Tulip yog cov tshuaj uas yog pab pawg pawg lipid-txo cov tshuaj, cov nyhuv tseem ceeb ntawm cov no yog txo cov roj lipids. Nws muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb hauv zaj duab xis plhaub, puag ncig biconvex, ntawm cov ntawv sau "HLA 10", "HLA 20" lossis "HLA 40" tau sau, nyob ntawm seb ntau npaum li cas.
Cov khoom siv tseem ceeb ntawm Tulip yog atorvastatin (ib qho tshuaj muaj txiaj ntsig ntawm pawg ntawm statins).
Ntxiv rau atorvastatin, cov tshuaj muaj pes tsawg leeg kuj suav nrog lactose monohydrate, polysorbate, magnesium oxide, hyprolose, magnesium stearate, microcrystalline cellulose. Cov roj ntsha zaj duab xis ntawm cov ntsiav tshuaj muaj hypromellose, hyprolose, titanium dioxide, talc thiab macrogol.
Cov qauv ntawm pharmacodynamics ntawm Tulip
Tulip, vim tias nws lub ntsiab ua ub ua no atorvastatin, muaj lipid-txo cov nyhuv. Nws yog raws li qhov tseeb hais tias atorvastatin yog ib qho kev xaiv sib tw enzyme inhibitor hu ua HMG-CoA reductase. Qhov enzyme no yog lub luag haujlwm rau kev hloov pauv ntawm 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonic acid. Mevalonic acid yog ib qho tshuaj muaj kuab rau cov cholesterol, ntau dua, cov kua roj lipophilic cawv ntau dua.
Cov roj khov ua ke nrog triglycerides khi rau cov lipoproteins ntau qhov tsawg kawg nkaus thaum lawv sib sau, uas yog ua rau hauv lub siab. Tom qab ntawd lawv dhau mus rau hauv cov ntshav ntshav, los ntawm kev lawv nkag mus rau cov ntaub so ntswg ntxiv ntawm lub cev. Tsawg lipoproteins ua rau cov lipoproteins uas tsis muaj ntau vim yog kev cuam tshuam nrog cov kis tshwj xeeb.
Nws tau hais txog kev tshawb fawb thiab kev sim ua pov thawj tias qib ntawm cov roj cholesterol tag nrho thiab nws cov feem cuam tshuam nrog qis lipoproteins tsawg, cais tawm cov lipoproteins tsawg kawg, nrog rau cov khoom lag luam protein apolipoprotein B tuaj yeem nce ntxiv. Kev nce rau hauv cov ntsuas saum toj no yog ua rau kev txhim kho atherosclerosis thiab cov kab mob ntawm cov hlab plawv (xws li mob plawv, mob angina pectoris, kub siab, myocardial infarction, mob hlab ntsha tawg). Nyob rau tib lub sijhawm, nce qib ntawm qhov siab ntawm lipoproteins, ntawm qhov tsis sib xws, yog suav tias yog kev tiv thaiv kev tiv thaiv.
Cov kev kho mob tseem ceeb ntawm Tulip muaj raws li hauv qab no:
- Kev txwv tsis pub muaj kev ua kom zoo nkauj thiab txo qis ntawm cov nyiaj tag nrho thiab cuam tshuam nrog qis lipoproteins cov roj uas txhaws taus, apolipoprotein B nyob rau hauv cov neeg mob uas muaj cov kab mob xws li homo- thiab heterozygous tsev neeg hypercholesterolemia, thawj hypercholesterolemia, tshuaj tiv thaiv hyperlipidemia.
- Kev txwv tsis pub coj los ua ke thiab txo cov roj (cholesterol) ntawm cov lipoproteins uas tsis tshua muaj siab, triglycerides.
- Kev nce siab ntawm apolipoprotein A thiab cov roj cholesterol siab lipoprotein ntau.
- Txo cov theem ntawm cov roj lipoprotein ntau dua nruab nrab, uas yog qhov tshwj xeeb rau cov neeg mob dysbetalipoproteinemia.
- Nrog raug xaiv koob tshuaj, ib qho kev txo qis lipoproteins tsawg hauv cov neeg mob kev txom nyem los ntawm homozygous tsev neeg hypercholesterolemia, nyob rau hauv uas tiv thaiv (tiv thaiv kab mob, tsis muaj zog) rau lwm cov lipid-txo cov tshuaj tau pom.
- Nws tsis pab txhawb rau kev txhim kho oncological neoplasms (tsis yog mob nqaij hlav).
- Tsis ua rau muaj kev hloov ntau yam (kev hloov pauv) hauv lub cev (tsis hloov pauv hauv cev).
