Enzymes yog qhov tsim nyog txhawm rau zom cov zaub mov nkag mus rau hauv lub cev thiab rho tawm cov as-ham tseem ceeb ntawm nws. Ua mob rau qaub ncaug, txiav thiab mob plab zais tuaj yeem tso zis tsis pub lwm tus paub. Vim tias qhov no, ib tus neeg yog saturated nrog txhua lub nruab nrog cev nrog cov ntsiab lus tseem ceeb.
Yog hais tias tsis muaj cov enzymes tsis txaus, lub plab zom mov yog qhov siab. Khoom noj khoom haus hauv qhov no tsis tuaj yeem tsoo, nws pib nthuav tawm thiab ua rau lub plab ntim khoom ntau ntxiv.
Lub physiology ntawm tus neeg noj qab haus huv yog qhov tias cov kab mob proteolytic enzymes ntawm lub txiav yuav ua hluavtaws thiab nkag mus rau cov hnyuv me. Yog li, cov khoom noj tau zom thiab nqus tau, cov Cheebtsam tau tawg, thiab tom qab ntawd hloov mus rau hauv cov vitamins thiab amino acids, qhov no yog txoj haujlwm ntawm cov zaub mov.
Cov enzymes ua cov txiav ua dab los
Tib neeg lub cev tau teeb tsa txoj hauv kev uas txhua tus enzyme muaj nws txoj haujlwm. Qhov txiav ua haujlwm ntxiv nyob rau hauv ua ke nrog lub zais zis zais.
Thaum cov kua tsib yog nyob rau hauv txoj hnyuv, ua haujlwm ntawm cov enzymes yog qhib kom ua haujlwm. Tom ntej no, lub duodenum yog ntim nrog kua txiv pancreatic. Qhov khoom siv no muaj cov hnoos qeev, dej, bicarbonates thiab cov zaub mov, uas pab txo cov acidity ntawm lub plab.
Lub enzymes tseem ceeb uas ua los ntawm cov txiav yog amylase, lipase thiab protease. Nws kuj tseem muaj lwm yam kev ua dej caw.
- Nuc thov yog koom nrog hauv kev txaug ntawm nucleic acids, DNA thiab RNA, uas ua rau lub hauv paus ntawm kev noj zaub mov.
- Protease nyob rau hauv daim ntawv ntawm elastase pab zom cov tuab nqaijrog thiab elastin. Trypsins thiab chymotrypsins, zoo li pais plab pepsin, zom cov zaub mov muaj protein ntau. Kuj tseem koom nrog hauv kev zom zaub mov yog carboxypeptidases.
- Amylases cov metabolism hauv cov pluas mov tsis haum, zom cov glycogen thiab cov hmoov txhuv nplej siab.
- Cov tshuaj Steapsins pab zom cov cov rog rog.
- Lipase muaj cov nyhuv ncaj nraim rau triglycerides; cov rog no raug coated nrog cov kua tsib, uas ua rau lub siab ua haujlwm rau lub plab hnyuv lumen.
Cov txheej txheem pab ua kom cov protein ua peptides, tom qab ntawd, siv cov carboxypeptidase, cov khoom sib txuas yooj yim hloov mus rau hauv cov amino acid thiab nqus hauv cov hnyuv. Tus naj npawb ntawm cov enzymes tsawg zuj zus nrog lub hnub nyoog, thiab lawv qib yuav txo vim kis kab mob.
Amylases koom nrog hauv kev puas tsuaj ntawm cov nyom carbohydrates lossis polysaccharides rau dextrin thiab maltose. Tom qab ntawd, kev tsim cov suab thaj yooj yim - cov piam thaj thiab fructose, uas tau nqus rau hauv txoj hnyuv. Feem ntau amylase tau pom nyob rau hauv lub txiav, thiab cov enzyme no tseem muaj nyob hauv cov qaub ncaug salivary.
Lipases zom cov roj molecules, sib sau glycerin thiab fatty acids. Ua ntej kev zom mov, cov rog tau tawg ua ke los ntawm cov kua tsib kua qaub. Tsis tas li, cov enzymes no hloov cov vitamins E, D, A, K rau hauv lub zog.
Ntxiv rau kev nqus ntawm cov khoom noj khoom haus, pancreatic enzymes muaj kev cuam tshuam txog cov khoom noj metabolic thiab hloov pauv, tswj ntshav qabzib.
