Cov neeg mob uas nyob nrog lipid metabolism cov teeb meem feem ntau muaj kev xaiv, uas zoo dua - Atorvastatin lossis Rosuvastatin? Txawm hais tias Rosuvastatin tau siv ntau dua tsis ntev los no, nws tsis yooj yim sua kom muab cov lus teb rau lo lus nug no, vim tias txhua yam tshuaj muaj ob qho zoo thiab qhov tsis zoo.
Ob qho tshuaj yuav tsum noj rau pathologies xws li sib xyaw lossis homozygous hypercholesterolemia (nce LDL), hypertriglyceridemia (ntau triglycerol) thiab atherosclerosis (txoj kev nqaim ntawm cov lumen ntawm cov hlab ntshav vim qhov tsawg ntawm cov roj ntshav plaques). Lawv kuj tseem siv los tiv thaiv cov mob atherosclerosis - kub siab, mob plawv, mob plawv thiab mob plawv nres.
Txij li thaum muaj qhov sib txawv ntawm qhov sib txawv ntawm cov tshuaj tiv thaiv, kev phiv tshuaj, pharmacokinetics thiab pharmacodynamics, nws yog qhov yuav tsum tau tshawb pom yam tshuaj twg zoo dua thiab nyab xeeb.
Dab tsi yog statins?
Statins suav nrog cov pab pawg coob coob ntawm cov tshuaj siv kom txo qis ntawm LDL thiab VLDL hauv cov ntshav.
Hauv kev kho mob niaj hnub, cov tshuaj statins tsis tuaj yeem muaj kev tiv thaiv thiab kho mob atherosclerosis, hypercholisterinemia (kev sib xyaw lossis homozygous), nrog rau cov kab mob plawv.
Feem ntau, cov tshuaj ntawm cov pab pawg no muaj tib txoj kev kho mob, i.e. qis dua LDL thiab VLDL qib. Txawm li cas los xij, vim muaj ntau yam kev ua haujlwm thiab pabcuam ntu, muaj qee qhov sib txawv uas yuav tsum tau muab coj los txiav txim txhawm rau kom zam dhau kev phiv tshuaj.
Statins feem ntau muab faib ua I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) thiab IV tiam (Pitavastatin, Rosuvastatin).
Statins tuaj yeem yog lub zog ntawm keeb kwm thiab hluavtaws. Rau cov kws tshaj lij, kev xaiv cov tshuaj qis-nruab nrab, lossis cov tshuaj siab yog qhov tseem ceeb rau tus neeg mob.
Rosuvastatin thiab Atorvastatin feem ntau siv los txo cov roj (cholesterol). Txhua yam ntawm cov tshuaj muaj cov yam ntxwv:
Rosuvastatin hais txog statins ntawm plaub tiam neeg. Tus lipid-txo tus neeg sawv cev yog tag nrho hluavtaws nrog qhov nruab nrab qhov ntau ntawm cov khoom siv nquag. Nws yog tsim nyob rau hauv ntau cov cim lag luam, piv txwv li, Krestor, Mertenil, Rosucard, Rosart, thiab lwm yam.
Atorvastatin hais txog statins ntawm lub cim thib peb. Ib yam li nws cov analogue, nws muaj keeb kwm hluavtaws, tab sis muaj qhov siab ntawm cov tshuaj nquag.
Muaj cov lus txhais ntau ntawm cov tshuaj xws li Atoris, Liprimar, Toovacard, Vazator, thiab lwm yam.
Tshuaj lom neeg muaj pes tsawg leeg ntawm cov tshuaj
Ob qho tshuaj no muaj nyob hauv daim foos. Rosuvastatin yog tsim nyob rau hauv ntau qhov kev siv tshuaj - 5, 10 thiab 20 mg ntawm tib cov tshuaj tivthaiv. Atorvastatin tawm hauv kev noj tshuaj ntawm 10,20,40 thiab 80 mg ntawm cov tshuaj xyaw nquag. Hauv qab no yog cov lus piv piv ua ntu pab cuam ntawm ob tus neeg sawv cev zoo ntawm statins.
| Rosuvastatin | Txoj Kev Noj Qab Haus Huv (Atorvastatin) |
| Hypromellose, hmoov txhuv nplej siab, titanium dioxide, crospovidone, microcrystalline cellulose, triacetin, magnesium stearate, silicon dioxide, titanium dioxide, carmine zas. | Lactose monohydrate, croscarmellose sodium, titanium dioxide, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, microcrystalline cellulose, |
Lub ntsiab sib txawv ntawm Rosuvastatin thiab Atorvastatin yog lawv lub cev ua haujlwm ntawm lub cev. Qhov zoo ntawm rosuvastatin yog tias nws tau yooj yim tawg hauv cov ntshav ntshav thiab lwm yam kua, i.e. yog hydrophilic. Atorvastatin muaj lwm qhov ntxiv: nws yog soluble hauv cov rog, i.e. yog lipophilic.
