kev sib txawv. Yog li, yuav ua li cas Siv Combogliz Prolong kom raug thiaj li kom tsis txhob ua mob rau koj tus kheej? Cov kws kho mob thiab cov neeg mob hais li cas txog nws? Cia peb sim nkag siab txog cov teeb meem no.
Pharmacological kev txiav txim ntawm cov tshuaj
Cov tshuaj no yog tsim los ntawm Asmeskas chaw lag luam kws tshuaj Bristol-Myers Squibb.
Cov chaw tsim tshuaj lag luam tsim cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj uas muaj ob yam tshuaj - metformin thiab saxagliptin hauv cov tshuaj tsim nyog: 1000 mg thiab 2.5 mg, 500 mg thiab 5 mg, 1000 mg thiab 5 mg.
Ntxiv rau, cov ntsiav tshuaj tseem ceeb suav nrog qee qhov ntawm cov khoom siv pabcuam:
- magnesium stearate;
- sodium carmellose;
- hypromellose.
Txhua lub ntsiav tshuaj ntawm cov tshuaj no tau npog hauv peb txheej, uas muaj cov tshuaj sib txawv. Txij li thaum cov tshuaj sib txuas ua ke ob tus kab mob hypoglycemic, nws zoo txo cov suab thaj hauv cov neeg mob. Xav txog cov yam ntxwv ntawm qhov cuam tshuam rau cov kua nplaum ntawm txhua tus.
Metformin, ua tus sawv cev ntawm pab pawg lojuanuanide, ua rau muaj kev tso ntshav siab ntev, yog li txo qis nws cov ntshav hauv cov ntshav qab zib. Cov tshuaj no tsis ua rau kev txhim kho hauv lub xeev hypoglycemic thiab hyperinsulinemia. Qhov kev ua ntawm metformin yog qhia:
- Yuav kom txo cov ntau lawm ntawm cov piam thaj los ntawm lub siab.
- Kev nce ntxiv peripheral nqus ntawm cov piam thaj.
- Kev siv ntshav qabzib.
- Txhawm rau txhim kho cell ua kom haum rau cov kua dej.
- Txhawm rau kom txo qis plab hnyuv tawm.
Nws yuav tsum raug sau tseg tias thaum lub sij hawm siv Metformin tsis muaj kev hloov pauv hauv kev ua kom cov khoom qab zib-txo cov tshuaj hormones. Txawm li cas los xij, cov neeg mob ntshav qab zib yuav tsum tau ceeb toom thaum sawv ntxov thiab lub sijhawm noj mov, thaum muaj cov insulin tsawg dua.
Saxagliptin provokes kev tso tawm cov tshuaj hormones incretin, uas yog, HIP thiab GLP-1, uas nkag rau ntawm lub plab hnyuv mus rau hauv cov hlab ntshav. Lawv pab ua rau cov txheej txheem zoo li no:
- qhov kev tso tawm ntawm cov tshuaj insulin los ntawm beta hlwb ntawm islet apparatus;
- txo qis hauv glucagon ntau lawm los ntawm pancreatic alpha cells.
Qhov tshwj xeeb ntawm saxagliptin yog tias kev tivthaiv txo cov ntsiab lus ntawm cov neeg mob cov ntshav ntawm lub plab khoob thiab thaum noj mov.
Tom qab tus neeg mob yuav siv koob tshuaj Combogliz Prolong, qhov siab tshaj plaws ntawm metformin yog pom tom qab xya teev.
Saxagliptin, raws li txoj cai, yog metabolized, sib sau lub ntsiab metabolite, thiab metformin yuav luag tsis ncau. Yog li, lawv raug cais tawm tsis hloov pauv los ntawm ob lub raum.
Cov lus qhia rau kev siv tshuaj
Nws yog qhov tsim nyog yuav tsum rov qab nco qab tias cov tshuaj tsuas yog muag hauv cov tshuaj. Tus kws kho mob tshwj xeeb uas tau muab cov tshuaj no yuav tsum xaiv nws raws li cov txheej txheem xws li cov piam thaj hauv lub cev, muaj cov kab mob concomitant, thiab kev noj qab haus huv ntawm tus neeg mob.
Thaum tus neeg mob yuav tau txais cov cuab yeej no, cov lus qhia rau kev siv yuav tsum tau kawm. Yog tias koj muaj lus nug, tus neeg mob yuav tsum nrog koj tus kws kho mob tham.
