Nrog kev nce qib ntawm cov ntshav qab zib tsis-insulin, cov neeg mob tsis tuaj yeem tswj tau theem ntawm glycemia siv cov khoom noj tshwj xeeb thiab kev tawm dag zog. Onglisa yog suab thaj txo cov tshuaj uas siv rau hauv cov xwm txheej zoo li no txhawm rau txhawm rau ua kom cov ntshav qabzib nyob hauv cov ntshav.
Zoo li ib yam tshuaj twg, Onglisa muaj qee qhov sib txuam, cov kev coj ua tsis zoo, nrog rau cov yam ntxwv ntawm kev siv. Yog li, ua ntej siv cov tshuaj, koj yuav tsum nrhiav kom paub cov ncauj lus kom ntxaws txog nws.
Onglisa (hauv lat. Onglyza) yog ib hom tshuaj muaj npe uas siv thoob ntiaj teb ntshav qab zib hom 2. Lub npe thoob ntiaj teb nonproprietary (INN) ntawm cov tshuaj yog Saxagliptin.
Cov chaw tsim tshuaj txog tus sawv cev hypoglycemic yog lub tuam txhab American pharmacological Bristol-Myers Squibb. Lub ntsiab tivthaiv - saxagliptin raug suav hais tias yog ib qho ntawm cov kev xaiv muaj zog tshaj plaws thim rov qab cov kev sib tw ntawm dipeptidyl peptidase-4 (DPP-4). Qhov no txhais tau hais tias thaum cov tshuaj noj ntawm qhov ncauj, cov tshuaj yeeb tshuaj tseem ceeb tshaj qhov kev txiav txim ntawm DPP-4 enzyme thaum nruab hnub.
Ntxiv rau saxagliptin, Ongliz ntsiav tshuaj muaj ib qho me me ntawm cov khoom siv ntxiv - lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, macrogol, talc, titanium dioxide, magnesium stearate thiab qee yam. Ua raws li daim ntawv tso tawm, ib ntsiav tshuaj ntawm cov tshuaj yuav muaj 2.5 lossis 5 mg ntawm cov tshuaj nquag.
Tus neeg sawv cev rau cov kab mob vwm Onglisa ua li cas tom qab nws nkag mus rau hauv tib neeg lub cev? Saxagliptin nrawm rau hauv lub plab zom mov, nws cov ntsiab lus siab tshaj plaws nyob rau hauv cov ntshav ntshav tau pom 2-4 teev tom qab noj. Cov tshuaj muaj cov nyhuv zoo li no:
- Ua kom nce qib ntawm ISU thiab GLP-1.
- Txo cov ntsiab lus ntawm glucagon, thiab tseem txhim kho cov tshuaj tiv thaiv ntawm cov hlwb hlwb, uas ua kom muaj kev nce qib hauv C-peptides thiab insulin.
- Nws provokes tso tawm ntawm lub suab thaj txo qis hormone los ntawm beta hlwb nyob hauv lub txiav.
- Tiv thaiv kev tso tawm ntawm glucagon los ntawm alpha cells ntawm islets ntawm Langerhans.
Los ntawm kev ua rau cov txheej txheem saum toj no hauv lub cev, cov tshuaj Onglis txhim kho cov txiaj ntsig ntawm glycated hemoglobin (HbA1c), cov ntshav qabzib nyob rau ntawm lub plab thiab tom qab noj mov. Cov kws kho mob tuaj yeem sau tshuaj rau hauv cov tshuaj sib xyaw nrog lwm cov kab mob hypoglycemic (metformin, glibenclamide lossis thiazolidinediones).
Cov tshuaj ua kom nquag pliag yog tawm ntawm lub cev hauv daim ntawv tsis hloov pauv thiab hauv daim ntawv ntawm kev siv tshuaj tiv thaiv nrog cov kua tsib thiab tso zis.
Qhov nruab nrab, lub raum tshem tawm ntawm saxagliptin yog 230 ml ib feeb, thiab qhov siab glomerular pom (GFR) yog 120 ml ib feeb.