Raws li cov cwj pwm no, cov nyhuv ntawm Rosuvastatin yog feem ntau qhia rau lub hlwb ntawm daim siab parenchyma, thiab Atorvastatin - rau cov qauv ntawm lub hlwb.
Pharmacokinetics thiab pharmacodynamics - sib txawv
Twb tau nyob rau theem ntawm kev noj cov ntsiav tshuaj, muaj qhov sib txawv ntawm lawv txoj kev nqus. Yog li, kev siv Rosuvastatin tsis nyob ntawm lub caij ntawm hnub lossis pluas noj. Atorvastatin yuav tsum tsis txhob noj ib txhij nrog zaub mov noj, li qhov no cuam tshuam tsis zoo rau kev nqus ntawm cov nquag tivthaiv. Cov ntsiab lus ntau ntawm Atorvastatin tau tiav tom qab 1-2 teev, thiab Rosuvastatin - tom qab 5 teev.
Lwm qhov txawv ntawm statins yog lawv cov metabolism. Hauv tib neeg lub cev, Atorvastatin tau hloov pauv mus ua ib qho kev tsis txaus ntseeg siv daim siab ua haujlwm siab. Yog li, cov haujlwm ntawm cov tshuaj cuam tshuam ncaj qha rau kev ua haujlwm ntawm lub siab.
Nws kuj tseem cuam tshuam los ntawm cov tshuaj uas tau siv ib txhij nrog atorvastatin. Nws cov tshuaj analogue, ntawm qhov tsis sib xws, vim tias muab tshuaj rau qis dua, kev coj ua tsis cuam tshuam nrog lwm cov tshuaj. Txawm hais tias qhov no tsis cawm nws los ntawm qhov muaj qhov tshwm sim tsis zoo.
Atorvastatin feem ntau mob cov kua tsib.
Tsis zoo li ntau tus neeg sawv cev ntawm statins, Rosuvastatin yuav luag tsis txaus nyob rau hauv daim siab: ntau dua 90% ntawm cov tshuaj raug tshem tawm tsis hloov pauv los ntawm txoj hnyuv thiab tsuas yog 5-10% los ntawm lub raum.
Cov tshuaj tiv thaiv thiab kev tsis haum
Muaj cov contraindications thiab kev ua tsis zoo yog qhov tseem ceeb thaum xaiv cov tshuaj pom zoo tshaj plaws. Cov hauv qab no yog cov kabmob tseem ceeb thiab kev ua haujlwm uas kev siv tshuaj yeeb raug txwv, nrog rau kev phiv ntxiv.
| Cov Yuav Tsum Muaj | |
| Rosuvastatin | Atorvastatin |
| Tus neeg rhiab. Cev xeeb tub thiab lactation. Kev puas tsuaj rau hepatocytes thiab txhawb kev nce siab hauv lub siab enzymes. Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo. Myopathy los yog ib tug predisposition rau nws. Kev kho zoo nrog cyclosporine thiab fibrates. Hlaus plawv kawg. Kev haus cawv mus ntev Myotoxicity thaum noj lwm HMG-CoA reductase inhibitors. Kev siv cov tshuaj tiv thaiv kab mob HIV tiv thaiv. Cov sawv cev ntawm haiv neeg ntawm Mongoloid (tsuas yog cov koob tshuaj tsawg kawg nkaus raug tso cai). | Hypersensitivity rau lub Cheebtsam. Ntxiv kev ua haujlwm ntawm daim siab enzymes. Kev Yug Me Nyuam thiab lub sijhawm lactation. Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, tshwj tsis yog kev kho rau tus mob muaj keeb heterozygous kab mob hypercholesterolemia. Tsis muaj pov thawj txaus tsim nyog. Kev siv cov tshuaj tiv thaiv kab mob HIV tiv thaiv. Lub siab ua mob rau daim siab. |
| Kev phiv tshuaj | |