Cov tshuaj Combogliz Prolong tau pom zoo kom noj tshuaj tawm suab thaum yav tsaus ntuj. Tus neeg mob yuav tsum nqos tag nrho lub ntsiav tshuaj thiab haus nws nrog dej.
Thaum pib ntawm kev kho mob, qhov ntau npaum ntawm cov tshuaj yog 500 mg + 2.5 mg ib hnub, dhau sijhawm nws yuav ua kom siab txog li 1000 mg + 5 mg (2 ntsiav tshuaj). Txij li metformin tuaj yeem muaj qhov tsis zoo ntawm lub plab zom mov, nws cov tshuaj ntau yuav tsum tau nce ntau zuj zus. Cov kev hloov pauv hauv lub cev no tsis tas yuav ntshai: vim kev hloov kho rau cov khoom, ua haujlwm ntawm lub plab zom mov yog rov tsim kho. Raws li qhov tshwm sim, tus neeg mob yws yws ntawm xeev ntuav, ntuav, raws plab, saj ntawm hlau hauv lub qhov ncauj, tsis qab los noj mov thiab flatulence.
Thaum hloov mus rau kev kho mob nrog Combogliz Prolong nrog rau lwm cov tshuaj txo cov ntshav qab zib, koj yuav tsum tau ua tshwj xeeb. Xws li kev txiav txim siab yuav tsum pom zoo nrog tus kws kho mob uas koom nrog ntawd. Qhov no yog vim muaj qhov tseeb tias cov chaw tsim khoom lag luam tsis ua cov kev tshawb fawb tshwj xeeb txog kev ua tau zoo thiab tsis muaj kev phom sij ntawm cov tshuaj Combogliz Prolong tom qab siv lwm yam kab mob hypoglycemic.
Txawm li cas los xij, nrog kev siv tshuaj ib txhij thiab cov tshuaj tiv thaiv ntawm CYP3A4 / 5 isoenzymes, nws yog ib qho tsim nyog yuav tsum tau noj tsawg kawg ntawm saxagliptin - 2.5 mg. Cov tshuaj muaj xws li:
- Indinavir.
- Ketoconazole
- Nefazodon.
- Itraconazole.
- Atazanavir thiab lwm tus.
Cov neeg mob ntshav qab zib yuav tsum tau siv cov tshuaj nrog ceev faj, raws li kev tshawb fawb pom tias nws tuaj yeem ua rau lub raum ua haujlwm tsis zoo.
Cov tshuaj yuav tsum khaws cia ntawm qhov kub uas tsis tau tshaj +30 degrees Celsius. Cov neeg laus yuav tsum ua kom ntseeg tau tias cov menyuam yaus tsis ncav cuag lub ntim khoom kom zam dhau qhov tsis zoo.
Txee lub neej yog 3 xyoos, thaum nws tas sij hawm, kev siv cov tshuaj yog nruj me ntsis txwv tsis pub.
Txoj kev tiv thaiv kom tsis txhob siv tshuaj
Txij li thaum tsis muaj kev tshawb fawb txog kev tshawb fawb hauv thaj tsam ntawm kev ua tau zoo thiab tsis muaj kev phom sij ntawm cov tshuaj Comboglize, cov lus qhia tsis suav nws siv rau hauv menyuam yaus (tsawg dua 18 xyoo), zoo li thaum lub sijhawm cev xeeb tub thiab pub niam mis. Tsis tas li, cov nyhuv ntawm cov tshuaj rau lub cev ntawm cov neeg mob ntshav qab zib hom 1 thiab soj ntsuam cov tshuaj insulin kuj tsis tau kawm.