Thawj qhov pib tshwm sim tom qab ob lub lim tiam ntawm kev kho mob hnyav, qhov siab tshaj plaws yuav pom tau tom qab plaub lub lis piam.
Tshaj siab tshaj plaws txuas ntxiv txuas ntxiv thoob plaws hauv lub sij hawm ntawm kev kho mob.
Cov hauv paus ntawm Tulip Pharmacokinetics
Cov tshuaj sai heev thiab tag nrho nqus, uas yog, nqus. Qhov siab tshaj plaws ntawm cov tshuaj nquag tau pom nyob hauv cov ntshav ib mus rau ob teev tom qab noj cov ntsiav tshuaj. Qhov nqus dej poob qis me ntsis thaum noj mov, tab sis cov neeg kawm ntawv qib qis ntawm cov roj lipoprotein tsawg tsawg yuav hloov pauv tsis hloov.
Cov tshuaj raug pom zoo kom noj thaum sawv ntxov, vim hais tias qhov concentration ntawm cov tshuaj nquag hauv cov ntshav thaum yav tsaus ntuj yog kwv yees li ib feem peb qis dua tom qab siv nws thaum sawv ntxov. Tab sis nws tau pom tias lub sijhawm nruab hnub tsis muaj feem cuam tshuam rau theem ntawm kev txo qis lipoprotein cholesterol. Nws yog qhov tseeb tias qhov ntau dua qhov noj tshuaj uas tus neeg mob coj, ntau nws yuav nqus tau.
Lub bioavailability ntawm cov tshuaj li ntawm 12 txog 14%. Xws li cov taw qhia qis yog vim qhov tseeb tias cov tshuaj yauv yauv pauv qee yam pauv hloov pauv hauv daim siab thiab lub plab zom mov. Tulip khi rau cov protein yuav luag 100%.
Kev tshawb nrhiav pom pom tias qhov tshuaj lom ntawm cov nquag hauv cov ntshav liab yog plaub zaug qis dua nws cov ntsiab lus hauv ntshav ntshav.
Lub ntsiab hloov pauv hauv lub cev tshwm sim nrog cov tshuaj feem ntau yog nyob hauv daim siab. Tus txheej txheem no raug teeb meem los ntawm qee yam isoenzymes, vim tias qhov chaw tshuaj lom neeg cov tshuaj tiv thaiv metabolites tau tsim, vim tias cov tshuaj tseem ceeb ntawm cov tshuaj pom tau hais - inhibition of HMG-CoA reductase. Ua tsaug rau lub sijhawm ntev ua ntawm metabolites, cov nyhuv ntawm cov tshuaj mob rau ib hnub.
Kev tshem tawm ntawm cov tshuaj yog nqa tawm los ntawm kev mob plab hnyuv. Ib nrab-lub neej ntawm cov tshuaj - lub sij hawm thaum lub sij hawm uas nws cov concentration nyob rau hauv cov ntshav yog halved - yog 14 teev. Ib nrab-lub neej ntawm kev ua hleb ntawm enzyme yog li ib hnub. Hauv chav kawm tshawb fawb tso zis, tsis pub ntau tshaj 2% ntawm qhov tshuaj tau txais ntawm cov tshuaj tuaj yeem raug kuaj pom. Nws yuav tsum tau yug los hauv lub siab tias Tulip tsis raug tawm thaum lub sijhawm hemodialysis vim yog txoj kev sib txuas zoo nrog cov plasma protein.
Hauv cov poj niam, qhov kev xav ntau tshaj tshaj uas nyob hauv txiv neej 20%, thiab qhov nqus nqus tau tsawg dua 10%.
Hauv cov neeg mob uas raug mob los ntawm kev mob ntshav siab vim yog haus dej cawv, qhov siab tshaj plaws yog 16 zaug siab dua, thiab tus nqi nqus yog 11 zaug siab dua li ib txwm.
Qhov siab tshaj plaws thiab kev nqus ntawm cov tshuaj tsawg dua los ntawm kwv yees li 40% hauv cov neeg laus dua li cov neeg hluas, tab sis cov neeg kawm ntawv qib qis hauv qib qis lipoprotein cholesterol tsis hloov pauv.
Qhov concentration ntawm cov tshuaj hauv cov ntshav thiab nws cov nyhuv ua kom zoo tsis cuam tshuam los ntawm lub raum kev ua haujlwm.
Kev qhia rau kev siv tshuaj
Cov tshuaj Tulip yog lub cim tshiab hauv kev kho mob ntawm ntau yam kab mob cuam tshuam nrog cov roj ntsha tsis txaus lipid. Tsom qee cov lus pom zoo rau kev muab tshuaj Tulip.
