Tricyclic antidepressant nrog antihistamine, anticholinergic kev txiav txim siab. Nws yog siv los kho tsis tsuas yog muaj kev nyuaj siab xwb, tab sis kuj somatoform neurosis nrog kev puas tsuaj rau lub plab zom mov, txoj hlab ntsws thiab lwm yam khoom hauv nruab nrog cev.
Npe
Lub npe thoob ntiaj teb: Amitriptyline.
ATX
Cov tshuaj tiv thaiv kev ntxhov siab, N06A A09.
Tso cov ntawv thiab cov nyob ua ke
Ntsiav tshuaj
25 mg ntawm yam muaj sia nyob hauv ib ntsiav tshuaj muaj nyob rau hauv pob ntawm 20, 50, 100 pcs.
Amitriptyline yog siv los kho tsis tsuas yog muaj kev ntxhov siab, tab sis kuj tseem somatoform neuroses.
Daim ntawv tsis tso tawm
Ib qho tshuaj tov ntawm 10 mg / ml 10 ampoules ntawm 2 ml rau kev txhaj tshuaj intramuscular. Dragees rau cov menyuam yaus ntawm 10 thiab 25 mg, ib pob ntawm 50 pcs.
Mechanism ntawm kev ua
Tricyclic compound. Nws cov txiaj ntsig yog pom tau vim yog thaiv qhov rov cuam tshuam ntawm neurotransmitters - adrenaline, norepinephrine, serotonin, dopamine. Raws li qhov tshwm sim, cov tshuaj yeeb yaj kiab tau teev nyob rau hauv synaptic cleft ntev dua thiab ntau zuj zus. Lub siab hloov kho, lub hlwb kev ua ub no sib zog.
Nws muaj cov tshuaj anticholinergic, antihistamine nyhuv, vim tias nws yog siv los ua sedative, tiv thaiv kev ntxhov siab thiab pw tsaug zog hauv ncoo. Nws yog timoanaleptic, Muaj qhov cuam tshuam tsis zoo lub siab uas muaj qhov tshwj xeeb ntawm ob leeg zoo siab thiab inhibition. Stimulating thiab inhibitory cuam tshuam rau cov leeg poob siab yog koob tshuaj.
Cov Tshuaj Pharmacokinetics
Raug rho tawm los ntawm lub plab zom mov. Qhov siab tshaj plaws tau tiav 2-12 teev tom qab kev tswj hwm. Khoom noj tsis cuam tshuam rau kev nqus ntawm cov tshuaj. Feem ntau ntawm nws - 92-95% khi rau cov protein ntshav.
Nkag tau los ntawm cov ntshav-hlwb thiab hematoplacental teeb meem, zoo li mus rau hauv niam cov kua mis.
Kev mob plab zom mov tshwm sim hauv lub siab, tawm hauv lub raum. Qhov kev tshem tawm ib nrab-lub neej yog 40-75 teev.
Dab tsi xav tau rau
Hais txog psychoanaleptics. Nws yog siv rau hauv kev kho mob kev nyuab siab ntawm txhua txoj kev etiology, feem ntau endogenous, nyob rau hauv uas qhov sib npaug ntawm cov neurotransmitters tsis muaj zog. Nws yog siv rau asthenovegetative syndrome, schizophrenic psychosis, kev puas siab puas ntsws, nrog los ntawm kev ntxhov siab, insomnia.
Amitriptyline yog siv rau kev mob hlwb nrog rau kev ntxhov siab.
Raws li cov cuab yeej nrog kev txiav txim siab anticholinergic, relieves cramps nyob rau hauv chim siab plob tsis so tswj syndrome, hyperactive neurogenic zais zis, enuresis. Nws muaj cov nyhuv anti-inflammatory vim cov nyhuv antihistamine.
Txo cov acidity ntawm lub plab, nthuav tawm M-anticholinergic thiab H1-histamine-thaiv cov nyhuv, uas tso cai rau nws siv rau lub plab mob thiab mob plab duodenal (raws li kev nthuav qhia ntawm somatoform neurosis).
Nws yog siv rau kev mob ntsws asthma - nws muaj cov nyhuv ua kom mob hlwb thiab nthuav cov ntsws me, txo lawv cov zais kev hnoos qeev.