Cov lus qhia rau kev siv ntsiav tshuaj
Ua ntej yuav noj cov tshuaj, tus neeg mob yuav tsum tau sab laj nrog nws tus kws saib xyuas kev noj qab haus huv uas yuav txiav txim seb ib tug neeg noj npaum li cas raws li cov ntshav qab zib cov ntshav qab zib. Thaum muas cov tshuaj Onglisa, cov lus qhia rau kev siv yuav tsum ua tib zoo nyeem thiab yog tias koj muaj lus nug nug lawv tus kws kho mob.
Cov ntsiav tshuaj tau siv tsis hais lub sijhawm noj mov, ntxuav nrog lub khob dej. Yog tias cov tshuaj tshwm sim raws li kev kho mob monotherapy, ces cov tshuaj txhua hnub yog 5 mg. Yog tias tus kws kho mob tau sau ntawv rau kev kho mob sib xyaw, tom qab ntawd nws raug tso cai siv Ongliza 5 mg ib hnub nrog metformin, thiazolidinediones thiab lwm yam tshuaj hypoglycemic.
Ua ke nrog Onglisa thiab metformin, koj yuav tsum tau ua raws li thawj cov koob tshuaj 5 mg thiab 500 mg, ntsig txog. Nws yog nruj me ntsis txwv tsis pub noj ob zaug hauv rooj plaub thaum tus neeg mob tsis nco qab noj cov tshuaj kom raws sijhawm. Thaum nws nco qab txog qhov no, nws yuav tsum tau haus ib ntsiav tshuaj.
Tshwj xeeb tshaj yog cov neeg mob nyob raum tsis ua hauj lwm. Nrog rau daim ntawv me ntawm lub raum tsis ua haujlwm, nws tsis tas yuav kho qhov tshuaj ntawm cov tshuaj. Hauv cov neeg mob uas mob raum lossis hnyav lub raum tsis ua haujlwm, nrog rau cov neeg mob hemodialysis, noj tshuaj rau txhua hnub yog 2.5 mg. Ntxiv rau, thaum siv cov tshuaj CYP 3A4 / 5 muaj zog heev, qhov muab tshuaj ntawm Onglis yuav tsum muaj tsawg heev (2.5 mg).
Cov chaw tsim khoom lag luam qhia txog lub ntim cov hnub tas sij hawm, uas feem ntau 3 xyoos. Cov tshuaj tau muab tso kom deb ntawm cov menyuam yaus ntawm qhov kub ntawm tsis tshaj 30 degrees.
Cov tshuaj tiv thaiv thiab ua kom raug mob
Txij li thaum lub chaw tsim khoom tsis ua cov kev ntsuas ntau txaus ntsig txog kev siv tshuaj Ongliz rau kev siv tshuaj tiv thaiv kab mob ntshav qab zib, kev siv cov tshuaj insulin ntau ntxiv, tseem muaj menyuam yaus thiab thaum tiav hluas, muaj qee qhov, txwv tsis pub siv tshuaj yeeb.
Tsis tas li ntawd, lees paub kev pom zoo contraindications rau kev siv yog mob ntshav qab zib ketoacidosis, lactation thiab cev xeeb tub, hypersensitivity rau lub Cheebtsam ntawm cov tshuaj, lactase tsis txaus, qabzib-galactose malabsorption thiab mob rwj rau galactose.
Tus kws kho mob tsaj qhov zoo thiab qhov tsis zoo ua ntej sau ntawv rau Onglis siv tshuaj rau cov neeg laus uas muaj mob me me thiab mob raum tsis txaus ua ke nrog sulfonylurea derivatives.
Qee zaum hauv kev siv tshuaj, cov kev xav tsis zoo tuaj yeem tshwm sim. Cov tshuaj Onglisa muaj ob peb ntawm, txawm li cas los xij, tus neeg mob tuaj yeem yws txog:
- sinusitis (mob rau ntawm lub qhov ntswg qhov ntswg);
- gagging;
- mob taub hau
- mob txeeb zig;
- kev txhim kho ntawm lub plab zom mov (mob plab hnyuv thiab lub plab);
- cov kab mob ua pa siab;
- nasopharyngitis (ua nyuaj siv Onglisa nrog metformin).