Ntxiv nrog rau cov lus saum toj no contraindications, ntshav qab zib yog txwv tsis pub noj cov tshuaj nyob rau hauv xws li mob:
- nrog rau tus kheej tsis kam rau cov tshuaj ntawm cov tshuaj;
- nrog galactose intolerance txij thaum yug los, nrog rau cov piam thaj-galactose malabsorption thiab lactase tsis txaus;
- nyob rau hauv cov kev tsis haum tshuaj loj uas muaj kev cuam tshuam ntau dua rau DPP-4 inhibitor (piv txwv, angioedema, anaphylaxis);
- nyob rau ntawm qhov muaj cov kab mob tseem ceeb uas tuaj yeem ua rau lub raum ua tsis taus: kub taub hau, hypoxia (sepsis, kev poob siab, kab mob bronchopulmonary, mob raum), ntau yam kab mob kis, lub cev qhuav dej vim yog zawv plab lossis ntuav;
- nrog lub raum tsis ua hauj lwm, thaum cov ntshav creatinine tsawg dua 1.4 mg / d (rau cov poj niam) thiab tsawg dua 1.5 mg / dl (rau cov txiv neej), zoo li tsis tshua muaj cim creatinine tshem tawm los ntawm septicemia, mob loj pathologies ntawm cov hlab plawv;
- nrog rau cov kab mob metabolic acidosis, tshwj xeeb yog cov ketoacidosis uas mob ntshav qab zib;
- nrog ntshav qab zib precoma thiab coma;
- nyob rau hauv muaj cov mob loj thiab mob ntev pathologies uas ua rau kom muaj sij hawm ntawm cov nqaij mos hypoxia;
- nrog rau kev qhia txog ntawm iodine-muaj qhov tsis zoo ntawm tus neeg sawv cev ob hnub ua ntej thiab tom qab xoo hluav taws xob thiab xoo xaim hluav taws xob;
- thaum nyob ntawm cov zaub mov tshwj xeeb (tsawg dua 1000 kcal ib hnub);
- nrog rau kev qaug tshuaj lom ntau nrog ethanol lossis qaug cawv quav ntev dhau los;
- nrog kev phais mob thiab raug mob hnyav uas xav tau kev qhia ntawm cov tshuaj insulin;
- nrog daim siab ua haujlwm siab;
- nrog lactic acidosis.
Raws li tau hais dhau los, kev siv cov tshuaj Combogliz Prolong yog qhov tsim nyog nrog kev saib xyuas tshwj xeeb rau cov neeg laus laus (txij li 60 xyoo), tshwj xeeb tshaj yog cov neeg ua haujlwm uas cuam tshuam nrog kev siv lub cev nyhav, nrog rau cov neeg uas raug mob pancreatitis.
Tej yam yuav phom sij thiab raug ntau
Muaj qee kis, vim kev siv tsis raug tshuaj, qhov tshwm sim ntawm qhov tsis zoo qhov tsis zoo yog qhov ua tau. Cov lus no nthuav qhia txog cov kev mob tshwm sim feem ntau cuam tshuam nrog kev siv Combogliz Prolong.
| Kev phiv tshuaj nrog monotherapy thiab kho cov kev kho mob | |
| Saxagliptin | Tus mob migraine, sinusitis, kis tus kab mob rau hauv genitourinary system, mob plab thiab ntuav, txhim kho thrombocytopenia, raws plab, ib lub xeev ntawm hypoglycemia, nasopharyngitis, urticaria, gastroenteritis, o ntawm lub ntsej muag, mob leeg, pancreatitis. |
| Metformin | Cov tshuaj tiv thaiv cuam tshuam nrog kev hloov kho ntawm lub cev mus rau qhov khoom ntawd - raws plab, xeev siab, ntuav, nce roj ntxiv, saj hloov. |
Tsis tas li ntawd, thaum lub sijhawm kawm tshawb nrhiav, nws tau pom tias dhau ib lub sijhawm ntev ntawm kev noj saxagliptin, muaj tsawg dua ntawm cov lymphocytes, ntxiv rau cov vitamin B12.
Overdose cov neeg mob muaj tsawg heev, txawm li cas los xij, nrog lub sijhawm ntev siv cov tshuaj, nws yog qhov ua tau. Saxagliptin tsis ua rau muaj kev qaug cawv ntawm lub cev, tab sis yog tias muaj ib qho kev haus ntau dhau nws tuaj yeem tshem tawm siv cov txheej txheem uas siv kho mob (hemodialysis). Muaj kev kho mob raws qab.
Kuj muaj ntau qhov sau tseg tias kev haus ntau tshaj plaws ntawm metformin. Cov tsos mob tseem ceeb yog hypoglycemia thiab lactic acidosis, uas feem ntau yog nrog lub raum tsis ua haujlwm. Cov tsos mob tseem ceeb ntawm tus kab mob lactic acidosis yog:
- Nkees
- Kev ua pa tsis ua haujlwm.
- Mob plab.
- Hypotension lossis hypothermia.
- Neej Hmoob.
- Txom Nyem Bradyarrhythmia.
Hauv qhov xwm txheej phem tshaj plaws, kev tsis meej pem tshwm sim, uas tuaj yeem ua rau txoj kev tsis nco qab. Cov cim tseem ceeb ntawm kev kub siab yog qaug zog, kiv taub hau, tsaus muag, tsaug zog, npau taws, tsaus muag. Metformin 850 tseem raug ntiab tawm los ntawm hemodialysis, nws yuav tsum tau yug los hauv lub siab tias kev tshem tawm tau nce mus txog 170 ml ib feeb.
