Yuav kom tau txais kev them nyiaj ncua ntev rau cov ntshav qab zib, ntau yam tshuaj tua kab mob insulin ntau. Insulin Lizpro yog qhov tseem niaj hnub thiab muaj kev tiv thaiv ultra-luv-yeeb tshuaj uas tswj cov metabolism hauv qabzib.
Cov cuab yeej no tuaj yeem qhia tau rau kev siv los ntawm cov ntshav qab zib ntawm cov hnub nyoog sib txawv. Insulin Lizpro tuaj yeem tsim kho rau cov menyuam yaus muaj ntshav qab zib.
Piv nrog luv luv ua yeeb yam insulin, Insulin Lizpro ua tau nrawm dua, vim nws qhov nqus tau siab.
Pharmacological kev ua thiab kev ntsuas
Lizpro biphasic insulin yog tsim los siv cov thev naus laus zis DNA thev naus laus zis. Muaj kev cuam tshuam nrog kev txais ntawm cytoplasmic membrane ntawm cov hlwb, ib qho insulin-receptor complex tau tsim, uas tsim kho cov txheej txheem sab hauv cov hlwb, suav nrog kev sib txuas ntawm cov enzymes tseem ceeb.
Qhov kev txo qis hauv cov ntshav qab zib cov ntsiab lus tau piav qhia los ntawm qhov nce ntxiv hauv nws qhov kev ua haujlwm siab, nrog rau kev nce ntxiv thiab nqus los ntawm cov hlwb. Cov piam thaj tuaj yeem txo qis vim qhov qis dua ntawm nws tus kheej los ntawm daim siab los yog los ntawm kev ua rau glycogenogenesis thiab lipogenesis.
Lyspro insulin yog DNA tso tawm qhov sib txawv ntawm qhov rov qab sib txig ntawm lysine thiab proline amino acid seem ntawm 28th thiab 29 txoj haujlwm ntawm insulin B saw. Cov tshuaj muaj 75% cov tshuaj tiv thaiv kev ncua thiab 25% insulin lispro.
Cov tshuaj muaj cov teebmeem anabolic thiab kev tswj ntawm cov metabolism hauv qabzib. Hauv cov ntaub so ntswg (tshwj tsis yog lub hlwb cov ntaub so ntswg), kev hloov pauv ntawm cov piam thaj thiab amino acids mus rau lub cell ceev, uas ua rau muaj kev tsim cov glycogen los ntawm cov piam thaj hauv lub siab.
Cov tshuaj no txawv ntawm cov tshuaj insulins hauv kev ua haujlwm sai ntawm lub cev thiab qhov tsawg kawg ntawm kev phiv.
Cov tshuaj pib ua yeeb yam tom qab 15 feeb, uas tau piav qhia los ntawm kev nqus siab. Yog li, nws tuaj yeem siv sijhawm li 10-15 feeb ua ntej noj mov. Cov tshuaj insulin tsis tu ncua yog muab tsis pub tsawg tshaj ib nrab ib teev.
Tus nqi ntawm kev nqus tau cuam tshuam los ntawm qhov chaw txhaj tshuaj thiab lwm yam. Lub ncov ntawm kev nqis tes ua tau pom nyob hauv thaj tsam 0.5 - 2.5 teev. Cov tshuaj Insulin Lizpro ua rau plaub teev.
Lizpro insulin hloov yog qhia rau cov neeg uas muaj ntshav qab zib hom mob ntshav qab zib mellitus, tshwj xeeb tshaj yog hais tias tsis nkag rau lwm yam tshuaj insulin. Ntxiv rau qhov no, nws yog siv nyob rau hauv xws li:
- postprandial hyperglycemia,
- subcutaneous insulin kuj nyob rau hauv daim ntawv mob.
Cov tshuaj tseem yog siv rau hom 2 mob ntshav qab zib mellitus nrog cov tshuaj tiv thaiv hypoglycemic qhov ncauj tshuaj.
Lizpro insulin tuaj yeem kho rau kev cuam tshuam cov pathologies ib nrab.
Cov lus qhia rau kev siv tshuaj
Cov lus qhia rau kev siv tshuaj qhia pom tias koob tshuaj yuav tsum tau muab xam raws theem ntawm glycemia. Yog tias tsim nyog, cov tshuaj yog muab ua ke nrog cov tshuaj insulins ntev, lossis nrog cov tshuaj sulfonylurea.