Nws cov nyhuv ua kom loog kuj tseem qhia rau fibromyalgia, mob taub hau (mob taub hau). Tshem tawm txoj kev ntxhov siab psychomotor, ntxhov siab, insomnia. Cov cuab yeej ntawm cov tshuaj tiv thaiv kab mob los txo qis ntau lawm ntawm kev nyuaj siab hormone - cortisol - tau teeb tsa, tiv thaiv lub hlwb hlwb los ntawm kev tuag.
Nws raug siv tshuaj tiv thaiv kab mob rau kev noj zaub mov tsis nco qab - tsis nco qab, mob plab, thiab rau neurocirculatory dystonia.
Vim tias qhov sib npaug ntawm qhov ua rau mob sedative thiab txhawb kev ua kom zoo, Amitriptyline tsis ua rau cov tsos mob tsim khoom - pom kev tsis meej, tsis pom kev, mania, hypomania - tsis zoo li Imipramine.
Amitriptyline pab tshem tawm insomnia.
Cov Yuav Tsum Muaj
Cov tshuaj yog contraindicated nyob rau hauv kev mob siab rau nws, mob loj atherosclerosis, mob hlab plawv, mob plawv tsis ua haujlwm, mob siab rau hepatic (suav nrog nrog porphyria), manic psychoses, kev kho mob nrog monoamine oxidase inhibitors (tsis pub dhau 2 lub lis piam tom qab kev siv tshuaj tag).
Koj tsis tuaj yeem siv cov tshuaj no rau cov poj niam cev xeeb tub thiab cov menyuam hnub nyoog qis dua 16 xyoo.
Yuav noj li cas
Kev noj tshuaj ntau yog txiav txim siab nyob ntawm kab mob pathology thiab hnub nyoog ntawm cov neeg mob.
Cov neeg laus ntau npaum li cas
Txhawm rau kho kev nyuaj siab, qhov koob tshuaj 25 mg yog siv, nyob rau tom ntej 5-6 hnub nws tau nce ntxiv kom txog thaum kho tau zoo.
Nrog kev kho mob hauv tsev, qhov siab tshaj plaws yog 200 mg.
Tom qab kev txhim kho, qhov koob tshuaj yog maj mam txo kom qhov tsawg kawg nkaus pib siv, feem ntau 50-100 mg ib hnub. Qhov ntau zaus ntawm kev tswj hwm yog 2-3 zaug hauv ib hnub lossis ib zaug thaum hmo ntuj, vim tias muaj cov ntsiav tshuaj tsaug zog.
Qhov txiaj ntsig ntawm kev noj tshuaj yog 2-3 zaug hauv ib hnub lossis ib zaug thaum tsaus ntuj.
Yog tias hnub tsis tuaj kawm ntawv, cov kev nkag mus tom ntej yog ua tsis tiav. Lub sij hawm ntawm kev kho mob yog 3-6 lub hlis. Hauv cov neeg laus dua, kev kho mob pib nrog ib koob tshuaj 25 mg, nce nce zuj zus, txij li cov thauj khoom ntawm cov hlab plawv yog ua tau.
Kev noj tshuaj rau me nyuam
Cov menyuam yaus 6-12 xyoo 10-30 mg ib hnub lossis suav txog qhov hnyav ntawm 1-5 mg / kg ib hnub.
Noj cov tshuaj rau ntshav qab zib
Vim tias nce qhov kev txiav txim ntawm adrenaline, ib qho tshuaj tiv thaiv kab mob nce siab ntxiv ntawm cov piam thaj hauv cov ntshav, yog li ntawd, hauv cov ntshav qab zib mellitus, cov koob tshuaj tau nce ntxiv kom zoo, tswj qhov ntsuas no.
Ntau npaum li cas yog siv tau
Nws muab cia rau hauv lub cev rau 80-150 teev. Tom qab lub sijhawm no, nws twb tshwm lawm.
Yuav ua li cas rho tawm amitriptyline
Kev tshem tawm cov tsos mob yog tshwm sim los ntawm kev txob taus, insomnia, mob taub hau, asthenia. Yog li, kev tshem tawm ntawm cov tshuaj yuav tsum tshwm sim maj mam muab - cov koob tshuaj yog txo qis.
