Aries yog cov tshuaj uas tau muab kho ua tshuaj kho rau kev kuaj pom tus mob hypercholesterolemia thiab mob plawv hauv cov neeg mob. Lub hauv paus ua haujlwm tseem ceeb ntawm cov tshuaj yog simvastatin. Cov kab ke no tau hais tawm lipid-txo cov yam ntxwv.
Cov tshuaj yog nyob rau hauv daim ntawv ntawm ntsiav tshuaj. Cov neeg tsim cov tshuaj no yog Lavxias lub chaw lag luam tshuaj OZON LLC. Cov duab ntawm cov ntsiav tshuaj yog ib txwm puag ncig. Cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj ua lub ntsiab lus nquag suav nrog simvastatin hauv ib qho ntim ntawm 10 lossis 20 mg.
Ntxiv nrog rau qhov tseem ceeb hauv cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj, muaj tag nrho cov kab ke ntxiv:
- ascorbic acid;
- citric acid;
- gelatinized hmoov txhuv nplej siab;
- lactose;
- titanium dioxide;
- magnesium stearate;
- talc;
- propylene glycol;
- cov roj castor;
- pob kws nplej siab.
Cov tshuaj muaj muag hauv cov khw muag tshuaj hauv daim ntawv ntawm cov ntsiav tshuaj ntim hauv pob khoom contour, txhua qhov muaj 10, 20 lossis 50 daim. Ntim qhov ntim tau muab tso rau hauv cov thawv ntawv uas ua los ntawm cov duab los qhia.
Kev siv ntawm cov tshuaj yog nqa tawm tsuas yog muaj daim ntawv tshuaj ntawm cov kws kho mob tuaj koom.
Txee lub neej ntawm cov tshuaj yog 3 xyoos. Kev khaws cia ntawm cov tshuaj yuav tsum tau ua nyob rau hauv qhov chaw tiv thaiv los ntawm tshav ntuj. Cia qhov kub thiab txias yuav tsum tsis siab tshaj +25 degrees Celsius. Qhov chaw ntim khoom yuav tsum raug tiv thaiv los ntawm ya raws thiab tawm ntawm qhov ncav cuag cov menyuam.
Tom qab hnub tas sijhawm, cov tshuaj no pov tseg.
Pharmacodynamics thiab pharmacokinetics ntawm cov tshuaj
Cov tshuaj Ovenkor hais txog lipid-txo cov tshuaj synthesized artificially. Kev npaj ntawm cov tshuaj yog nqa tawm los ntawm fermentation ntawm cov khoom tau los ntawm pathogenic Aspergillusterreus saprophyte fungus.
Qhov ua kom lactone tsis muaj zog txaus, ua raws li kev ua kom tiav ntawm hydroxy acid derivative.
Cov nquag metabolite ntawm simvastatin inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase.
Daim kev cai tswj hwm enzyme catalyzes qhov pib cov tshuaj tiv thaiv thaum pib los ntawm HMG-CoA mevalonate.
Kev hloov pauv ntawm HMG-CoA rau mevalonate sawv cev rau theem pib ntawm cov roj (synthesis). Kev siv cov simvastatin tsis ua rau kev txhim kho hauv lub cev ntawm cov txheej txheem ntawm kev txuam nrog cov tshuaj tsis haum uas muaj peev xwm. HMG-CoA yog hloov pauv tau yooj yim rau acetyl-CoA. Qhov kev sib xyaw ua ke no koom nrog hauv lub cev hauv cov txheej txheem ntau ntawm cov khoom noj hauv lub cev.
Rau simvastatin, cov khoom hauv qab no yog cov yam ntxwv:
- Txo cov plasma theem ntawm triglycerides, LDL thiab VLDL, nrog rau cov roj (cholesterol) tag nrho.
- Kev nce ntawm HDL concentration thiab txo qis hauv kev sib piv ntawm cov lipoproteins uas tsis muaj tsawg thiab lipoproteins ntau ntom.
- Txo kev sib piv ntawm cov roj (cholesterol) tag nrho thiab HDL.