| Muaj mob taub hau, teeb meem kev sib koom tes, kev hais dav dav. Kev tsim cov proteinuria thiab hematuria. Cov tawv nqaij ua pob khaus, ua pob khaus, khaus. Kev ua tsis taus ntawm cov leeg hlwb. Dyspepsia, poob plab tsis muaj zog, o ua paug ntawm tus kabmob (pancreatitis). Tsis-insulin-mob ntshav qab zib mellitus. Kev loj hlob ntawm lub mis hauv tus txiv neej. Lub xub ntiag ntawm hnoos qhuav, txog siav. Stevens-Johnson Syndrome. | Kev tsim tawm ntawm nasopharyngitis, mob txeeb zig. Qhov tshwm sim ntawm thrombocytopenia. Hypo- thiab hyperglycemia, anorexia. Kev mob taub hau, paresthesia, kev txhim kho peripheral neuropathy, hypesthesia, amnesia, kiv taub hau, dysgeusia. Hnov tsis hnov lus, tsis tseeb, pom kev tsis hnov lus. Mob caj pas, mob ntswg. Dyspeptic tsis meej, belching, epigastric mob, kev loj hlob ntawm pancreatitis. Urticaria, tawv nqaij tawm pob, Quincke's edema. Cov tsos ntawm gynecomastia. Ntau cov kev tsis txaus siab hauv cov leeg leeg. Kab mob siab, mob siab, ua haujlwm cholestasis. Hyperthermia, asthenia, malaise. Ntxiv kev ua haujlwm ntawm daim siab enzymes, QC thiab kev soj ntsuam zoo rau leukocytes hauv zis. |
Kev ua tau zoo thiab cov neeg siv khoom lub tswv yim
Lub luag haujlwm tseem ceeb ntawm cov tshuaj statin yog txhawm rau txo qis ntawm LDL hauv cov ntshav thiab nce qib HDL.
Yog li, xaiv ntawm Atorvastatin thiab Rosuvastatin, peb yuav tsum piv qhov zoo li cas lawv txo cov roj (cholesterol).
Cov kev tshawb fawb tshawb fawb tsis ntev los no tau ua pov thawj tias rosuvastatin yog ib hom tshuaj uas ua tau zoo dua.
Cov chaw soj ntsuam kuaj mob raug nthuav tawm hauv qab no:
- Nrog kev sib luag ntawm cov tshuaj, Rosuvastatin txo LDL roj los ntawm 10% zoo dua li nws cov tshuaj tiv thaiv. Qhov txiaj ntsig zoo no tso cai rau kev siv cov tshuaj rau cov neeg mob uas muaj mob hypercholesterolemia.
- Qhov nquag ntawm txoj kev loj hlob ntawm cov hlab plawv cov teeb meem thiab qhov pib ntawm lub txiaj ntsig tuag yuav ua rau siab dua hauv Atorvastatin.
- Qhov tshwm sim ntawm kev phiv tshuaj yog tib yam rau ob qho tshuaj.
Kev sib piv ntawm cov txiaj ntsig ntawm kev txo qis ntawm cov "phem" cov roj (cholesterol) tau ua pov thawj qhov tseeb tias Rosuvastatin yog ib qho tshuaj zoo dua. Txawm li cas los xij, ib qho yuav tsum tsis txhob hnov qab txog cov xwm txheej zoo li no muaj qhov sib txuam ntawm contraindications, phiv thiab nqi. Ib qho kev sib piv ntawm tus nqi ntawm ob cov tshuaj tau nthuav tawm hauv lub rooj.
| Tsuas tshuaj, cov naj npawb ntawm cov ntsiav tshuaj | Rosuvastatin | Atorvastatin |
| 5mg Tsis Yog 30 | 335 RUB | - |
| 10mg Tsis Yog 30 | 360 rubles | 125 txhuam |
| 20mg Tsis Yog 30 | 485 RUB | 150 rub |
| 40mg No. 30 | - | 245 RUB |
| 80mg No. 30 | - | 490 rub |
Yog li, atorvastatin yog qhov pheej yig dua uas cov neeg tau nyiaj tsawg yuav them taus.
Qhov ntawd yog qhov uas cov neeg mob xav txog tshuaj - Rosuvastatin muaj kev tiv thaiv zoo thiab tsis muaj teeb meem. Thaum nws noj, roj (cholesterol) phem yuav txo tau
Kev sib piv ntawm cov tshuaj pab tau los xaus tias nyob rau theem tam sim no ntawm kev txhim kho tshuaj, thawj txoj haujlwm ntawm cov tshuaj zoo tshaj plaws rau cov roj (cholesterol) yog nyob ntawm cov statins ntawm plaub tiam, suav nrog Rosuvastatin.
Hais txog cov tshuaj Rosuvastatin thiab nws cov analogues tau piav qhia hauv video hauv kab lus no.
