Exenatide: nqe thiab analogues ntawm Bayeta

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Cov tshuaj Baeta, cov tshuaj nquag muaj ntawm uas yog exenatide, yog suav tias yog qhov tshuaj tsis muaj zog hypoglycemic. Lub cuab yeej yog siv rau hauv kev kho mob ntshav qab zib hom 2, tshwj xeeb yog lub nra hnyav dhau rog.

Qhov ua tau zoo ntawm cov tshuaj no cuam tshuam nrog cov tshuab ntawm kev ua ntawm qhov tseem ceeb tshaj plaws, uas txo cov ntshav hauv lub ntsej muag hauv cov ntshav.

Nws tsub kom cov kua dej tso tawm tsis zais, thiab tseem, los ntawm kev ua kom muaj zog ntau zuj zus ntxiv, nws kuj tseem muaj lwm yam qab zib txo cov teebmeem:

  • txhim kho txoj haujlwm ntawm pancreatic beta hlwb, uas ua rau kev nce hauv insulin ntau lawm;
  • txo cov kev zais ntawm glucagon, uas ua rau cov ntsiab lus qabzib hauv nplooj siab;
  • slows tso tawm ntawm lub plab.

Qhov txiaj ntsig tseem ceeb ntawm ib yam khoom xws li exenatide yog tias nws nce tsim tawm ntawm cov tshuaj insulin los ntawm parenchyma, thiab tom qab ntawd nres nws txoj kev tso cia thaum cov ntshav qabzib rov qab mus rau qub.

Yog li, qhov ntxim nyiam ntawm lub xeev qhov hypoglycemic nyob rau hauv tus neeg yog yuav luag xoom.

Tom qab cov tshuaj nkag mus rau hauv tib neeg lub cev, nws tam sim ntawd pib ua thiab ncav lub ncov hauv nws cov kev ua hauv ob teev. Lub sijhawm ntawm exenatide yog 24 teev, yog li qhov kev taw qhia ntawm nws ib hnub ib zaug muab txo qis hauv qab zib thaum lub sijhawm 24 teev.

Tsis tas li ntawd, exenatide txo qhov qab los noj mov uas yog ntshav qab zib, vim li ntawd, nws tau noj tsawg dua, kev ua kom lub plab zom mov qis, thiab nws tsis plam tawm sai li sai tau.

Yog li, xws li cov khoom tsis tsuas yog tswj kom ntshav qab zib cov ntshav, tab sis kuj tseem pab kom tshem tau cov khoom hnyav ntxiv 4-5 kilo.

Cov lus qhia rau kev siv tshuaj

Tsuas yog cov tshuaj uas muaj exenatide yog Baeta. Ntxiv rau cov ntsiab lus tseem ceeb, muaj cov ntsiab lus me me ntawm cov tshuaj ntxiv: sodium acetate trihydrate, mannitol, metacresol, acetic acid thiab dej distilled.

Nws yog tsim los ntawm ob lub tuam txhab Swedish - AstraZeneca thiab Bristol-Myers Squibb Co (BMS). Baeta tsuas muaj ib daim ntawv tsuas tshuaj - 250 mg ampoules uas muaj cov tshuaj ntshiab, rau txhua qhov muaj cov cwj mem tshwj xeeb nrog lub ntim ntawm 1.2 lossis 2.4 ml.

Cov tshuaj yog muag los ntawm cov tshuaj, yog li tsuas yog tus kws kho mob koom nrog tuaj yeem sau nws rau tus neeg mob. Tom qab tus neeg mob kis tau ampoules, nws yuav tsum ua tib zoo nyeem cov lus qhia rau kev siv.

Cov tshuaj no siv ob qho tib si nrog monotherapy thiab nrog kev kho ntxiv ntawm hom 2 mob ntshav qab zib mellitus, thaum nws tsis tuaj yeem tswj hwm qhov theem ntawm glycemia. Cov kev qhia muaj cov npe tshuaj uas koj tuaj yeem sib txuas nrog Bayet cov tshuaj:

  • loj lag luam loj;
  • sulfonylurea derivatives;
  • Thiazolidinedione;
  • kev sib xyaw ntawm thiazolidinedione thiab metformin;
  • kev sib xyaw ua ke ntawm sulfonylurea thiab metformin.

Qhov ntau npaum ntawm cov tshuaj yog 5 mcg ib hnub 1 teev ua ntej noj mov loj. Nws yog txhaj rau hauv qab daim tawv nqaij hauv plab, forearm lossis ncej puab. Yog tias qhov kev kho mob tau ua tiav, tom qab 30 hnub cov koob tshuaj tau nce rau 10 mcg ob zaug ib hnub. Kev sib txuas ntawm cov tshuaj nrog sulfonylurea derivatives, qhov koob tshuaj ntawm tom kawg yuav tsum raug txo kom tsis txhob txo qis hauv qab zib. Thaum lub sij hawm qhia txog kev daws teeb meem, yuav tsum ua raws li cov cai hauv qab no:

  1. cov tshuaj tsis tau noj tom qab noj mov;
  2. Tsis txhob txhaj tshuaj rau hauv plab los yog intramuscularly;
  3. yog tias cov kev daws teeb meem tau hloov xim lossis muaj cov nplais, nws yuav tsum tsis txhob siv;
  4. thaum kho, antibody ntau lawm yog ua tau.

Cov tshuaj yuav tsum nyob rau hauv qhov chaw tsaus tsaus kom deb ntawm cov menyuam yaus ntawm qhov kub ntawm 2-8C.