Cov nyhuv ntawm kev siv cov tshuaj yog pom twb 14 hnub tom qab pib ntawm kev siv kaw lus ntawm Ovenkor.
Yuav kom ua tiav qhov ua tau zoo tshaj plaws, nws yuav tsum tau yauv mus rau ib lub sijhawm ntawm kev kho mob, lub sijhawm uas yog los ntawm 4 rau 6 lub lis piam.
Yog tias tsim nyog, tus kws kho mob mus kawm ntawv tau ntev cov kev kho mob, uas yuav pab txhawb lub txiaj ntsig ntawm cov tshuaj. Ntev ntev ntawm kev siv cov tshuaj ua rau kev maj mam hloov dua siab tshiab ntawm cov roj cholesterol hauv tus neeg mob lub cev.
Simvastatin muaj kev kawm siab ntawm kev nqus. Qhov siab tshaj plaws ntawm cov tshuaj yog ua tiav hauv lub cev tom qab 1.3-2.5 teev. Tom qab 12 teev tom qab siv cov tshuaj, qhov txo qis hauv nws qhov kev mob siab hauv tus neeg mob cov ntshav los ntawm 90% yog pom.
Cov khoom ua si nquag ntawm Ovenkor tuaj yeem khi rau cov ntshav plasma protein. Cov qib ntawm protein khi yog txog 95%.
Ib nrab-lub neej ntawm kev ua kom nquag plias ntawm cov tshuaj yog 1.9 teev.
Kev nqhis ntawm cov khoom noj tshwj xeeb yog nqa los ntawm txoj hnyuv ua ib feem ntawm quav. Daim ntawv tsis ua haujlwm ntawm cov metabolites yog tawm los ntawm lub raum hauv qhov zis.
Li ntawm 60% ntawm cov quav ua quav tawm ntawm lub cev, thiab txog 10-15% ntawm cov tshuaj tawm hauv cov zis.
Cov lus qhia rau kev siv tshuaj
Ua ntej thov Ovenkor, koj yuav tsum kawm cov lus qhia rau kev siv ntau yam, ntxiv rau qhov no, koj yuav tsum paub koj tus kheej nrog tus nqi ntawm cov tshuaj nrog kev tshuaj xyuas ntawm cov neeg mob thiab kho tus kws kho mob, koj yuav tsum kawm cov analogues ntawm cov tshuaj nyob rau hauv cov ntaub ntawv ntawm kev hloov yog tias tsim nyog.
Ua ntej noj cov tshuaj, tus neeg mob tau sau daim ntawv so tswj hwm hypocholesterol.
Thaum muab tshuaj rau, cov tshuaj txhua hnub tuaj yeem txawv ntawm 1- txog 80 mg.
Qhov pom zoo kom pib noj yog 10 mg; qhov ntau kawg yog 80 mg. Cov koob tshuaj hloov kho yog nqa nrog ib ntu ntawm 4 lub lis piam. Feem ntau, qhov noj tshuaj zoo yog 20 mg ib hnub twg.
Kev siv tshuaj zoo ntawm Ovenkor nyob rau hauv qhov muaj mob plawv los yog mob siab thaum muaj kev pheej hmoo siab ntawm kev tsim muaj cov kev mob tsis zoo no yog los ntawm 20 txog 40 mg rau ib hnub. Thaum pib theem ntawm kev kho, ib qho tshuaj nyob rau hauv qhov ntau npaum ntawm 20 mg yog siv thiab tom qab 4 lub lis piam qhov tshuaj yog kho rau 40 mg.
Yog tias cov tshuaj roj ntau dua li 140 mg / dl raug tshawb pom hauv lub cev, qhov ntau ntawm cov tshuaj yog txo.
Kev siv tshuaj tsawg kawg nkaus yog siv nyob rau hauv qhov chaw uas tus neeg mob tau mob raum tsis ua haujlwm lossis thaum ua rau kev kho mob sib xyaw ua ke nrog Cyclosporine, Danazole, Gemfibrozil lossis lwm qhov ua mob.