Kev tshem tawm tus mob yog pom muaj mob taub hau.
Sab sij huam
Hauv ntau lub plab hnyuv siab raum, cov kev mob tshwm sim ntawm lawv tus kheej sib xws.
Kev kho mob txoj hnyuv
Cov nyhuv anticholinergic yog nrog kev poob qis hauv kev ua kom muaj salivation, lub qhov ncauj qhuav, qhov txo qis hauv lub plab acidity, xeev siab, ntuav, qeeb ntawm lub cev muaj zog, thiab kub siab. Tej zaum qhov kev txhim kho ntawm cov kab mob tuag tes tuag taw, cem quav, raws plab.
Hematopoietic plab hnyuv siab raum
Txo cov lej ntawm leukocytes thiab platelets, eosinophilia.
Los ntawm ib sab ntawm cov metabolism
Qhov hnyav nce, ceg nrawm, gynecomastia thiab lwm yam cuam tshuam txog endocrine, nce ntshav qab zib.
Nruab nrab hauv lub paj hlwb
Kiv taub hau, tsis muaj zog, orthostatic cev qhuav dej, tinnitus, npau suav phem. Rau cov teeb meem nrog cov thyroid caj pas (hypothyroidism), noj cov tshuaj ua rau lub xeev manic lossis hypomania. Tej zaum muaj kev nyuaj siab ntau ntxiv nrog ib tug nyiam nws tus kheej. Nrog qaug dab peg, nws tuaj yeem ua kom nce siab ntxiv ntawm qaug dab peg.
Rau cov teeb meem nrog cov thyroid caj pas (hypothyroidism), noj cov tshuaj ua rau lub xeev manic.
Kev ua xua
Nrog rau kev nkag siab ntau dhau los, nws ua rau tawv nqaij ua pob khaus, khaus, qee zaum Quincke's edema, tshuaj tiv thaiv anaphylactoid, ua tsis taus pa.
Cov lus qhia tshwj xeeb
Kev siv cov tshuaj hauv ntau yam mob yuav tsum ceev faj.
Siv thaum cev xeeb tub thiab lactation
Nws tuaj yeem siv tsis tau thaum cev xeeb tub thiab lactation. Muaj peev xwm ua rau muaj kev phom sij los ntawm cov tshuaj lom rau hauv lub hlwb ntawm kev tsim tus me nyuam hauv plab, cov me nyuam yug tshiab.
Siv rau lub sijhawm qub
Lawv siv nrog ceev faj, vim tias hauv hnub nyoog laus muaj kev pheej hmoo ntawm kev mob ntshav siab thiab kev tawm tsam ntawm myocardial infarction.
Nrog lub siab ua haujlwm tsis zoo
Kev kho mob yog ua tiav nyob rau hauv kev tswj hwm ntawm ACT, ALT, ncaj qha bilirubin, alkaline phosphatase, transglutaminase qib. Yog tias tsim nyog, hepatoprotectors siv.
Yog tias daim siab ua haujlwm tsis zoo, kev kho Amitriptyline yog ua raws li kev tswj hwm theem ntawm AcT, Alt.
Nrog lub raum tsis ua haujlwm
Creatinine thiab urea hauv cov ntshav raug saib xyuas.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Hypnotic nyhuv txo qis.
Cawv tau zoo
Txhim kho lub tshuaj lom ntawm ethanol. Tsis sib xws nrog cawv.
Noj ntau dhau
Nws ua tau nws tus kheej xws li pom kev tsis hnov qab, ploj ntawm txoj kev tsis nco qab, kev txhim kho ntawm cov neeg tuag tes tuag taw, kev qaug dab peg, txo lub cev kub, tawv nqaij.
Thaum raug lom, ua rau yus hnovqab lossis tuag taus.
Nws yog tsim nyog pais plab lavage, yuam diuresis, hemodialysis.
Kev cuam tshuam nrog lwm yam tshuaj
Nws raug txwv tsis pub siv tshuaj tiv thaiv kab mob nrog MAO inhibitors (Furazolidone, St. John lub wort, thiab lwm yam), tricyclic antidepressants (Clomipramine, Imipramine), sympatholytics - Reserpine, SSRIs (Clozapine, thiab lwm yam) - serotonin syndrome yog tau.