Yuav kom txo cov roj (cholesterol) tag nrho, cov roj lipoprotein tsawg, roj av apolipoprotein B, triglycerides, thiab cov roj lipoprotein ntau rau cov neeg mob uas muaj cov roj ntshav ntau ntau, cov roj ntsha heterozygous tsev neeg thiab tsis muaj tsev neeg hypercholesterolemia, nrog rau cov zaub mov noj kom txo qis cov roj (cholesterol).
Txog kev kho mob los ntawm kev sib xyaw ua ke hyperelipidemia ntawm hom thib ob raws li Frederickson yog tias kev noj haus thiab lwm txoj hauv kev kho tsis muaj yam ua rau xav tau.
Txhawm rau kom txo qis qhov ntau ntawm tag nrho thiab qis-lipoprotein-txuam cov roj cholesterol hauv cov neeg mob kev txom nyem los ntawm homozygous tsev neeg hypercholesterolemia thaum kev noj zaub mov noj thiab lwm txoj kev kho tau ua tsis tau zoo;
Txhawm rau tiv thaiv kev txhim kho ntawm cov teeb meem cuam tshuam nrog kev mob plawv hauv cov neeg mob tsis muaj kev soj ntsuam cov kab mob plawv, tab sis nyob rau ntawm qhov muaj qee yam kev pheej hmoo rau kev txhim kho xws li: kev laus, haus luam yeeb ntev, ntshav siab, ntshav qab zib mellitus nrog cov teeb meem, cov roj cholesterol siab lipoproteins ntom, cov kab mob muaj keeb.
Kev tiv thaiv ntawm kev txhim kho ntawm cov teeb meem cuam tshuam nrog cov hlab plawv cov ntshav hauv cov neeg mob kev mob plawv, kom txo qis cov neeg tuag, txo kev pheej hmoo ntawm lub plawv nres, mob hlab ntsha tawg, thiab tsev kho mob.
Txoj kev tiv thaiv kom tsis txhob siv tshuaj
Zoo li feem ntau cov tshuaj, Tulip muaj ib tug xov tooj ntawm contraindications.
Muaj cov contraindications uas twb muaj lawm yuav tsum raug coj los txiav txim thaum sau daim ntawv yuav tshuaj los ntawm tus kws kho mob.
Kev siv tus kheej nrog cov tshuaj no yog txwv tsis pub siv.
Cov Lus hauv qab no rau contraindications rau kev siv Tulip yog qhov txawv:
- cev xeeb tub thiab lub sijhawm pub mis;
- exacerbated mob siab daim siab;
- kev nce siab hauv kev ua haujlwm ntawm daim siab enzymes los ntawm ntau dua peb zaug hauv kev sib piv nrog cov kev cai nrog qhov kev paub tsis paub txog (vim li cas);
- muaj hnub nyoog yau, txij li cov nyhuv ntawm cov tshuaj rau ib tus kab mob ua lub cev tsis tshua nkag siab;
- lactase deficiency, cov tib neeg tsis haum rau cov kua mis qab zib, ib qho kev ua txhaum ntawm nws txoj kev zom thiab assimilation, vim tias lactose yog ib feem ntawm cov tshuaj;
- kev fab tshuaj tiv thaiv atorvastatin lossis lwm yam tshuaj ntawm cov tshuaj.
Qee qhov xwm txheej, kev siv tshuaj yeeb tshuaj yuav qee qhov txwv lossis yuav tsum tau ua nrog ceev faj. Cov no muaj xws li:
- Kev haus cawv mus ntev
- Cov kab mob ua rau lub siab thiab hlwb ua ke.
- Pathology ntawm cov leeg hlwb.
- Lub cev tsis txaus hluav taws xob tsis txaus.
- Kev ntshaib plab metabolic.
- Endocrine Kev Tsis Txaus Siab
- Cov ntshav siab qis.
- Yam 1 ntshav qab zib.
- Mob ntshav qab zib Hom 2.
- Septic kev puas tsuaj rau lub cev.
- Tswj tsis pub yuag yuag.
- Kev phais loj thiab raug mob.
Ceev faj yog yuav tsum tau thaum siv cov tshuaj nyob rau hauv lub xub ntiag ntawm txhua yam mob stroke hauv keeb kwm.
Cov lus qhia rau kev siv tshuaj
Feem ntau, cov tshuaj Tulip raug tshuaj los ntawm tus kws kho plawv. Tam sim ntawd ua ntej kev teem kho kev kho mob lipid, tus neeg mob yuav tsum hloov mus rau qhov noj zaub mov tshwj xeeb, uas pab txo qis roj thiab saib nws thoob plaws hauv kev kho mob.