Tsis tas li ntawd, cov khoom nruab nrog sab hauv muaj peev xwm tsim cov tshuaj hormonal uas tswj cov txheej txheem biochemical.
Pancreatic Tsis Raug
Feem ntau, tus mob hlaus paug cuam tshuam thaum ib tus neeg tsis saib xyuas nws kev noj qab haus huv thiab ua rau lub neej muaj kev phom sij. Hauv qee kis, pathology tuaj yeem tsim kho yog tias tus neeg mob noj zaub mov tsis zoo, tsis noj mov raws sij hawm, thiab haus dej haus cawv.
Rau tej yam txawv txawv cov tsos mob thiab hnov mob ncus, koj yuav tsum mus ntsib tus kws kho mob zuaj zuaj, mus tshuaj ntsuam tag nrho thiab tshawb pom dab tsi los cuam tshuam hauv lub cev.
Yog tias txoj cai ntawm kev noj zaub mov zoo yog tsis ua raws li, tus kws kho mob feem ntau kuaj xyuas kab mob pancreatitis. Tus kab mob no yuav muaj mob los yog mob ntev.
- Cov mob huam sai tuaj yog muaj mob yog tias tus txiav tsis ua hauj lwm zoo, thiab cov enzymes uas tau ua ntej yuav pib ua haujlwm. Raws li qhov tshwm sim, txoj kev txiav tawm ntawm lub qog nws pib. Tus neeg hnov mob hnyav hauv plab, ua npaws, ntuav, mob plab zom mov. Nws yog ib qho tseem ceeb kom nrhiav kev kho mob kom raws sijhawm kom tsis txhob muaj teeb meem loj.
- Tus mob txham ntev zuj zus, tus neeg mob yuav tsis paub tias muaj tus kab mob no. Hauv lub xeev no, cov ntaub so ntswg pancreatic yog cov tawv ncauj, cov khoom nruab nrog sab hauv tsis zais cov enzymes txoj cai. Hauv cov mob no, ntshav qab zib feem ntau muaj qhov tshwm sim vim tias qhov tsis txaus ntawm cov tshuaj insulin.
Cov tsos mob ntawm ib hom mob ntawm pancreatitis yog nrog los ntawm kev hlwv, pob ntseg, raws plab, mob qhov mob ntawm lub txiav.
Txhawm rau tiv thaiv kev txhim kho ntawm cov kev mob tshwm sim, nws yog ib qho tseem ceeb kom pib kho tus kab mob raws sij hawm, sai li sai tau thawj cov tsos mob ntawm tus mob pancreatitis.
Pancreatic enzyme assay
Txhawm rau txheeb xyuas cov kab mob pathology, tus kws kho mob tau sau ntawv kuaj ntshav biochemical, kuaj ntshav thiab ntshav ntshav kuj tau kuaj xyuas. Lub hom phiaj tseem ceeb ntawm kev kuaj mob yog txiav txim siab txog qib lipase, elastase thiab amylase. Yuav kuaj ntshav rau cov enzymes ua ntshav.
Cov feem ntau kawm cov ntshav amylase. Yog tias qhov kev tshawb nrhiav enzymatic qhia txog qib amylase ntau dua ntawm 130, feem ntau tus neeg yuav mob pancreatitis. Ntawm qhov ntsuas qhov ntsuas 0-130, teeb meem hauv kev ua haujlwm ntawm kab mob pancreas tau qhia. Yog tias cov kev cai ntau dhau tom qab peb kev kuaj mob, kuaj pom muaj mob ntawm cov ua tsis taus pa lossis cov hnyuv perforation.
Cov ntshav ntshav yog siv los txiav txim siab seb cov qib lipase. Thaum tus kab mob nqus dej tsis zoo, qhov feem pua ntawm cov enzymes tuaj yeem nce txog 90 feem pua. Yog tias theem tsis ua li qub, thiab amylase dhau lawm, tus neeg tej zaum yuav muaj cov kab mob sib txawv.
Siv biochemistry, tus kws kho mob kuaj pom tus kab mob thiab xaiv txoj kev kho mob tsim nyog. Yuav kom tau txais cov ntaub ntawv raug, qhov kev txiav txim siab txog qib ntawm cov enzymes tau nqa tawm ntawm lub plab khoob thaum sawv ntxov.