Kev txhaj tshuaj yog ua rau subcutaneously nyob rau hauv cov chaw ntawm tus neeg mob lub cev:
- lub duav
- plab
- pob tw
- xub pwg.
Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom lawv tsis siv ntau dua 1 zaug hauv ib hlis. Tsis txhob muab kev txhaj tshuaj rau hauv cov chaw uas muaj cov hlab ntshav nyob ze heev.
Cov neeg muaj mob hepatic thiab lub raum tsis txaus tej zaum yuav muaj cov kab mob insulin siab thiab muaj qhov xav tau tsawg. Qhov no yuav tsum tau saib xyuas tas li ntawm glycemia thiab kev kho sij hawm kom deb ntawm cov ntau npaum li cas ntawm cov tshuaj.
Lub Humalog syringe mem (Humapen) tam sim no muaj; nws yooj yim dua rau siv. Muaj ntau txoj kev xaiv rau chav ntsuas no, qhov ntsuas me tshaj yog kawm tiav ntawm 0.5 units.
Xws li txhais tau tias yog muag:
- "Humapen Luxura". Cov khoom lag luam muaj lub vijtsam hluav taws xob uas qhia pom lub sijhawm ntawm kev txhaj tshuaj zaum kawg thiab qhov luaj li cas ntawm cov tshuaj tso cai.
- Humapen Ergo. Cwj mem nrog tus nqi zoo tshaj plaws rau nyiaj.
Cov tshuaj Insulin Lizpro, thiab Humapen koob txhaj tshuaj yog muag ntawm tus nqi tsim nyog thiab muaj kev tshuaj xyuas zoo.
Sab nraud thiab contraindications
Cov tshuaj Insulin Lizpro muaj cov nram qab no contraindications:
- ib tug neeg intolerance,
- ntshav qab zib,
- tshuaj insulinoma.
Intolerance qhia hauv kev tsis haum tshuaj:
- urticaria
- angioedema nrog kub taub hau,
- txog siav
- txos cov ntshav siab.
Cov tsos mob ntawm kev mob ntshav qab zib qhia tias qhov ntau npaum ntawm cov tshuaj yog xaiv tsis raug lossis qhov yuam kev yog qhov xaiv tsis raug ntawm qhov chaw lossis txoj kev txhaj tshuaj. Daim foos ntawm cov tshuaj insulin no yuav tsum tsis txhob txhaj tshuaj, tab sis subcutaneously.
Tsis tshua muaj neeg mob, hypoglycemic coma yuav tshwm sim.
Lipodystrophy yog tsim yog tias qhov txhaj tshuaj subcutaneous tau ua tsis raug.
Cov tsos mob hauv qab no ntawm kev siv tshuaj ntau dhau ntawm cov tshuaj yog qhov txawv:
- nkees
- hws
- lub plawv dhia ceev
- kev tshaib kev nqhis
- ntxhov siab
- paresthesia nyob rau hauv lub qhov ncauj,
- pallor ntawm daim tawv nqaij,
- mob taub hau
- tshee
- ntuav
- teeb meem pw tsaug zog
- insomnia
- Kev Nyuaj Siab
- txob taus
- coj tus cwj pwm tsis zoo
- kev pom thiab hais lus tsis meej,
- glycemic coma
- cramps.
Yog tias tus neeg nco qab, ces dextrose hauv sab hauv yog qhia. Glucagon tuaj yeem muab tshuaj rau hauv ncau, subcutaneously thiab intramuscularly. Thaum hypoglycemic coma yog tsim, txog 40 ml ntawm 40% dextrose kev daws teeb meem yog muab tshuaj rau. Kev kho mob txuas ntxiv mus kom txog rau thaum tus neeg mob tawm ntawm qhov tsis nco qab.
Feem ntau, tib neeg zam cov tshuaj Insulin Lizpro yam tsis muaj kev cuam tshuam zoo.
Qee qhov xwm txheej, kev tos txais tuaj yeem yuav txawv ntawm kev ua haujlwm qis.