Cov neeg tsim khoom lag luam tsis qhia cov teeb meem kev noj tshuaj ntau dhau. Txawm li cas los xij, thaum cov paib tshwm sim uas tuaj yeem ua rau pom kev noj ntau dhau, hemodialysis yog siv los tshem tawm saxagliptin thiab nws cov metabolites tawm ntawm lub cev.
Kev kho mob raws lub siab kuj ua.
Cov yam ntxwv ntawm kev cuam tshuam nrog lwm yam tshuaj
Tsis zoo li lwm cov tshuaj tiv thaiv kab mob, piv txwv li, Metformin, Onglis tshuaj tuaj yeem siv nrog rau yuav luag txhua txoj kev. Txawm li cas los xij, yog tias muaj cov kab mob sib xyaw ua ke, tus mob ntshav qab zib yuav tsum mus rau kws kho mob qhov chaw ua haujlwm kom cais tawm qhov tsis zoo uas yuav tshwm sim los ntawm cov tshuaj no.
Qee cov tshuaj, xws li carbamazepine, phenytoin, phenobarbital, dexamethasone, rifampicin, uas yog cov inducers ntawm CYP 3A4 / 5 isoenzymes, tuaj yeem txo cov ntsiab lus ntawm cov metabolites theem pib ntawm cov yam muaj sia. Yog li, vim tias kev noj cov tshuaj no nce siab theem ntawm cov piam thaj hauv ntshav qab zib.
Vim yog qhov tseeb tias sulfonylurea derivatives ua rau muaj qhov tshwm sim ntau ntawm cov kev mob ntshav qab zib, lawv ntau npaum li cas thaum siv nrog Onglisa yuav tsum raug txo kom tsawg.
Hauv cov ntawv qhia txuas nrog muaj cov lus qhia rau noj Onglisa. Vim tias txoj kev hais daws no ua rau kiv taub hau qee kis, nws raug nquahu kom cov neeg mob uas txoj haujlwm muaj feem cuam tshuam nrog kev tsav tsheb thiab tshuab tswj lub cev yuav tsum raug tshem tawm ntawm kev ua haujlwm zoo li no thaum lawv siv tshuaj.
Qhov no tsuas yog kev xav tias vim tias tsis muaj kev tshawb fawb tau tshawb pom txog qhov cuam tshuam ntawm cov tshuaj rau ntawm kev nthuav dav.
Xyuas cov tshuaj thiab nws cov nqi
Hauv Is Taws Nem koj tuaj yeem pom ntau cov lus zoo hais txog tus neeg sawv cev hypoglycemic Onglisa. Qhov no yog cov tshuaj zoo uas ua rau txo qis ntshav qab zib hauv ntshav qab zib nrog hom 2. Ntawm qhov zoo ntawm cov tshuaj yog yooj yim ntawm kev siv, ib qho kev tsis tshua muaj tshwm sim tshwm sim thiab nws cov hauj lwm zoo.
Cov kev xav tsis zoo tsuas yog feem ntau ntsig txog tus nqi ntawm cov tshuaj. Txij li nws tsim tawm txawv teb chaws, cov nqi tsheb thauj mus los, kev lis kev cai tshem tawm ntawm cov tshuaj, thiab lwm yam nce ntxiv. Txoj cai tswj hwm tus nqi yog tsom rau cov neeg mob uas muaj theem ntawm kev muaj txiaj ntsig. Yog li, tus nqi rau 1 ntim ntawm Onglisa, uas muaj 30 ntsiav tshuaj ntawm 5 mg txhua, ib ncua ntawm 1835 txog 2170 rubles Lavxias. Txuag qee cov nyiaj, cov neeg mob yuav xaj mus yuav cov tshuaj online. Tus nqi ntawm cov tshuaj yuav hauv Is Taws Nem yuav qis dua qhov muag hauv khw muag tshuaj tsis tu ncua.