Kev qhia rau siv raws li cov lus qhia yog
- muaj cov hypercholesterolemia;
- muaj nyob rau hauv lub cev ntawm IHD lossis kev ntsuas ua ntej rau kev txhim kho ntawm qhov kev ua txhaum no.
Cov kev tiv thaiv tsis haum rau kev siv tshuaj yog:
- Cov kab mob siab nyob hauv daim foos.
- Porphyria.
- Myopathy
- Lub hnub nyoog ntawm tus neeg mob mus txog 18 xyoo.
- Cev xeeb tub thiab lactation.
- Lub xub ntiag ntawm ib tug neeg intolerance.
Xyuam xim thaum noj cov tshuaj yuav tsum ua kom zoo nrog kev haus cawv, muaj cov leeg ntshav ntawm cov neeg mob, thiab nrog cov tshuaj tiv thaiv kab mob. Ib qho ntxiv, qhov yuav tsum tau ceev faj yog tias tus neeg mob muaj mob vwm thiab pathology hauv lub suab ntawm cov pob txha pob txha ntawm qhov tsis paub meej txog kev tsim tawm.
Thaum siv yeeb tshuaj, qhov tshwm sim ntawm kev phiv los ntawm cov tshuaj tau tshwm sim raws li hauv qab no:
- mob hauv plab;
- cem quav, flatulence, xeev siab, mob leeg, mob rau daim siab, txhawb kom ntuav;
- mob taub hau
- peripheral neuropathy;
- Kiv taub hau
- insomnia
- npaws
- khaus
- urticaria;
- nce rau lub plawv dhia, ua haujlwm tsis txaus, tsis muaj potency.
Yog tias pom thawj yam tshwm sim ntawm kev mob tshwm sim, Qhov cub yuav tsum tau tsum.
Tus nqi ntawm cov tshuaj, nws analogues thiab tshuaj xyuas txog cov tshuaj
Ua raws li kev tshuaj xyuas cov neeg mob thiab kev kho mob kws kho mob, Ovencor yog txoj hauv kev muaj txiaj ntsig zoo ntawm kev sib ntaus sib tua hauv cov kab mob ntshav siab hauv lub cev. Ib qho ntawm cov xwm txheej rau kev ua tiav qhov kev ua tau zoo hauv kev coj ua ntawm txoj kev kho yuav tsum tau ua raws li kev noj haus kom nruj. Qhov tsis zoo ntawm kev noj tshuaj yog qhov muaj peev xwm nthuav dav hauv tus neeg mob ntawm ntau yam kev mob tshwm sim uas tuaj yeem ua rau muaj kev tshem tawm txoj kev kho mob.
Tus nqi ntawm Ovenkor nyob rau lub sijhawm tam sim no hauv cov khw muag tshuaj hauv Lavxias Federation khwv yees li ntawm 300 txog 600 rubles rau ib pob, nyob ntawm thaj av ntawd.
Cov tshuaj hauv qab no yog cov qauv tshuaj tiv thaiv kab mob:
- Simvastatin.
- Vero-simvastatin.
- Zokor.
- Atherostat.
- Zovatin.
- Avestitin.
- Simvastol.
- Simvakard.
- Simlo.
- Holvasim.
- Zorstat.
Tus nqi ntawm analogues ntawm cov tshuaj tseem ceeb tuaj yeem hloov hauv ntau yam tseem ceeb. Yog li, piv txwv li, Simvastatin muaj tus nqi ntawm 41 rubles rau 30 ntsiav tshuaj, txhua tus muaj 10 mg ntawm cov khoom xyaw nquag, thiab Vasilip muaj tus nqi 124 rubles rau ib pob uas muaj 14 ntsiav tshuaj, txhua tus muaj 10 mg ntawm cov khoom xyaw nquag.
Ua ntej koj xaiv qhov zoo tshaj plaws ntawm cov kab noj coj ua kom hloov cov tshuaj loj, koj yuav tsum sab laj nrog koj tus kws kho mob.
Nws puas tsim nyog nws coj cov neeg txawj ntse statins yuav qhia hauv qhov yeeb yaj kiab hauv tsab xov xwm no.