Kev siv tshuaj tiv thaiv kab mob nrog MAO inhibitors, tricyclic antidepressants, sympatholytics yog txwv tsis pub.
Txhim kho cov nyhuv inhibitory rau lub hauv nruab nrab cov hlab ntsha ntawm haus cawv, tshuaj tiv thaiv kab mob (Atarax, Triftazin), barbiturates, tshuaj rau Parkinson tus kab mob. Txo cov mob hnyav npaum li cas ntawm cov nyhuv antihypertensive ntawm beta-blockers thiab lwm yam tshuaj rau kub siab. Txo cov haujlwm ntawm cov tshuaj anticonvulsants.
Barbiturates thiab carbamazepine txo cov tshuaj ntawm cov tshuaj, nrawm nws cov kev nthuav dav, cimetidine, ntawm qhov tsis sib thooj, ua rau nws muaj kev tuav hauv cov ntshav. Kev siv yooj yim nrog Sucralfate txo kev nqus.
Thaum ua ke nrog cov thyroid hormones, ib qho kev nce ntawm arrhythmia thiab psychomotor ntxhov siab, qhov ua txhaum ntawm lub plawv atherosclerosis, thiab tachycardia tau sau tseg.
Kev sib raug zoo nrog Grandaxin yog siv los kho cov tsis tsaug zog, tsaug zog ntau dua. Nrog anticholinergic blockers - kev txhim kho ntawm tuag tes tuag taw kev khaus.
Cov qauv ntawm amitriptyline
Cov tshuaj yeeb dej caw yog tsim los ntawm ntau lub tuam txhab (Nycomed, Grindeks, Ozone, Zentiva) raws li ib feem ntawm kev npaj analog ntawm Anafranil, Saroten, Doxepin, Clofranil, thiab lwm yam.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Tso tawm los ntawm kev kho mob.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Hauv qee lub tsev muag tshuaj, cov tshuaj tau muag tom khw muag tshuaj.
Nqi
Tus nqi ntawm pob 50 ntim yog 21-30 rubles. 10 ampoules ntawm 2 ml, 10 mg / ml raug nqi 52 rubles.
Cov lus thiab cov kev mob uas khaws cia ntawm cov tshuaj Amitriptyline
Khaws rau hauv qhov chaw qhuav qhuav nrog cua kub tsis tshaj 25 ° C. Khaws tsis ncav cuag ntawm cov menyuam yaus. Txee lub neej yog 3 xyoos.
Kev txheeb xyuas txog amitriptyline
Kev tshuaj xyuas ntawm ob tus kws tshaj lij thiab lawv cov neeg mob txog cov tshuaj feem ntau zoo.
Neeg puas hlwb
Vlasov V.A.
Cov tshuaj no pheej yig thiab ua tau zoo. Ntau lub phiv tsis tuaj yeem zam txawm tias muaj kev tshawb fawb tau ntau xyoo lawm. Ua pov thawj los ntawm lub sijhawm thiab kev coj ua. Txawm li cas los xij, nws tsis haum rau txhua tus neeg mob, qee qhov yuav ua rau muaj kev xav tua tus kheej, yog li ntawd nws raug nquahu kom nqa tawm kev kho mob yam tsis haum.
Andreev A.L.
Nws pom tias nws cov hauj lwm zoo tsis yog hauv kev nyuaj siab xwb, tab sis kuj nyob hauv psychosomatic pathology - cov neeg mob lub plab, mob hawb pob, mob plab hnyuv rov ua haujlwm thaum noj. Txawm li cas los xij, kev quav yeeb tshuaj muaj peev xwm ua tau.
Cov neeg mob
Michael K.
Cov tshuaj tiv thaiv kab mob no pab rau qhov mob. Kuv tau mob los ntawm chim siab plob tsis so tswj syndrome. Cov tshuaj no tseem txhim kho mus ob peb vas.
Dmitry Sh.
Muaj lub plab mob rwj, qhov kev ntxhov siab ntawm kev ua haujlwm ua rau nws qhov tsos. Tus kws kho mob plab zom mov tau qhia cov tshuaj no. Los ntawm cov kev mob tshwm sim, Kuv pom tias tsaug zog thiab poob qis me ntsis ntawm libido thiab potency.