Txawm hais tias txoj kev xav zoo ntawm cov neeg mob thiab cov kws kho mob txog cov tshuaj tiv thaiv kab mob, rau qee qhov nws tsis haum. Hauv Is Taws Nem koj tuaj yeem qee zaum pom cov lus tias cov tshuaj tsis muaj cov suab thaj txo qis txhua lub sijhawm. Yog li, cov kws kho mob tau tshaj tawm cov tshuaj Onglisa ua ib qho ntxiv rau kev kho mob nrog Siofor lossis Diabeton.
Peb yuav tsum tsis txhob hnov qab tias cov ntsiav tshuaj lawv tus kheej tsis tuaj yeem muaj cov txiaj ntsig zoo ntawm kev txo qis qib ntawm glycemia.
Tsuas yog cov kev noj haus thiab kev ua tej nyom yuav pab ua kom tiav qhov xav tau.
Cov tshuaj zoo sib xws
Muaj qee kis, kev noj cov tshuaj Onglisa ua tsis tau.
Tom qab ntawd tus kws kho mob tau ntsib nrog kev ua haujlwm ntawm kev kho lub teeb meem kev kho mob ntawm nws tus neeg mob.
Tus kws kho mob tshwj xeeb xaiv cov tshuaj uas muaj cov tshuaj sib xyaw nrog, lossis muaj cov tshuaj kho zoo sib xws.
Hauv qab no yog cov yeeb yam nrov tshaj plaws ntawm cov tshuaj Onglisa.
- Galvus - nquag compound vildagliptin, raug nqi 789 rubles.
- Vipidia - nquag compound alogliptin, raug nqi 1241 rubles.
- Januvia - nquag compound sitagliptin, tus nqi ntawm 1634 rubles.
- Glucovans - nquag sib txuas glibenclamide + metformin hydrochloride, tus nqi 270 rubles
- Trazhenta - lub chaw sib txuas ua ke linagliptin, tus nqi ntawm 1711 rubles.
Analogues ntawm cov tshuaj Onglisa yog kim heev, tsuas yog ua rau Glucovans thiab Glucofage. Hmoov tsis zoo, cov tshuaj tsis raug tawm dawb nyob ntawm nqe lus nyiam. Tab sis tus neeg mob muaj txoj cai thov nws tus kws kho mob los hloov cov tshuaj Ongliz uas muaj tshuaj kho mob uas tau tso tawm dawb nrog cov tshuaj kom tsim nyog. Txog rau cov ntshav qab zib, Metformin, Glibenclamide, Glyclazide, Glimepiride thiab lwm yam tshuaj tuaj yeem muab rau kev ua kom zoo dua.
Txhua tus kws kho mob thiab tus neeg mob ib tus zuj zus txiav txim siab qhov zoo tshaj plaws rau nws. Tom qab tag nrho, cov tshuaj muaj peev xwm ua tau zoo, tab sis kim heev thiab, hloov pauv, pheej yig, tab sis tsis muab cov nyhuv hypoglycemic zoo. Qhov kev xaiv zoo tshaj plaws yog tus nqi rau cov nyiaj.
Mob ntshav qab zib mellitus yog ib qho mob hnyav uas yuav tsum tau saib xyuas tshwj xeeb. Yog li tias cov piam thaj kom tsis nce, koj yuav tsum tsis txhob noj tshuaj nkaus xwb raws li kws kho mob pom zoo, tab sis kuj ua raws kev noj zaub mov kom nruj thiab ua lub neej muaj sia.
Qee tus ntseeg tias Onglisa yog qhov tshuaj zoo tshaj plaws uas muaj saxagliptin. Tab sis peb yuav tsum tsis txhob hnov qab tias txhua yam tshuaj tuaj yeem muaj kev phom sij. Yog li, cov neeg mob yuav tsum ua tib zoo nyeem cov lus piav qhia ntawm cov tshuaj. Tsuas yog ib txoj hauv kev tsim nyog rau kev tswj ntshav qab zib yuav tswj cov ntshav cov ntshav qabzib.
Dr. Gorchakov yuav tham txog cov ntsiab cai ntawm kev kho mob ntshav qab zib hom 2 hauv yeeb yaj kiab hauv tsab xov xwm no.