Txhawm rau kom tsis txhob noj tshuaj ntau dhau thiab muaj kev phiv tshuaj, tus neeg mob yuav tsum ua raws txhua tus kws kho mob cov lus pom zoo thiab tsis yog siv tshuaj rau tus kheej.
Nov yog ob lub hauv paus ntsiab lus uas yuav tiv thaiv tau qhov tsis xav ua tom qab.
Kev cuam tshuam nrog lwm yam tshuaj
Nws yuav tsum nco ntsoov tias tsis yog txhua yam tshuaj tuaj yeem siv nrog lwm tus. Txij li thaum muaj ntau yam tshuaj nyob nruab nrab ntawm qhov sib xyaw ntawm cov tshuaj, qhov no tuaj yeem ua rau kev tsis haum.
Yog li, qee cov tshuaj tuaj yeem txo cov ntshav qog ntshav ntawm saxagliptin thiab metformin, vim li ntawd, cov ntshav qabzib hauv cov ntshav nce siab. Hloov siab, lwm tus txhim kho cov suab thaj txo qis ntawm lub Cheebtsam, ua rau cov ntsiab lus qab zib tsawg dua.
| Saxagliptin | Metformin |
| Txhim khu kev mob hyperglycemic | |
| Pioglitazone, rifampicin, aluminium hydroxide / magnesium hydroxide / simethicone. | GCS, thiazide diuretics, nikitinic acid Isoniazid, estrogens, cov thyroid hormones, sympathomimetics, phenothiazines, qeeb calcium channel blocker, phenytoin. |
| Ua rau lub qog ntshav qab zib | |
| Diltiazem, Amprenavir, Erythromycin, Fluconazole, Aprepitant, Verapamil, kua txiv kab ntxwv, Ketoconazole, muaj zog isoenzymes CYP3A4 / 5, Glibenclamide, Ketoconazole, Famotidine, sulfonylurea derivatives. | Cov tshuaj Cationic, Furosemide, Nifedipine, cov tshuaj muaj ethanol. |
Yog li, nws raug txwv tsis pub noj tshuaj rau ntawm koj tus kheej. Ua ntej koj yuav tsum mus ntsib tus kws kho mob uas tuaj yeem xaiv qhov sib txawv ntawm cov tshuaj.
Nqi thiab tshuaj xyuas ntawm kws kho mob, cov neeg mob
Qhov twg yuav Combogliz Prolong? Zoo, cov tshuaj muaj peev xwm yuav tau tom chaw muag tshuaj tsis tu ncua lossis tso ib qho kev txiav txim ntawm lub vev xaib ua haujlwm ntawm Lavxias tus neeg muag khoom.
Cov tshuaj xaiv los ntawm tus neeg mob yuav tsum tau ua raws li ob qho kev ntsuas - kho cov nyhuv thiab nws tus nqi.
Tus nqi ntawm cov tshuaj nyob ntawm nws daim ntawv tso tawm, yog li ntawd, nws txawv nyob rau hauv cov kev txwv no:
- 1000 mg + 5 mg (28 ntsiav tshuaj hauv ib pob): ntawm 2730 txog 3250 rubles Lavxias;
- 1000 mg + 2.5 mg (56 ntsiav tshuaj rau ib pob): ntawm 2,600 txog 3,130 rubles Lavxias.
Raws li koj tuaj yeem pom, tus nqi yog siab heev, vim tias Combogliz Prolong yog cov tshuaj yeeb tshuaj. Nov yog nws qhov teeb meem tseem ceeb, vim tias cov neeg mob uas tau nyiaj tsawg thiab nruab nrab tsis tuaj yeem them taus cov kev kho mob kim kim no.
Nws yuav tsum raug sau tseg tias tsis muaj ntau cov lus qhia txog kev siv tshuaj los ntawm cov neeg mob. Yeej, hauv Is Taws Nem koj tuaj yeem tshawb xyuas cov kws kho mob, ntau leej uas hu cov cuab yeej no tshwj xeeb. Raws li lawv, cov tshuaj tsis tsuas yog ua rau cov piam thaj hauv ntshav qab zib hauv ntshav qab zib, tab sis kuj pab tswj hwm lawv qhov hnyav, ua tsaug rau cov tshuaj metformin uas muaj nyob hauv.