Cov ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj, tsis hais noj mov dab tsi. Qhov siab tshaj plaws niaj hnub tsim nyog noj tshuaj yog 80 mg / hnub. Kev xaiv koob tshuaj yog nqa tawm ntawm txhua tus neeg mob. Feem ntau, noj Tulip pib nrog 10 mg / hnub. ib zaug.
Li thaj tsam ob mus rau plaub lub lis piam tom qab pib kev kho mob, nws yog ib qho tsim nyog yuav tsum ua qhov lipid profile los tswj cov theem ntawm lipids hauv cov ntshav. Yog tias cov txiaj ntsig tsis sib xws nrog kev kho, qhov koob tshuaj yuav tsum tau rov xaiv dua.
Hauv thawj qhov sib xyaw thiab hypercholesterolemia, Tulip feem ntau kho nyob rau hauv ib qho nyiaj ntawm 10 mg / hnub. ntawm ib mus. Yog tias tsim nyog, cov koob tshuaj tau raug tso cai kom maj mam nce mus rau 80 mg / hnub. nyob rau hauv kev tswj hwm ntawm kev ntsuas ntsuas.
Nrog homozygous kab mob siab hypercholesterolemia, cov tshuaj yog tshuaj ntawm 80 mg / hnub.
Rau kev tiv thaiv kab mob vascular thiab kab mob hauv lub plawv, koob tshuaj 10 mg / hnub Yog pom zoo. Hauv cov kis tshwj xeeb, txog 80 mg / hnub.
Rau cov neeg mob uas muaj lub raum tsis ua hauj lwm zoo, nrog rau cov neeg mob laus, qhov koob tsis tau xaiv ib tus zuj zus, tab sis yog raws li kev pom zoo.
Rau cov neeg mob uas muaj teeb meem mob siab, qhov koob tshuaj tseem nyob li qub, txawm li cas los xij kev kuaj mob lub siab.
Yog tias lawv nce ntau dua los ntawm peb zaug, qhov koob tshuaj yuav tsum raug txo lossis cov tshuaj yuav tsum tau lawb tawm.
Kev phiv tshuaj los ntawm cov tshuaj
Cov kev mob tshwm sim tuaj yeem tshwm sim hauv ntau hom los ntawm cov kab ke hauv nruab nrog cev.
Kev tiv thaiv kab mob - tus kheej tsis kam ua, anaphylactic kev hloov pauv.
Lub cev tsis muaj zog - mob taub hau, pw tsaug zog, npau suav phem, kiv taub hau, zoo nkaus li tsis muaj zog, txo qis tawm lossis saj ntawm qhov muag, qhov tsis hnov qab, tsis nco qab neuropathy.
Cov plab hnyuv siab hauv lub cev - lub suab nrov lossis lub suab nrov hauv lub pob ntseg, poob qis ntawm qhov muag pom, hnov lus tsis zoo.
Kev zom plab system - cem quav, ntau dhau hws, kem plab, xeev siab, ntuav, mob, mob plab, ua haujlwm hauv lub siab, ua rau lub siab ua haujlwm tsis ua haujlwm thiab hla ntawm cov kua tsib.
Musculoskeletal system - mob rau cov leeg thiab pob qij txha, lawv o, mob plab, mob nraub qaum, mob rau cov leeg thiab leeg mob ntawm cov leeg, myopathy.
Cov tawv nqaij thiab nqaij subcutaneous rog - tawv nqaij ua pob khaus, edema, khaus, urticaria, alopecia areata, erythema, Stevens-Johnson thiab Lyell syndromes.
Metabolism - nce ntxiv lossis txo ntshav qabzib hauv ntshav.
Cov kab mob ntshav hematopoietic yog ib qho kev txo qis hauv cov ntshav platelet.
Kab mob ua pa - mob ntawm pharynx thiab mob ntswg, mob caj pas, mob ntswg.
Cov ntsuas ntsuas yog qhov nce ntxiv hauv kev ua si ntawm creatine phosphokinase thiab daim siab enzymes.
Lwm qhov kev tshwm sim suav nrog kev qaug zog, ua tsis taus pa, kub ib ce, o ntawm cov nqaj, rog, kev loj hlob ntawm lub mis rau cov txiv neej, thiab ntshav qab zib mellitus.
Xws li cov analogues ntawm Tulip li Torvakard, Akorta, Atoris, Atorvastatin, Vasilip, Rosuvastatin muaj.
Cov tshuaj muaj peev xwm yuav tau nyob ntawm txhua lub tsev muag tshuaj nrog rau cov tshuaj uas kws kho mob tau sau ntawm tus nqi pheej yig - qhov nruab nrab kwv yees li 250 rubles. Kev tshuaj xyuas txog cov tshuaj feem ntau zoo.
Statins tau piav qhia hauv daim video hauv kab lus no.