Txee lub neej yog 2 xyoos, thiab kev daws teeb meem hauv cov xaum xaum yog 30 hnub ntawm qhov kub tsis tshaj 25 degrees.

Cov tshuaj tiv thaiv thiab kev tsis haum

Zoo li lwm yam tshuaj, Cov tshuaj Bayeta muaj qee qhov contraindications:

  • yam 1 mob ntshav qab zib mellitus;
  • ketoacidosis (mob hauv cov metabolism hauv cov metabolism);
  • lub raum tsis ua haujlwm (Tus nqi CC tsawg dua 30 ml / min);
  • ib tug neeg raug rau cov tshuaj ntawm cov tshuaj;
  • pathology ntawm lub plab tsis muaj kem plab;
  • nqa tus menyuam thiab pub niam mis;
  • cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo.

Rau ib qho laj thawj twg, piv txwv li, nrog kev siv tshuaj tsis raug, cov kev mob tshwm sim tuaj yeem tshwm sim:

  1. kev ua xua - urticaria, ua pob rau ntawm daim tawv nqaij, khaus;
  2. kev cuam tshuam ntawm lub plab zom mov - xeev siab thiab ntuav, ua pa ntau dhau, cem quav lossis zawv plab, tsis qab los noj thiab hnyav;
  3. kev cuam tshuam ntawm lub hauv nruab nrab lub paj hlwb - voos, nkees, kiv taub hau nrog ntshav qab zib thiab mob taub hau;
  4. hepatic los yog lub raum tsis ua haujlwm;
  5. ntxiv cov ntshiab creatinine;
  6. hypoglycemic lub xeev, hyperhidrosis, pancreatitis.

Hauv cov xwm txheej zoo li no, tus neeg mob yuav tsum sab laj nrog tus kws kho mob uas yuav kho cov kev kho mob.

Tej zaum koj yuav xav tau kom txo qhov noj ntau npaum li cas lossis tseem tsum tsis xav noj cov tshuaj no.

Tus nqi, tshuaj xyuas thiab analogues tshuaj

Cov tshuaj Baeta tuaj yeem yuav tom chaw muag tshuaj lossis ua ib qho xaj hauv Is Taws Nem. Txij li thaum cov tshuaj ntshuam tuaj, tus nqi rau nws yog, raws li, siab heev. Yog li ntawd, tsis yog txhua tus muaj peev xwm them taus yuav nws.

Tus nqi nws txawv nyob ntawm seb qhov ntim ntawm qhov kev daws teeb meem, cov nqi thauj khoom thiab cov npoo ntawm cov muag khoom:

  • 1.2 ml syringe cwj mem - los ntawm 4246 txog 6398 rubles Lavxias;
  • 2.4 ml koob txhaj tshuaj - los ntawm 5301 txog 8430 Lavxias rubles.

Coob tus neeg mob uas tau txais Bayet cov tshuaj tau txaus siab rau cov tshuaj no. Firstly, nws tsuas yog siv ib zaug ib hnub, thiab thib ob, nws yeej txo cov piam thaj thiab lub cev qhov hnyav hauv cov neeg rog.

Txawm li cas los xij, tom qab tso tawm cov tshuaj, cov tuam ntxhab ua txoj kev tshawb fawb los ntawm kev lag luam hauv kev xaiv cov neeg mob xaiv. Cov txiaj ntsig ntawm txoj kev tshawb pom pom tias feem coob ntawm cov neeg siv tshuaj muaj cov kev tsis zoo hauv qab no:

  1. Flatulence, cem quav, nyob rau hauv tsis tshua muaj tshwm sim - mob pancreatitis.
  2. Urticaria, pruritus, alopecia (plaub hau poob), mob taub hau, mob pob sawv maculopapular.
  3. Lub cev qhuav dej vim ntuav, tsis tuaj yeem poob qhov hnyav.
  4. Qaug zog, tsis muaj los yog cuam tshuam ntawm saj.
  5. Lub raum khiav tsis zoo, ua rau qib creatinine siab, lub raum tsis ua haujlwm lossis nws qhov kev ua tsis zoo.
  6. Qee zaum cov tshuaj tiv thaiv anaphylactic.

Raws li rau cov analogues uas muaj tib lub tshuaj nquag, lawv tsis muaj nyob. Hauv Lavxias pharmacological ua lag luam, koj tuaj yeem nrhiav cov tshuaj uas muaj cov tshuaj zoo sib xws xwb. Cov no suav nrog incretin mimetics - Viktoza thiab Januvius. Cov lus qhia ntxaws ntxiv txog lawv tuaj yeem nrhiav hauv Is Taws Nem lossis nug koj tus kws kho mob.

Thiab yog li, exenatide, uas muaj nyob hauv kev npaj Bayeta, txo qis ntshav qabzib hauv cov ntshav thiab tsis ua rau cov ntshav qis. Tus kws kho mob sau cov tshuaj no, tshem tawm qhov ua tau contraindications, phiv tshuaj thiab coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob. Thov cov kev kho kom zoo, koj tuaj yeem tshem tawm cov tsos mob ntshav qab zib kom ntev. Noj qab nyob zoo!

Yuav kom tau txais cov nyiaj them tuaj ncua, kev kho mob ntshav qab zib hom 2 yuav tsum muaj txhij txhua. Yuav kho tus kab mob li cas yuav qhia tus kws tshaj lij hauv video hauv kab lus no.

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