Txawm li cas los xij, tsuas yog cov neeg mob uas ua raws li cov qauv kev qhia txog kev noj zaub mov noj ntshav qab zib mellitus thiab ib txwm koom nrog kev kho mob lub cev muaj peev xwm txo lub cev qhov hnyav. Raws li lawv hais, khawv koob tshuaj ntsiav los ntawm tag nrho cov mob tsis muaj nyob.
Yog li, feem ntau cov neeg mob nco ntsoov tias kev kho mob ntawm cov tshuaj yog siv tau zoo heev: tom qab nws siv, ib txwm muaj ntshav qab zib cov ntshav siab tau khaws cia. Tab sis nws qib yuav “dhia” thaum tus neeg mob ntshav qab zib tsis ua raws li kev noj zaub mov, ua rau nws tus kheej noj khoom qab zib thiab lwm yam khoom noj tsis raug cai, zoo li thaum lub sij hawm muaj kev npau taws heev.
Feem ntau, nws tuaj yeem pom tau tias Combogliz Prolong yog qhov siv tau ncaj ncees thiab siv tau tshuaj. Txawm li cas los xij, koj yuav tsum xub tham nrog tus kws kho mob txog kev siv nws.
Cov tshuaj zoo sib xws
Qee lub sij hawm tus neeg mob noj cov tshuaj no muaj qhov xav tsis haum. Qhov no tej zaum yuav yog vim kev tsis txaus ntseeg rau nws cov khoom siv, ntau yam contraindications thiab cov zoo li.
Hauv cov xwm txheej zoo li no, tus kws kho mob pib kho qhov kev kho mob kom zoo thiab xaiv lwm txoj kev kho ntxiv uas zoo ib yam li nws qhov kev kho mob. Ntawm cov tshuaj yeeb yaj kiab uas nrov tshaj plaws ntawm cov tshuaj Combogliz Prolong, cia peb xaiv:
- Yanumet - ib hom tshuaj uas muaj metfomin thiab saxagliptin. Qhov txawv tseem ceeb yog tias Janumet tuaj yeem siv nrog kev kho tshuaj insulin, zoo li nrog gamma receptor agonists. Kev ntsuam xyuas cov neeg mob ntshav qab zib tau raug kev txom nyem los ntawm ib hom tshuaj insulin-ywj pheej yog qhov zoo dua. Tus nqi nruab nrab ntawm cov tshuaj Yanumet (100 mg + 50 mg, 56 ntsiav tshuaj) yog 2830 rubles.
- Galvus Met yog ib cov tshuaj uas nws lub ntsiab yog vildagliptin thiab metfomin. Txawm hais tias nws muaj pes tsawg leeg sib txawv ntau dua los ntawm Combogliz Prolong, nws muaj tib lub txiaj ntsig hypoglycemic. Nws tuaj yeem ua ke nrog cov tshuaj insulin, sulfonylurea derivatives, thiab metformin. Tus nqi nruab nrab ntawm 1 pob muaj 30 ntsiav tshuaj (50 mg + 1000 mg) yog 1,540 rubles.
- Xr comboglyce yog lwm qhov zoo hypoglycemic. Nws muaj cov metformin thiab saxagliptin. Qhov ntau npaum li cas ntawm cov tshuaj Comboglize Xr yog txiav txim los ntawm tus kws koom tshwj xeeb, uas siv mus rau hauv tus neeg mob lub xeev ntawm kev noj qab haus huv. Cov tshuaj Combogliz Xr, zoo li Combogliz Prolong, tsis yog siv rau hauv menyuam yaus thiab poj niam cev xeeb tub. Ntawm cov kev coj tsis zoo nrog Combogliz Xr, nws tuaj yeem pom tias lawv zoo ib yam li Combogliz Prolong. Tus nqi nruab nrab ntawm Xr Comboglise (2.5 + 1000mg, 28 ntsiav tshuaj) yog 1650 rubles.
Yog li, Combogliz Prolong yog ib qho tshuaj zoo hauv kev tawm tsam tiv thaiv cov tsos mob ntawm tus mob ntshav qab zib, tshwj xeeb nrog hyperglycemia. Txawm li cas los xij, yog tias koj tsis tuaj yeem yuav nws, xaiv qhov kev xaiv zoo tshaj plaws uas yuav muaj lub txiaj ntsig zoo.
Ntxiv nrog rau Combogliz Prolong, muaj lwm yam tshuaj muaj suab thaj txo. Tus kws tshaj lij yuav qhia ntau ntxiv txog lawv hauv daim yeeb yaj kiab hauv tsab xov xwm no.