Yog tias tsim nyog, kev soj ntsuam ntawm cov quav thiab tso zis tawm ntxiv.
Tshuaj kho mob nkeeg
Niaj hnub no ntawm kev muag khoom yog qhov kev xaiv ntau yam ntawm txhua yam tshuaj kho los kho tus txiav. Lub txiaj ntsig tseem ceeb ntawm cov tshuaj no yog rov sau daim enzymes uas ploj lawm.
Cov tshuaj muaj tshuaj sib txawv, nyob ntawm qhov muaj pes tsawg leeg, txoj kev tsim khoom thiab cov qauv tso tawm. Cov khoom siv tseem ceeb yog cov nqaij nyuj lossis nqaij npuas ua nqaij hlav.
Kuj tseem muaj tshuaj uas suav nrog kua tsib. Tab sis xws li cov enzyme npaj tau contraindicated hauv mob huam thiab mob txha nqaj qaum, kab mob siab, mob peptic thiab ua haujlwm tsis zoo ntawm duodenum, mob thiab lwm txoj hnyuv pathologies.
- Ua ntej noj cov tshuaj, lub cev thiab cov txiav yuav tsum npaj rau kev kho enzyme. Txhawm rau ua qhov no, siv cov tshuaj ua ntej tsis haum tshuaj Papaverin, Tsis-Shpa, Drotaverin, uas daws qhov mob. Ib qho ntxiv, lawv siv ntau yam tshuaj pleev xim.
- Yog tias kuaj pom tus kab mob hauv menyuam yaus, tus kws kho mob tau sau ntawv rau cov menyuam yaus tshwj xeeb siv tshuaj lossis xaiv qhov tsim nyog noj raws li tus neeg mob lub hnub nyoog. Thaum kho cov menyuam yaus, cov tshuaj tau sib xyaw nrog mis lossis dej haus.
- Pancreatic enzymes yog ib feem ntawm cov ntsiav tshuaj xws li Mezim-Forte, Abomin, Creon, Festal, Digestal, Betaine, Enzistal, Panzinorm, Penzital thiab lwm yam.
- Niaj hnub no, ntawm kev muag koj tuaj yeem nrhiav cov enzymes ntawm tsob nroj, fungal lossis microbial keeb kwm, tus neeg mob tuaj yeem xaiv cov tshuaj tom qab kev pom zoo nrog tus kws kho mob uas koom nrog. Kev npaj nrog tsob ntoo cog ntoo muaj roj ua kom sib xyaw, yog li lawv tuaj yeem sib xyaw zoo nrog cov zaub mov thiab yuav nqus tau sai dua.
Ntxiv nrog rau kev noj tshuaj, cov chav kawm ntawm kev kho mob suav nrog ua raws li kev noj haus tshwj xeeb. Tus neeg mob raug tso cai tsuas yog noj cov zaub mov muaj roj tsawg dua tsis ntxiv nqaij, nqaij npuas thiab kua zaub. Tsis tas li ntawd, nws raug nquahu kom haus tsawg kawg ob litres ib hnub ntawm dej alkaline ntxhia dej.
Yog tias ib tus neeg muaj exocrine pancreatic tsis txaus, cov tshuaj Pancreatin yog tshuaj. Nws yog siv rau dysbiosis, mob plab peptic, thaum lub plab zom mov muaj qhov nce ntawm hydrochloric acid thiab pepsin, mob plab los yog mob plab hnyuv, thiab ua tsis tau qog ua ntshav tsis txaus.
Txhawm rau nce cov kev ua haujlwm ntawm cov txiav thiab txhim kho zus tau tej cov enzymes, cov tshuaj yog siv uas muaj pacreatin, hemicellulase, kua tsib kua qaub thiab lwm yam. Vim tias qhov no, cov haujlwm ntawm lub plab thiab lub zais zis ua rau lub zog hloov zuj zus, thiab kev tsim cov roj ntsha hauv plab hnyuv tau txo. Cov kev kho mob zoo li no tau hais tseg yog tias cov tsos mob tau nrog mob plab, hlwv, cem quav.
Cov ntaub ntawv hais txog kev ua rau pancreatic yog muab hauv video hauv tsab xov xwm no.