Cov yam ntxwv ntawm kev cuam tshuam nrog lwm yam tshuaj
Lizpro insulin yuav tsum tsis txhob siv nrog lwm cov tshuaj ntsuab. Kev tiv thaiv hypoglycemic ntawm cov tshuaj kho kom zoo:
- MAO inhibitors
- androgens
- ACE
- mebendazole,
- sulfonamides,
- carbonic anhydrase,
- theophylline
- anabolic tshuaj yuam
- lithium npaj
- NSAIDs
- chloroquinine,
- bromocriptine
- tetracyclines
- ketoconazole,
- clofibrate
- fenfluramine,
- quinine
- cyclophosphamide
- ethanol
- pyridoxine
- quinidine.
Cov nyhuv hypoglycemic yog tsis muaj zog los ntawm:
- estrogens
- glucagon,
- heparin
- somatropin,
- danazol
- GKS,
- tshuaj tiv thaiv qhov ncauj
- tshuaj kho mob
- cov thyroid hormones
- calcium antagonists
- sympathomimetics
- morphine
- clonidine
- tricyclic cov tshuaj tiv thaiv kab mob,
- diazoxide
- tshuaj maj
- nicotine
- phenytoin
- BMKK.
Qhov kev ua no tuaj yeem ua rau ob leeg tsis muaj zog thiab txhim kho:
- Octreotide
- beta blockers,
- reserpine
- pentamidine.
Cov Ntaub Ntawv Tshwj Xeeb
Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam nruj ntawm txoj hauv kev ntawm kev coj tshuaj uas tsim los ntawm kws kho mob.
Thaum hloov mus rau cov neeg mob rau Insulin Lizpro nrog kev siv tshuaj insulin sai sai, yuav tsum tau txhaj tshuaj kom haum. Thaum cov koob tshuaj txhua hnub ntawm ib tus neeg siab dua 100 units, qhov hloov ntawm ib hom tshuaj insulin mus rau lwm tus yog ua tiav nyob hauv cov chaw nyob ruaj khov.
Qhov xav tau rau kev noj tshuaj ntxiv ntawm cov insulin tuaj yeem tsim kho vim:
- kis kab mob
- kev ntxhov siab
- nce tus nqi ntawm cov carbohydrates nyob rau hauv cov zaub mov,
- thaum noj tshuaj nrog hyperglycemic kev ua si: cov thyroid hormones, thiazide diuretics thiab lwm yam tshuaj.
Txo xav tau cov tshuaj insulin tuaj yeem ua nrog daim siab lossis lub raum tsis ua haujlwm, ua haujlwm lub cev, lossis thaum noj tshuaj nrog hypoglycemic kev ua si. Xws li cov nyiaj:
- tsis-xaiv beta-blockers,
- MAO inhibitors
- sulfonamides.
Txoj kev pheej hmoo ntawm hypoglycemia txo ib tus neeg lub peev xwm los tsav tsheb thiab tswj ntau cov txheej txheem.
Cov neeg mob ntshav qab zib tuaj yeem tiv thaiv qog ntshav qab zib tsawg los ntawm kev noj cov piam thaj lossis zaub mov uas muaj cov khoom noj ua ke hauv carbohydrates.
Tus kws kho mob uas tuaj koom yuav tsum paub txog qhov tseeb ntawm cov ntshav qab zib, txij li txoj kev noj tshuaj yuav tsum tau kho.
Cov nqi thiab cov qauv ntawm cov tshuaj
Tam sim no, Insulin Lizpro raug muag ntawm tus nqi ntawm 1800 txog 2000 rubles.
Cov tshuaj ntawm cov tshuaj Insulin Lizpro yog:
- Cov tshuaj insulin Humalog Mix 25.
- Tshuaj Insulin Humalog Mix 50.
Lwm qhov txawv ntawm cov insulin exogenous yog ob-theem insulin aspar.
Nws yog ib qho tseem ceeb kom nco ntsoov tias koj siv tsis tau cov tshuaj Insulin Lizpro vim yog kev txiav txim siab ywj pheej. Cov tshuaj yuav tsum tau noj tsuas yog tom qab nws teem caij los ntawm tus kws kho mob tuaj koom. Dosages tseem yog lub luag haujlwm ntawm tus kws kho mob.
Cov lus piav qhia thiab cov cai tswjfwm kev siv Lizpro insulin yog muaj nyob rau hauv video hauv tsab xov xwm no.
